Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer

Telomerase deficiency impairs glucose metabolism and insulin secretion

(2016) Doreen Kuhlow et al.   Aging-US

Telomerase-Based Pharmacologic Enhancement of Antiviral Function of Human CD8+ T Lymphocytes

(2014) S. R. Fauce et al.   JOURNAL OF IMMUNOLOGY

The telomerase activator TA-65 elongates short telomeres and increases health span of adult/old mice without increasing cancer incidence

(2011) Bruno Bernardes de Jesus et al.   AGING CELL

Telomere dysfunction induces metabolic and mitochondrial compromise

(2011) Ergün Sahin et al.   NATURE

Expansive Gene Transfer in the Rat CNS Rapidly Produces Amyotrophic Lateral Sclerosis Relevant Sequelae When TDP-43 is Overexpressed

(2010) David B Wang et al.   MOLECULAR THERAPY

Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice

(2010) Mariela Jaskelioff et al.   NATURE

Mammalian Rap1 controls telomere function and gene expression through binding to telomeric and extratelomeric sites

(2010) Paula Martinez et al.   NATURE CELL BIOLOGY

A Natural Product Telomerase Activator As Part of a Health Maintenance Program

(2010) Calvin B. Harley et al.   REJUVENATION RESEARCH

Inducible adeno-associated virus vectors promote functional angiogenesis in adult organisms via regulated vascular endothelial growth factor expression

(2009) Sabrina Tafuro et al.   CARDIOVASCULAR RESEARCH

Telomerase, mitochondria and oxidative stress

(2009) Gabriele Saretzki   EXPERIMENTAL GERONTOLOGY

High AAV vector purity results in serotype- and tissue-independent enhancement of transduction efficiency

(2009) E Ayuso et al.   GENE THERAPY

Analyses and comparisons of telomerase activity and telomere length in human T and B cells: Insights for epidemiology of telomere maintenance

(2009) Jue Lin et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Identification methods in newborn C57BL/6 mice: a developmental and behavioural evaluation

(2009) M J Castelhano-Carlos et al.   LABORATORY ANIMALS

Intravenous Administration of Self-complementary AAV9 Enables Transgene Delivery to Adult Motor Neurons

(2009) Sandra Duque et al.   MOLECULAR THERAPY

Telomerase modulates Wnt signalling by association with target gene chromatin

(2009) Jae-Il Park et al.   NATURE

Sequence variants at the TERT-CLPTM1L locus associate with many cancer types

(2009) Thorunn Rafnar et al.   NATURE GENETICS

Telomere shortening relaxes X chromosome inactivation and forces global transcriptome alterations

(2009) S. Schoeftner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intramuscular Administration of AAV1-Lipoprotein Lipase S447X Lowers Triglycerides in Lipoprotein Lipase–Deficient Patients

(2008) Erik S. Stroes et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Long-term correction of inhibitor-prone hemophilia B dogs treated with liver-directed AAV2-mediated factor IX gene therapy

(2008) G. P. Niemeyer et al.   BLOOD

Telomerase Reverse Transcriptase Delays Aging in Cancer-Resistant Mice

(2008) Antonia Tomás-Loba et al.   CELL

The longest telomeres: a general signature of adult stem cell compartments

(2008) I. Flores et al.   GENES & DEVELOPMENT

Recent developments in adeno‐associated virus vector technology

(2008) Hildegard Büning et al.   JOURNAL OF GENE MEDICINE

Increased telomerase activity and comprehensive lifestyle changes: a pilot study

(2008) Dean Ornish et al.   LANCET ONCOLOGY

Analysis of AAV Serotypes 1–9 Mediated Gene Expression and Tropism in Mice After Systemic Injection

(2008) Carmela Zincarelli et al.   MOLECULAR THERAPY

Intravascular AAV9 preferentially targets neonatal neurons and adult astrocytes

(2008) Kevin D Foust et al.   NATURE BIOTECHNOLOGY

Lung cancer susceptibility locus at 5p15.33

(2008) James D McKay et al.   NATURE GENETICS

Safety and Efficacy of Gene Transfer for Leber's Congenital Amaurosis

(2008) Albert M. Maguire et al.   NEW ENGLAND JOURNAL OF MEDICINE