An overview of process development for antibody-drug conjugates produced by chemical conjugation technology
出版年份 2020 全文链接
标题
An overview of process development for antibody-drug conjugates produced by chemical conjugation technology
作者
关键词
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出版物
EXPERT OPINION ON BIOLOGICAL THERAPY
Volume -, Issue -, Pages 1-13
出版商
Informa UK Limited
发表日期
2020-11-04
DOI
10.1080/14712598.2021.1846714
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Alpha- and Beta-Amanitin Total Synthesis
- (2020) Christian Lutz et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Antibody–Drug Conjugate Payloads; Study of Auristatin Derivatives
- (2020) Michinori Akaiwa et al. CHEMICAL & PHARMACEUTICAL BULLETIN
- Bis(vinylsulfonyl)piperazines as efficient linkers for highly homogeneous antibody-drug conjugates
- (2020) Rong Huang et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Proof of site-specificity of antibody-drug conjugates produced by chemical conjugation technology: AJICAP first generation
- (2020) Yutaka Matsuda et al. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
- Cysteine-specific protein multi-functionalization and disulfide bridging using 3-bromo-5-methylene pyrrolones
- (2020) Yingqian Zhang et al. Nature Communications
- Bispecific Antibodies and Antibody–Drug Conjugates for Cancer Therapy: Technological Considerations
- (2020) Hyunbo Shim Biomolecules
- Recent progress in transglutaminase-mediated assembly of antibody-drug conjugates
- (2020) Hendrik Schneider et al. ANALYTICAL BIOCHEMISTRY
- Glycan-Mediated Technology for Obtaining Homogeneous Site-Specific Conjugated Antibody–Drug Conjugates: Synthesis and Analytical Characterization by Using Complementary Middle-up LC/HRMS Analysis
- (2020) Bastiaan L. Duivelshof et al. ANALYTICAL CHEMISTRY
- Sacituzumab govitecan, a novel, third-generation, antibody-drug conjugate (ADC) for cancer therapy
- (2020) David M. Goldenberg et al. EXPERT OPINION ON BIOLOGICAL THERAPY
- Evaluation of hydrophobic‐interaction‐chromatography Resins for purification of antibody‐drug conjugates using a mimetic model with adjustable hydrophobicity
- (2020) Egbert Müller et al. JOURNAL OF SEPARATION SCIENCE
- Protein–Protein Cross-Coupling via Palladium–Protein Oxidative Addition Complexes from Cysteine Residues
- (2020) Heemal H. Dhanjee et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Advances in engineering local drug delivery systems for cancer immunotherapy
- (2020) Peter Abdou et al. Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology
- Pharmacokinetics of trastuzumab deruxtecan (T-DXd), a novel anti-HER2 antibody-drug conjugate, in HER2-positive tumour-bearing mice
- (2020) Hiromi Okamoto et al. XENOBIOTICA
- Synthesis and Biological Evaluation of Antibody Drug Conjugates Based on an Antibody Expression System: Conamax
- (2020) Zhala Tawfiq et al. ACS Omega
- Analytical Comparison of Antibody-drug Conjugates Based on Good Manufacturing Practice Strategies
- (2020) Zhala TAWFIQ et al. ANALYTICAL SCIENCES
- Antibody-drug conjugates (ADCs) delivering pyrrolobenzodiazepine (PBD) dimers for cancer therapy
- (2020) John A. Hartley EXPERT OPINION ON BIOLOGICAL THERAPY
- B-Cell Maturation Antigen (BCMA) as a Target for New Drug Development in Relapsed and/or Refractory Multiple Myeloma
- (2020) Hanley N. Abramson INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Application of Native Ion Exchange Mass Spectrometry to Intact and Subunit Analysis of Site-Specific Antibody–Drug Conjugates Produced by AJICAP First Generation Technology
- (2020) Yutaka Matsuda et al. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
- Insight into Temperature Dependency and Design of Experiments towards Process Development for Cysteine‐Based Antibody‐Drug Conjugates
- (2020) Yutaka Matsuda et al. ChemistrySelect
- Antibody–Drug Conjugates: The Last Decade
- (2020) Nicolas Joubert et al. Pharmaceuticals
- Site-Specific Chemical Conjugation of Antibodies by Using Affinity Peptide for the Development of Therapeutic Antibody Format
- (2019) Satoshi Kishimoto et al. BIOCONJUGATE CHEMISTRY
- Dextramabs: A Novel Format of Antibody‐Drug Conjugates Featuring a Multivalent Polysaccharide Scaffold
- (2019) Hendrik Schneider et al. ChemistryOpen
- AJICAP: Affinity Peptide Mediated Regiodivergent Functionalization of Native Antibodies
- (2019) Kei Yamada et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- The Role of Organic Synthesis in the Emergence and Development of Antibody-Drug Conjugates as Targeted Cancer Therapies
- (2019) Kyriacos C. Nicolaou et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Recent Chemical Approaches for Site‐specific Conjugation of Native Antibodies: Technologies toward Next Generation Antibody‐Drug Conjugates
- (2019) Kei Yamada et al. CHEMBIOCHEM
- Polatuzumab vedotin in combination with immunochemotherapy in patients with previously untreated diffuse large B-cell lymphoma: an open-label, non-randomised, phase 1b–2 study
- (2019) Hervé Tilly et al. LANCET ONCOLOGY
- Synthesis and Feasibility Evaluation of a new Trastuzumab Conjugate Integrated with Paclitaxel and 89 Zr for Theranostic Application Against HER2‐Expressing Breast Cancers
- (2019) Joo Hee Jang et al. ChemistryOpen
- Antibody-drug conjugates- stability and formulation
- (2019) Corinna Duerr et al. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
- Comparison of Analytical Methods for Antibody–Drug Conjugates Produced by Chemical Site-Specific Conjugation: First-Generation AJICAP
- (2019) Yutaka Matsuda et al. ANALYTICAL CHEMISTRY
- Natural product derived privileged scaffolds in drug discovery
- (2019) Emma K Davison et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Development of a high yielding expression platform for the introduction of non-natural amino acids in protein sequences
- (2019) Gargi Roy et al. mAbs
- Antibody-Drug Conjugates: A Comprehensive Review
- (2019) Puregmaa Khongorzul et al. MOLECULAR CANCER RESEARCH
- Good Manufacturing Practice Strategy for Antibody–Drug Conjugate Synthesis Using Site-Specific Chemical Conjugation: First-Generation AJICAP
- (2019) Yutaka Matsuda et al. ACS Omega
- Trastuzumab Deruxtecan in Previously Treated HER2-Positive Breast Cancer
- (2019) Shanu Modi et al. NEW ENGLAND JOURNAL OF MEDICINE
- Gram-Scale Antibody–Drug Conjugate Synthesis by Site-Specific Chemical Conjugation: AJICAP First Generation
- (2019) Yutaka Matsuda et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Antibody drug conjugates: Development, characterization, and regulatory considerations
- (2019) Nagavendra Kommineni et al. POLYMERS FOR ADVANCED TECHNOLOGIES
- Review transglutaminases: part II—industrial applications in food, biotechnology, textiles and leather products
- (2019) Lovaine Duarte et al. WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
- Generation of Potent Anti-HER1/2 Immunotoxins by Protein Ligation Using Split Inteins
- (2018) Thomas Pirzer et al. ACS Chemical Biology
- Divergent Strategy in Natural Product Total Synthesis
- (2018) Lei Li et al. CHEMICAL REVIEWS
- Fate of Antibody-Drug Conjugates in Cancer Cells
- (2018) Cécile Chalouni et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Highly homogeneous antibody modification through optimisation of the synthesis and conjugation of functionalised dibromopyridazinediones
- (2018) Calise Bahou et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- Process Development and Structural Characterization of an Anti-Notch 3 Antibody–Drug Conjugate
- (2018) Durgesh V. Nadkarni et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- An overview of the total synthesis of africane-type sesquiterpenoids
- (2018) Yutaka Matsuda et al. TETRAHEDRON LETTERS
- Reduction–rebridging strategy for the preparation of ADPN-based antibody–drug conjugates
- (2018) Oleksandr Koniev et al. MedChemComm
- Qualitative analysis of antibody-drug conjugates (ADCs): an experimental comparison of analytical techniques of cysteine-linked ADCs
- (2018) Malin Källsten et al. ANALYST
- Bioconjugation with Maleimides: A useful Tool for Chemical Biology
- (2018) Pedro Miguel pimenta Gois et al. CHEMISTRY-A EUROPEAN JOURNAL
- Bioprocess development of antibody-drug conjugate production for cancer treatment
- (2018) Jianfa Ou et al. PLoS One
- Inotuzumab ozogamicin: a CD22 mAb–drug conjugate for adult relapsed or refractory B-cell precursor acute lymphoblastic leukemia
- (2018) Ilana R Yurkiewicz et al. Drug Design Development and Therapy
- Proximity-Induced Site-Specific Antibody Conjugation
- (2018) Chenfei Yu et al. BIOCONJUGATE CHEMISTRY
- Antibody-drug conjugates (ADCs) for cancer therapy: Strategies, challenges, and successes
- (2018) Meghdad Abdollahpour-Alitappeh et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Is hydrophobic interaction chromatography the most suitable technique to characterize site-specific antibody-drug conjugates?
- (2018) Valentina D’Atri et al. JOURNAL OF CHROMATOGRAPHY A
- Deamidation and isomerization liability analysis of 131 clinical-stage antibodies
- (2018) Xiaojun Lu et al. mAbs
- Comprehensive preclinical pharmacokinetic evaluations of trastuzumab deruxtecan (DS-8201a), a HER2-targeting antibody-drug conjugate, in cynomolgus monkeys
- (2018) Yoko Nagai et al. XENOBIOTICA
- A Hexa-rhodium Metallopeptide Catalyst for Site-Specific Functionalization of Natural Antibodies
- (2017) Jun Ohata et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Site-selective orientated immobilization of antibodies and conjugates for immunodiagnostics development
- (2017) Min Shen et al. METHODS
- Highly Potent, Anthracycline-based Antibody–Drug Conjugates Generated by Enzymatic, Site-specific Conjugation
- (2017) Nikolas Stefan et al. MOLECULAR CANCER THERAPEUTICS
- Novel Hybrid Compound of a Plinabulin Prodrug with an IgG Binding Peptide for Generating a Tumor Selective Noncovalent-Type Antibody–Drug Conjugate
- (2016) Kyohei Muguruma et al. BIOCONJUGATE CHEMISTRY
- Novel antibody drug conjugates containing exatecan derivative-based cytotoxic payloads
- (2016) Takashi Nakada et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Cost evaluation of antibody production processes in different operation modes
- (2016) Stephan Klutz et al. CHEMICAL ENGINEERING SCIENCE
- DS-8201a, A Novel HER2-Targeting ADC with a Novel DNA Topoisomerase I Inhibitor, Demonstrates a Promising Antitumor Efficacy with Differentiation from T-DM1
- (2016) Y. Ogitani et al. CLINICAL CANCER RESEARCH
- Extension of in vivo half-life of biologically active molecules by XTEN protein polymers
- (2016) Vladimir N. Podust et al. JOURNAL OF CONTROLLED RELEASE
- Practical method development for the separation of monoclonal antibodies and antibody-drug-conjugate species in hydrophobic interaction chromatoraphy, part 2: Optimization of the phase system
- (2016) Alessandra Cusumano et al. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
- Transition Metal-Free Tryptophan-Selective Bioconjugation of Proteins
- (2016) Yohei Seki et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- In-depth structural characterization of Kadcyla® (ado-trastuzumab emtansine) and its biosimilar candidate
- (2016) Liuxi Chen et al. mAbs
- Processes for Constructing Homogeneous Antibody Drug Conjugates
- (2016) David Y. Jackson ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Improved variants of SrtA for site-specific conjugation on antibodies and proteins with high efficiency
- (2016) Long Chen et al. Scientific Reports
- Antibody-drug conjugates: recent advances in conjugation and linker chemistries
- (2016) Kyoji Tsuchikama et al. Protein & Cell
- Chemoenzymatic Conjugation of Toxic Payloads to the Globally Conserved N-Glycan of Native mAbs Provides Homogeneous and Highly Efficacious Antibody–Drug Conjugates
- (2015) Remon van Geel et al. BIOCONJUGATE CHEMISTRY
- Effect of Attachment Site on Stability of Cleavable Antibody Drug Conjugates
- (2015) Magdalena Dorywalska et al. BIOCONJUGATE CHEMISTRY
- LASIC: Light Activated Site-Specific Conjugation of Native IgGs
- (2015) James Z. Hui et al. BIOCONJUGATE CHEMISTRY
- Fusion Proteins for Half-Life Extension of Biologics as a Strategy to Make Biobetters
- (2015) William R. Strohl BIODRUGS
- Synthetic approaches to the 2013 new drugs
- (2015) Hong X. Ding et al. BIOORGANIC & MEDICINAL CHEMISTRY
- A Polymer-Based Antibody-Vinca Drug Conjugate Platform: Characterization and Preclinical Efficacy
- (2015) A. V. Yurkovetskiy et al. CANCER RESEARCH
- Functional native disulfide bridging enables delivery of a potent, stable and targeted antibody–drug conjugate (ADC)
- (2015) João P. M. Nunes et al. CHEMICAL COMMUNICATIONS
- Characterization of antibody drug conjugate positional isomers at cysteine residues by peptide mapping LC–MS analysis
- (2015) Marie-Claire Janin-Bussat et al. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
- IMGN853, a Folate Receptor- (FR )-Targeting Antibody-Drug Conjugate, Exhibits Potent Targeted Antitumor Activity against FR -Expressing Tumors
- (2015) O. Ab et al. MOLECULAR CANCER THERAPEUTICS
- Site-Specific Conjugation of Monomethyl Auristatin E to Anti-CD30 Antibodies Improves Their Pharmacokinetics and Therapeutic Index in Rodent Models
- (2015) F. Lhospice et al. MOLECULAR PHARMACEUTICS
- In Vitro and In Vivo Evaluation of Cysteine Rebridged Trastuzumab–MMAE Antibody Drug Conjugates with Defined Drug-to-Antibody Ratios
- (2015) Penny Bryant et al. MOLECULAR PHARMACEUTICS
- Reducing hydrophobicity of homogeneous antibody-drug conjugates improves pharmacokinetics and therapeutic index
- (2015) Robert P Lyon et al. NATURE BIOTECHNOLOGY
- Production of soluble and active microbial transglutaminase inEscherichia colifor site-specific antibody drug conjugation
- (2015) Mathias Rickert et al. PROTEIN SCIENCE
- Native mass spectrometry and ion mobility characterization of trastuzumab emtansine, a lysine-linked antibody drug conjugate
- (2015) Julien Marcoux et al. PROTEIN SCIENCE
- Site-Specific Photoconjugation of Antibodies Using Chemically Synthesized IgG-Binding Domains
- (2014) Anna Perols et al. BIOCONJUGATE CHEMISTRY
- Improving the Serum Stability of Site-Specific Antibody Conjugates with Sulfone Linkers
- (2014) James T. Patterson et al. BIOCONJUGATE CHEMISTRY
- Bridging Disulfides for Stable and Defined Antibody Drug Conjugates
- (2014) George Badescu et al. BIOCONJUGATE CHEMISTRY
- Production of Site-Specific Antibody–Drug Conjugates Using Optimized Non-Natural Amino Acids in a Cell-Free Expression System
- (2014) Erik S. Zimmerman et al. BIOCONJUGATE CHEMISTRY
- Separation of mAbs molecular variants by analytical hydrophobic interaction chromatography HPLC: overview and applications
- (2014) Mark Haverick et al. mAbs
- Location Matters: Site of Conjugation Modulates Stability and Pharmacokinetics of Antibody Drug Conjugates
- (2013) Pavel Strop et al. CHEMISTRY & BIOLOGY
- Site-specific antibody drug conjugates for cancer therapy
- (2013) Siler Panowski et al. mAbs
- Methods for site-specific drug conjugation to antibodies
- (2013) Christopher R Behrens et al. mAbs
- Marketed therapeutic antibodies compendium
- (2012) Janice M. Reichert mAbs
- The discovery and development of brentuximab vedotin for use in relapsed Hodgkin lymphoma and systemic anaplastic large cell lymphoma
- (2012) Peter D Senter et al. NATURE BIOTECHNOLOGY
- Covalent Immunoglobulin Labeling through a Photoactivable Synthetic Z Domain
- (2011) Anna Konrad et al. BIOCONJUGATE CHEMISTRY
- Influence of Affinity and Antigen Internalization on the Uptake and Penetration of Anti-HER2 Antibodies in Solid Tumors
- (2011) S. I. Rudnick et al. CANCER RESEARCH
- Trastuzumab Emtansine: A Unique Antibody-Drug Conjugate in Development for Human Epidermal Growth Factor Receptor 2-Positive Cancer
- (2011) P. M. LoRusso et al. CLINICAL CANCER RESEARCH
- Brentuximab Vedotin (SGN-35)
- (2011) J. Katz et al. CLINICAL CANCER RESEARCH
- Analytical methods for physicochemical characterization of antibody drug conjugates
- (2011) Aditya Wakankar et al. mAbs
- Engineered Thio-Trastuzumab-DM1 Conjugate with an Improved Therapeutic Index to Target Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer
- (2010) J. R. Junutula et al. CLINICAL CANCER RESEARCH
- Tyrosine Bioconjugation through Aqueous Ene-Type Reactions: A Click-Like Reaction for Tyrosine
- (2010) Hitoshi Ban et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Redox Economy in Organic Synthesis
- (2009) Noah Z. Burns et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- The economies of synthesis
- (2009) Timothy Newhouse et al. CHEMICAL SOCIETY REVIEWS
- Protecting-group-free synthesis as an opportunity for invention
- (2009) Ian S. Young et al. Nature Chemistry
- Antibody Conjugates of 7-Ethyl-10-hydroxycamptothecin (SN-38) for Targeted Cancer Chemotherapy
- (2008) Sung-Ju Moon et al. JOURNAL OF MEDICINAL CHEMISTRY
- Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index
- (2008) Jagath R Junutula et al. NATURE BIOTECHNOLOGY
- Targeted Cancer Therapy: Conferring Specificity to Cytotoxic Drugs
- (2007) Ravi V. J. Chari ACCOUNTS OF CHEMICAL RESEARCH
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