The NaV1.7 sodium channel: from molecule to man

Functional profiles of SCN9A variants in dorsal root ganglion neurons and superior cervical ganglion neurons correlate with autonomic symptoms in small fibre neuropathy

(2012) Chongyang Han et al.   BRAIN

Membrane properties and electrogenesis in the distal axons of small dorsal root ganglion neurons in vitro

(2012) Dmytro V. Vasylyev et al.   JOURNAL OF NEUROPHYSIOLOGY

Sodium Channel Nav1.7 Is Essential for Lowering Heat Pain Threshold after Burn Injury

(2012) S. D. Shields et al.   JOURNAL OF NEUROSCIENCE

Reduction of Voltage Gated Sodium Channel Protein in DRG by Vector Mediated miRNA Reduces Pain in Rats with Painful Diabetic Neuropathy

(2012) Munmun Chattopadhyay et al.   Molecular Pain

Expression of Nav1.7 in DRG Neurons Extends from Peripheral Terminals in the Skin to Central Preterminal Branches and Terminals in the Dorsal Horn

(2012) Joel A Black et al.   Molecular Pain

Nav1.7-related small fiber neuropathy: Impaired slow-inactivation and DRG neuron hyperexcitability

(2012) C. Han et al.   NEUROLOGY

Distinct Nav1.7-dependent pain sensations require different sets of sensory and sympathetic neurons

(2012) Michael S. Minett et al.   Nature Communications

Structural modelling and mutant cycle analysis predict pharmacoresponsiveness of a Nav1.7 mutant channel

(2012) Yang Yang et al.   Nature Communications

Gene therapy for pain: Results of a phase I clinical trial

(2011) David J. Fink et al.   ANNALS OF NEUROLOGY

Gain of function NaV1.7 mutations in idiopathic small fiber neuropathy

(2011) Catharina G. Faber et al.   ANNALS OF NEUROLOGY

NaChBac: The Long Lost Sodium Channel Ancestor

(2011) Kalypso Charalambous et al.   BIOCHEMISTRY

Discovery of XEN907, a spirooxindole blocker of NaV1.7 for the treatment of pain

(2011) Sultan Chowdhury et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Deletion mutation of sodium channel NaV1.7 in inherited erythromelalgia: enhanced slow inactivation modulates dorsal root ganglion neuron hyperexcitability

(2011) X. Cheng et al.   BRAIN

Vector-mediated release of GABA attenuates pain-related behaviors and reduces NaV1.7 in DRG neurons

(2011) Munmun Chattopadhyay et al.   EUROPEAN JOURNAL OF PAIN

NaV1.7 accumulates and co-localizes with phosphorylated ERK1/2 within transected axons in early experimental neuromas

(2011) Anna-Karin Persson et al.   EXPERIMENTAL NEUROLOGY

Voltage-Gated Sodium Channel Nav1.7 Maintains the Membrane Potential and Regulates the Activation and Chemokine-Induced Migration of a Monocyte-Derived Dendritic Cell Subset

(2011) K. Kis-Toth et al.   JOURNAL OF IMMUNOLOGY

Identification of a Potent, State-Dependent Inhibitor of Nav1.7 with Oral Efficacy in the Formalin Model of Persistent Pain

(2011) Howard Bregman et al.   JOURNAL OF MEDICINAL CHEMISTRY

Physiological interactions between Nav1.7 and Nav1.8 sodium channels: a computer simulation study

(2011) Jin-Sung Choi et al.   JOURNAL OF NEUROPHYSIOLOGY

Nav1.7 is the Predominant Sodium Channel in Rodent Olfactory Sensory Neurons

(2011) Hye-Sook Ahn et al.   Molecular Pain

Intra- and Interfamily Phenotypic Diversity in Pain Syndromes Associated with a Gain-of-Function Variant of NaV1.7

(2011) Mark Estación et al.   Molecular Pain

Interactions of Key Charged Residues Contributing to Selective Block of Neuronal Sodium Channels by  -Conotoxin KIIIA

(2011) J. R. McArthur et al.   MOLECULAR PHARMACOLOGY

Loss-of-function mutations in sodium channel Nav1.7 cause anosmia

(2011) Jan Weiss et al.   NATURE

The crystal structure of a voltage-gated sodium channel

(2011) Jian Payandeh et al.   NATURE

 -Conotoxins that differentially block sodium channels NaV1.1 through 1.8 identify those responsible for action potentials in sciatic nerve

(2011) M. J. Wilson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Molecular Basis of Acid Insensitivity in the African Naked Mole-Rat

(2011) E. S. J. Smith et al.   SCIENCE

Sodium Channels in Normal and Pathological Pain

(2010) Sulayman D. Dib-Hajj et al.   Annual Review of Neuroscience

Alternative splicing may contribute to time-dependent manifestation of inherited erythromelalgia

(2010) Jin-Sung Choi et al.   BRAIN

Targeting Primary Afferent Nerves for Novel Antitussive Therapy

(2010) Bradley J. Undem et al.   CHEST

A Nonsense Mutation in the SCN9A Gene in Congenital Insensitivity to Pain

(2010) Mazen Kurban et al.   DERMATOLOGY

Two novel mutations of SCN9A (Nav1.7) are associated with partial congenital insensitivity to pain

(2010) Roland Staudl et al.   EUROPEAN JOURNAL OF PAIN

Human voltage-gated sodium channel mutations that cause inherited neuronal and muscle channelopathies increase resurgent sodium currents

(2010) Brian W. Jarecki et al.   JOURNAL OF CLINICAL INVESTIGATION

ERK1/2 Mitogen-Activated Protein Kinase Phosphorylates Sodium Channel Nav1.7 and Alters Its Gating Properties

(2010) S. Stamboulian et al.   JOURNAL OF NEUROSCIENCE

Recommendations for the Pharmacological Management of Neuropathic Pain: An Overview and Literature Update

(2010) Robert H. Dworkin et al.   MAYO CLINIC PROCEEDINGS

Mutations at opposite Ends of the DIII/S4-S5 Linker of Sodium Channel NaV1.7 Produce Distinct Pain Disorders

(2010) Xiaoyang Cheng et al.   Molecular Pain

Paroxysmal extreme pain disorder: a molecular lesion of peripheral neurons

(2010) Jin-Sung Choi et al.   Nature Reviews Neurology

Electrophysiology and beyond: Multiple roles of Na+ channel β subunits in development and disease

(2010) Gustavo A. Patino et al.   NEUROSCIENCE LETTERS

Isoform-specific and pan-channel partners regulate trafficking and plasma membrane stability; and alter sodium channel gating properties

(2010) Sulayman D. Dib-Hajj et al.   NEUROSCIENCE LETTERS

Signaling complexes of voltage-gated sodium and calcium channels

(2010) William A. Catterall   NEUROSCIENCE LETTERS

Voltage-gated sodium channel organization in neurons: Protein interactions and trafficking pathways

(2010) Christophe Leterrier et al.   NEUROSCIENCE LETTERS

Pain perception is altered by a nucleotide polymorphism in SCN9A

(2010) F. Reimann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cyclization of conotoxins to improve their biopharmaceutical properties

(2010) Richard J. Clark et al.   TOXICON

A sodium channel geneSCN9Apolymorphism that increases nociceptor excitability

(2009) Mark Estacion et al.   ANNALS OF NEUROLOGY

A novel Nav1.7 mutation producing carbamazepine-responsive erythromelalgia

(2009) Tanya Z. Fischer et al.   ANNALS OF NEUROLOGY

Early- and late-onset inherited erythromelalgia: genotype–phenotype correlation

(2009) Chongyang Han et al.   BRAIN

Subtype-selective targeting of voltage-gated sodium channels

(2009) Steve England et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mexiletine-responsive erythromelalgia due to a new Nav1.7 mutation showing use-dependent current fall-off

(2009) Jin-Sung Choi et al.   EXPERIMENTAL NEUROLOGY

Transfection of rat or mouse neurons by biolistics or electroporation

(2009) Sulayman D Dib-Hajj et al.   Nature Protocols

Two novel SCN9A mutations causing insensitivity to pain

(2009) K. B. Nilsen et al.   PAIN

A Role of SCN9A in Human Epilepsies, As a Cause of Febrile Seizures and As a Potential Modifier of Dravet Syndrome

(2009) Nanda A. Singh et al.   PLoS Genetics

Multiple sodium channel isoforms and mitogen-activated protein kinases are present in painful human neuromas

(2008) Joel A. Black et al.   ANNALS OF NEUROLOGY

Imidazopyridines: A novel class of hNav1.7 channel blockers

(2008) Clare London et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Voltage-gated sodium channels in pain states: Role in pathophysiology and targets for treatment

(2008) Sulayman D. Dib-Hajj et al.   BRAIN RESEARCH REVIEWS

A Pore-blocking Hydrophobic Motif at the Cytoplasmic Aperture of the Closed-state Nav1.7 Channel Is Disrupted by the Erythromelalgia-associated F1449V Mutation

(2008) Angelika Lampert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tarantula Huwentoxin-IV Inhibits Neuronal Sodium Channels by Binding to Receptor Site 4 and Trapping the Domain II Voltage Sensor in the Closed Configuration

(2008) Yucheng Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NaV1.7 Gain-of-Function Mutations as a Continuum: A1632E Displays Physiological Changes Associated with Erythromelalgia and Paroxysmal Extreme Pain Disorder Mutations and Produces Symptoms of Both Disorders

(2008) M. Estacion et al.   JOURNAL OF NEUROSCIENCE

Continuous  -Opioid Receptor Activation Reduces Neuronal Voltage-Gated Sodium Channel (NaV1.7) Levels through Activation of Protein Kinase C in Painful Diabetic Neuropathy

(2008) M. Chattopadhyay et al.   JOURNAL OF NEUROSCIENCE

Differential Block of Sensory Neuronal Voltage-Gated Sodium Channels by Lacosamide [(2R)-2-(Acetylamino)-N-benzyl-3-methoxypropanamide], Lidocaine, and Carbamazepine

(2008) P. L. Sheets et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Voltage-gated sodium channels in nociceptiveversusnon-nociceptive nodose vagal sensory neurons innervating guinea pig lungs

(2008) Kevin Kwong et al.   JOURNAL OF PHYSIOLOGY-LONDON

Paroxysmal Extreme Pain Disorder M1627K Mutation in Human Nav1.7 Renders DRG Neurons Hyperexcitable

(2008) Sulayman D Dib-Hajj et al.   Molecular Pain

Mutation I136V Alters Electrophysiological Properties of the NaV1.7 Channel in a Family with Onset of Erythromelalgia in the Second Decade

(2008) Xiaoyang Cheng et al.   Molecular Pain

Sensory and motor complications of local anesthetics

(2008) Peter Gerner et al.   MUSCLE & NERVE

Selective Inflammatory Pain Insensitivity in the African Naked Mole-Rat (Heterocephalus glaber)

(2008) Thomas J Park et al.   PLOS BIOLOGY