Deacetylation of Miro1 by HDAC6 blocks mitochondrial transport and mediates axon growth inhibition

HDAC6 is a therapeutic target in mutant GARS-induced Charcot-Marie-Tooth disease

(2018) Veronick Benoy et al.   BRAIN

MCU Interacts with Miro1 to Modulate Mitochondrial Functions in Neurons

(2018) Robert F. Niescier et al.   JOURNAL OF NEUROSCIENCE

Inhibition of histone deacetylase 6 (HDAC6) protects against vincristine-induced peripheral neuropathies and inhibits tumor growth

(2018) Lawrence Van Helleputte et al.   NEUROBIOLOGY OF DISEASE

Aberrant GlyRS-HDAC6 interaction linked to axonal transport deficits in Charcot-Marie-Tooth neuropathy

(2018) Zhongying Mo et al.   Nature Communications

Reaching the brain: Advances in optic nerve regeneration

(2017) Larry I. Benowitz et al.   EXPERIMENTAL NEUROLOGY

HDAC6 inhibition effectively reverses chemotherapy-induced peripheral neuropathy

(2017) Karen Krukowski et al.   PAIN

ROS regulation of axonal mitochondrial transport is mediated by Ca2+ and JNK in Drosophila

(2017) Pin-Chao Liao et al.   PLoS One

HDAC6 inhibition reverses axonal transport defects in motor neurons derived from FUS-ALS patients

(2017) Wenting Guo et al.   Nature Communications

A high mitochondrial transport rate characterizes CNS neurons with high axonal regeneration capacity

(2017) Romain Cartoni et al.   PLoS One

Progressive Decrease of Mitochondrial Motility during Maturation of Cortical Axons In Vitro and In Vivo

(2016) Tommy L. Lewis et al.   CURRENT BIOLOGY

Facilitation of axon regeneration by enhancing mitochondrial transport and rescuing energy deficits

(2016) Bing Zhou et al.   JOURNAL OF CELL BIOLOGY

In vivo imaging of axonal transport in murine motor and sensory neurons

(2016) Katherine L. Gibbs et al.   JOURNAL OF NEUROSCIENCE METHODS

The Mammalian-Specific Protein Armcx1 Regulates Mitochondrial Transport during Axon Regeneration

(2016) Romain Cartoni et al.   NEURON

Miro phosphorylation sites regulate Parkin recruitment and mitochondrial motility

(2016) Evgeny Shlevkov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

There's Something Wrong with my MAM; the ER–Mitochondria Axis and Neurodegenerative Diseases

(2016) Sebastien Paillusson et al.   TRENDS IN NEUROSCIENCES

Amyloid β oligomers elicit mitochondrial transport defects and fragmentation in a time-dependent and pathway-specific manner

(2016) Yanfang Rui et al.   Molecular Brain

EGF-induced sodium influx regulates EGFR trafficking through HDAC6 and tubulin acetylation

(2015) Seung Joon Lee et al.   BMC CELL BIOLOGY

Regulation of mitochondrial transport in neurons

(2015) Mei-Yao Lin et al.   EXPERIMENTAL CELL RESEARCH

Inhibition of Rho-kinase differentially affects axon regeneration of peripheral motor and sensory nerves

(2015) Abhijeet R. Joshi et al.   EXPERIMENTAL NEUROLOGY

Miro's N-Terminal GTPase Domain Is Required for Transport of Mitochondria into Axons and Dendrites

(2015) M. Babic et al.   JOURNAL OF NEUROSCIENCE

Histone acetylation inhibitors promote axon growth in adult dorsal root ganglia neurons

(2015) Shen Lin et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Mitochondrial dynamics and inherited peripheral nerve diseases

(2015) Davide Pareyson et al.   NEUROSCIENCE LETTERS

Systemic administration of epothilone B promotes axon regeneration after spinal cord injury

(2015) J. Ruschel et al.   SCIENCE

Intramuscular Injections Along the Motor End Plates: A Minimally Invasive Approach to Shuttle Tracers Directly into Motor Neurons

(2015) Rahul Mohan et al.   Jove-Journal of Visualized Experiments

Lysine 27 Ubiquitination of the Mitochondrial Transport Protein Miro Is Dependent on Serine 65 of the Parkin Ubiquitin Ligase

(2014) Nicol Birsa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chromophore-assisted laser inactivation - towards a spatiotemporal-functional analysis of proteins, and the ablation of chromatin, organelle and cell function

(2014) Y. Sano et al.   JOURNAL OF CELL SCIENCE

The myriad roles of Miro in the nervous system: axonal transport of mitochondria and beyond

(2014) Kyu-Sun Lee et al.   Frontiers in Cellular Neuroscience

Phosphorylation of Parkin at Serine65 is essential for activation: elaboration of a Miro1 substrate-based assay of Parkin E3 ligase activity

(2014) A. Kazlauskaite et al.   Open Biology

Axon growth inhibition by RhoA/ROCK in the central nervous system

(2014) Yuki Fujita et al.   Frontiers in Neuroscience

TRAK/Milton Motor-Adaptor Proteins Steer Mitochondrial Trafficking to Axons and Dendrites

(2013) Myrrhe van Spronsen et al.   NEURON

Mitochondria Coordinate Sites of Axon Branching through Localized Intra-axonal Protein Synthesis

(2013) Mirela Spillane et al.   Cell Reports

WIS-neuromath enables versatile high throughput analyses of neuronal processes

(2012) Ida Rishal et al.   Developmental Neurobiology

The axonal transport of mitochondria

(2012) W. M. Saxton et al.   JOURNAL OF CELL SCIENCE

Deleterious effects of mitochondrial ROS generated by KillerRed photodynamic action in human cell lines and C. elegans

(2012) Toshiharu Shibuya et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Proteomic Analyses Reveal Divergent Ubiquitylation Site Patterns in Murine Tissues

(2012) Sebastian A. Wagner et al.   MOLECULAR & CELLULAR PROTEOMICS

HDAC6 Inhibitor Blocks Amyloid Beta-Induced Impairment of Mitochondrial Transport in Hippocampal Neurons

(2012) Chaeyoung Kim et al.   PLoS One

Proteomic Analysis of Lysine Acetylation Sites in Rat Tissues Reveals Organ Specificity and Subcellular Patterns

(2012) Alicia Lundby et al.   Cell Reports

HDAC6 inhibitors reverse axonal loss in a mouse model of mutant HSPB1–induced Charcot-Marie-Tooth disease

(2011) Constantin d'Ydewalle et al.   NATURE MEDICINE

Mitochondrial matrix Ca2+ as an intrinsic signal regulating mitochondrial motility in axons

(2011) K. T. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microtubule Stabilization Reduces Scarring and Causes Axon Regeneration After Spinal Cord Injury

(2011) F. Hellal et al.   SCIENCE

Difference Tracker: ImageJ plugins for fully automated analysis of multiple axonal transport parameters

(2010) Simon Andrews et al.   JOURNAL OF NEUROSCIENCE METHODS

Rational Design and Simple Chemistry Yield a Superior, Neuroprotective HDAC6 Inhibitor, Tubastatin A

(2010) Kyle V. Butler et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

HDAC6 Regulates Mitochondrial Transport in Hippocampal Neurons

(2010) Sigeng Chen et al.   PLoS One

Rho-Associated Kinase II (ROCKII) Limits Axonal Growth after Trauma within the Adult Mouse Spinal Cord

(2009) P. Duffy et al.   JOURNAL OF NEUROSCIENCE

HDAC6 is a target for protection and regeneration following injury in the nervous system

(2009) M. A. Rivieccio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

(2009) C. Choudhary et al.   SCIENCE

Mice Lacking Histone Deacetylase 6 Have Hyperacetylated Tubulin but Are Viable and Develop Normally

(2008) Y. Zhang et al.   MOLECULAR AND CELLULAR BIOLOGY

A functional equivalent of endoplasmic reticulum and Golgi in axons for secretion of locally synthesized proteins

(2008) Tanuja T. Merianda et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Co-operative Versus Independent Transport of Different Cargoes by Kinesin-1

(2008) Jennetta W. Hammond et al.   TRAFFIC