标题
Targeting the cytoskeleton against metastatic dissemination
作者
关键词
-
出版物
CANCER AND METASTASIS REVIEWS
Volume -, Issue -, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2021-01-20
DOI
10.1007/s10555-020-09936-0
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Correction: The Rho/ROCK pathway for lysophosphatidic acid-induced proteolytic enzyme expression and ovarian cancer cell invasion
- (2019) K. J. Jeong et al. ONCOGENE
- Src and SHP2 coordinately regulate the dynamics and organization of vimentin filaments during cell migration
- (2019) Cheng-Yi Yang et al. ONCOGENE
- Benproperine, an ARPC2 inhibitor, suppresses cancer cell migration and tumor metastasis
- (2019) Yae Jin Yoon et al. BIOCHEMICAL PHARMACOLOGY
- Pimozide suppresses cancer cell migration and tumor metastasis through binding to ARPC2, a subunit of the Arp2/3 complex
- (2019) Jiyeon Choi et al. CANCER SCIENCE
- The R-Enantiomer of Ketorolac Delays Mammary Tumor Development in Mouse Mammary Tumor Virus-Polyoma Middle T Antigen (MMTV-PyMT) Mice
- (2018) Amanda S. Peretti et al. AMERICAN JOURNAL OF PATHOLOGY
- Rho Kinase Inhibition by AT13148 Blocks Pancreatic Ductal Adenocarinoma Invasion and Tumor Growth
- (2018) Nicola Rath et al. CANCER RESEARCH
- Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer
- (2018) Mathieu Unbekandt et al. CANCER RESEARCH
- Intermediate filaments control collective migration by restricting traction forces and sustaining cell–cell contacts
- (2018) Chiara De Pascalis et al. JOURNAL OF CELL BIOLOGY
- Complexes of α6β4 integrin and vimentin signal to regulate epithelial cell migration
- (2018) Zachary T. Colburn et al. JOURNAL OF CELL SCIENCE
- AGC kinases, mechanisms of regulation and innovative drug development
- (2018) Alejandro E. Leroux et al. SEMINARS IN CANCER BIOLOGY
- The Actin Cytoskeleton and Actin-Based Motility
- (2018) Tatyana Svitkina Cold Spring Harbor Perspectives in Biology
- On-target action of anti-tropomyosin drugs regulates glucose metabolism
- (2018) Anthony J. Kee et al. Scientific Reports
- ROCK inhibitor enhances the growth and migration of BRAF-mutant skin melanoma cells
- (2018) Fei Chang et al. CANCER SCIENCE
- Combinatorial expression of microtubule-associated EB1 and ATIP3 biomarkers improves breast cancer prognosis
- (2018) Sylvie Rodrigues-Ferreira et al. BREAST CANCER RESEARCH AND TREATMENT
- Fascin-1 is a Novel Prognostic Biomarker Associated with Tumor Invasiveness in Adrenocortical Carcinoma
- (2018) Giada Poli et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Assessment of VAV2 Expression Refines Prognostic Prediction in Adrenocortical Carcinoma
- (2017) Silviu Sbiera et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Characterization of a Dual Rac/Cdc42 Inhibitor MBQ-167 in Metastatic Cancer
- (2017) Tessa Humphries-Bickley et al. MOLECULAR CANCER THERAPEUTICS
- Identification of Cancer-Targeted Tropomyosin Inhibitors and Their Synergy with Microtubule Drugs
- (2017) Mark A. Currier et al. MOLECULAR CANCER THERAPEUTICS
- Cytokeratin-14 contributes to collective invasion of salivary adenoid cystic carcinoma
- (2017) Xiao-lei Gao et al. PLoS One
- Dosage-dependent regulation ofVAV2expression by steroidogenic factor-1 drives adrenocortical carcinoma cell invasion
- (2017) Carmen Ruggiero et al. Science Signaling
- Intermediate Filaments and the Plasma Membrane
- (2017) Jonathan C.R. Jones et al. Cold Spring Harbor Perspectives in Biology
- VAV2: a novel prognostic marker and a druggable target for adrenocortical carcinoma
- (2017) Carmen Ruggiero et al. Oncotarget
- Pharmacological Rac1 inhibitors with selective apoptotic activity in human acute leukemic cell lines
- (2017) Maia Cabrera et al. Oncotarget
- KRT8 upregulation promotes tumor metastasis and is predictive of a poor prognosis in clear cell renal cell carcinoma
- (2017) Hai-Song Tan et al. Oncotarget
- Therapeutic sensitivity to Rac GTPase inhibition requires consequential suppression of mTORC1, AKT, and MEK signaling in breast cancer
- (2017) Riley A. Hampsch et al. Oncotarget
- Discovery and characterization of small molecule Rac1 inhibitors
- (2017) Jamie L. Arnst et al. Oncotarget
- Downregulation of LIMK1–ADF/cofilin by DADS inhibits the migration and invasion of colon cancer
- (2017) Jian Su et al. Scientific Reports
- Dosage-dependent regulation ofVAV2expression by steroidogenic factor-1 drives adrenocortical carcinoma cell invasion
- (2017) Carmen Ruggiero et al. Science Signaling
- Tropomyosin-1 acts as a potential tumor suppressor in human oral squamous cell carcinoma
- (2017) Hao Pan et al. PLoS One
- Novel Insights into the Roles of Rho Kinase in Cancer
- (2016) Lei Wei et al. ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS
- Both Talin-1 and Talin-2 correlate with malignancy potential of the human hepatocellular carcinoma MHCC-97 L cell
- (2016) Kun-peng Fang et al. BMC CANCER
- Vimentin-mediated regulation of cell motility through modulation of beta4 integrin protein levels in oral tumor derived cells
- (2016) Crismita Dmello et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Improving fascin inhibitors to block tumor cell migration and metastasis
- (2016) Shaoqin Han et al. Molecular Oncology
- Inhibitors of Rho kinase (ROCK) signaling revert the malignant phenotype of breast cancer cells in 3D context
- (2016) Masahiro Matsubara et al. Oncotarget
- A small molecule inhibitor of tropomyosin dissociates actin binding from tropomyosin-directed regulation of actin dynamics
- (2016) Teresa T. Bonello et al. Scientific Reports
- High Vimentin Expression Associated with Lymph Node Metastasis and Predicated a Poor Prognosis in Oral Squamous Cell Carcinoma
- (2016) Shuli Liu et al. Scientific Reports
- The skeleton in the closet: actin cytoskeletal remodeling in β-cell function
- (2015) Caroline Arous et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- HA-1077 inhibits cell migration/invasion of oral squamous cell carcinoma
- (2015) Simone de Sales Costa Moreira Carboni et al. ANTI-CANCER DRUGS
- The regulatory roles of ROCK and MRCK kinases in the plasticity of cancer cell migration
- (2015) Vijay Pralhad Kale et al. CANCER LETTERS
- Pancreatic Cancer Cell Migration and Metastasis Is Regulated by Chemokine-Biased Agonism and Bioenergetic Signaling
- (2015) I. Roy et al. CANCER RESEARCH
- Vimentin–ERK Signaling Uncouples Slug Gene Regulatory Function
- (2015) Reetta Virtakoivu et al. CANCER RESEARCH
- Rho Kinase Inhibitors Block Melanoma Cell Migration and Inhibit Metastasis
- (2015) Amine Sadok et al. CANCER RESEARCH
- A Novel Pharmacologic Activity of Ketorolac for Therapeutic Benefit in Ovarian Cancer Patients
- (2015) Y. Guo et al. CLINICAL CANCER RESEARCH
- Intermediate filament mechanics in vitro and in the cell: from coiled coils to filaments, fibers and networks
- (2015) Sarah Köster et al. CURRENT OPINION IN CELL BIOLOGY
- From equator to pole: splitting chromosomes in mitosis and meiosis
- (2015) Eris Duro et al. GENES & DEVELOPMENT
- Rac1 is correlated with aggressiveness and a potential therapeutic target for gastric cancer
- (2015) JUN JI et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- The evolution of compositionally and functionally distinct actin filaments
- (2015) P. W. Gunning et al. JOURNAL OF CELL SCIENCE
- Pharmacokinetics of Rac inhibitor EHop-016 in mice by ultra-performance liquid chromatography tandem mass spectrometry
- (2015) Tessa Humphries-Bickley et al. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
- Critical off-target effects of the widely used Rac1 inhibitors NSC23766 and EHT1864 in mouse platelets
- (2015) S. Dütting et al. JOURNAL OF THROMBOSIS AND HAEMOSTASIS
- Microtubule-dependent transport and dynamics of vimentin intermediate filaments
- (2015) Caroline Hookway et al. MOLECULAR BIOLOGY OF THE CELL
- Regulation of cell proliferation by ERK and signal-dependent nuclear translocation of ERK is dependent on Tm5NM1-containing actin filaments
- (2015) Galina Schevzov et al. MOLECULAR BIOLOGY OF THE CELL
- A novel tropomyosin isoform functions at the mitotic spindle and Golgi in Drosophila
- (2015) Lauren M. Goins et al. MOLECULAR BIOLOGY OF THE CELL
- R-Ketorolac Targets Cdc42 and Rac1 and Alters Ovarian Cancer Cell Behaviors Critical for Invasion and Metastasis
- (2015) Y. Guo et al. MOLECULAR CANCER THERAPEUTICS
- Knockdown of myosin VI by lentivirus-mediated short hairpin RNA suppresses proliferation of melanoma
- (2015) HUI LI et al. Molecular Medicine Reports
- Clinical and tumor significance of tropomyosin-1 expression levels in renal cell carcinoma
- (2015) JIN WANG et al. ONCOLOGY REPORTS
- ROCK inhibitor Y-27632 inhibits the growth, migration, and invasion of Tca8113 and CAL-27 cells in tongue squamous cell carcinoma
- (2015) Zhi-Ming Wang et al. TUMOR BIOLOGY
- Targeted inhibition of fascin function blocks tumour invasion and metastatic colonization
- (2015) Fang-Ke Huang et al. Nature Communications
- Transmigration characteristics of breast cancer and melanoma cells through the brain endothelium: Role of Rac and PI3K
- (2015) Judit Molnár et al. Cell Adhesion & Migration
- Cellular Adhesion Promotes Prostate Cancer Cells Escape from Dormancy
- (2015) Nazanin Ruppender et al. PLoS One
- Novel Activities of Select NSAID R-Enantiomers against Rac1 and Cdc42 GTPases
- (2015) Tudor I. Oprea et al. PLoS One
- Targeting of Rac GTPases blocks the spread of intact human breast cancer
- (2015) Elad Katz et al. Oncotarget
- JG6, a novel marine-derived oligosaccharide, suppresses breast cancer metastasis via binding to cofilin
- (2015) Xun Huang et al. Oncotarget
- The effect of ROCK-1 activity change on the adhesive and invasive ability of Y79 retinoblastoma cells
- (2014) Jing Wang et al. BMC CANCER
- Elevated expression of myosin X in tumours contributes to breast cancer aggressiveness and metastasis
- (2014) R Cao et al. BRITISH JOURNAL OF CANCER
- RhoA Mutations Identified in Diffuse Gastric Cancer
- (2014) Jin Zhou et al. CANCER CELL
- A novel selective multikinase inhibitor of ROCK and MRCK effectively blocks cancer cell migration and invasion
- (2014) Vijay Pralhad Kale et al. CANCER LETTERS
- CDC42 Inhibition Suppresses Progression of Incipient Intestinal Tumors
- (2014) R. Sakamori et al. CANCER RESEARCH
- Cofilin Drives Cell-Invasive and Metastatic Responses to TGF-β in Prostate Cancer
- (2014) Joanne Collazo et al. CANCER RESEARCH
- PTEN inhibits the invasion and metastasis of gastric cancer via downregulation of FAK expression
- (2014) Ling-Li Zhang et al. CELLULAR SIGNALLING
- Fascin Plays a Role in Stress Fiber Organization and Focal Adhesion Disassembly
- (2014) Nadia Elkhatib et al. CURRENT BIOLOGY
- Formins Determine the Functional Properties of Actin Filaments in Yeast
- (2014) Matthew Johnson et al. CURRENT BIOLOGY
- Homeostatic Actin Cytoskeleton Networks Are Regulated by Assembly Factor Competition for Monomers
- (2014) Thomas A. Burke et al. CURRENT BIOLOGY
- Myosin 1e is a component of the invadosome core that contributes to regulation of invadosome dynamics
- (2014) Jessica L. Ouderkirk et al. EXPERIMENTAL CELL RESEARCH
- Loss of SMAD4 Alters BMP Signaling to Promote Colorectal Cancer Cell Metastasis via Activation of Rho and ROCK
- (2014) Philip W. Voorneveld et al. GASTROENTEROLOGY
- Fascin Is Regulated by Slug, Promotes Progression of Pancreatic Cancer in Mice, and Is Associated With Patient Outcomes
- (2014) Ang Li et al. GASTROENTEROLOGY
- Fascin1 in carcinomas: Its regulation and prognostic value
- (2014) Yafeng Ma et al. INTERNATIONAL JOURNAL OF CANCER
- Mutant p53–associated myosin-X upregulation promotes breast cancer invasion and metastasis
- (2014) Antti Arjonen et al. JOURNAL OF CLINICAL INVESTIGATION
- The actin-myosin regulatory MRCK kinases: regulation, biological functions and associations with human cancer
- (2014) Mathieu Unbekandt et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Bradykinin enhances invasion of malignant glioma into the brain parenchyma by inducing cells to undergo amoeboid migration
- (2014) Stefanie Seifert et al. JOURNAL OF PHYSIOLOGY-LONDON
- Mechanistic adaptability of cancer cells strongly affects anti-migratory drug efficacy
- (2014) W. Sun et al. Journal of the Royal Society Interface
- Keratin 19 expression correlates with poor prognosis in breast cancer
- (2014) Nuzhat N. Kabir et al. MOLECULAR BIOLOGY REPORTS
- Recurrent gain-of-function mutations of RHOA in diffuse-type gastric carcinoma
- (2014) Miwako Kakiuchi et al. NATURE GENETICS
- A recurrent inactivating mutation in RHOA GTPase in angioimmunoblastic T cell lymphoma
- (2014) Hae Yong Yoo et al. NATURE GENETICS
- Somatic RHOA mutation in angioimmunoblastic T cell lymphoma
- (2014) Mamiko Sakata-Yanagimoto et al. NATURE GENETICS
- Talin1 phosphorylation activates β1 integrins: a novel mechanism to promote prostate cancer bone metastasis
- (2014) J-K Jin et al. ONCOGENE
- Vimentin regulates lung cancer cell adhesion through a VAV2–Rac1 pathway to control focal adhesion kinase activity
- (2014) L S Havel et al. ONCOGENE
- Novel Pharmacologic Targeting of Tight Junctions and Focal Adhesions in Prostate Cancer Cells
- (2014) Patrick J. Hensley et al. PLoS One
- ROCK Inhibition Activates MCF-7 Cells
- (2014) Seungwon Yang et al. PLoS One
- The Actin Targeting Compound Chondramide Inhibits Breast Cancer Metastasis via Reduction of Cellular Contractility
- (2014) Magdalena H. Menhofer et al. PLoS One
- The Rac Inhibitor EHop-016 Inhibits Mammary Tumor Growth and Metastasis in a Nude Mouse Model
- (2014) Linette Castillo-Pichardo et al. Translational Oncology
- A novel biomarker Linc00974 interacting with KRT19 promotes proliferation and metastasis in hepatocellular carcinoma
- (2014) J Tang et al. Cell Death & Disease
- Preclinical Development of Novel Rac1-GEF Signaling Inhibitors using a Rational Design Approach in Highly Aggressive Breast Cancer Cell Lines
- (2013) Georgina Cardama et al. Anti-Cancer Agents in Medicinal Chemistry
- Serum Talin-1 is a Potential Novel Biomarker for Diagnosis of Hepatocellular Carcinoma in Egyptian Patients
- (2013) Mahmoud M. Youns et al. Asian Pacific Journal of Cancer Prevention
- In vitro and in vivo effects of geranylgeranyltransferase I inhibitor P61A6 on non-small cell lung cancer cells
- (2013) Drazen B Zimonjic et al. BMC CANCER
- ATIP3, a Novel Prognostic Marker of Breast Cancer Patient Survival, Limits Cancer Cell Migration and Slows Metastatic Progression by Regulating Microtubule Dynamics
- (2013) A. Molina et al. CANCER RESEARCH
- A Novel Class of Anticancer Compounds Targets the Actin Cytoskeleton in Tumor Cells
- (2013) J. R. Stehn et al. CANCER RESEARCH
- Collective Invasion in Breast Cancer Requires a Conserved Basal Epithelial Program
- (2013) Kevin J. Cheung et al. CELL
- Metastasis of aggressive amoeboid sarcoma cells is dependent on Rho/ROCK/MLC signaling
- (2013) Jan Kosla et al. Cell Communication and Signaling
- Small Molecules CK-666 and CK-869 Inhibit Actin-Related Protein 2/3 Complex by Blocking an Activating Conformational Change
- (2013) Byron Hetrick et al. CHEMISTRY & BIOLOGY
- Regulation of Cell Proliferation and Migration by Keratin19-Induced Nuclear Import of Early Growth Response-1 in Breast Cancer Cells
- (2013) J.-h. Ju et al. CLINICAL CANCER RESEARCH
- Rab25 Regulates Invasion and Metastasis in Head and Neck Cancer
- (2013) P. Amornphimoltham et al. CLINICAL CANCER RESEARCH
- Microtubules and actin crosstalk in cell migration and division
- (2013) Tara Kafiyeh Akhshi et al. Cytoskeleton
- Effect of L-homocysteine on endothelial cell-cell junctions following F-actin stabilization through tropomyosin-1 overexpression
- (2013) MACIEJ GAGAT et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- FRAX597, a Small Molecule Inhibitor of the p21-activated Kinases, Inhibits Tumorigenesis of Neurofibromatosis Type 2 (NF2)-associated Schwannomas
- (2013) Silvia Licciulli et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cell Type-specific Signaling Function of RhoA GTPase: Lessons from Mouse Gene Targeting
- (2013) Xuan Zhou et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Keratin 8 and 18 Loss in Epithelial Cancer Cells Increases Collective Cell Migration and Cisplatin Sensitivity through Claudin1 Up-regulation
- (2013) Anne-Marie Fortier et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Characterization of a Cdc42 Protein Inhibitor and Its Use as a Molecular Probe
- (2013) Lin Hong et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- P21-Activated Kinase 1 (PAK1) as a Therapeutic Target in BRAF Wild-Type Melanoma
- (2013) Christy C. Ong et al. JNCI-Journal of the National Cancer Institute
- Targeting Cdc42 with the small molecule drug AZA197 suppresses primary colon cancer growth and prolongs survival in a preclinical mouse xenograft model by downregulation of PAK1 activity
- (2013) Karin Zins et al. Journal of Translational Medicine
- Combined Inhibition of HER1/EGFR and RAC1 Results in a Synergistic Antiproliferative Effect on Established and Primary Cultured Human Glioblastoma Cells
- (2013) G. Karpel-Massler et al. MOLECULAR CANCER THERAPEUTICS
- Identification of novel ROCK inhibitors with anti-migratory and anti-invasive activities
- (2013) R A Patel et al. ONCOGENE
- Cytochalasin D promotes pulmonary metastasis of B16 melanoma through expression of tissue factor
- (2013) FENG-YING HUANG et al. ONCOLOGY REPORTS
- microRNA-124 Inhibits Migration and Invasion by Down-Regulating ROCK1 in Glioma
- (2013) Liwen An et al. PLoS One
- A Rac1/Cdc42 GTPase-Specific Small Molecule Inhibitor Suppresses Growth of Primary Human Prostate Cancer Xenografts and Prolongs Survival in Mice
- (2013) Karin Zins et al. PLoS One
- Keratins significantly contribute to cell stiffness and impact invasive behavior
- (2013) K. Seltmann et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Small molecule targeting Cdc42–intersectin interaction disrupts Golgi organization and suppresses cell motility
- (2013) Amy Friesland et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Correlation between microtubule-associated gene expression and chemosensitivity of patients with stage II non-small cell lung cancer
- (2013) HONG JIANG et al. Experimental and Therapeutic Medicine
- Association of the epithelial-to-mesenchymal transition phenotype with responsiveness to the p21-activated kinase inhibitor, PF-3758309, in colon cancer models
- (2013) Todd M. Pitts et al. Frontiers in Pharmacology
- Tumor P-Glycoprotein Correlates with Efficacy of PF-3758309 in in vitro and in vivo Models of Colorectal Cancer
- (2013) Erica Lynn Bradshaw-Pierce et al. Frontiers in Pharmacology
- The Natural Product Cucurbitacin E Inhibits Depolymerization of Actin Filaments
- (2012) Pia M. Sörensen et al. ACS Chemical Biology
- Cucurbitacin E inhibits breast tumor metastasis by suppressing cell migration and invasion
- (2012) Tao Zhang et al. BREAST CANCER RESEARCH AND TREATMENT
- Expression of Serum Response Factor in Gastric Carcinoma and Its Molecular Mechanisms Involved in the Regulation of the Invasion and Migration of SGC-7901 Cells
- (2012) Min Zhao et al. CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
- Induction of the Stem-like Cell Regulator CD44 by Rho Kinase Inhibition Contributes to the Maintenance of Colon Cancer-Initiating Cells
- (2012) H. Ohata et al. CANCER RESEARCH
- ROCK1 and ROCK2 Are Required for Non-Small Cell Lung Cancer Anchorage-Independent Growth and Invasion
- (2012) D. Vigil et al. CANCER RESEARCH
- RKI-1447 Is a Potent Inhibitor of the Rho-Associated ROCK Kinases with Anti-Invasive and Antitumor Activities in Breast Cancer
- (2012) R. A. Patel et al. CANCER RESEARCH
- AT13148 Is a Novel, Oral Multi-AGC Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity
- (2012) T. A. Yap et al. CLINICAL CANCER RESEARCH
- Myosin-IXA Regulates Collective Epithelial Cell Migration by Targeting RhoGAP Activity to Cell-Cell Junctions
- (2012) Tatiana Omelchenko et al. CURRENT BIOLOGY
- Enrichment of cell populations in metaphase, anaphase, and telophase by synchronization using nocodazole and blebbistatin: A novel method suitable for examining dynamic changes in proteins during mitotic progression
- (2012) Yuki Matsui et al. EUROPEAN JOURNAL OF CELL BIOLOGY
- Kinetic properties and small-molecule inhibition of human myosin-6
- (2012) Sarah M. Heissler et al. FEBS LETTERS
- Genetic and epigenetic alterations are involved in the regulation of TPM1 in cholangiocarcinoma
- (2012) WEI YANG et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Molecular Mechanism of Fascin Function in Filopodial Formation
- (2012) Shengyu Yang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Nonmuscle Myosin II Is Required for Internalization of the Epidermal Growth Factor Receptor and Modulation of Downstream Signaling
- (2012) Jong Hyun Kim et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Characterization of EHop-016, Novel Small Molecule Inhibitor of Rac GTPase
- (2012) Brenda L. Montalvo-Ortiz et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cdc42 promotes transendothelial migration of cancer cells through β1 integrin
- (2012) Nicolas Reymond et al. JOURNAL OF CELL BIOLOGY
- The RhoA pathway mediates MMP-2 and MMP-9-independent invasive behavior in a triple-negative breast cancer cell line
- (2012) Katerina D. Fagan-Solis et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Direct inhibition of myosin II effectively blocks glioma invasion in the presence of multiple motogens
- (2012) Sanja Ivkovic et al. MOLECULAR BIOLOGY OF THE CELL
- Modulation of MicroRNA-194 and Cell Migration by HER2-Targeting Trastuzumab in Breast Cancer
- (2012) Xiao-Feng Le et al. PLoS One
- Cooperative Anti-Invasive Effect of Cdc42/Rac1 Activation and ROCK Inhibition in SW620 Colorectal Cancer Cells with Elevated Blebbing Activity
- (2012) Marion de Toledo et al. PLoS One
- ROCK1 Inhibition Promotes the Self-Renewal of a Novel Mouse Mammary Cancer Stem Cell
- (2012) David J. Castro et al. STEM CELLS
- Inhibiting myosin-ATPase reveals a dynamic range of mitochondrial respiratory control in skeletal muscle
- (2011) Christopher G. R. Perry et al. BIOCHEMICAL JOURNAL
- 7-Chloro-6-piperidin-1-yl-quinoline-5,8-dione (PT-262), a novel ROCK inhibitor blocks cytoskeleton function and cell migration
- (2011) Chih-Chien Tsai et al. BIOCHEMICAL PHARMACOLOGY
- The Rho-kinase inhibitor inhibits proliferation and metastasis of small cell lung cancer
- (2011) Xueying Yang et al. BIOMEDICINE & PHARMACOTHERAPY
- Tropomyosin: The Gatekeeper's View of the Actin Filament Revealed
- (2011) Roberto Dominguez BIOPHYSICAL JOURNAL
- Oncogenic BRAF Induces Melanoma Cell Invasion by Downregulating the cGMP-Specific Phosphodiesterase PDE5A
- (2011) Imanol Arozarena et al. CANCER CELL
- Vimentin in cancer and its potential as a molecular target for cancer therapy
- (2011) Arun Satelli et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Inactivation of MYO5B Promotes Invasion and Motility in Gastric Cancer Cells
- (2011) Wenjie Dong et al. DIGESTIVE DISEASES AND SCIENCES
- Anoikis Disruption of Focal Adhesion-Akt Signaling Impairs Renal Cell Carcinoma
- (2011) Shinichi Sakamoto et al. EUROPEAN UROLOGY
- Human hepatocellular carcinomas with “Stemness”-related marker expression: keratin 19 expression and a poor prognosis
- (2011) Haeryoung Kim et al. HEPATOLOGY
- The role of non-muscle myosin IIA in aggregation and invasion of human MCF-7 breast cancer cells
- (2011) Lara Derycke et al. INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
- Mechanism and Specificity of Pentachloropseudilin-mediated Inhibition of Myosin Motor Activity
- (2011) Krishna Chinthalapudi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Signal Transducers and Activators of Transcription 3 (STAT3) Directly Regulates Cytokine-induced Fascin Expression and Is Required for Breast Cancer Cell Migration
- (2011) Marylynn Snyder et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The evolution of the cytoskeleton
- (2011) Bill Wickstead et al. JOURNAL OF CELL BIOLOGY
- LPA1-induced migration requires nonmuscle myosin II light chain phosphorylation in breast cancer cells
- (2011) Jong Hyun Kim et al. JOURNAL OF CELLULAR PHYSIOLOGY
- A Proteomic Study of Myosin II Motor Proteins during Tumor Cell Migration
- (2011) Venkaiah Betapudi et al. JOURNAL OF MOLECULAR BIOLOGY
- Myosin II motor activity in the lateral amygdala is required for fear memory consolidation
- (2011) C. F. Gavin et al. LEARNING & MEMORY
- Inhibition of Rho-associated coiled-coil containing protein kinase enhances the activation of epidermal growth factor receptor in pancreatic cancer cells
- (2011) Masanori Nakashima et al. Molecular Cancer
- The 'invisible hand': regulation of RHO GTPases by RHOGDIs
- (2011) Rafael Garcia-Mata et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Androgen-Induced Cell Migration: Role of Androgen Receptor/Filamin A Association
- (2011) Gabriella Castoria et al. PLoS One
- Fascin Is a Key Regulator of Breast Cancer Invasion That Acts via the Modification of Metastasis-Associated Molecules
- (2011) Monther Al-Alwan et al. PLoS One
- Resveratrol suppresses human colon cancer cell proliferation and induces apoptosis via targeting the pentose phosphate and the talin-FAK signaling pathways-A proteomic approach
- (2011) Jairam Vanamala et al. Proteome Science
- Inhibition of Rac controls NPM–ALK-dependent lymphoma development and dissemination
- (2011) A Colomba et al. Blood Cancer Journal
- Cardiomyocyte contractile status is associated with differences in fibronectin and integrin interactions
- (2010) Xin Wu et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Control of Actin Filament Treadmilling in Cell Motility
- (2010) Beáta Bugyi et al. Annual Review of Biophysics
- 4′-Acetoamido-4-hydroxychalcone, a chalcone derivative, inhibits glioma growth and invasion through regulation of the tropomyosin 1 gene
- (2010) Bo Mi Ku et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Cucurbitacin E as a new inhibitor of cofilin phosphorylation in human leukemia U937 cells
- (2010) Souichi Nakashima et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- miR-145 and miR-133a function as tumour suppressors and directly regulate FSCN1 expression in bladder cancer
- (2010) T Chiyomaru et al. BRITISH JOURNAL OF CANCER
- Effect of fasudil on growth, adhesion, invasion, and migration of 95D lung carcinoma cells in vitro
- (2010) Xueying Yang et al. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
- Rho-kinase inhibitor, fasudil, suppresses glioblastoma cell line progression in vitro and in vivo
- (2010) Lin Deng et al. CANCER BIOLOGY & THERAPY
- βIII-Tubulin Is a Multifunctional Protein Involved in Drug Sensitivity and Tumorigenesis in Non–Small Cell Lung Cancer
- (2010) Joshua A. McCarroll et al. CANCER RESEARCH
- The Mitotic Kinase Aurora-A Induces Mammary Cell Migration and Breast Cancer Metastasis by Activating the Cofilin-F-actin Pathway
- (2010) L.-h. Wang et al. CANCER RESEARCH
- Talin1 Promotes Tumor Invasion and Metastasis via Focal Adhesion Signaling and Anoikis Resistance
- (2010) S. Sakamoto et al. CANCER RESEARCH
- AACR Centennial Series: The Biology of Cancer Metastasis: Historical Perspective
- (2010) J. E. Talmadge et al. CANCER RESEARCH
- Matrix Metalloproteinases: Regulators of the Tumor Microenvironment
- (2010) Kai Kessenbrock et al. CELL
- Macrophage Diversity Enhances Tumor Progression and Metastasis
- (2010) Bin-Zhi Qian et al. CELL
- The Actin-Bundling Protein Fascin Stabilizes Actin in Invadopodia and Potentiates Protrusive Invasion
- (2010) Ang Li et al. CURRENT BIOLOGY
- The actin gene family: Function follows isoform
- (2010) Benjamin J. Perrin et al. Cytoskeleton
- Cancer Dissemination—Lessons from Leukocytes
- (2010) Chris D. Madsen et al. DEVELOPMENTAL CELL
- RhoGDI signaling provides targets for cancer therapy
- (2010) Michael A. Harding et al. EUROPEAN JOURNAL OF CANCER
- Rho-kinase inhibitor upregulates migration by altering focal adhesion formation via the Akt pathway in colon cancer cells
- (2010) Seiji Adachi et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Fascin: A key regulator of cytoskeletal dynamics
- (2010) Asier Jayo et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Fasudil Inhibits Lysophosphatidic Acid-Induced Invasiveness of Human Ovarian Cancer Cells
- (2010) Seiji Ogata et al. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
- Synthetic Triterpenoids Target the Arp2/3 Complex and Inhibit Branched Actin Polymerization
- (2010) Ciric To et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Signaling Role of Cdc42 in Regulating Mammalian Physiology
- (2010) Jaime Melendez et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Actin, microtubules, and vimentin intermediate filaments cooperate for elongation of invadopodia
- (2010) Marie Schoumacher et al. JOURNAL OF CELL BIOLOGY
- MicroRNA control of podosome formation in vascular smooth muscle cells in vivo and in vitro
- (2010) Manuela Quintavalle et al. JOURNAL OF CELL BIOLOGY
- Epithelial-Mesenchymal Transition in Cancer: Parallels Between Normal Development and Tumor Progression
- (2010) Douglas S. Micalizzi et al. JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA
- Prognostic Impact of Fascin-1 Expression is More Significant in Advanced Colorectal Cancer
- (2010) Seung Yeop Oh et al. JOURNAL OF SURGICAL RESEARCH
- Rho kinase inhibitor fasudil suppresses migration and invasion though down-regulating the expression of VEGF in lung cancer cell line A549
- (2010) Fang Zhu et al. MEDICAL ONCOLOGY
- Keratin 8/18 Modulation of Protein Kinase C-mediated Integrin-dependent Adhesion and Migration of Liver Epithelial Cells
- (2010) François Bordeleau et al. MOLECULAR BIOLOGY OF THE CELL
- P-cadherin counteracts myosin II-B function: implications in melanoma progression
- (2010) Koen Jacobs et al. Molecular Cancer
- Blockade of Rac1 Activity Induces G1 Cell Cycle Arrest or Apoptosis in Breast Cancer Cells through Downregulation of Cyclin D1, Survivin, and X-Linked Inhibitor of Apoptosis Protein
- (2010) T. Yoshida et al. MOLECULAR CANCER THERAPEUTICS
- Migrastatin analogues target fascin to block tumour metastasis
- (2010) Lin Chen et al. NATURE
- Cell mechanics and the cytoskeleton
- (2010) Daniel A. Fletcher et al. NATURE
- Gain of miR-151 on chromosome 8q24.3 facilitates tumour cell migration and spreading through downregulating RhoGDIA
- (2010) Jie Ding et al. NATURE CELL BIOLOGY
- miR-145-dependent targeting of Junctional Adhesion Molecule A and modulation of fascin expression are associated with reduced breast cancer cell motility and invasiveness
- (2010) M Götte et al. ONCOGENE
- Vimentin is a novel AKT1 target mediating motility and invasion
- (2010) Q-S Zhu et al. ONCOGENE
- Keratins in health and cancer: more than mere epithelial cell markers
- (2010) V Karantza ONCOGENE
- Vimentin regulates EMT induction by Slug and oncogenic H-Ras and migration by governing Axl expression in breast cancer
- (2010) K Vuoriluoto et al. ONCOGENE
- Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth
- (2010) B. W. Murray et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes
- (2010) J. H. Taube et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Common themes in centriole and centrosome movements
- (2010) Sue Vaughan et al. TRENDS IN CELL BIOLOGY
- Epithelial-Mesenchymal Transition
- (2009) Michael W. Klymkowsky et al. AMERICAN JOURNAL OF PATHOLOGY
- Total Synthesis of Pentabromo- and Pentachloropseudilin, and Synthetic Analogues-Allosteric Inhibitors of Myosin ATPase
- (2009) René Martin et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Presence of activating KRAS mutations correlates significantly with expression of tumour suppressor genes DCN and TPM1 in colorectal cancer
- (2009) Vid Mlakar et al. BMC CANCER
- Rho GDP Dissociation Inhibitor 2 Suppresses Metastasis via Unconventional Regulation of RhoGTPases
- (2009) K. Moissoglu et al. CANCER RESEARCH
- Aptamer-Derived Peptides as Potent Inhibitors of the Oncogenic RhoGEF Tgat
- (2009) Nathalie Bouquier et al. CHEMISTRY & BIOLOGY
- Identification and Characterization of a Small Molecule Inhibitor of Formin-Mediated Actin Assembly
- (2009) Syed A. Rizvi et al. CHEMISTRY & BIOLOGY
- A Cell Active Chemical GEF Inhibitor Selectively Targets the Trio/RhoG/Rac1 Signaling Pathway
- (2009) Nathalie Bouquier et al. CHEMISTRY & BIOLOGY
- Semisynthetic Latrunculin Derivatives as Inhibitors of Metastatic Breast Cancer: Biological Evaluations, Preliminary Structure-Activity Relationship and Molecular Modeling Studies
- (2009) Mohammad A. Khanfar et al. ChemMedChem
- Cytokeratin 19 regulates endoplasmic reticulum stress and inhibits ERp29 expression via p38 MAPK/XBP-1 signaling in breast cancer cells
- (2009) I Fon Bambang et al. EXPERIMENTAL CELL RESEARCH
- Upregulation of myosin Va by Snail is involved in cancer cell migration and metastasis
- (2009) Linxiang Lan et al. INTERNATIONAL JOURNAL OF CANCER
- Protease-dependent versus -independent cancer cell invasion programs: three-dimensional amoeboid movement revisited
- (2009) Farideh Sabeh et al. JOURNAL OF CELL BIOLOGY
- - and -cytoplasmic actins display distinct distribution and functional diversity
- (2009) V. Dugina et al. JOURNAL OF CELL SCIENCE
- Epidermolysis bullosa simplex: a paradigm for disorders of tissue fragility
- (2009) Pierre A. Coulombe et al. JOURNAL OF CLINICAL INVESTIGATION
- Toward unraveling the complexity of simple epithelial keratins in human disease
- (2009) M. Bishr Omary et al. JOURNAL OF CLINICAL INVESTIGATION
- Significance of fascin expression in laryngeal squamous cell carcinoma
- (2009) A Durmaz et al. JOURNAL OF LARYNGOLOGY AND OTOLOGY
- Virtual Screening Approach for the Identification of New Rac1 Inhibitors
- (2009) Nicola Ferri et al. JOURNAL OF MEDICINAL CHEMISTRY
- Oncogenic function of microtubule end-binding protein 1 in breast cancer
- (2009) Xin Dong et al. JOURNAL OF PATHOLOGY
- Temporal Quantitative Proteomics by iTRAQ 2D-LC-MS/MS and Corresponding mRNA Expression Analysis Identify Post-Transcriptional Modulation of Actin-Cytoskeleton Regulators During TGF-β-Induced Epithelial-Mesenchymal Transition
- (2009) Venkateshwar G. Keshamouni et al. JOURNAL OF PROTEOME RESEARCH
- Blockade of Protein Geranylgeranylation Inhibits Cdk2-Dependent p27Kip1 Phosphorylation on Thr187 and Accumulates p27Kip1 in the Nucleus: Implications for Breast Cancer Therapy
- (2009) A. Kazi et al. MOLECULAR AND CELLULAR BIOLOGY
- In vivo antitumor effect of a novel inhibitor of protein geranylgeranyltransferase-I
- (2009) J. Lu et al. MOLECULAR CANCER THERAPEUTICS
- An allosteric kinase inhibitor binds the p21-activated kinase autoregulatory domain covalently
- (2009) J. Viaud et al. MOLECULAR CANCER THERAPEUTICS
- Characterization of two classes of small molecule inhibitors of Arp2/3 complex
- (2009) B. J. Nolen et al. NATURE
- Talin phosphorylation by Cdk5 regulates Smurf1-mediated talin head ubiquitylation and cell migration
- (2009) Cai Huang et al. NATURE CELL BIOLOGY
- 8p22 MTUS1 Gene Product ATIP3 Is a Novel Anti-Mitotic Protein Underexpressed in Invasive Breast Carcinoma of Poor Prognosis
- (2009) Sylvie Rodrigues-Ferreira et al. PLoS One
- The Tail of Integrins, Talin, and Kindlins
- (2009) M. Moser et al. SCIENCE
- Actin, a Central Player in Cell Shape and Movement
- (2009) T. D. Pollard et al. SCIENCE
- Blebbistatin extends culture life of adult mouse cardiac myocytes and allows efficient and stable transgene expression
- (2008) Zhyldyz Kabaeva et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Smooth-muscle myosin mutations in hereditary non-polyposis colorectal cancer syndrome
- (2008) N Vickaryous et al. BRITISH JOURNAL OF CANCER
- NET1-mediated RhoA activation facilitates lysophosphatidic acid-induced cell migration and invasion in gastric cancer
- (2008) D Murray et al. BRITISH JOURNAL OF CANCER
- Myosin light-chain kinase contributes to the proliferation and migration of breast cancer cells through cross-talk with activated ERK1/2
- (2008) Xiaolei Zhou et al. CANCER LETTERS
- Tube Travel: The Role of Proteases in Individual and Collective Cancer Cell Invasion
- (2008) P. Friedl et al. CANCER RESEARCH
- MicroRNA-21 targets tumor suppressor genes in invasion and metastasis
- (2008) Shuomin Zhu et al. CELL RESEARCH
- An Isoform-Selective, Small-Molecule Inhibitor Targets the Autoregulatory Mechanism of p21-Activated Kinase
- (2008) Sean W. Deacon et al. CHEMISTRY & BIOLOGY
- Blockade of RhoRho-associated coiled coil-forming kinase signaling can prevent progression of hepatocellular carcinoma in matrix metalloproteinase-dependent manner
- (2008) Feng Xue et al. HEPATOLOGY RESEARCH
- Talin at a glance
- (2008) D. R. Critchley et al. JOURNAL OF CELL SCIENCE
- Structure and Function of Skeletal Muscle in Zebrafish Early Larvae
- (2008) Ying Dou et al. JOURNAL OF GENERAL PHYSIOLOGY
- Latrunculin A and Its C-17-O-Carbamates Inhibit Prostate Tumor Cell Invasion and HIF-1 Activation in Breast Tumor Cells⊥
- (2008) Khalid A. El Sayed et al. JOURNAL OF NATURAL PRODUCTS
- Overexpression of Rho GDP-Dissociation Inhibitor Alpha Is Associated with Tumor Progression and Poor Prognosis of Colorectal Cancer
- (2008) Liang Zhao et al. JOURNAL OF PROTEOME RESEARCH
- Targeting Large Kinase Active Site with Rigid, Bulky Octahedral Ruthenium Complexes
- (2008) Jasna Maksimoska et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Activation of Nuclear Factor- B Pathway by Simvastatin and RhoA Silencing Increases Doxorubicin Cytotoxicity in Human Colon Cancer HT29 Cells
- (2008) C. Riganti et al. MOLECULAR PHARMACOLOGY
- The S100A8–serum amyloid A3–TLR4 paracrine cascade establishes a pre-metastatic phase
- (2008) Sachie Hiratsuka et al. NATURE CELL BIOLOGY
- A tal(in) of cell spreading
- (2008) Margaret Frame et al. NATURE CELL BIOLOGY
- Unregulated smooth-muscle myosin in human intestinal neoplasia
- (2008) P. Alhopuro et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Effects of lovastatin on Rho isoform expression, activity, and association with guanine nucleotide dissociation inhibitors
- (2007) Stephanie J. Turner et al. BIOCHEMICAL PHARMACOLOGY
Become a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get StartedAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started