Molecular Mechanisms for the Regulation of Insulin-Stimulated Glucose Uptake by Small Guanosine Triphosphatases in Skeletal Muscle and Adipocytes

Immunofluorescent detection of the activation of the small GTPase Rac1 in mouse skeletal muscle fibers

(2015) Nobuyuki Takenaka et al.   ANALYTICAL BIOCHEMISTRY

Role of the guanine nucleotide exchange factor in Akt2-mediated plasma membrane translocation of GLUT4 in insulin-stimulated skeletal muscle

(2014) Nobuyuki Takenaka et al.   CELLULAR SIGNALLING

A critical role of the small GTPase Rac1 in Akt2-mediated GLUT4 translocation in mouse skeletal muscle

(2014) Nobuyuki Takenaka et al.   FEBS Journal

Akt2 regulates Rac1 activity in the insulin-dependent signaling pathway leading to GLUT4 translocation to the plasma membrane in skeletal muscle cells

(2013) Shinsuke Nozaki et al.   CELLULAR SIGNALLING

Tiam-1, a GEF for Rac1, plays a critical role in metformin-mediated glucose uptake in C2C12 cells

(2013) Ga Young You et al.   CELLULAR SIGNALLING

Akt and Rac1 signaling are jointly required for insulin-stimulated glucose uptake in skeletal muscle and downregulated in insulin resistance

(2013) Lykke Sylow et al.   CELLULAR SIGNALLING

Rac1 Signaling Is Required for Insulin-Stimulated Glucose Uptake and Is Dysregulated in Insulin-Resistant Murine and Human Skeletal Muscle

(2013) L. Sylow et al.   DIABETES

Plekhg4 Is a Novel Dbl Family Guanine Nucleotide Exchange Factor Protein for Rho Family GTPases

(2013) Meghana Gupta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rac-1 Superactivation Triggers Insulin-independent Glucose Transporter 4 (GLUT4) Translocation That Bypasses Signaling Defects Exerted by c-Jun N-terminal kinase (JNK)- and Ceramide-induced Insulin Resistance

(2013) Tim Ting Chiu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Glucose Transporter Translocation in Health and Diabetes

(2012) Jonathan S. Bogan   Annual Review of Biochemistry

Role of RalA downstream of Rac1 in insulin-dependent glucose uptake in muscle cells

(2012) Shinsuke Nozaki et al.   CELLULAR SIGNALLING

Grp1 Plays a Key Role in Linking Insulin Signaling to Glut4 Recycling

(2012) Jian Li et al.   DEVELOPMENTAL CELL

Rac1 Is a Novel Regulator of Contraction-Stimulated Glucose Uptake in Skeletal Muscle

(2012) L. Sylow et al.   DIABETES

Rab10 and myosin-Va mediate insulin-stimulated GLUT4 storage vesicle translocation in adipocytes

(2012) Yu Chen et al.   JOURNAL OF CELL BIOLOGY

PI3K signalling: the path to discovery and understanding

(2012) Bart Vanhaesebroeck et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

C2 Domain-Containing Phosphoprotein CDP138 Regulates GLUT4 Insertion into the Plasma Membrane

(2011) Xiangyang Xie et al.   Cell Metabolism

Rac1 signalling towards GLUT4/glucose uptake in skeletal muscle

(2011) Tim T. Chiu et al.   CELLULAR SIGNALLING

Inhibition or Ablation of p21-activated Kinase (PAK1) Disrupts Glucose Homeostatic Mechanismsin Vivo

(2011) Zhanxiang Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of P-Rex1 as a Novel Rac1-Guanine Nucleotide Exchange Factor (GEF) That Promotes Actin Remodeling and GLUT4 Protein Trafficking in Adipocytes

(2011) Demis Balamatsias et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insulin-stimulated GLUT4 Protein Translocation in Adipocytes Requires the Rab10 Guanine Nucleotide Exchange Factor Dennd4C

(2011) Hiroyuki Sano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exocyst function regulated by effector phosphorylation

(2011) Xiao-Wei Chen et al.   NATURE CELL BIOLOGY

Crucial role of the small GTPase Rac1 in insulin-stimulated translocation of glucose transporter 4 to the mouse skeletal muscle sarcolemma

(2010) Shuji Ueda et al.   FASEB JOURNAL

Analysis of candidate genes on chromosome 20q12-13.1 reveals evidence for BMI mediated association of PREX1 with type 2 diabetes in European Americans

(2010) Joshua P. Lewis et al.   GENOMICS

Rab8A and Rab13 are activated by insulin and regulate GLUT4 translocation in muscle cells

(2010) Y. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Muscle cells engage Rab8A and myosin Vb in insulin-dependent GLUT4 translocation

(2008) Shuhei Ishikura et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Activation of the small GTPase Rac1 by a specific guanine-nucleotide-exchange factor suffices to induce glucose uptake into skeletal-muscle cells

(2008) Shuji Ueda et al.   BIOLOGY OF THE CELL

CaMKII-Mediated Phosphorylation of the Myosin Motor Myo1c Is Required for Insulin-Stimulated GLUT4 Translocation in Adipocytes

(2008) Ming Fai Yip et al.   Cell Metabolism

Membrane traffic in the secretory pathway

(2008) S. Loubéry et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

GLUT4 Vesicle Recruitment and Fusion Are Differentially Regulated by Rac, AS160, and Rab8A in Muscle Cells

(2008) Varinder K. Randhawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PI3K/Akt: getting it right matters

(2008) T F Franke   ONCOGENE