Analytical methods for physicochemical characterization of antibody drug conjugates

Physicochemical Stability of the Antibody−Drug Conjugate Trastuzumab-DM1: Changes due to Modification and Conjugation Processes

(2010) Aditya A. Wakankar et al.   BIOCONJUGATE CHEMISTRY

Engineered Thio-Trastuzumab-DM1 Conjugate with an Improved Therapeutic Index to Target Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer

(2010) J. R. Junutula et al.   CLINICAL CANCER RESEARCH

Charge heterogeneity of a therapeutic monoclonal antibody conjugated with a cytotoxic antitumor antibiotic, calicheamicin

(2010) Eiki Maeda et al.   JOURNAL OF CHROMATOGRAPHY A

Assessing monoclonal antibody product quality attribute criticality through clinical studies

(2010) Andrew M. Goetze et al.   mAbs

Brentuximab Vedotin (SGN-35) for Relapsed CD30-Positive Lymphomas

(2010) Anas Younes et al.   NEW ENGLAND JOURNAL OF MEDICINE

Potent antibody drug conjugates for cancer therapy

(2009) Peter D Senter   CURRENT OPINION IN CHEMICAL BIOLOGY

Novel anti-tubulin cytotoxic agents for breast cancer

(2009) Patrick G Morris et al.   Expert Review of Anticancer Therapy

Synthesis and Preliminary Biological Evaluation of High-Drug-Load Paclitaxel-Antibody Conjugates for Tumor-Targeted Chemotherapy

(2009) Sherly Quiles et al.   JOURNAL OF MEDICINAL CHEMISTRY

Anti-CD22-MCC-DM1 and MC-MMAF Conjugates: Impact of Assay Format on Pharmacokinetic Parameters Determination

(2008) Jean-Philippe Stephan et al.   BIOCONJUGATE CHEMISTRY

Heterogeneity of Monoclonal Antibodies Revealed by Charge-Sensitive Methods

(2008) J. Vlasak et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Application of imaging capillary IEF for characterization and quantitative analysis of recombinant protein charge heterogeneity

(2008) Zoran Sosic et al.   ELECTROPHORESIS

Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index

(2008) Jagath R Junutula et al.   NATURE BIOTECHNOLOGY

Targeted Cancer Therapy: Conferring Specificity to Cytotoxic Drugs

(2007) Ravi V. J. Chari   ACCOUNTS OF CHEMICAL RESEARCH

Selection of Reaction Additives Used in the Preparation of Monomeric Antibody−Calicheamicin Conjugates

(2007) Irwin Hollander et al.   BIOCONJUGATE CHEMISTRY