Structure of mycobacterial ATP synthase bound to the tuberculosis drug bedaquiline

Cryo-EM structures provide insight into how E. coli F1Fo ATP synthase accommodates symmetry mismatch

(2020) Meghna Sobti et al.   Nature Communications

Structural comparison of the vacuolar and Golgi V-ATPases from Saccharomyces cerevisiae

(2019) Thamiya Vasanthakumar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The structure of the catalytic domain of the ATP synthase fromMycobacterium smegmatisis a target for developing antitubercular drugs

(2019) Alice Tianbu Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

3,5-Dialkoxypyridine analogues of bedaquiline are potent antituberculosis agents with minimal inhibition of the hERG channel

(2019) Hamish S. Sutherland et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Ionophoric effects of the antitubercular drug bedaquiline

(2018) Kiel Hards et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure, mechanism, and regulation of the chloroplast ATP synthase

(2018) Alexander Hahn et al.   SCIENCE

ISOLDE: a physically realistic environment for model building into low-resolution electron-density maps

(2018) Tristan Ian Croll   Acta Crystallographica Section D-Structural Biology

ORBIT: a New Paradigm for Genetic Engineering of Mycobacterial Chromosomes

(2018) Kenan C. Murphy et al.   mBio

A Bayesian approach to beam-induced motion correction in cryo-EM single-particle analysis

(2018) Jasenko Zivanov et al.   IUCrJ

The uniqueness of subunit α of mycobacterial F-ATP synthases: An evolutionary variant for niche adaptation

(2017) Priya Ragunathan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

(2017) Ali Punjani et al.   NATURE METHODS

UCSF ChimeraX: Meeting modern challenges in visualization and analysis

(2017) Thomas D. Goddard et al.   PROTEIN SCIENCE

Atomic model for the dimeric FOregion of mitochondrial ATP synthase

(2017) Hui Guo et al.   SCIENCE

Bedaquiline Targets the ε Subunit of Mycobacterial F-ATP Synthase

(2016) Subhashri Kundu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Cryo-EM structures of the autoinhibited E. coli ATP synthase in three rotational states

(2016) Meghna Sobti et al.   eLife

Structure of a thermophilic F1-ATPase inhibited by an ε-subunit: deeper insight into the ε-inhibition mechanism

(2015) Yasuo Shirakihara et al.   FEBS Journal

Electron cryomicroscopy observation of rotational states in a eukaryotic V-ATPase

(2015) Jianhua Zhao et al.   NATURE

EMRinger: side chain–directed model and map validation for 3D cryo-electron microscopy

(2015) Benjamin A Barad et al.   NATURE METHODS

Structure of the mycobacterial ATP synthase Fo rotor ring in complex with the anti-TB drug bedaquiline

(2015) L. Preiss et al.   Science Advances

ATP synthase in mycobacteria: Special features and implications for a function as drug target

(2014) Ping Lu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Ultrastable gold substrates for electron cryomicroscopy

(2014) C. J. Russo et al.   SCIENCE

Escherichia coliF1Fo-ATP Synthase with a b/δ Fusion Protein Allows Analysis of the Function of the Individual b Subunits

(2013) Chathurada S. Gajadeera et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fabrication of carbon films with ∼500nm holes for cryo-EM with a direct detector device

(2013) Chelsea R. Marr et al.   JOURNAL OF STRUCTURAL BIOLOGY

RELION: Implementation of a Bayesian approach to cryo-EM structure determination

(2012) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

Diarylquinolines, synthesis pathways and quantitative structure–activity relationship studies leading to the discovery of TMC207

(2011) Jerome Guillemont et al.   Future Medicinal Chemistry

Structure of the ATP synthase catalytic complex (F1) from Escherichia coli in an autoinhibited conformation

(2011) Gino Cingolani et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Probing the Interaction of the Diarylquinoline TMC207 with Its Target Mycobacterial ATP Synthase

(2011) Anna C. Haagsma et al.   PLoS One

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

R207910 (TMC207) : un nouvel antibiotique pour le traitement de la tuberculose

(2009) N. Lounis et al.   MEDECINE ET MALADIES INFECTIEUSES

Selectivity of TMC207 towards Mycobacterial ATP Synthase Compared with That towards the Eukaryotic Homologue

(2008) A. C. Haagsma et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Diarylquinolines Are Bactericidal for Dormant Mycobacteria as a Result of Disturbed ATP Homeostasis

(2008) Anil Koul et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Improved Cryogen for Plunge Freezing

(2008) William F. Tivol et al.   MICROSCOPY AND MICROANALYSIS