Emerging Evidence of Translational Control by AU-Rich Element-Binding Proteins

The AU-rich element landscape across human transcriptome reveals a large proportion in introns and regulation by ELAVL1/HuR

(2018) Tala Bakheet et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Stress Granule Assembly Disrupts Nucleocytoplasmic Transport

(2018) Ke Zhang et al.   CELL

Chromatin Modification and Global Transcriptional Silencing in the Oocyte Mediated by the mRNA Decay Activator ZFP36L2

(2018) Jennifer N. Dumdie et al.   DEVELOPMENTAL CELL

Tryptophan-Mediated Interactions between Tristetraprolin and the CNOT9 Subunit Are Required for CCR4-NOT Deadenylase Complex Recruitment

(2018) D. Bulbrook et al.   JOURNAL OF MOLECULAR BIOLOGY

RNA-binding proteins control gene expression and cell fate in the immune system

(2018) Martin Turner et al.   NATURE IMMUNOLOGY

Long noncoding RNA OCC-1 suppresses cell growth through destabilizing HuR protein in colorectal cancer

(2018) Yang Lan et al.   NUCLEIC ACIDS RESEARCH

GAPDH as a model non-canonical AU-rich RNA binding protein

(2018) Elsa D. Garcin   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

TDP-43 enhances translation of specific mRNAs linked to neurodegenerative disease

(2018) Nagammal Neelagandan et al.   NUCLEIC ACIDS RESEARCH

TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics

(2017) Ian R. Mackenzie et al.   NEURON

Impact of RNA structure on ZFP36L2 interaction with luteinizing hormone receptor mRNA

(2017) Christopher B. Ball et al.   RNA

Post-transcriptional Inhibition of Hsc70-4/HSPA8 Expression Leads to Synaptic Vesicle Cycling Defects in Multiple Models of ALS

(2017) Alyssa N. Coyne et al.   Cell Reports

Neuronal ELAVL proteins utilize AUF-1 as a co-partner to induce neuron-specific alternative splicing of APP

(2017) Apostolia Fragkouli et al.   Scientific Reports

Co-regulation of mRNA translation by TDP-43 and Fragile X Syndrome protein FMRP

(2016) Pritha Majumder et al.   ACTA NEUROPATHOLOGICA

The RNA-Binding Proteins Zfp36l1 and Zfp36l2 Enforce the Thymic β-Selection Checkpoint by Limiting DNA Damage Response Signaling and Cell Cycle Progression

(2016) Katharina U. Vogel et al.   JOURNAL OF IMMUNOLOGY

The cAMP pathway regulates mRNA decay through phosphorylation of the RNA-binding protein TIS11b/BRF1

(2016) Felicitas Rataj et al.   MOLECULAR BIOLOGY OF THE CELL

The expanding universe of ribonucleoproteins: of novel RNA-binding proteins and unconventional interactions

(2016) Benedikt M. Beckmann et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Recruitment of the 4EHP-GYF2 cap-binding complex to tetraproline motifs of tristetraprolin promotes repression and degradation of mRNAs with AU-rich elements

(2016) Rui Fu et al.   RNA

Arginine methylation enhances the RNA chaperone activity of the West Nile virus host factor AUF1 p45

(2016) Susann Friedrich et al.   RNA

RNA-binding proteins ZFP36L1 and ZFP36L2 promote cell quiescence

(2016) A. Galloway et al.   SCIENCE

Hallmarks of cancer and AU-rich elements

(2016) Khalid S. A. Khabar   Wiley Interdisciplinary Reviews-RNA

KH–RNA interactions: back in the groove

(2015) Giuseppe Nicastro et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

IRE mRNA riboregulators use metabolic iron (Fe2+) to control mRNA activity and iron chemistry in animals

(2015) Elizabeth C. Theil   Metallomics

Tristetraprolin Recruits Eukaryotic Initiation Factor 4E2 To Repress Translation of AU-Rich Element-Containing mRNAs

(2015) Xianzun Tao et al.   MOLECULAR AND CELLULAR BIOLOGY

AREsite2: an enhanced database for the comprehensive investigation of AU/GU/U-rich elements

(2015) Jörg Fallmann et al.   NUCLEIC ACIDS RESEARCH

Metabolic Enzymes Enjoying New Partnerships as RNA-Binding Proteins

(2015) Alfredo Castello et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The RNA-binding proteomes from yeast to man harbour conserved enigmRBPs

(2015) Benedikt M. Beckmann et al.   Nature Communications

ZFP36L1 promotes monocyte/macrophage differentiation by repressing CDK6

(2015) Ming-Tai Chen et al.   Scientific Reports

Futsch/MAP1B mRNA Is a Translational Target of TDP-43 and Is Neuroprotective in a Drosophila Model of Amyotrophic Lateral Sclerosis

(2014) A. N. Coyne et al.   JOURNAL OF NEUROSCIENCE

AUF1 p45 Promotes West Nile Virus Replication by an RNA Chaperone Activity That Supports Cyclization of the Viral Genome

(2014) S. Friedrich et al.   JOURNAL OF VIROLOGY

MicroRNAs Trigger Dissociation of eIF4AI and eIF4AII from Target mRNAs in Humans

(2014) Akira Fukao et al.   MOLECULAR CELL

Temporally defined neocortical translation and polysome assembly are determined by the RNA-binding protein Hu antigen R

(2014) M. L. Kraushar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

H19 long noncoding RNA controls the mRNA decay promoting function of KSRP

(2014) Matteo Giovarelli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HuD Regulates Coding and Noncoding RNA to Induce APP→Aβ Processing

(2014) Min-Ju Kang et al.   Cell Reports

Emerging mechanisms of mRNP remodeling regulation

(2014) Chyi-Ying A. Chen et al.   Wiley Interdisciplinary Reviews-RNA

Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis

(2013) Chih-Hao Chang et al.   CELL

Peptides modeled on the RGG domain of AUF1/hnRNP-D regulate 3′ UTR-dependent gene expression

(2013) Abigail Fellows et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Stress granules as crucibles of ALS pathogenesis

(2013) Yun R. Li et al.   JOURNAL OF CELL BIOLOGY

Structural basis for the recruitment of the human CCR4–NOT deadenylase complex by tristetraprolin

(2013) Marc R Fabian et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Specificity factors in cytoplasmic polyadenylation

(2013) Amanda Charlesworth et al.   Wiley Interdisciplinary Reviews-RNA

TDP-43 regulates the mammalian spinogenesis through translational repression of Rac1

(2012) Pritha Majumder et al.   ACTA NEUROPATHOLOGICA

Glyceraldehyde-3-phosphate dehydrogenase regulates cyclooxygenase-2 expression by targeting mRNA stability

(2012) Yuki Ikeda et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins

(2012) Alfredo Castello et al.   CELL

RGG motif proteins: Modulators of mRNA functional states

(2012) Purusharth Rajyaguru et al.   CELL CYCLE

Protein kinase C stimulates HuD-mediated mRNA stability and protein expression of neurotrophic factors and enhances dendritic maturation of hippocampal neurons in culture

(2012) Chol Seung Lim et al.   HIPPOCAMPUS

A novel function for the survival motoneuron protein as a translational regulator

(2012) Gabriel Sanchez et al.   HUMAN MOLECULAR GENETICS

Characterization of ΔN-Zfp36l2Mutant Associated with Arrest of Early Embryonic Development and Female Infertility

(2012) Silvia B. V. Ramos   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel 4EHP-GIGYF2 Translational Repressor Complex Is Essential for Mammalian Development

(2012) M. Morita et al.   MOLECULAR AND CELLULAR BIOLOGY

The Survival of Motor Neuron (SMN) Protein Interacts with the mRNA-Binding Protein HuD and Regulates Localization of Poly(A) mRNA in Primary Motor Neuron Axons

(2011) C. Fallini et al.   JOURNAL OF NEUROSCIENCE

A novel function of Tis11b/BRF1 as a regulator of Dll4 mRNA 3′-end processing

(2011) Agnès Desroches-Castan et al.   MOLECULAR BIOLOGY OF THE CELL

Neuron-specific ELAV/Hu proteins suppress HuR mRNA during neuronal differentiation by alternative polyadenylation

(2011) Kyle D. Mansfield et al.   NUCLEIC ACIDS RESEARCH

Functional and direct interaction between the RNA binding protein HuD and active Akt1

(2011) Toshinobu Fujiwara et al.   NUCLEIC ACIDS RESEARCH

Interaction of survival of motor neuron (SMN) and HuD proteins with mRNA cpg15 rescues motor neuron axonal deficits

(2011) B. Akten et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HuD interacts with survival motor neuron protein and can rescue spinal muscular atrophy-like neuronal defects

(2010) Lisa Hubers et al.   HUMAN MOLECULAR GENETICS

MAPKAP Kinase 2 Blocks Tristetraprolin-directed mRNA Decay by Inhibiting CAF1 Deadenylase Recruitment

(2010) Francesco P. Marchese et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deletion of the RNA-binding proteins ZFP36L1 and ZFP36L2 leads to perturbed thymic development and T lymphoblastic leukemia

(2010) Daniel J Hodson et al.   NATURE IMMUNOLOGY

Sirtuin 1 regulation of developmental genes during differentiation of stem cells

(2010) V. Calvanese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The roles of TTP and BRF proteins in regulated mRNA decay

(2010) Sandhya Sanduja et al.   Wiley Interdisciplinary Reviews-RNA

LPS induces KH-type splicing regulatory protein-dependent processing of microRNA-155 precursors in macrophages

(2009) Tina Ruggiero et al.   FASEB JOURNAL

The ELAV Protein HuD Stimulates Cap-Dependent Translation in a Poly(A)- and eIF4A-Dependent Manner

(2009) Akira Fukao et al.   MOLECULAR CELL

The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs

(2009) Michele Trabucchi et al.   NATURE

Spinal muscular atrophy: why do low levels of survival motor neuron protein make motor neurons sick?

(2009) Arthur H. M. Burghes et al.   NATURE REVIEWS NEUROSCIENCE

Phosphorylation-mediated unfolding of a KH domain regulates KSRP localization via 14-3-3 binding

(2009) Irene Díaz-Moreno et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Alternative polyadenylation variants of the RNA binding protein, HuR: abundance, role of AU-rich elements and auto-Regulation

(2009) Wijdan Al-Ahmadi et al.   NUCLEIC ACIDS RESEARCH

A Combinatorial Code for CPE-Mediated Translational Control

(2008) Maria Piqué et al.   CELL

RNA recognition motifs: boring? Not quite

(2008) Antoine Cléry et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Glyceraldehyde-3-Phosphate Dehydrogenase Regulates Endothelin-1 Expression by a Novel, Redox-Sensitive Mechanism Involving mRNA Stability

(2008) F. Rodriguez-Pascual et al.   MOLECULAR AND CELLULAR BIOLOGY

Chaperone Hsp27, a Novel Subunit of AUF1 Protein Complexes, Functions in AU-Rich Element-Mediated mRNA Decay

(2008) K. S. Sinsimer et al.   MOLECULAR AND CELLULAR BIOLOGY

The Multifunctional Protein Glyceraldehyde-3-Phosphate Dehydrogenase Is Both Regulated and Controls Colony-Stimulating Factor-1 Messenger RNA Stability in Ovarian Cancer

(2008) Y. Zhou et al.   MOLECULAR CANCER RESEARCH

Far upstream element binding protein 2 interacts with enterovirus 71 internal ribosomal entry site and negatively regulates viral translation

(2008) Jing-Yi Lin et al.   NUCLEIC ACIDS RESEARCH

AGC kinases regulate phosphorylation and activation of eukaryotic translation initiation factor 4B

(2008) A G M van Gorp et al.   ONCOGENE