Tumor Reliance on Cytosolic versus Mitochondrial One-Carbon Flux Depends on Folate Availability

Metabolic Profiling Reveals a Dependency of Human Metastatic Breast Cancer on Mitochondrial Serine and One-Carbon Unit Metabolism

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SHMT inhibition is effective and synergizes with methotrexate in T-cell acute lymphoblastic leukemia

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Serine Catabolism by SHMT2 Is Required for Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl-tRNAs

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Increased formate overflow is a hallmark of oxidative cancer

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Mice deficient in the Shmt2 gene have mitochondrial respiration defects and are embryonic lethal

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Mitochondrial translation requires folate-dependent tRNA methylation

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Mitochondrial One-Carbon Pathway Supports Cytosolic Folate Integrity in Cancer Cells

(2018) Yuxiang Zheng et al.   CELL

SFXN1 is a mitochondrial serine transporter required for one-carbon metabolism

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Metabolic Reprogramming by Folate Restriction Leads to a Less Aggressive Cancer Phenotype

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HMDB 4.0: the human metabolome database for 2018

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Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma

(2017) Gregory S. Ducker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SAMTOR is anS-adenosylmethionine sensor for the mTORC1 pathway

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Reversal of Cytosolic One-Carbon Flux Compensates for Loss of the Mitochondrial Folate Pathway

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A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate

(2016) Michael E Pacold et al.   Nature Chemical Biology

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HTSeq--a Python framework to work with high-throughput sequencing data

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Serine Deprivation Enhances Antineoplastic Activity of Biguanides

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Tracing Compartmentalized NADPH Metabolism in the Cytosol and Mitochondria of Mammalian Cells

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Quantitative flux analysis reveals folate-dependent NADPH production

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A comprehensive transcriptional portrait of human cancer cell lines

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Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer

(2014) Roland Nilsson et al.   Nature Communications

Fatty Acid Labeling from Glutamine in Hypoxia Can Be Explained by Isotope Exchange without Net Reductive Isocitrate Dehydrogenase (IDH) Flux

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Glutamine-driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia

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IsoCor: correcting MS data in isotope labeling experiments

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Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells

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Metabolite Profiling Identifies a Key Role for Glycine in Rapid Cancer Cell Proliferation

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Compartmentalization of Mammalian Folate-Mediated One-Carbon Metabolism

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Cytoplasmic Serine Hydroxymethyltransferase Regulates the Metabolic Partitioning of Methylenetetrahydrofolate but Is Not Essential in Mice

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Absolute quantitation of intracellular metabolite concentrations by an isotope ratio-based approach

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