Functional native disulfide bridging enables delivery of a potent, stable and targeted antibody–drug conjugate (ADC)
出版年份 2015 全文链接
标题
Functional native disulfide bridging enables delivery of a potent, stable and targeted antibody–drug conjugate (ADC)
作者
关键词
-
出版物
CHEMICAL COMMUNICATIONS
Volume 51, Issue 53, Pages 10624-10627
出版商
Royal Society of Chemistry (RSC)
发表日期
2015-06-01
DOI
10.1039/c5cc03557k
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- A mild TCEP-based para-azidobenzyl cleavage strategy to transform reversible cysteine thiol labelling reagents into irreversible conjugates
- (2015) Antoine Maruani et al. CHEMICAL COMMUNICATIONS
- A plug-and-play approach to antibody-based therapeutics via a chemoselective dual click strategy
- (2015) Antoine Maruani et al. Nature Communications
- Bridging Disulfides for Stable and Defined Antibody Drug Conjugates
- (2014) George Badescu et al. BIOCONJUGATE CHEMISTRY
- Regioselective and Stoichiometrically Controlled Conjugation of Photodynamic Sensitizers to a HER2 Targeting Antibody Fragment
- (2014) Francesca Bryden et al. BIOCONJUGATE CHEMISTRY
- Production of Site-Specific Antibody–Drug Conjugates Using Optimized Non-Natural Amino Acids in a Cell-Free Expression System
- (2014) Erik S. Zimmerman et al. BIOCONJUGATE CHEMISTRY
- Next generation maleimides enable the controlled assembly of antibody–drug conjugates via native disulfide bond bridging
- (2014) Felix F. Schumacher et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- Acid-cleavable thiomaleamic acid linker for homogeneous antibody–drug conjugation
- (2013) Lourdes Castañeda et al. CHEMICAL COMMUNICATIONS
- Maturing antibody–drug conjugate pipeline hits 30
- (2013) Asher Mullard NATURE REVIEWS DRUG DISCOVERY
- Homogeneous antibody fragment conjugation by disulfide bridging introduces ‘spinostics’
- (2013) Felix F. Schumacher et al. Scientific Reports
- Antibody-Drug Conjugates for the Treatment of Cancer
- (2012) John A. Flygare et al. Chemical Biology & Drug Design
- Antibody–drug conjugates – a perfect synergy
- (2012) John R Adair et al. EXPERT OPINION ON BIOLOGICAL THERAPY
- Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates
- (2012) Ben-Quan Shen et al. NATURE BIOTECHNOLOGY
- Trastuzumab Emtansine for HER2-Positive Advanced Breast Cancer
- (2012) Sunil Verma et al. NEW ENGLAND JOURNAL OF MEDICINE
- In Situ Maleimide Bridging of Disulfides and a New Approach to Protein PEGylation
- (2011) Felix F. Schumacher et al. BIOCONJUGATE CHEMISTRY
- Tunable reagents for multi-functional bioconjugation: reversible or permanent chemical modification of proteins and peptides by control of maleimide hydrolysis
- (2011) Chris P. Ryan et al. CHEMICAL COMMUNICATIONS
- Bromopyridazinedione-mediated protein and peptide bioconjugation
- (2011) Vijay Chudasama et al. CHEMICAL COMMUNICATIONS
- Investigational antibody drug conjugates for solid tumors
- (2011) Puja Sapra et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Engineered Thio-Trastuzumab-DM1 Conjugate with an Improved Therapeutic Index to Target Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer
- (2010) J. R. Junutula et al. CLINICAL CANCER RESEARCH
- Antibody–drug conjugates: targeted drug delivery for cancer
- (2010) Stephen C Alley et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Protein Modification, Bioconjugation, and Disulfide Bridging Using Bromomaleimides
- (2010) Mark E. B. Smith et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Antibody−Drug Conjugates: Linking Cytotoxic Payloads to Monoclonal Antibodies
- (2009) Laurent Ducry et al. BIOCONJUGATE CHEMISTRY
- Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index
- (2008) Jagath R Junutula et al. NATURE BIOTECHNOLOGY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started