Expanding Axonal Transcriptome Brings New Functions for Axonally Synthesized Proteins in Health and Disease

FUS inclusions disrupt RNA localization by sequestering kinesin-1 and inhibiting microtubule detyrosination

(2017) Kyota Yasuda et al.   JOURNAL OF CELL BIOLOGY

Differential roles of α-, β-, and γ-actin in axon growth and collateral branch formation in motoneurons

(2017) Mehri Moradi et al.   JOURNAL OF CELL BIOLOGY

Non-nuclear Pool of Splicing Factor SFPQ Regulates Axonal Transcripts Required for Normal Motor Development

(2017) Swapna Thomas-Jinu et al.   NEURON

A new cis -acting motif is required for the axonal SMN-dependent Anxa2 mRNA localization

(2017) Khalil Rihan et al.   RNA

ALS Along the Axons – Expression of Coding and Noncoding RNA Differs in Axons of ALS models

(2017) Nimrod Rotem et al.   Scientific Reports

Messenger RNAs localized to distal projections of human stem cell derived neurons

(2017) Rebecca L. Bigler et al.   Scientific Reports

Mislocated FUS is sufficient for gain-of-toxic-function amyotrophic lateral sclerosis phenotypes in mice

(2016) Gen Shiihashi et al.   BRAIN

Dynamic Axonal Translation in Developing and Mature Visual Circuits

(2016) Toshiaki Shigeoka et al.   CELL

Toxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss

(2016) Jelena Scekic‐Zahirovic et al.   EMBO JOURNAL

Protein synthetic machinery and mRNA in regenerating tips of spinal cord axons in lamprey

(2016) Li-Qing Jin et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Deficiency of the Survival of Motor Neuron Protein Impairs mRNA Localization and Local Translation in the Growth Cone of Motor Neurons

(2016) Claudia Fallini et al.   JOURNAL OF NEUROSCIENCE

Distal Alternative Last Exons Localize mRNAs to Neural Projections

(2016) J. Matthew Taliaferro et al.   MOLECULAR CELL

Analysis of piRNA-Like Small Non-coding RNAs Present in Axons of Adult Sensory Neurons

(2016) Monichan Phay et al.   MOLECULAR NEUROBIOLOGY

The RNA-binding protein SFPQ orchestrates an RNA regulon to promote axon viability

(2016) Katharina E Cosker et al.   NATURE NEUROSCIENCE

The local expression and trafficking of tyrosine hydroxylase mRNA in the axons of sympathetic neurons

(2016) Noreen M. Gervasi et al.   RNA

Two Modes of the Axonal Interferon Response Limit Alphaherpesvirus Neuroinvasion

(2016) Ren Song et al.   mBio

Local synthesis of dynein cofactors matches retrograde transport to acutely changing demands

(2016) Joseph M. Villarin et al.   Nature Communications

Nucleolin-Mediated RNA Localization Regulates Neuron Growth and Cycling Cell Size

(2016) Rotem Ben-Tov Perry et al.   Cell Reports

Dynamic Changes in Local Protein Synthetic Machinery in Regenerating Central Nervous System Axons after Spinal Cord Injury

(2016) Rahul Sachdeva et al.   NEURAL PLASTICITY

Axonal PPARγ promotes neuronal regeneration after injury

(2015) Juan Pablo Lezana et al.   Developmental Neurobiology

Glutamate Stimulates Local Protein Synthesis in the Axons of Rat Cortical Neurons by Activating α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors and Metabotropic Glutamate Receptors

(2015) Wei-Lun Hsu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of precursor microRNAs within distal axons of sensory neuron

(2015) Hak Hee Kim et al.   JOURNAL OF NEUROCHEMISTRY

Axonal Amphoterin mRNA Is Regulated by Translational Control and Enhances Axon Outgrowth

(2015) T. T. Merianda et al.   JOURNAL OF NEUROSCIENCE

mRNAs and Protein Synthetic Machinery Localize into Regenerating Spinal Cord Axons When They Are Provided a Substrate That Supports Growth

(2015) A. L. Kalinski et al.   JOURNAL OF NEUROSCIENCE

The C9orf72 repeat expansion disrupts nucleocytoplasmic transport

(2015) Ke Zhang et al.   NATURE

Mitochondrial dynamics and inherited peripheral nerve diseases

(2015) Davide Pareyson et al.   NEUROSCIENCE LETTERS

Whole transcriptome profiling reveals the RNA content of motor axons

(2015) Michael Briese et al.   NUCLEIC ACIDS RESEARCH

ALS-causative mutations in FUS/TLS confer gain and loss of function by altered association with SMN and U1-snRNP

(2015) Shuying Sun et al.   Nature Communications

Dynamic Change and Target Prediction of Axon-Specific MicroRNAs in Regenerating Sciatic Nerve

(2015) Monichan Phay et al.   PLoS One

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

Axonally Synthesized ATF4 Transmits a Neurodegenerative Signal across Brain Regions

(2014) Jimena Baleriola et al.   CELL

APC Is an RNA-Binding Protein, and Its Interactome Provides a Link to Neural Development and Microtubule Assembly

(2014) Nicolas Preitner et al.   CELL

Regulation of mRNA transport, localization and translation in the nervous system of mammals (Review)

(2014) CARLO MARIA DI LIEGRO et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

(278) Mechanisms of dysfunctional mitochondria evoked pain

(2014) O. Melemedjian et al.   JOURNAL OF PAIN

C9orf72 nucleotide repeat structures initiate molecular cascades of disease

(2014) Aaron R. Haeusler et al.   NATURE

Axonal Transport of TDP-43 mRNA Granules Is Impaired by ALS-Causing Mutations

(2014) Nael H. Alami et al.   NEURON

Targeting Axonal Protein Synthesis in Neuroregeneration and Degeneration

(2014) Jimena Baleriola et al.   Neurotherapeutics

Presynaptic Localization of Smn and hnRNP R in Axon Terminals of Embryonic and Postnatal Mouse Motoneurons

(2014) Benjamin Dombert et al.   PLoS One

Subcellular transcriptome alterations in a cell culture model of spinal muscular atrophy point to widespread defects in axonal growth and presynaptic differentiation

(2014) Lena Saal et al.   RNA

Efficient Retrograde Transport of Pseudorabies Virus within Neurons Requires Local Protein Synthesis in Axons

(2013) Orkide O. Koyuncu et al.   Cell Host & Microbe

Local translation in neuronal processes-in vivotests of a “heretical hypothesis”

(2013) Rotem B. Perry et al.   Developmental Neurobiology

Identification of axon-enriched MicroRNAs localized to growth cones of cortical neurons

(2013) Yukio Sasaki et al.   Developmental Neurobiology

Subcellular transcriptomics-Dissection of the mRNA composition in the axonal compartment of sensory neurons

(2013) Adi Minis et al.   Developmental Neurobiology

The RNA-binding protein Fus directs translation of localized mRNAs in APC-RNP granules

(2013) Kyota Yasuda et al.   JOURNAL OF CELL BIOLOGY

A HuD-ZBP1 ribonucleoprotein complex localizes GAP-43 mRNA into axons through its 3′ untranslated region AU-rich regulatory element

(2013) Soonmoon Yoo et al.   JOURNAL OF NEUROCHEMISTRY

Axonal Localization of Neuritin/CPG15 mRNA in Neuronal Populations through Distinct 5' and 3' UTR Elements

(2013) T. T. Merianda et al.   JOURNAL OF NEUROSCIENCE

Axonal Translation of  -Catenin Regulates Synaptic Vesicle Dynamics

(2013) A. M. Taylor et al.   JOURNAL OF NEUROSCIENCE

Intra-axonal Synthesis of Eukaryotic Translation Initiation Factors Regulates Local Protein Synthesis and Axon Growth in Rat Sympathetic Neurons

(2013) A. N. Kar et al.   JOURNAL OF NEUROSCIENCE

Axonally Synthesized  -Actin and GAP-43 Proteins Support Distinct Modes of Axonal Growth

(2013) C. J. Donnelly et al.   JOURNAL OF NEUROSCIENCE

Target-Derived Neurotrophins Coordinate Transcription and Transport of Bclw to Prevent Axonal Degeneration

(2013) K. E. Cosker et al.   JOURNAL OF NEUROSCIENCE

Axonal transport deficits and neurodegenerative diseases

(2013) Stéphanie Millecamps et al.   NATURE REVIEWS NEUROSCIENCE

RNA Toxicity from the ALS/FTD C9ORF72 Expansion Is Mitigated by Antisense Intervention

(2013) Christopher J. Donnelly et al.   NEURON

mTORC1 inhibition induces pain via IRS-1-dependent feedback activation of ERK

(2013) Ohannes K. Melemedjian et al.   PAIN

KSRP Modulation of GAP-43 mRNA Stability Restricts Axonal Outgrowth in Embryonic Hippocampal Neurons

(2013) Clark W. Bird et al.   PLoS One

Genome-wide identification of mRNAs associated with the protein SMN whose depletion decreases their axonal localization

(2013) F. Rage et al.   RNA

Mitochondria Coordinate Sites of Axon Branching through Localized Intra-axonal Protein Synthesis

(2013) Mirela Spillane et al.   Cell Reports

Local Translation of Extranuclear Lamin B Promotes Axon Maintenance

(2012) Byung C. Yoon et al.   CELL

Axonal transcription factors signal retrogradely in lesioned peripheral nerve

(2012) Keren Ben-Yaakov et al.   EMBO JOURNAL

The ALS disease protein TDP-43 is actively transported in motor neuron axons and regulates axon outgrowth

(2012) Claudia Fallini et al.   HUMAN MOLECULAR GENETICS

Axonal transport of neural membrane protein 35 mRNA increases axon growth

(2012) Tanuja T. Merianda et al.   JOURNAL OF CELL SCIENCE

Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study

(2012) Elisa Majounie et al.   LANCET NEUROLOGY

New competition in RNA regulation

(2012) Anastasia Khvorova et al.   NATURE BIOTECHNOLOGY

Single-molecule assays reveal that RNA localization signals regulate dynein–dynactin copy number on individual transcript cargoes

(2012) Mamta Amrute-Nayak et al.   NATURE CELL BIOLOGY

Axonal mRNA localization and local protein synthesis in nervous system assembly, maintenance and repair

(2012) Hosung Jung et al.   NATURE REVIEWS NEUROSCIENCE

Subcellular Knockout of Importin β1 Perturbs Axonal Retrograde Signaling

(2012) Rotem Ben-Tov Perry et al.   NEURON

Identification of a cis-acting element that localizes mRNA to synapses

(2012) E. J. Meer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Growth Cone MKK7 mRNA Targeting Regulates MAP1b-Dependent Microtubule Bundling to Control Neurite Elongation

(2012) Daniel Feltrin et al.   PLOS BIOLOGY

Five Questions about Viral Trafficking in Neurons

(2012) L. W. Enquist   PLoS Pathogens

The actin nucleating Arp2/3 complex contributes to the formation of axonal filopodia and branches through the regulation of actin patch precursors to filopodia

(2011) Mirela Spillane et al.   Developmental Neurobiology

Limited availability of ZBP1 restricts axonal mRNA localization and nerve regeneration capacity

(2011) Christopher J Donnelly et al.   EMBO JOURNAL

Independent localization of MAP2, CaMKIIα and β-actin RNAs in low copy numbers

(2011) Martin Mikl et al.   EMBO REPORTS

The Survival of Motor Neuron (SMN) Protein Interacts with the mRNA-Binding Protein HuD and Regulates Localization of Poly(A) mRNA in Primary Motor Neuron Axons

(2011) C. Fallini et al.   JOURNAL OF NEUROSCIENCE

Local translation of ATP synthase subunit 9 mRNA alters ATP levels and the production of ROS in the axon

(2011) Orlangie Natera-Naranjo et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Targeting Adenosine Monophosphate-Activated Protein Kinase (AMPK) in Preclinical Models Reveals a Potential Mechanism for the Treatment of Neuropathic Pain

(2011) Ohannes K Melemedjian et al.   Molecular Pain

Patterns of pain: Meta-analysis of microarray studies of pain

(2011) Michael L. LaCroix-Fralish et al.   PAIN

Interaction of survival of motor neuron (SMN) and HuD proteins with mRNA cpg15 rescues motor neuron axonal deficits

(2011) B. Akten et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ZBP1 recognition of  -actin zipcode induces RNA looping

(2010) J. A. Chao et al.   GENES & DEVELOPMENT

The heterogeneous nuclear ribonucleoprotein-R is necessary for axonal β-actin mRNA translocation in spinal motor neurons

(2010) Michael Glinka et al.   HUMAN MOLECULAR GENETICS

Conserved 3′-Untranslated Region Sequences Direct Subcellular Localization of Chaperone Protein mRNAs in Neurons

(2010) Deepika Vuppalanchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Altered Intracellular Ca2+ Homeostasis in Nerve Terminals of Severe Spinal Muscular Atrophy Mice

(2010) R. Ruiz et al.   JOURNAL OF NEUROSCIENCE

Subcellular Profiling Reveals Distinct and Developmentally Regulated Repertoire of Growth Cone mRNAs

(2010) K. H. Zivraj et al.   JOURNAL OF NEUROSCIENCE

IL-6- and NGF-Induced Rapid Control of Protein Synthesis and Nociceptive Plasticity via Convergent Signaling to the eIF4F Complex

(2010) O. K. Melemedjian et al.   JOURNAL OF NEUROSCIENCE

Regulation of axonal trafficking of cytochrome c oxidase IV mRNA

(2010) Armaz Aschrafi et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

An NGF-responsive element targets myo-inositol monophosphatase-1 mRNA to sympathetic neuron axons

(2010) Catia Andreassi et al.   NATURE NEUROSCIENCE

Identification and quantitative analyses of microRNAs located in the distal axons of sympathetic neurons

(2010) O. Natera-Naranjo et al.   RNA

Transcriptome analysis of embryonic and adult sensory axons reveals changes in mRNA repertoire localization

(2010) L. F. Gumy et al.   RNA

Predicting in vivo binding sites of RNA-binding proteins using mRNA secondary structure

(2010) X. Li et al.   RNA

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Rethinking ALS: The FUS about TDP-43

(2009) Clotilde Lagier-Tourenne et al.   CELL

RhoA/ROCK1 signaling regulates stress granule formation and apoptosis

(2009) Nien-Pei Tsai et al.   CELLULAR SIGNALLING

TDP-43 Is Intrinsically Aggregation-prone, and Amyotrophic Lateral Sclerosis-linked Mutations Accelerate Aggregation and Increase Toxicity

(2009) Brian S. Johnson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Reporter of Local Dendritic Translocation Shows Plaque- Related Loss of Neural System Function in APP-Transgenic Mice

(2009) M. Meyer-Luehmann et al.   JOURNAL OF NEUROSCIENCE

Impaired Synaptic Vesicle Release and Immaturity of Neuromuscular Junctions in Spinal Muscular Atrophy Mice

(2009) L. Kong et al.   JOURNAL OF NEUROSCIENCE

Axonal mRNA in Uninjured and Regenerating Cortical Mammalian Axons

(2009) A. M. Taylor et al.   JOURNAL OF NEUROSCIENCE

Dynein motor contributes to stress granule dynamics in primary neurons

(2009) N.-P. Tsai et al.   NEUROSCIENCE

Novel recognition motifs and biological functions of the RNA-binding protein HuD revealed by genome-wide identification of its targets

(2009) Federico Bolognani et al.   NUCLEIC ACIDS RESEARCH

Synapse- and Stimulus-Specific Local Translation During Long-Term Neuronal Plasticity

(2009) D. O. Wang et al.   SCIENCE

Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6

(2009) C. Vance et al.   SCIENCE

Mutations in the FUS/TLS Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis

(2009) T. J. Kwiatkowski et al.   SCIENCE

Fragile X Mental Retardation Protein is involved in protein synthesis-dependent collapse of growth cones induced by Semaphorin-3A

(2009) Chanxia Li   Frontiers in Neural Circuits

Distinct Role of Long 3′ UTR BDNF mRNA in Spine Morphology and Synaptic Plasticity in Hippocampal Neurons

(2008) Juan Ji An et al.   CELL

MicroRNA-338 Regulates Local Cytochrome c Oxidase IV mRNA Levels and Oxidative Phosphorylation in the Axons of Sympathetic Neurons

(2008) A. Aschrafi et al.   JOURNAL OF NEUROSCIENCE

Genome-wide screen reveals APC-associated RNAs enriched in cell protrusions

(2008) Stavroula Mili et al.   NATURE

Intra-axonal translation and retrograde trafficking of CREB promotes neuronal survival

(2008) Llewellyn J. Cox et al.   NATURE CELL BIOLOGY

Localized Regulation of Axonal RanGTPase Controls Retrograde Injury Signaling in Peripheral Nerve

(2008) Dmitry Yudin et al.   NEURON

Local Translation in Primary Afferent Fibers Regulates Nociception

(2008) Lydia Jiménez-Díaz et al.   PLoS One

TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis

(2008) J. Sreedharan et al.   SCIENCE