Structure of an activated DNA-PK and its implications for NHEJ

DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis

(2020) Zhengping Shao et al.   NATURE

Structures and regulations of ATM and ATR, master kinases in genome integrity

(2020) Rhys M Williams et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

An Antiviral DNA Response without the STING?

(2020) Katheryn Meek   TRENDS IN IMMUNOLOGY

Structure of substrate-bound SMG1-8-9 kinase complex reveals molecular basis for phosphorylation specificity

(2020) Lukas M Langer et al.   eLife

The molecular basis and disease relevance of non-homologous DNA end joining

(2020) Bailin Zhao et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dimers of DNA-PK create a stage for DNA double-strand break repair

(2020) Amanda K. Chaplin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DNA-PKcs phosphorylation at the T2609 cluster alters the repair pathway choice during immunoglobulin class switch recombination

(2020) Jennifer L. Crowe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural insights into the critical DNA damage sensors DNA-PKcs, ATM and ATR

(2019) Domagoj Baretic et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Near-Complete Structure and Model of Tel1ATM from Chaetomium thermophilum Reveals a Robust Autoinhibited ATP State

(2019) Marijke Jansma et al.   STRUCTURE

Deletion of the SAPS1 subunit of protein phosphatase 6 in mice increases radiosensitivity and impairs the cellular DNA damage response

(2019) Jaroslaw Dziegielewski et al.   DNA REPAIR

InsP6 binding to PIKK kinases revealed by the cryo-EM structure of an SMG1–SMG8–SMG9 complex

(2019) Yair Gat et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dissection of DNA double-strand-break repair using novel single-molecule forceps

(2018) Jing L. Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dissection of DNA double-strand-break repair using novel single-molecule forceps

(2018) Jing L. Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

XLF and APLF bind Ku80 at two remote sites to ensure DNA repair by non-homologous end joining

(2018) Clement Nemoz et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response

(2017) Andrew N. Blackford et al.   MOLECULAR CELL

Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40

(2017) Haijuan Yang et al.   NATURE

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

(2017) Ali Punjani et al.   NATURE METHODS

Cryo-EM structure of the DNA-PK holoenzyme

(2017) Humayun Sharif et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA-PKcs structure suggests an allosteric mechanism modulating DNA double-strand break repair

(2017) Bancinyane L. Sibanda et al.   SCIENCE

A pipeline approach to single-particle processing inRELION

(2017) Rafael Fernandez-Leiro et al.   Acta Crystallographica Section D-Structural Biology

Restoration of ATM Expression in DNA-PKcs–Deficient Cells Inhibits Signal End Joining

(2016) Jessica A. Neal et al.   JOURNAL OF IMMUNOLOGY

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

Two-Stage Synapsis of DNA Ends during Non-homologous End Joining

(2016) Thomas G.W. Graham et al.   MOLECULAR CELL

Differential Phosphorylation of DNA-PKcs Regulates the Interplay between End-Processing and End-Ligation during Nonhomologous End-Joining

(2015) Wenxia Jiang et al.   MOLECULAR CELL

Crystal structure of the V(D)J recombinase RAG1–RAG2

(2015) Min-Sung Kim et al.   NATURE

Polo-like kinase 1 (PLK1) and protein phosphatase 6 (PP6) regulate DNA-dependent protein kinase catalytic subunit (DNA-PKcs) phosphorylation in mitosis

(2014) Pauline Douglas et al.   BIOSCIENCE REPORTS

PIKKs — the solenoid nest where partners and kinases meet

(2014) Domagoj Baretić et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

DNA-PK: A dynamic enzyme in a versatile DSB repair pathway

(2014) Anthony J. Davis et al.   DNA REPAIR

mTOR kinase structure, mechanism and regulation

(2013) Haijuan Yang et al.   NATURE

Quantifying the local resolution of cryo-EM density maps

(2013) Alp Kucukelbir et al.   NATURE METHODS

PP6 Regulatory Subunit R1 Is Bidentate Anchor for Targeting Protein Phosphatase-6 to DNA-dependent Protein Kinase

(2012) Amol S. Hosing et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RELION: Implementation of a Bayesian approach to cryo-EM structure determination

(2012) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

Inhibition of Homologous Recombination by DNA-Dependent Protein Kinase Requires Kinase Activity, Is Titratable, and Is Modulated by Autophosphorylation

(2011) J. A. Neal et al.   MOLECULAR AND CELLULAR BIOLOGY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Nuclear export complexes in the frame

(2010) Atlanta G Cook et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Activation of DNA-PK by Ionizing Radiation Is Mediated by Protein Phosphatase 6

(2009) Jun Mi et al.   PLoS One

Cryo-EM Structure of the DNA-Dependent Protein Kinase Catalytic Subunit at Subnanometer Resolution Reveals α Helices and Insight into DNA Binding

(2008) Dewight R. Williams et al.   STRUCTURE