FoxO1 signaling as a therapeutic target for type 2 diabetes and obesity

Triterpenoids from Cyclocarya paliurus that Enhance Glucose Uptake in 3T3-L1 Adipocytes

(2019) Zhu-Jun Fang et al.   MOLECULES

PAQR3 regulates phosphorylation of FoxO1 in insulin-resistant HepG2 cells via NF-κB signaling pathway

(2019) Lihao Chen et al.   EXPERIMENTAL CELL RESEARCH

Antidiabetic effects of different polysaccharide fractions from Artemisia sphaerocephala Krasch seeds in db/db mice

(2019) Junjun Li et al.   FOOD HYDROCOLLOIDS

FOXO1 inhibition potentiates endothelial angiogenic functions in diabetes via suppression of ROCK1/Drp1-mediated mitochondrial fission

(2018) Yundi Shi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Qing Gan Zi Shen Tang alleviates adipose tissue dysfunction with up-regulation of SIRT1 in spontaneously hypertensive rat

(2018) Yao Zhu et al.   BIOMEDICINE & PHARMACOTHERAPY

Moringa concanensis Nimmo ameliorates hyperglycemia in 3T3-L1 adipocytes by upregulating PPAR-γ, C/EBP-α via Akt signaling pathway and STZ-induced diabetic rats

(2018) Brindha Banu Balakrishnan et al.   BIOMEDICINE & PHARMACOTHERAPY

Liraglutide ameliorates early renal injury by the activation of renal FoxO1 in a type 2 diabetic kidney disease rat model

(2018) Pin Chen et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Ameliorative effect of panaxynol on the reduction in high-molecular-weight adiponectin secretion from 3T3-L1 adipocytes treated with palmitic acids

(2018) Michiyo Takagi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cilostazol alleviates streptozotocin-induced testicular injury in rats via PI3K/Akt pathway

(2018) Mervat Z. Mohamed et al.   LIFE SCIENCES

Licorice flavonoid oil enhances muscle mass in KK- A y mice

(2018) Yasukiyo Yoshioka et al.   LIFE SCIENCES

Antidiabetic Activity of Ergosterol from Pleurotus Ostreatus in KK-Ay Mice with Spontaneous Type 2 Diabetes Mellitus

(2018) Mingrui Xiong et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Catalpol ameliorates hepatic insulin resistance in type 2 diabetes through acting on AMPK/NOX4/PI3K/AKT pathway

(2018) Jiting Yan et al.   PHARMACOLOGICAL RESEARCH

Gelidium elegans Extract Ameliorates Type 2 Diabetes via Regulation of MAPK and PI3K/Akt Signaling

(2018) Jia Choi et al.   Nutrients

Discovery of pancreastatin inhibitor PSTi8 for the treatment of insulin resistance and diabetes: studies in rodent models of diabetes mellitus

(2018) Zakir Hossain et al.   Scientific Reports

The PI3K/AKT pathway in obesity and type 2 diabetes

(2018) Xingjun Huang et al.   International Journal of Biological Sciences

Effect of oral magnesium sulfate administration on blood glucose hemostasis via inhibition of gluconeogenesis and FOXO1 gene expression in liver and muscle in diabetic rats

(2018) Ayeshe Barooti et al.   BIOMEDICINE & PHARMACOTHERAPY

Investigations on the effects of ginsenoside-Rg1 on glucose uptake and metabolism in insulin resistant HepG2 cells

(2018) Xiaoming Fan et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Hypoglycemic effects of polysaccharides from corn silk (Maydis stigma) and their beneficial roles via regulating the PI3K/Akt signaling pathway in L6 skeletal muscle myotubes

(2018) Qingwen Guo et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Effect of Radix isatidis polysaccharide on alleviating insulin resistance in type 2 diabetes mellitus cells and rats

(2018) Ji-ping Li et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Biochemical and molecular evidence on the role of vaspin in early detection of the insulin resistance in a rat model of high-fat diet and use of diazinon

(2018) Armin Salek-Maghsoudi et al.   TOXICOLOGY

Hypoglycemic effect of Hypericum attenuatum Choisy extracts on type 2 diabetes by regulating glucolipid metabolism and modulating gut microbiota

(2018) Du-Xin Jin et al.   Journal of Functional Foods

Therapeutic potential of buckwheat hull flavonoids in db/db mice, a model of type 2 diabetes

(2018) Pengcheng Li et al.   Journal of Functional Foods

Anthocyanins from dietary black soybean potentiate glucose uptake in L6 rat skeletal muscle cells via up-regulating phosphorylated Akt and GLUT4

(2018) Zhongqin Chen et al.   Journal of Functional Foods

Raspberry ketone and Garcinia Cambogia rebalanced disrupted insulin resistance and leptin signaling in rats fed high fat fructose diet

(2018) Reem T. Attia et al.   BIOMEDICINE & PHARMACOTHERAPY

Hypoglycemic activity of the extracts of Belamcanda chinensis leaves (BCLE) on KK-Ay mice

(2018) Ying Guo et al.   BIOMEDICINE & PHARMACOTHERAPY

MicroRNA-21 regulates hepatic glucose metabolism by targeting FOXO1

(2017) Ailing Luo et al.   GENE

The impact of FOXO-1 to cardiac pathology in diabetes mellitus and diabetes-related metabolic abnormalities

(2017) Dimitry A. Chistiakov et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Eburicoic Acid, a Triterpenoid Compound from Antrodia camphorata, Displays Antidiabetic and Antihyperlipidemic Effects in Palmitate-Treated C2C12 Myotubes and in High-Fat Diet-Fed Mice

(2017) Cheng-Hsiu Lin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inhibitory Effect of Piceatannol on TNF-α-Mediated Inflammation and Insulin Resistance in 3T3-L1 Adipocytes

(2017) Yanfang Li et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The role of FoxO1 in interleukin-1β-induced autostimulation in retina endothelial cells and retinas of diabetic rats

(2017) Lina Wu et al.   MICROVASCULAR RESEARCH

Plasma bradykinin and early diabetic nephropathy lesions in type 1 diabetes mellitus

(2017) Kevin M. Wheelock et al.   PLoS One

A global perspective on FOXO1 in lipid metabolism and lipid-related diseases

(2017) Yue Li et al.   PROGRESS IN LIPID RESEARCH

Endothelial APLNR regulates tissue fatty acid uptake and is essential for apelin’s glucose-lowering effects

(2017) Cheol Hwangbo et al.   Science Translational Medicine

Ethanol extract of Atractylodis macrocephalae Rhizoma ameliorates insulin resistance and gut microbiota in type 2 diabetic db/db mice

(2017) Wen-You Zhang et al.   Journal of Functional Foods

Porphyromonas gingivalis attenuates the insulin-induced phosphorylation and translocation of forkhead box protein O1 in human hepatocytes

(2016) Haruna Takamura et al.   ARCHIVES OF ORAL BIOLOGY

Valproic acid reduces insulin-resistance, fat deposition and FOXO1-mediated gluconeogenesis in type-2 diabetic rat

(2016) Sabbir Khan et al.   BIOCHIMIE

Hyperfibrinolysis increases blood-brain barrier permeability by a plasmin- and bradykinin-dependent mechanism

(2016) O. A. Marcos-Contreras et al.   BLOOD

Direct Hepatocyte Insulin Signaling Is Required for Lipogenesis but Is Dispensable for the Suppression of Glucose Production

(2016) Paul M. Titchenell et al.   Cell Metabolism

Sodium butyrate reduces insulin-resistance, fat accumulation and dyslipidemia in type-2 diabetic rat: A comparative study with metformin

(2016) Sabbir Khan et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Pharmacological inhibition of S6K1 increases glucose metabolism and Akt signalling in vitro and in diet-induced obese mice

(2016) Michael Shum et al.   DIABETOLOGIA

FoxO1 Plays an Important Role in Regulating β-Cell Compensation for Insulin Resistance in Male Mice

(2016) Ting Zhang et al.   ENDOCRINOLOGY

FoxO1 Deacetylation Decreases Fatty Acid Oxidation in β-Cells and Sustains Insulin Secretion in Diabetes

(2016) Ja Young Kim-Muller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epigenomic and transcriptional control of insulin resistance

(2016) E. D. Rosen   JOURNAL OF INTERNAL MEDICINE

Mulberry anthocyanin extract ameliorates insulin resistance by regulating PI3K/AKT pathway in HepG2 cells and db/db mice

(2016) Fujie Yan et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

FoxO1: a novel insight into its molecular mechanisms in the regulation of skeletal muscle differentiation and fiber type specification

(2016) Meng Xu et al.   Oncotarget

Integrated Regulation of Hepatic Lipid and Glucose Metabolism by Adipose Triacylglycerol Lipase and FoxO Proteins

(2016) Wenwei Zhang et al.   Cell Reports

Targeting FOXO1 as an option to treat obesity?

(2015) Tobias B Dansen et al.   CELL CYCLE

Irisin inhibits hepatic gluconeogenesis and increases glycogen synthesis via the PI3K/Akt pathway in type 2 diabetic mice and hepatocytes

(2015) T.-Y. Liu et al.   CLINICAL SCIENCE

Insulin Regulates Retinol Dehydrogenase Expression and All-trans-retinoic Acid Biosynthesis through FoxO1

(2015) Kristin M. Obrochta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular mechanism of PPARα action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease

(2015) Michal Pawlak et al.   JOURNAL OF HEPATOLOGY

BMI-related progression of atypical PKC-dependent aberrations in insulin signaling through IRS-1, Akt, FoxO1 and PGC-1α in livers of obese and type 2 diabetic humans

(2015) Mini P. Sajan et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Overexpression of the FoxO1 Ameliorates Mesangial Cell Dysfunction in Male Diabetic Rats

(2015) Guijun Qin et al.   MOLECULAR ENDOCRINOLOGY

Review of aerobic glycolysis and its key enzymes - new targets for lung cancer therapy

(2015) Xue-bing Li et al.   Thoracic Cancer

Hypoglycemic activities of lyophilized powder ofGynura divaricataby improving antioxidant potential and insulin signaling in type 2 diabetic mice

(2015) Bing-Qing Xu et al.   Food & Nutrition Research

Fasting Plasma Glucose as Initial Screening for Diabetes and Prediabetes in Irish Adults: The Diabetes Mellitus and Vascular Health Initiative (DMVhi)

(2015) Margaret Sinnott et al.   PLoS One

Targeting FoxO1 with AS1842856 Suppresses Adipogenesis

(2014) Peng Zou et al.   CELL CYCLE

Urocortin 3 activates AMPK and AKT pathways and enhances glucose disposal in rat skeletal muscle

(2014) Manon M Roustit et al.   JOURNAL OF ENDOCRINOLOGY

Advanced Glycation End Products and Diabetic Complications

(2014) Varun Parkash Singh et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

FOXO1-dependent up-regulation of MAP kinase phosphatase 3 (MKP-3) mediates glucocorticoid-induced hepatic lipid accumulation in mice

(2014) Bin Feng et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Roles of glucose transporter-1 and the phosphatidylinositol 3-kinase/protein kinase B pathway in cancer radioresistance (Review)

(2014) JIN FANG et al.   Molecular Medicine Reports

MicroRNA-21 activates hepatic stellate cells via PTEN/Akt signaling

(2013) Jun Wei et al.   BIOMEDICINE & PHARMACOTHERAPY

Vascular Complications of Diabetes: Mechanisms of Injury and Protective Factors

(2013) Christian Rask-Madsen et al.   Cell Metabolism

FoxO transcription factors: their roles in the maintenance of skeletal muscle homeostasis

(2013) Anthony M. J. Sanchez et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Hepatic Overexpression of ATP Synthase   Subunit Activates PI3K/Akt Pathway to Ameliorate Hyperglycemia of Diabetic Mice

(2013) C. Wang et al.   DIABETES

Loss of TIMP3 underlies diabetic nephropathy via FoxO1/STAT1 interplay

(2013) Loredana Fiorentino et al.   EMBO Molecular Medicine

(−)-Epicatechin rich cocoa mediated modulation of oxidative stress regulators in skeletal muscle of heart failure and type 2 diabetes patients

(2013) Israel Ramirez-Sanchez et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure

(2012) Chutima Talchai et al.   CELL

Anti-obesity drugs: past, present and future

(2012) R. J. Rodgers et al.   Disease Models & Mechanisms

Effects of orexin A on proliferation, survival, apoptosis and differentiation of 3T3-L1 preadipocytes into mature adipocytes

(2012) M. Skrzypski et al.   FEBS LETTERS

Cyanidin-3-O-β-glucoside, a typical anthocyanin, exhibits antilipolytic effects in 3T3-L1 adipocytes during hyperglycemia: Involvement of FoxO1-mediated transcription of adipose triglyceride lipase

(2012) Honghui Guo et al.   FOOD AND CHEMICAL TOXICOLOGY

Analysis ofFoxo1-regulated genes usingFoxo1-deficient pancreatic β cells

(2012) Satsuki Miyazaki et al.   GENES TO CELLS

Diabetes triggers a PARP1 mediated death pathway in the heart through participation of FoxO1

(2012) Prasanth Puthanveetil et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Insulin Resistance

(2012) Alan R. Sinaiko et al.   JOURNAL OF PEDIATRICS

Bradykinin inhibits hepatic gluconeogenesis in obese mice

(2012) Carlos Castilho Barros et al.   LABORATORY INVESTIGATION

Hepatic FoxO1 Integrates Glucose Utilization and Lipid Synthesis through Regulation of Chrebp O-Glycosylation

(2012) Yukari Ido-Kitamura et al.   PLoS One

Anti-Obesity Drugs: A Review about Their Effects and Safety

(2012) Jun Goo Kang et al.   Diabetes & Metabolism Journal

Regulation of glucose metabolism via hepatic forkhead transcription factor 1 (FoxO1) by Morinda citrifolia (noni) in high-fat diet-induced obese mice

(2011) Pratibha V. Nerurkar et al.   BRITISH JOURNAL OF NUTRITION

FoxO1 integrates insulin signaling to VLDL production

(2011) Adama Kamagate et al.   CELL CYCLE

Brain glucose sensing and neural regulation of insulin and glucagon secretion

(2011) B. Thorens   DIABETES OBESITY & METABOLISM

Cardiac triglyceride accumulation following acute lipid excess occurs through activation of a FoxO1–iNOS–CD36 pathway

(2011) Prasanth Puthanveetil et al.   FREE RADICAL BIOLOGY AND MEDICINE

JNK regulates FoxO-dependent autophagy in neurons

(2011) P. Xu et al.   GENES & DEVELOPMENT

Hepatic FoxOs Regulate Lipid Metabolism via Modulation of Expression of the Nicotinamide Phosphoribosyltransferase Gene

(2011) Rongya Tao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT1 controls lipolysis in adipocytes via FOXO1-mediated expression of ATGL

(2011) Partha Chakrabarti et al.   JOURNAL OF LIPID RESEARCH

Apelin stimulates glucose uptake through the PI3K/Akt pathway and improves insulin resistance in 3T3-L1 adipocytes

(2011) Shunming Zhu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

MAPK phosphatase–3 promotes hepatic gluconeogenesis through dephosphorylation of forkhead box O1 in mice

(2010) Zhidan Wu et al.   JOURNAL OF CLINICAL INVESTIGATION

Rise in antiobesity drug prescribing for children and adolescents in the UK: a population-based study

(2009) Russell M. Viner et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

FoxO1 Haploinsufficiency Protects Against High-Fat Diet-Induced Insulin Resistance With Enhanced Peroxisome Proliferator-Activated Receptor   Activation in Adipose Tissue

(2009) J. J. Kim et al.   DIABETES

Dietary Curcumin Significantly Improves Obesity-Associated Inflammation and Diabetes in Mouse Models of Diabesity

(2008) Stuart P. Weisberg et al.   ENDOCRINOLOGY

O-glycosylation of FoxO1 increases its transcriptional activity towards the glucose 6-phosphatase gene

(2008) MeiShiue Kuo et al.   FEBS LETTERS

Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation

(2008) Hart S Dengler et al.   NATURE IMMUNOLOGY