A Mitochondrial Polymorphism Alters Immune Cell Metabolism and Protects Mice from Skin Inflammation

Propionic Acid Shapes the Multiple Sclerosis Disease Course by an Immunomodulatory Mechanism

(2020) Alexander Duscha et al.   CELL

Elevated Gut Microbiome-Derived Propionate Levels Are Associated With Reduced Sterile Lung Inflammation and Bacterial Immunity in Mice

(2019) Xiaoli Tian et al.   Frontiers in Microbiology

A Natural mtDNA Polymorphism in Complex III Is a Modifier of Healthspan in Mice

(2019) Misa Hirose et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Maternally Inherited Differences within Mitochondrial Complex I Control Murine Healthspan

(2019) Misa Hirose et al.   Genes

Role of the IL-23/IL-17 Axis in Psoriasis and Psoriatic Arthritis: The Clinical Importance of Its Divergence in Skin and Joints

(2018) Marie-Astrid Boutet et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Low-level mitochondrial heteroplasmy modulates DNA replication, glucose metabolism and lifespan in mice

(2018) Misa Hirose et al.   Scientific Reports

IL-17A is functionally relevant and a potential therapeutic target in bullous pemphigoid

(2018) Lenche Chakievska et al.   JOURNAL OF AUTOIMMUNITY

Mitochondrial fidelity and metabolic agility control immune cell fate and function

(2018) Michael N. Sack   JOURNAL OF CLINICAL INVESTIGATION

Cutting Edge: TGF-β and Phosphatidylinositol 3-Kinase Signals Modulate Distinct Metabolism of Regulatory T Cell Subsets

(2018) Bhavana Priyadharshini et al.   JOURNAL OF IMMUNOLOGY

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

(2018) Evanna L. Mills et al.   NATURE

Mitochondrial genetic medicine

(2018) Douglas C. Wallace   NATURE GENETICS

The mitochondrial respiratory chain is essential for haematopoietic stem cell function

(2017) Elena Ansó et al.   NATURE CELL BIOLOGY

Mitochondrial gene polymorphism is associated with gut microbial communities in mice

(2017) Misa Hirose et al.   Scientific Reports

Hormetic potential of methylglyoxal, a side-product of glycolysis, in switching tumours from growth to death

(2017) Marie-Julie Nokin et al.   Scientific Reports

Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming

(2016) Michael D. Buck et al.   CELL

The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction

(2016) Nicole E. Scharping et al.   IMMUNITY

Propionate Increases Hepatic Pyruvate Cycling and Anaplerosis and Alters Mitochondrial Metabolism

(2016) Rachel J. Perry et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lifespan effects of mitochondrial mutations

(2016) Misa Hirose et al.   NATURE

Mitochondrial and nuclear DNA matching shapes metabolism and healthy ageing

(2016) Ana Latorre-Pellicer et al.   NATURE

Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression

(2016) Valerie A Gerriets et al.   NATURE IMMUNOLOGY

Stable nuclear expression ofATP8andATP6genes rescues a mtDNA Complex Vnullmutant

(2016) Amutha Boominathan et al.   NUCLEIC ACIDS RESEARCH

Mitochondrial Dysfunction Prevents Repolarization of Inflammatory Macrophages

(2016) Jan Van den Bossche et al.   Cell Reports

Mitochondrial gene polymorphisms alter hepatic cellular energy metabolism and aggravate diet-induced non-alcoholic steatohepatitis

(2016) Torsten Schröder et al.   Molecular Metabolism

Leukotrienes Do Not Modulate the Course of Aldara™-induced Psoriasiform Dermatitis in Mice

(2015) T Sezin et al.   ACTA DERMATO-VENEREOLOGICA

Dietary Fatty Acids Directly Impact Central Nervous System Autoimmunity via the Small Intestine

(2015) Aiden Haghikia et al.   IMMUNITY

T cell metabolism drives immunity

(2015) Michael D. Buck et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Radiosensitive Hematopoietic Cells Determine the Extent of Skin Inflammation in Experimental Epidermolysis Bullosa Acquisita

(2015) Hiroaki Iwata et al.   JOURNAL OF IMMUNOLOGY

Sterol metabolism controls T H 17 differentiation by generating endogenous RORγ agonists

(2015) Xiao Hu et al.   Nature Chemical Biology

The MetaCyc database of metabolic pathways and enzymes and the BioCyc collection of pathway/genome databases

(2015) Ron Caspi et al.   NUCLEIC ACIDS RESEARCH

Normalization of CD4 + T cell metabolism reverses lupus

(2015) Yiming Yin et al.   Science Translational Medicine

Methylglyoxal, the dark side of glycolysis

(2015) Igor Allaman et al.   Frontiers in Neuroscience

Memory CD8+ T Cells Use Cell-Intrinsic Lipolysis to Support the Metabolic Programming Necessary for Development

(2014) David O’Sullivan et al.   IMMUNITY

Phylogenetic distribution of three pathways for propionate production within the human gut microbiota

(2014) Nicole Reichardt et al.   ISME Journal

Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis

(2014) Aurélien Trompette et al.   NATURE MEDICINE

De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells

(2014) Luciana Berod et al.   NATURE MEDICINE

A review of the mitochondrial and glycolytic metabolism in human platelets and leukocytes: Implications for their use as bioenergetic biomarkers

(2014) Philip A. Kramer et al.   Redox Biology

Mitochondria Are Required for Antigen-Specific T Cell Activation through Reactive Oxygen Species Signaling

(2013) Laura A. Sena et al.   IMMUNITY

Metabolic Pathways in Immune Cell Activation and Quiescence

(2013) Erika L. Pearce et al.   IMMUNITY

Methods for defining distinct bioenergetic profiles in platelets, lymphocytes, monocytes and neutrophils and the oxidative burst from human blood

(2013) Balu K Chacko et al.   LABORATORY INVESTIGATION

Specific mitochondrial DNA mutation in mice regulates diabetes and lymphoma development

(2012) O. Hashizume et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the yeast F1Fo-ATP synthase dimer and its role in shaping the mitochondrial cristae

(2012) K. M. Davies et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mouse mtDNA mutant model of Leber hereditary optic neuropathy

(2012) C. S. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial Respiratory Capacity Is a Critical Regulator of CD8+ T Cell Memory Development

(2011) Gerritje J.W. van der Windt et al.   IMMUNITY

Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets

(2011) R. D. Michalek et al.   JOURNAL OF IMMUNOLOGY

High Throughput Microplate Respiratory Measurements Using Minimal Quantities Of Isolated Mitochondria

(2011) George W. Rogers et al.   PLoS One

Assembly and oligomerization of human ATP synthase lacking mitochondrial subunits a and A6L

(2010) Ilka Wittig et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The innate immune system in host mice targets cells with allogenic mitochondrial DNA

(2010) Kaori Ishikawa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Role of nuclear-encoded subunit Vb in the assembly and stability of cytochromecoxidase complex: implications in mitochondrial dysfunction and ROS production

(2009) Domenico Galati et al.   BIOCHEMICAL JOURNAL

Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice Is Mediated via the IL-23/IL-17 Axis

(2009) L. van der Fits et al.   JOURNAL OF IMMUNOLOGY

Butyrate and propionate induced activated or non-activated neutrophil apoptosis via HDAC inhibitor activity but without activating GPR-41/GPR-43 pathways

(2009) Michiko Aoyama et al.   NUTRITION

MouseCyc: a curated biochemical pathways database for the laboratory mouse

(2009) Alexei V Evsikov et al.   GENOME BIOLOGY

Dissecting the effects of mtDNA variations on complex traits using mouse conplastic strains

(2008) X. Yu et al.   GENOME RESEARCH