标题
When stem cells grow old: phenotypes and mechanisms of stem cell aging
作者
关键词
-
出版物
DEVELOPMENT
Volume 143, Issue 1, Pages 3-14
出版商
The Company of Biologists
发表日期
2016-01-05
DOI
10.1242/dev.130633
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- The role of p38b MAPK in age-related modulation of intestinal stem cell proliferation and differentiation in Drosophila
- (2016) Joung-Sun Park et al. Aging-US
- Elimination of Unfit Cells Maintains Tissue Health and Prolongs Lifespan
- (2015) Marisa M. Merino et al. CELL
- GDF11 Increases with Age and Inhibits Skeletal Muscle Regeneration
- (2015) Marc A. Egerman et al. Cell Metabolism
- The NAD+-Dependent SIRT1 Deacetylase Translates a Metabolic Switch into Regulatory Epigenetics in Skeletal Muscle Stem Cells
- (2015) James G. Ryall et al. Cell Stem Cell
- Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects
- (2015) Jerome Mertens et al. Cell Stem Cell
- Circulating Growth Differentiation Factor 11/8 Levels Decline With AgeNovelty and Significance
- (2015) Tommaso Poggioli et al. CIRCULATION RESEARCH
- Automated Assay of Telomere Length Measurement and Informatics for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort
- (2015) Kyle Lapham et al. GENETICS
- Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells
- (2015) Dagmar Walter et al. NATURE
- Characterization of extracellular DDX4- or Ddx4-positive ovarian cells
- (2015) Silvia F Hernandez et al. NATURE MEDICINE
- Adult human and mouse ovaries lack DDX4-expressing functional oogonial stem cells
- (2015) Hua Zhang et al. NATURE MEDICINE
- Oogonial stem cells as a model to study age-associated infertility in women
- (2015) Neha Garg et al. REPRODUCTION FERTILITY AND DEVELOPMENT
- Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness
- (2015) P. Katajisto et al. SCIENCE
- Variation in cancer risk among tissues can be explained by the number of stem cell divisions
- (2015) C. Tomasetti et al. SCIENCE
- Automated Assay of Telomere Length Measurement and Informatics for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort
- (2015) Kyle Lapham et al. GENETICS
- DNA methylation age of blood predicts all-cause mortality in later life
- (2015) Riccardo E Marioni et al. GENOME BIOLOGY
- Geroncogenesis: Metabolic Changes during Aging as a Driver of Tumorigenesis
- (2014) Lindsay E. Wu et al. CANCER CELL
- PGRP-SC2 Promotes Gut Immune Homeostasis to Limit Commensal Dysbiosis and Extend Lifespan
- (2014) Linlin Guo et al. CELL
- Prolonged Fasting Reduces IGF-1/PKA to Promote Hematopoietic-Stem-Cell-Based Regeneration and Reverse Immunosuppression
- (2014) Chia-Wei Cheng et al. Cell Stem Cell
- Epigenomic Profiling of Young and Aged HSCs Reveals Concerted Changes during Aging that Reinforce Self-Renewal
- (2014) Deqiang Sun et al. Cell Stem Cell
- Quiescent Hematopoietic Stem Cells Accumulate DNA Damage during Aging that Is Repaired upon Entry into Cell Cycle
- (2014) Isabel Beerman et al. Cell Stem Cell
- Glucose and Glutamine Metabolism Regulate Human Hematopoietic Stem Cell Lineage Specification
- (2014) Leal Oburoglu et al. Cell Stem Cell
- Dietary and Metabolic Control of Stem Cell Function in Physiology and Cancer
- (2014) Maria M. Mihaylova et al. Cell Stem Cell
- SIRT2 induces the checkpoint kinase BubR1 to increase lifespan
- (2014) B. J. North et al. EMBO JOURNAL
- Regenerative Hair Waves in Aging Mice and Extra-Follicular Modulators Follistatin, Dkk1, and Sfrp4
- (2014) Chih-Chiang Chen et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells
- (2014) Johanna Flach et al. NATURE
- Geriatric muscle stem cells switch reversible quiescence into senescence
- (2014) Pedro Sousa-Victor et al. NATURE
- Inhibition of JAK-STAT signaling stimulates adult satellite cell function
- (2014) Feodor D Price et al. NATURE MEDICINE
- Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice
- (2014) Saul A Villeda et al. NATURE MEDICINE
- Rejuvenation of the muscle stem cell population restores strength to injured aged muscles
- (2014) Benjamin D Cosgrove et al. NATURE MEDICINE
- Inducible depletion of satellite cells in adult, sedentary mice impairs muscle regenerative capacity without affecting sarcopenia
- (2014) Christopher S Fry et al. NATURE MEDICINE
- p38 MAPK signaling underlies a cell-autonomous loss of stem cell self-renewal in skeletal muscle of aged mice
- (2014) Jennifer D Bernet et al. NATURE MEDICINE
- Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence
- (2014) Giulio Genovese et al. NEW ENGLAND JOURNAL OF MEDICINE
- Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes
- (2014) Siddhartha Jaiswal et al. NEW ENGLAND JOURNAL OF MEDICINE
- Life-long in vivo cell-lineage tracing shows that no oogenesis originates from putative germline stem cells in adult mice
- (2014) Hua Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Preleukemic mutations in human acute myeloid leukemia affect epigenetic regulators and persist in remission
- (2014) M. R. Corces-Zimmerman et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors
- (2014) L. Katsimpardi et al. SCIENCE
- Restoring Systemic GDF11 Levels Reverses Age-Related Dysfunction in Mouse Skeletal Muscle
- (2014) M. Sinha et al. SCIENCE
- mTOR inhibition improves immune function in the elderly
- (2014) J. B. Mannick et al. Science Translational Medicine
- Aging Results in Molecular Changes in an Enriched Population of Undifferentiated Rat Spermatogonia1
- (2013) Catriona Paul et al. BIOLOGY OF REPRODUCTION
- An epigenetic component of hematopoietic stem cell aging amenable to reprogramming into a young state
- (2013) M. Wahlestedt et al. BLOOD
- Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging
- (2013) Ana P. Gomes et al. CELL
- Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy
- (2013) Francesco S. Loffredo et al. CELL
- Germline Energetics, Aging, and Female Infertility
- (2013) Jonathan L. Tilly et al. Cell Metabolism
- Proliferation-Dependent Alterations of the DNA Methylation Landscape Underlie Hematopoietic Stem Cell Aging
- (2013) Isabel Beerman et al. Cell Stem Cell
- ROS Production and NF-κB Activation Triggered by RAC1 Facilitate WNT-Driven Intestinal Stem Cell Proliferation and Colorectal Cancer Initiation
- (2013) Kevin B. Myant et al. Cell Stem Cell
- Adult hair follicle stem cells do not retain the older DNA strands in vivo during normal tissue homeostasis
- (2013) Sanjeev K. Waghmare et al. CHROMOSOME RESEARCH
- Actin Dynamics Affect Mitochondrial Quality Control and Aging in Budding Yeast
- (2013) Ryo Higuchi et al. CURRENT BIOLOGY
- Vascular-derived TGF-β increases in the stem cell niche and perturbs neurogenesis during aging and following irradiation in the adult mouse brain
- (2013) Jose R. Pineda et al. EMBO Molecular Medicine
- The asymmetric segregation of damaged proteins is stem cell–type dependent
- (2013) Mary Rose Bufalino et al. JOURNAL OF CELL BIOLOGY
- Ovarian stem cells—Potential roles in infertility treatment and fertility preservation
- (2013) Cheryl E. Dunlop et al. MATURITAS
- A canonical to non-canonical Wnt signalling switch in haematopoietic stem-cell ageing
- (2013) Maria Carolina Florian et al. NATURE
- Chromosome-specific nonrandom sister chromatid segregation during stem-cell division
- (2013) Swathi Yadlapalli et al. NATURE
- Molecular regulation of stem cell quiescence
- (2013) Tom H. Cheung et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Higher 5-hydroxymethylcytosine identifies immortal DNA strand chromosomes in asymmetrically self-renewing distributed stem cells
- (2013) Y. H. Huh et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Female mice lack adult germ-line stem cells but sustain oogenesis using stable primordial follicles
- (2013) L. Lei et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Nfatc1 orchestrates aging in hair follicle stem cells
- (2013) B. E. Keyes et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Quantification of healthy and atretic germ cells and follicles in the developing and post-natal ovary of the South American plains vizcacha, Lagostomus maximus: evidence of continuous rise of the germinal reserve
- (2013) P I F Inserra et al. REPRODUCTION
- DNA asymmetry and cell fate regulation in stem cells
- (2013) Siham Yennek et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Proteostasis and aging of stem cells
- (2013) David Vilchez et al. TRENDS IN CELL BIOLOGY
- Chromatin Modifications as Determinants of Muscle Stem Cell Quiescence and Chronological Aging
- (2013) Ling Liu et al. Cell Reports
- DNA methylation age of human tissues and cell types
- (2013) Steve Horvath GENOME BIOLOGY
- Effects of aging and reproduction on protein quality control in soma and gametes of Drosophila melanogaster
- (2012) Åsa Fredriksson et al. AGING CELL
- A Subpopulation of Adult Skeletal Muscle Stem Cells Retains All Template DNA Strands after Cell Division
- (2012) Pierre Rocheteau et al. CELL
- The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity
- (2012) Carles Cantó et al. Cell Metabolism
- Short-Term Calorie Restriction Enhances Skeletal Muscle Stem Cell Function
- (2012) Massimiliano Cerletti et al. Cell Stem Cell
- Cdc42 Activity Regulates Hematopoietic Stem Cell Aging and Rejuvenation
- (2012) Maria Carolina Florian et al. Cell Stem Cell
- Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer
- (2012) Bruno Bernardes de Jesus et al. EMBO Molecular Medicine
- Age-associated inflammation inhibits epidermal stem cell function
- (2012) J. Doles et al. GENES & DEVELOPMENT
- Genome-wide Methylation Profiles Reveal Quantitative Views of Human Aging Rates
- (2012) Gregory Hannum et al. MOLECULAR CELL
- The let-7–Imp axis regulates ageing of the Drosophila testis stem-cell niche
- (2012) Hila Toledano et al. NATURE
- The sirtuin SIRT6 regulates lifespan in male mice
- (2012) Yariv Kanfi et al. NATURE
- The aged niche disrupts muscle stem cell quiescence
- (2012) Joe V. Chakkalakal et al. NATURE
- mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake
- (2012) Ömer H. Yilmaz et al. NATURE
- A unique regulatory phase of DNA methylation in the early mammalian embryo
- (2012) Zachary D. Smith et al. NATURE
- Oocyte formation by mitotically active germ cells purified from ovaries of reproductive-age women
- (2012) Yvonne A R White et al. NATURE MEDICINE
- Identification of cortical germ cells in adult ovaries from three phyllostomid bats: Artibeus jamaicensis, Glossophaga soricina and Sturnira lilium
- (2012) Nivia Rocio Antonio-Rubio et al. REPRODUCTION FERTILITY AND DEVELOPMENT
- Clonal Evolution of Preleukemic Hematopoietic Stem Cells Precedes Human Acute Myeloid Leukemia
- (2012) M. Jan et al. Science Translational Medicine
- Transcriptional Analysis of Histone Deacetylase Family Members Reveal Similarities Between Differentiating and Aging Spermatogonial Stem Cells
- (2012) Amber E. Kofman et al. Stem Cell Reviews and Reports
- Modulation of Longevity and Tissue Homeostasis by the Drosophila PGC-1 Homolog
- (2011) Michael Rera et al. Cell Metabolism
- Autophagy is required for self-renewal and differentiation of adult human stem cells
- (2011) Souzan Salemi et al. CELL RESEARCH
- Redox Regulation by Keap1 and Nrf2 Controls Intestinal Stem Cell Proliferation in Drosophila
- (2011) Christine E. Hochmuth et al. Cell Stem Cell
- The Intestinal Stem Cell Signature Identifies Colorectal Cancer Stem Cells and Predicts Disease Relapse
- (2011) Anna Merlos-Suárez et al. Cell Stem Cell
- Lgr5 intestinal stem cells have high telomerase activity and randomly segregate their chromosomes
- (2011) Arnout G Schepers et al. EMBO JOURNAL
- Reduction in paracrine Wnt3 factors during aging causes impaired adult neurogenesis
- (2011) Masahiro Okamoto et al. FASEB JOURNAL
- Drosophila male germline stem cells do not asymmetrically segregate chromosome strands
- (2011) S. Yadlapalli et al. JOURNAL OF CELL SCIENCE
- Clonal analysis reveals multiple functional defects of aged murine hematopoietic stem cells
- (2011) Brad Dykstra et al. JOURNAL OF EXPERIMENTAL MEDICINE
- A review and appraisal of the DNA damage theory of ageing
- (2011) Alex A. Freitas et al. MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
- The ageing systemic milieu negatively regulates neurogenesis and cognitive function
- (2011) Saul A. Villeda et al. NATURE
- Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans
- (2011) Eric L. Greer et al. NATURE
- Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
- (2011) Darren J. Baker et al. NATURE
- Melanocyte stem cells: a melanocyte reservoir in hair follicles for hair and skin pigmentation
- (2011) Emi K. Nishimura Pigment Cell & Melanoma Research
- Accumulation of DNA Damage in Hematopoietic Stem and Progenitor Cells during Human Aging
- (2011) Claudia E. Rübe et al. PLoS One
- Interconversion Between Intestinal Stem Cell Populations in Distinct Niches
- (2011) N. Takeda et al. SCIENCE
- Intestinal epithelial stem cells do not protect their genome by asymmetric chromosome segregation
- (2011) Marion Escobar et al. Nature Communications
- SACK-Expanded Hair Follicle Stem Cells Display Asymmetric Nuclear Lgr5 Expression With Non-Random Sister Chromatid Segregation
- (2011) Yang Hoon Huh et al. Scientific Reports
- Dietary restriction enhances germline stem cell maintenance
- (2010) William Mair et al. AGING CELL
- A pathway that links reproductive status to lifespan in Caenorhabditis elegans
- (2010) Cynthia Kenyon Annals of the New York Academy of Sciences
- In Vivo and In Vitro Aging Is Detrimental to Mouse Spermatogonial Stem Cell Function
- (2010) J. A. Schmidt et al. BIOLOGY OF REPRODUCTION
- Hematopoietic Stem Cell Quiescence Promotes Error-Prone DNA Repair and Mutagenesis
- (2010) Mary Mohrin et al. Cell Stem Cell
- Caenorhabditis elegans reproductive aging: Regulation and underlying mechanisms
- (2010) Shijing Luo et al. GENESIS
- Bcl-2 and accelerated DNA repair mediates resistance of hair follicle bulge stem cells to DNA-damage-induced cell death
- (2010) Panagiota A. Sotiropoulou et al. NATURE CELL BIOLOGY
- Mild Hypoxia Enhances Proliferation and Multipotency of Human Neural Stem Cells
- (2010) Guido Santilli et al. PLoS One
- Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion
- (2010) I. Beerman et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Production of transgenic mice by random recombination of targeted genes in female germline stem cells
- (2010) Yong Zhang et al. Journal of Molecular Cell Biology
- Lifespan Extension by Preserving Proliferative Homeostasis in Drosophila
- (2010) Benoît Biteau et al. PLoS Genetics
- Relative roles of TGF-β1 and Wnt in the systemic regulation and aging of satellite cell responses
- (2009) Morgan E. Carlson et al. AGING CELL
- The growth hormone receptor gene-disrupted mouse fails to respond to an intermittent fasting diet
- (2009) Oge Arum et al. AGING CELL
- Hedgehog signaling maintains hair follicle stem cell phenotype in young and aged human skin
- (2009) Laure Rittié et al. AGING CELL
- Altered cellular dynamics and endosteal location of aged early hematopoietic progenitor cells revealed by time-lapse intravital imaging in long bones
- (2009) A. Kohler et al. BLOOD
- Genotoxic Stress Abrogates Renewal of Melanocyte Stem Cells by Triggering Their Differentiation
- (2009) Ken Inomata et al. CELL
- FoxO3 Regulates Neural Stem Cell Homeostasis
- (2009) Valérie M. Renault et al. Cell Stem Cell
- The germline stem cells of Drosophila melanogaster partition DNA non-randomly
- (2009) Phillip Karpowicz et al. EUROPEAN JOURNAL OF CELL BIOLOGY
- Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila
- (2009) N. Buchon et al. GENES & DEVELOPMENT
- Neural Stem and Progenitor Cells Retain Their Potential for Proliferation and Differentiation into Functional Neurons Despite Lower Number in Aged Brain
- (2009) H. Ahlenius et al. JOURNAL OF NEUROSCIENCE
- Telomere Shortening in Neural Stem Cells Disrupts Neuronal Differentiation and Neuritogenesis
- (2009) S. R. Ferron et al. JOURNAL OF NEUROSCIENCE
- Identification of sister chromatids by DNA template strand sequences
- (2009) Ester Falconer et al. NATURE
- Hematopoietic stem cell ageing is uncoupled from p16INK4A-mediated senescence
- (2009) J L Attema et al. ONCOGENE
- Disruption of Growth Hormone Receptor Prevents Calorie Restriction from Improving Insulin Action and Longevity
- (2009) Michael S. Bonkowski et al. PLoS One
- Insulin levels control female germline stem cell maintenance via the niche in Drosophila
- (2009) H.-J. Hsu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Exercise Increases Neural Stem Cell Number in a Growth Hormone-Dependent Manner, Augmenting the Regenerative Response in Aged Mice
- (2009) Daniel G. Blackmore et al. STEM CELLS
- Age-related changes of germline stem cell activity, niche signaling activity and egg production in Drosophila
- (2008) Rui Zhao et al. AGING CELL
- Epidermal stem cells are retained in vivo throughout skin aging
- (2008) Adam Giangreco et al. AGING CELL
- Age-related changes in Drosophila midgut are associated with PVF2, a PDGF/VEGF-like growth factor
- (2008) Na-Hyun Choi et al. AGING CELL
- Age-related increase in colorectal cancer stem cells in macroscopically normal mucosa of patients with adenomas: A risk factor for colon cancer
- (2008) Bhaumik B. Patel et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- A new mechanism for the aging of hematopoietic stem cells: aging changes the clonal composition of the stem cell compartment but not individual stem cells
- (2008) R. H. Cho et al. BLOOD
- Hmga2 Promotes Neural Stem Cell Self-Renewal in Young but Not Old Mice by Reducing p16Ink4a and p19Arf Expression
- (2008) Jinsuke Nishino et al. CELL
- Telomerase Reverse Transcriptase Delays Aging in Cancer-Resistant Mice
- (2008) Antonia Tomás-Loba et al. CELL
- SIRT1 Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression during Aging
- (2008) Philipp Oberdoerffer et al. CELL
- Mechanisms and Functional Implications of Adult Neurogenesis
- (2008) Chunmei Zhao et al. CELL
- Acetylated Lysine 56 on Histone H3 Drives Chromatin Assembly after Repair and Signals for the Completion of Repair
- (2008) Chin-Chuan Chen et al. CELL
- Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair
- (2008) Anne Wilson et al. CELL
- JNK Activity in Somatic Stem Cells Causes Loss of Tissue Homeostasis in the Aging Drosophila Gut
- (2008) Benoît Biteau et al. Cell Stem Cell
- Quality control of DNA break metabolism: in the ‘end’, it's a good thing
- (2008) Roland Kanaar et al. EMBO JOURNAL
- Aging and cancer resistance in lymphoid progenitors are linked processes conferred by p16Ink4a and Arf
- (2008) R. A.J. Signer et al. GENES & DEVELOPMENT
- The longest telomeres: a general signature of adult stem cell compartments
- (2008) I. Flores et al. GENES & DEVELOPMENT
- Centrosome misorientation reduces stem cell division during ageing
- (2008) Jun Cheng et al. NATURE
- Asymmetric segregation of protein aggregates is associated with cellular aging and rejuvenation
- (2008) A. B. Lindner et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Fat Metabolism Links Germline Stem Cells and Longevity in C. elegans
- (2008) M. C. Wang et al. SCIENCE
- Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
- (2008) Jean-Philippe Coppé et al. PLOS BIOLOGY
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started