Review
Biochemistry & Molecular Biology
Sylvain Latour
Summary: T lymphocytes play a central role in adaptive immunity, with their development and functions regulated by TCR signaling and co-signaling molecules. Mutations in TCR signaling components and co-stimulatory molecules can lead to immunodeficiencies and immune dysregulation, as well as susceptibility to specific pathogens.
BIOMEDICAL JOURNAL
(2022)
Article
Immunology
Hongwei Wu, Jingjing Dong, Haiyan Yu, Kang Wang, Weier Dai, Xinzhou Zhang, Nan Hu, Lianghong Yin, Donge Tang, Fanna Liu, Yong Dai
Summary: This study integrated single-cell RNA sequencing (scRNA-seq) and single-cell assay for transposase-accessible chromatin sequencing (scATAC-seq) to investigate the transcriptional program and chromosomal accessibility of peripheral mononuclear cells (PBMCs) in maintenance hemodialysis patients. The study found that hemodialysis suppressed the expression of immune-related genes in CD4+ T cells and monocytes, inhibited downstream pathways of T cell receptor signaling, and altered cellular communication patterns between PBMC subgroups. Additionally, hemodialysis affected the chromatin accessibility profile and expression of transcription factors. This study provides a valuable framework for studying hemodialysis-related immune dysregulation and identifies potential therapeutic targets.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Bahire Kalfaoglu, Jose Almeida-Santos, Chanidapa Adele Tye, Yorifumi Satou, Masahiro Ono
Summary: Research indicates that T-cells play crucial roles in the immunity to COVID-19, with dysregulation noted in severe cases. The impairment of FOXP3 induction in CD4(+) T-cells may lead to abnormal T-cell responses, while hyperactivated T-cells could potentially contribute to dysregulation and tissue destruction in severe COVID-19 patients.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Review
Immunology
Robert. C. C. Sterner, Rosalie. M. M. Sterner
Summary: CAR-T cell therapy has shown great potential in treating hematological malignancies, but the associated toxicities, such as ICANS, have hindered its widespread use. Understanding the mechanisms and developing solutions for ICANS is crucial for improving the efficacy and safety of CAR-T cell therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Brandilyn A. Peters, Jee-Young Moon, David B. Hanna, Olaf Kutsch, Margaret Fischl, Caitlin A. Moran, Adaora A. Adimora, Stephen Gange, Nadia R. Roan, Katherine G. Michel, Michael Augenbraun, Anjali Sharma, Alan Landay, Seema Desai, Robert C. Kaplan
Summary: Persistent CD4(+) T-cell activation and exhaustion may contribute to increased long-term mortality risk in women with HIV, independent of HIV disease progression.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Immunology
Xinle Cui, Clifford M. Snapper
Summary: EBV is strongly implicated in the etiology of multiple cancers, and vaccines targeting EBV have shown promise in prevention and treatment. Immune cell therapy, including adoptive T-cell therapy, has emerged as a promising approach in cancer treatment, especially in EBV-associated cancers.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Andrew Kent, Natalie V. Longino, Allison Christians, Eduardo Davila
Summary: T cell-based immunotherapies have shown significant anti-tumor effects, providing hope to cancer patients, but durable responses are not universal and immune-mediated toxicity can occur. Understanding the genetic, phenotypic and activation state nuances of T cells is crucial for optimizing therapeutic impact. Researchers are exploring therapeutic strategies targeting specific molecules to enhance anti-tumor T cell activity.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Changfu Yao, Stephanie A. Bora, Tanyalak Parimon, Tanzira Zaman, Oren A. Friedman, Joseph A. Palatinus, Nirmala S. Surapaneni, Yuri P. Matusov, Giuliana Cerro Chiang, Alexander G. Kassar, Nayan Patel, Chelsi E. R. Green, Adam W. Aziz, Harshpreet Suri, Jo Suda, Andres A. Lopez, Gislaine A. Martins, Barry R. Stripp, Sina A. Gharib, Helen S. Goodridge, Peter Chen
Summary: Recent studies have shown immunologic dysfunction in severely ill patients with COVID-19, particularly in those with ARDS, where defective antigen presentation and interferon responsiveness were observed in monocytes. There was also suppressed cytotoxic activity in NK cells and CD8 T lymphocytes, along with deficient B cell activation, indicating delayed viral clearance in severely ill patients. These findings suggest an immune imbalance in COVID-19 patients with ARDS, potentially contributing to a more severe disease course.
Review
Biochemistry & Molecular Biology
Bonah Kim, Won-Woo Lee
Summary: Zinc is an essential micronutrient with crucial roles in biological processes, and dysregulated zinc homeostasis can impair overall immune function and increase susceptibility to infection. Recent focus on zinc as a beneficial element for immune system support has led to investigations of its immunomodulatory roles in immune cells.
MOLECULES AND CELLS
(2021)
Article
Pharmacology & Pharmacy
Weizhen Li, Yang Zhou, Zhongen Wu, Yaoping Shi, Enming Tian, Yingqi Zhu, Tao Wang, Wei Dou, Xiangjing Meng, Ming Chen, Bo Zhai, Di Zhu
Summary: This study suggests that the combination of CAR T cell therapy targeting EpCAM with a Wnt inhibitor can overcome the limitations of CAR T cells in treating solid tumors.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Klaus Tenbrock, Thomas Rauen
Summary: T cells play a crucial role in the development of SLE, and their abnormalities provide potential targets for therapeutic intervention.
CLINICAL IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Dulari Jayawardena, Shubha Priyamvada, Takahiro Kageyama, Zachary White, Anoop Kumar, Theodor F. Griggs, Apurba Majumder, Ramsha Akram, Arivarasu N. Anbazhagan, Teruyuki Sano, Pradeep K. Dudeja
Summary: The down-regulation of chloride transporter SLC26A3 in colonocytes is associated with the pathogenesis of ulcerative colitis (UC) by triggering a type 2 immune response through IL-33 release, which is a result of altered epithelial-immune cell crosstalk.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Medicine, Research & Experimental
Osaretin E. Asowata, Alveera Singh, Abigail Ngoepe, Nicholas Herbert, Rabiah Fardoos, Kavidha Reddy, Yenzekile Zungu, Faith Nene, Ntombifuthi Mthabela, Dirhona Ramjit, Farina Karim, Katya Govender, Thumbi Ndung'u, J. Zachary Porterfield, John H. Adamson, Fusi G. Madela, Vukani T. Manzini, Frank Anderson, Alasdair Leslie, Henrik N. Kloverpris
Summary: Research conducted on a large cohort recruited from high HIV endemic areas in South Africa revealed that people living with HIV presented at a younger age for GI clinic investigation, with severe CD4(+) T cell depletion in the GI tract, particularly in the colon. Despite full suppression of plasma viremia, HIV-p24 staining showed persistent viral expression, emphasizing the irreversible loss of GI CD4(+) T cells as a key event in HIV pathogenesis in PLWH in South Africa.
Article
Immunology
Divisha Bhatia, Veselin Grozdanov, Wolfgang P. Ruf, Jan Kassubek, Albert C. Ludolph, Jochen H. Weishaupt, Karin M. Danzer
Summary: The dysregulation of peripheral immunity in Parkinson's Disease leads to a decrease in T-cell numbers, particularly CD8(+) cytotoxic T cells, and an upregulation of inflammatory genes, which are associated with disease severity. Additionally, PD T cells show increased activation upon stimulation, correlating with disease severity.
JOURNAL OF NEUROINFLAMMATION
(2021)
Review
Immunology
Suran L. Fernando, Helena S- Jang, Jamma Li
Summary: CVID is a heterogeneous collection of immune dysregulation disorders, with majority of patients experiencing non-infectious complications such as autoimmunity, enteropathy, polyclonal lymphocytosis, and malignancy. Advances in next generation sequencing have led to a better understanding of the genetic basis of CVID disorders, allowing for improved diagnosis and targeted therapies. The identification of cellular abnormalities in T-cell and B-cell compartments, along with the role of innate lymphoid cells in promoting inflammation, provides valuable insights into the immune dysregulation seen in CVID patients.
IMMUNOLOGY LETTERS
(2021)
Article
Hematology
Stefano Volpi, Elettra Santori, Katrina Abernethy, Masayuki Mizui, Carin I. M. Dahlberg, Mike Recher, Kelly Capuder, Eva Csizmadia, Douglas Ryan, Divij Mathew, George C. Tsokos, Scott Snapper, Lisa S. Westerberg, Adrian J. Thrasher, Fabio Candotti, Luigi D. Notarangelo
Review
Immunology
Ottavia M. Delmonte, Catharina Schuetz, Luigi D. Notarangelo
JOURNAL OF CLINICAL IMMUNOLOGY
(2018)
Editorial Material
Immunology
Luigi D. Notarangelo
JOURNAL OF EXPERIMENTAL MEDICINE
(2018)
Review
Immunology
Anna Villa, Luigi D. Notarangelo
IMMUNOLOGICAL REVIEWS
(2019)
Article
Medicine, Research & Experimental
Patrick Maffucci, Jose Chavez, Thomas J. Jurkiw, Patrick J. O'Brien, Jordan K. Abbott, Paul R. Reynolds, Austen Worth, Luigi D. Notarangelo, Kerstin Felgentreff, Patricia Cortes, Bertrand Boisson, Lin Radigan, Aurelie Cobat, Chitra Dinakar, Mohammad Ehlayel, Tawfeg Ben-Omran, Erwin W. Gelfand, Jean-Laurent Casanova, Charlotte Cunningham-Rundles
JOURNAL OF CLINICAL INVESTIGATION
(2018)
Article
Multidisciplinary Sciences
Diego Bertoli, Alessandra Sottini, Ruggero Capra, Cristina Scarpazza, Roberto Bresciani, Luigi D. Notarangelo, Luisa Imberti
SCIENTIFIC REPORTS
(2019)
Review
Hematology
Ottavia M. Delmonte, Anna Villa, Luigi D. Notarangelo
Letter
Immunology
Daniele Moratto, Marco Chiarini, Viviana Giustini, Federico Serana, Paola Magro, Aldo Maria Roccaro, Luisa Imberti, Francesco Castelli, Luigi Daniele Notarangelo, Eugenia Quiros-Roldan
JOURNAL OF CLINICAL IMMUNOLOGY
(2020)
Review
Immunology
Luigi D. Notarangelo, Rosa Bacchetta, Jean Laurent Casanova, Helen C. Su
SCIENCE IMMUNOLOGY
(2020)
Article
Hematology
Caridad Martinez, Frederic Ebstein, Sarah K. Nicholas, Marietta De Guzman, Lisa R. Forbes, Ottavia M. Delmonte, Marita Bosticardo, Riccardo Castagnoli, Robert Krance, Luigi D. Notarangelo, Elke Krueger, Jordan S. Orange, M. Cecilia Poli
Letter
Allergy
Muhammad Bilal Khalid, Sonia Gaspar Lemos, Katherine Myint-Hpu, Debbie Draper, Jennifer Stoddard, Julie E. Niemela, Sergio D. Rosenzweig, Stefania Pittaluga, Ottavia M. Delmonte, Luigi D. Notarangelo
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Biographical-Item
Immunology
Luigi D. Notarangelo, Sudhir Gupta
JOURNAL OF CLINICAL IMMUNOLOGY
(2022)
Article
Allergy
Riccardo Castagnoli, Ottavia M. Delmonte, Luigi D. Notarangelo
Summary: IEI, or primary immunodeficiencies, are disorders caused by mutations in genes involved in immune host defense and immune regulation. Advances in DNA sequencing technology have led to an exponential increase in the discovery of new genes associated with IEI in the past decade.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Review
Allergy
Francesca Pala, Luigi D. Notarangelo, Marita Bosticardo
Summary: In this review, the authors provide a summary of inborn errors of immunity characterized by T-cell lymphopenia due to defects in thymic stroma or hematopoietic-intrinsic defects of T-cell development. They also discuss recent advances in diagnostic tools and potential therapeutic approaches to correct thymic defects.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Letter
Medicine, Research & Experimental
Qian Zhang, Aurelie Cobat, Paul Bastard, Luigi D. Notarangelo, Helen C. Su, Laurent Abel, Jean-Laurent Casanova
JOURNAL OF CLINICAL INVESTIGATION
(2021)