NOTCH-induced rerouting of endosomal trafficking disables regulatory T cells in vasculitis

N-myristoyltransferase deficiency impairs activation of kinase AMPK and promotes synovial tissue inflammation

(2019) Zhenke Wen et al.   NATURE IMMUNOLOGY

CORVET, CHEVI and HOPS – multisubunit tethers of the endo-lysosomal system in health and disease

(2019) Jan van der Beek et al.   JOURNAL OF CELL SCIENCE

CD28 Signaling Controls Metabolic Fitness of Pathogenic T Cells in Medium and Large Vessel Vasculitis

(2019) Hui Zhang et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Matrix Metalloprotease-9 (MMP-9)-Producing Monocytes Enable T Cells to Invade the Vessel Wall and Cause Vasculitis

(2018) Ryu Watanabe et al.   CIRCULATION RESEARCH

Overlapping but distinct roles for NOTCH receptors in human cardiovascular disease

(2018) J.A.N. Meester et al.   CLINICAL GENETICS

How the phagocyte NADPH oxidase regulates innate immunity

(2018) David C. Thomas   FREE RADICAL BIOLOGY AND MEDICINE

Dysregulation of Rab5-mediated endocytic pathways in Alzheimer's disease

(2018) Wei Xu et al.   TRAFFIC

Noninfectious Manifestations and Complications of Chronic Granulomatous Disease

(2018) Sarah E Henrickson et al.   Journal of the Pediatric Infectious Diseases Society

Charcot Marie Tooth 2B Peripheral Sensory Neuropathy: How Rab7 Mutations Impact NGF Signaling?

(2017) Harry Liu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Notch Ligand Delta-like 4 Promotes Regulatory T Cell Identity in Pulmonary Viral Infection

(2017) Hung-An Ting et al.   JOURNAL OF IMMUNOLOGY

Immunoinhibitory checkpoint deficiency in medium and large vessel vasculitis

(2017) Hui Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The microvascular niche instructs T cells in large vessel vasculitis via the VEGF-Jagged1-Notch pathway

(2017) Zhenke Wen et al.   Science Translational Medicine

Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy

(2017) Eunice E. To et al.   Nature Communications

Rab GTPases in Immunity and Inflammation

(2017) Akriti Prashar et al.   Frontiers in Cellular and Infection Microbiology

Inhibition of JAK-STAT Signaling Suppresses Pathogenic Immune Responses in Medium and Large Vessel Vasculitis

(2017) Hui Zhang et al.   CIRCULATION

NADPH oxidase deficiency underlies dysfunction of aged CD8+ Tregs

(2016) Zhenke Wen et al.   JOURNAL OF CLINICAL INVESTIGATION

Colitis susceptibility in p47 phox−/− mice is mediated by the microbiome

(2016) E. Liana Falcone et al.   Microbiome

Multiple Roles of the Small GTPase Rab7

(2016) Flora Guerra et al.   Cells

NADPH oxidases: an overview from structure to innate immunity-associated pathologies

(2014) Arvind Panday et al.   Cellular & Molecular Immunology

Molecular Mechanisms for the Regulation of Insulin-Stimulated Glucose Uptake by Small Guanosine Triphosphatases in Skeletal Muscle and Adipocytes

(2014) Takaya Satoh   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

An Overview of the Intrathymic Intricacies of T Cell Development

(2014) D. K. Shah et al.   JOURNAL OF IMMUNOLOGY

RAB11-mediated trafficking in host–pathogen interactions

(2014) Annabel Guichard et al.   NATURE REVIEWS MICROBIOLOGY

Rab Proteins and the Compartmentalization of the Endosomal System

(2014) A. Wandinger-Ness et al.   Cold Spring Harbor Perspectives in Biology

Regulatory T cells in nonlymphoid tissues

(2013) Dalia Burzyn et al.   NATURE IMMUNOLOGY

Immune mechanisms in medium and large-vessel vasculitis

(2013) Cornelia M. Weyand et al.   Nature Reviews Rheumatology

A re-review of the association between the NOTCH4 locus and schizophrenia

(2012) Christina Shayevitz et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

The molecular basis of T cell acute lymphoblastic leukemia

(2012) Pieter Van Vlierberghe et al.   JOURNAL OF CLINICAL INVESTIGATION

CD8+CD45RA+CCR7+FOXP3+ T Cells with Immunosuppressive Properties: A Novel Subset of Inducible Human Regulatory T Cells

(2012) M. Suzuki et al.   JOURNAL OF IMMUNOLOGY

The Notch signalling system: recent insights into the complexity of a conserved pathway

(2012) K. G. Guruharsha et al.   NATURE REVIEWS GENETICS

Endocytosis, Recycling, and Regulated Exocytosis of Glucose Transporter 4

(2011) Kevin Foley et al.   BIOCHEMISTRY

Blocking the NOTCH Pathway Inhibits Vascular Inflammation in Large-Vessel Vasculitis

(2011) Kisha Piggott et al.   CIRCULATION

NADPH Oxidase Is Internalized by Clathrin-coated Pits and Localizes to a Rab27A/B GTPase-regulated Secretory Compartment in Activated Macrophages

(2011) Patrick Ejlerskov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IFN-γ and IL-17: the two faces of T-cell pathology in giant cell arteritis

(2010) Cornelia M Weyand et al.   CURRENT OPINION IN RHEUMATOLOGY

Vascular damage in giant cell arteritis

(2009) Kisha Piggott et al.   AUTOIMMUNITY

The Notch signaling pathway: Transcriptional regulation at Notch target genes

(2009) T. Borggrefe et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Macrophage NADPH Oxidase Flavocytochrome b Localizes to the Plasma Membrane and Rab11-Positive Recycling Endosomes

(2009) A.-J. Casbon et al.   JOURNAL OF IMMUNOLOGY

Rab GTPases as coordinators of vesicle traffic

(2009) Harald Stenmark   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Pathways and mechanisms of endocytic recycling

(2009) Barth D. Grant et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulatory T Cells and Immune Tolerance

(2008) Shimon Sakaguchi et al.   CELL

Evidence for a Superoxide Permeability Pathway in Endosomal Membranes

(2008) D. R. Mumbengegwi et al.   MOLECULAR AND CELLULAR BIOLOGY