Inherited SLP76 deficiency in humans causes severe combined immunodeficiency, neutrophil and platelet defects

Bridging the Gap: Modulatory Roles of the Grb2-Family Adaptor, Gads, in Cellular and Allergic Immune Responses

(2019) Deborah Yablonski   Frontiers in Immunology

ADAP is an upstream regulator that precedes SLP-76 at sites of TCR engagement and stabilizes signaling microclusters

(2018) Juliana B. Lewis et al.   JOURNAL OF CELL SCIENCE

Mutations in linker for activation of T cells (LAT) lead to a novel form of severe combined immunodeficiency

(2017) Chiara Bacchelli et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Dimerization of the adaptor Gads facilitates antigen receptor signaling by promoting the cooperative binding of Gads to the adaptor LAT

(2017) Sigalit Sukenik et al.   Science Signaling

Dimerization of the adaptor Gads facilitates antigen receptor signaling by promoting the cooperative binding of Gads to the adaptor LAT

(2017) Sigalit Sukenik et al.   Science Signaling

Early onset combined immunodeficiency and autoimmunity in patients with loss-of-function mutation in LAT

(2016) Baerbel Keller et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Severe combined immunodeficiency-an update

(2015) Emilia Cirillo et al.   Annals of the New York Academy of Sciences

The Linker for Activation of T Cells (LAT) Signaling Hub: From Signaling Complexes to Microclusters

(2015) Lakshmi Balagopalan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantitative Reduction of the TCR Adapter Protein SLP-76 Unbalances Immunity and Immune Regulation

(2015) Owen M. Siggs et al.   JOURNAL OF IMMUNOLOGY

Identification of ITK deficiency as a novel genetic cause of idiopathic CD4+ T-cell lymphopenia

(2014) N. K. Serwas et al.   BLOOD

Immunodeficiency and immune dysregulation associated with proximal defects of T cell receptor signaling

(2014) Luigi D Notarangelo   CURRENT OPINION IN IMMUNOLOGY

Partial defects of T-cell development associated with poor T-cell function

(2013) Luigi D. Notarangelo   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

SLP-76 Sterile α Motif (SAM) and Individual H5 α Helix Mediate Oligomer Formation for Microclusters and T-cell Activation

(2013) Hebin Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Congenital Neutrophil Defect Syndrome Associated with Mutations in VPS45

(2013) Thierry Vilboux et al.   NEW ENGLAND JOURNAL OF MEDICINE

A prospective evaluation of degranulation assays in the rapid diagnosis of familial hemophagocytic syndromes

(2012) Y. T. Bryceson et al.   BLOOD

Primary T-cell immunodeficiency with immunodysregulation caused by autosomal recessive LCK deficiency

(2012) Fabian Hauck et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Cold Urticaria, Immunodeficiency, and Autoimmunity Related toPLCG2Deletions

(2012) Michael J. Ombrello et al.   NEW ENGLAND JOURNAL OF MEDICINE

Sequential phosphorylation of SLP-76 at tyrosine 173 is required for activation of T and mast cells

(2011) Meirav Sela et al.   EMBO JOURNAL

A framework for variation discovery and genotyping using next-generation DNA sequencing data

(2011) Mark A DePristo et al.   NATURE GENETICS

Molecular Assessment of Thymus Capabilities in the Evaluation of T-Cell Immunodeficiency

(2010) Ninette Amariglio et al.   PEDIATRIC RESEARCH

Coordination of Receptor Signaling in Multiple Hematopoietic Cell Lineages by the Adaptor Protein SLP-76

(2010) M. S. Jordan et al.   Cold Spring Harbor Perspectives in Biology

Girls homozygous for an IL-2–inducible T cell kinase mutation that leads to protein deficiency develop fatal EBV-associated lymphoproliferation

(2009) Kirsten Huck et al.   JOURNAL OF CLINICAL INVESTIGATION