标题
The fibrotic and immune microenvironments as targetable drivers of metastasis
作者
关键词
-
出版物
BRITISH JOURNAL OF CANCER
Volume 124, Issue 1, Pages 27-36
出版商
Springer Science and Business Media LLC
发表日期
2020-11-26
DOI
10.1038/s41416-020-01172-1
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Framing cancer progression: influence of the organ‐ and tumour‐specific matrisome
- (2020) Maria Rafaeva et al. FEBS Journal
- Transcriptional diversity and bioenergetic shift in human breast cancer metastasis revealed by single-cell RNA sequencing
- (2020) Ryan T. Davis et al. NATURE CELL BIOLOGY
- Crosstalk with lung epithelial cells regulates Sfrp2-mediated latency in breast cancer dissemination
- (2020) Marco Montagner et al. NATURE CELL BIOLOGY
- FAK signaling in cancer-associated fibroblasts promotes breast cancer cell migration and metastasis by exosomal miRNAs-mediated intercellular communication
- (2020) Hsin-Jung Wu et al. ONCOGENE
- Cancer-associated fibroblast heterogeneity in axillary lymph nodes drives metastases in breast cancer through complementary mechanisms
- (2020) Floriane Pelon et al. Nature Communications
- Fibroblast Heterogeneity in the Pancreatic Tumor Microenvironment
- (2020) Erin Helms et al. Cancer Discovery
- Hedgehog Signaling Demarcates a Niche of Fibrogenic Peribiliary Mesenchymal Cells
- (2020) Vikas Gupta et al. GASTROENTEROLOGY
- Single-cell technologies in hepatology: new insights into liver biology and disease pathogenesis
- (2020) Prakash Ramachandran et al. Nature Reviews Gastroenterology & Hepatology
- Cancer associated fibroblast FAK regulates malignant cell metabolism
- (2020) Fevzi Demircioglu et al. Nature Communications
- Metastasis-initiating cells induce and exploit a fibroblast niche to fuel malignant colonization of the lungs
- (2020) Maren Pein et al. Nature Communications
- Single-cell analysis reveals fibroblast clusters linked to immunotherapy resistance in cancer
- (2020) Yann Kieffer et al. Cancer Discovery
- Reduction of Liver Metastasis Stiffness Improves Response to Bevacizumab in Metastatic Colorectal Cancer
- (2020) Ying Shen et al. CANCER CELL
- Targeting focal adhesion kinase in cancer cells and the tumor microenvironment
- (2020) James M. Murphy et al. EXPERIMENTAL AND MOLECULAR MEDICINE
- Monocyte-derived macrophages promote breast cancer bone metastasis outgrowth
- (2020) Ruo-Yu Ma et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Neutrophils: Orchestrators of the Malignant Phenotype
- (2020) Brian E. Hsu et al. Frontiers in Immunology
- FAK activity in cancer‐associated fibroblasts is a prognostic marker and a druggable key metastatic player in pancreatic cancer
- (2020) Sonia Zaghdoudi et al. EMBO Molecular Medicine
- MicroRNA interplay between hepatic stellate cell quiescence and activation
- (2020) Devaraj Ezhilarasan EUROPEAN JOURNAL OF PHARMACOLOGY
- Antineoplastic effects of targeting CCR5 and its therapeutic potential for colorectal cancer liver metastasis
- (2020) Asim Pervaiz et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- A stromal lysolipid-autotaxin signaling axis promotes pancreatic tumor progression
- (2019) Francesca R. Auciello et al. Cancer Discovery
- Exosomes from differentially activated macrophages influence dormancy or resurgence of breast cancer cells within bone marrow stroma
- (2019) Nykia D. Walker et al. Cell Death & Disease
- The emerging roles of macrophages in cancer metastasis and response to chemotherapy
- (2019) Luis Rivera Sanchez et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Defining the Hallmarks of Metastasis
- (2019) Danny R. Welch et al. CANCER RESEARCH
- The Extracellular Matrix Modulates the Metastatic Journey
- (2019) FuiBoon Kai et al. DEVELOPMENTAL CELL
- DDR2 controls breast tumor stiffness and metastasis by regulating Integrin mediated mechanotransduction in CAFs
- (2019) Samantha VH Bayer et al. eLife
- Metastatic breast carcinoma-associated fibroblasts have enhanced pro-tumorigenic properties related to increased IGF2 expression.
- (2019) Yirui Gui et al. CLINICAL CANCER RESEARCH
- Stromal integrin α11 regulates PDGFRβ signaling and promotes breast cancer progression
- (2019) Irina Primac et al. JOURNAL OF CLINICAL INVESTIGATION
- Heterogeneity of cancer-associated fibroblasts and roles in the progression, prognosis, and therapy of hepatocellular carcinoma
- (2019) Zeli Yin et al. Journal of Hematology & Oncology
- Are 90% of deaths from cancer caused by metastases?
- (2019) Hanna Dillekås et al. Cancer Medicine
- The Dark Side of Fibroblasts: Cancer-Associated Fibroblasts as Mediators of Immunosuppression in the Tumor Microenvironment
- (2019) Lea Monteran et al. Frontiers in Immunology
- Systems Biology of Cancer Metastasis
- (2019) Yasir Suhail et al. Cell Systems
- Resolving the fibrotic niche of human liver cirrhosis at single-cell level
- (2019) P. Ramachandran et al. NATURE
- CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan
- (2019) Claire Vennin et al. Nature Communications
- Embryonic mesothelial-derived hepatic lineage of quiescent and heterogenous scar-orchestrating cells defined but suppressed by WT1
- (2019) Timothy James Kendall et al. Nature Communications
- NLRP3 inflammasome in fibroblasts links tissue damage with inflammation in breast cancer progression and metastasis
- (2019) Nour Ershaid et al. Nature Communications
- Cellular Plasticity during Metastasis: New Insights Provided by Intravital Microscopy
- (2019) Andreia S. Margarido et al. Cold Spring Harbor Perspectives in Medicine
- Metabolic heterogeneity confers differences in melanoma metastatic potential
- (2019) Alpaslan Tasdogan et al. NATURE
- TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis
- (2018) Daniele V. F. Tauriello et al. NATURE
- Understanding the tumor immune microenvironment (TIME) for effective therapy
- (2018) Mikhail Binnewies et al. NATURE MEDICINE
- Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis
- (2018) Marion Curtis et al. Cell Metabolism
- TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells
- (2018) Sanjeev Mariathasan et al. NATURE
- Liver metastasis of pancreatic cancer: the hepatic microenvironment impacts differentiation and self-renewal capacity of pancreatic ductal epithelial cells
- (2018) Hendrike Knaack et al. Oncotarget
- Tumor-Stroma Mechanics Coordinate Amino Acid Availability to Sustain Tumor Growth and Malignancy
- (2018) Thomas Bertero et al. Cell Metabolism
- Immune regulation of metastasis: mechanistic insights and therapeutic opportunities
- (2018) Olga S. Blomberg et al. Disease Models & Mechanisms
- Dormant tumour cells, their niches and the influence of immunity
- (2018) Erica T. Goddard et al. NATURE CELL BIOLOGY
- Turning foes to friends: targeting cancer-associated fibroblasts
- (2018) Xueman Chen et al. NATURE REVIEWS DRUG DISCOVERY
- Remodeling of the Collagen Matrix in Aging Skin Promotes Melanoma Metastasis and Affects Immune Cell Motility
- (2018) Amanpreet Kaur et al. Cancer Discovery
- Age-Related Changes in HAPLN1 Increase Lymphatic Permeability and Affect Routes of Melanoma Metastasis
- (2018) Brett L. Ecker et al. Cancer Discovery
- NK cell heparanase controls tumor invasion and immune surveillance
- (2017) Eva M. Putz et al. JOURNAL OF CLINICAL INVESTIGATION
- Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer
- (2017) Daniel Öhlund et al. JOURNAL OF EXPERIMENTAL MEDICINE
- A permanent window for the murine lung enables high-resolution imaging of cancer metastasis
- (2017) David Entenberg et al. NATURE METHODS
- Mechanisms of hepatic stellate cell activation
- (2017) Takuma Tsuchida et al. Nature Reviews Gastroenterology & Hepatology
- Packaging and transfer of mitochondrial DNA via exosomes regulate escape from dormancy in hormonal therapy-resistant breast cancer
- (2017) Pasquale Sansone et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Deconstruction of a Metastatic Tumor Microenvironment Reveals a Common Matrix Response in Human Cancers
- (2017) Oliver M.T. Pearce et al. Cancer Discovery
- Breast cancer subtypes predict the preferential site of distant metastases: a SEER based study
- (2017) Qi Wu et al. Oncotarget
- The hepatic microenvironment essentially determines tumor cell dormancy and metastatic outgrowth of pancreatic ductal adenocarcinoma
- (2017) Lennart Lenk et al. OncoImmunology
- Characteristics and Significance of the Pre-metastatic Niche
- (2016) Yang Liu et al. CANCER CELL
- Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis
- (2016) Sebastian R. Nielsen et al. NATURE CELL BIOLOGY
- Notch3 drives development and progression of cholangiocarcinoma
- (2016) Rachel V. Guest et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Heterogeneity of metastatic pancreatic adenocarcinoma: Lung metastasis show better prognosis than liver metastasis—a case control study
- (2016) Claire Decoster et al. Oncotarget
- Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasis
- (2015) C. D. Madsen et al. EMBO REPORTS
- CCL2-induced chemokine cascade promotes breast cancer metastasis by enhancing retention of metastasis-associated macrophages
- (2015) Takanori Kitamura et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Stromal matrix metalloproteinase 2 regulates collagen expression and promotes the outgrowth of experimental metastases
- (2015) Andreia L Bates et al. JOURNAL OF PATHOLOGY
- IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis
- (2015) Seth B. Coffelt et al. NATURE
- Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver
- (2015) Bruno Costa-Silva et al. NATURE CELL BIOLOGY
- Epigenetic switch drives the conversion of fibroblasts into proinvasive cancer-associated fibroblasts
- (2015) Jean Albrengues et al. Nature Communications
- Osteoclasts control reactivation of dormant myeloma cells by remodelling the endosteal niche
- (2015) Michelle A. Lawson et al. Nature Communications
- Real-Time Imaging Reveals Local, Transient Vascular Permeability, and Tumor Cell Intravasation Stimulated by TIE2hi Macrophage-Derived VEGFA
- (2015) A. S. Harney et al. Cancer Discovery
- Breast Fibroblasts Modulate Early Dissemination, Tumorigenesis, and Metastasis through Alteration of Extracellular Matrix Characteristics
- (2015) Nancy Dumont et al. NEOPLASIA
- Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival
- (2014) Berna C. Özdemir et al. CANCER CELL
- Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma
- (2014) Andrew D. Rhim et al. CANCER CELL
- Extracellular matrix assembly: a multiscale deconstruction
- (2014) Janna K. Mouw et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- The Multifaceted Role of the Microenvironment in Liver Metastasis: Biology and Clinical Implications
- (2013) G. G. Van den Eynden et al. CANCER RESEARCH
- The perivascular niche regulates breast tumour dormancy
- (2013) Cyrus M. Ghajar et al. NATURE CELL BIOLOGY
- Immunosuppressive networks and checkpoints controlling antitumor immunity and their blockade in the development of cancer immunotherapeutics and vaccines
- (2013) A Q Butt et al. ONCOGENE
- Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer
- (2013) C. Feig et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Dependency of Colorectal Cancer on a TGF-β-Driven Program in Stromal Cells for Metastasis Initiation
- (2012) Alexandre Calon et al. CANCER CELL
- The BMP Inhibitor Coco Reactivates Breast Cancer Cells at Lung Metastatic Sites
- (2012) Hua Gao et al. CELL
- A CXCL1 Paracrine Network Links Cancer Chemoresistance and Metastasis
- (2012) Swarnali Acharyya et al. CELL
- Cancer Invasion and the Microenvironment: Plasticity and Reciprocity
- (2011) Peter Friedl et al. CELL
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Bone morphogenetic protein 7 in dormancy and metastasis of prostate cancer stem-like cells in bone
- (2011) Aya Kobayashi et al. JOURNAL OF EXPERIMENTAL MEDICINE
- CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis
- (2011) Bin-Zhi Qian et al. NATURE
- VEGF-A and Tenascin-C produced by S100A4+ stromal cells are important for metastatic colonization
- (2011) J. T. O'Connell et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion
- (2010) V. Gocheva et al. GENES & DEVELOPMENT
- Hypoxia-inducible factor-1α regulates the expression of genes in hypoxic hepatic stellate cells important for collagen deposition and angiogenesis
- (2010) Bryan L. Copple et al. LIVER INTERNATIONAL
- Hepatic Stellate Cells Secrete Angiopoietin 1 That Induces Angiogenesis in Liver Fibrosis
- (2008) Kojiro Taura et al. GASTROENTEROLOGY
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