The Dark Side of Fibroblasts: Cancer-Associated Fibroblasts as Mediators of Immunosuppression in the Tumor Microenvironment
出版年份 2019 全文链接
标题
The Dark Side of Fibroblasts: Cancer-Associated Fibroblasts as Mediators of Immunosuppression in the Tumor Microenvironment
作者
关键词
-
出版物
Frontiers in Immunology
Volume 10, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2019-08-02
DOI
10.3389/fimmu.2019.01835
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Lactate modulates CD4+ T-cell polarization and induces an immunosuppressive environment, which sustains prostate carcinoma progression via TLR8/miR21 axis
- (2019) G. Comito et al. ONCOGENE
- Blockade of fibroblast activation protein in combination with radiation treatment in murine models of pancreatic adenocarcinoma
- (2019) Andrew J. Gunderson et al. PLoS One
- Adventitial Stromal Cells Define Group 2 Innate Lymphoid Cell Tissue Niches
- (2019) Madelene W. Dahlgren et al. IMMUNITY
- Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic Targets
- (2019) Luca Cassetta et al. CANCER CELL
- The extracellular matrix in tumor progression and metastasis
- (2019) Johannes A. Eble et al. CLINICAL & EXPERIMENTAL METASTASIS
- The Extracellular Matrix Modulates the Metastatic Journey
- (2019) FuiBoon Kai et al. DEVELOPMENTAL CELL
- Cancer-associated fibroblasts as abettors of tumor progression at the crossroads of EMT and therapy resistance
- (2019) Micol Eleonora Fiori et al. Molecular Cancer
- Human Pancreatic Carcinoma-Associated Fibroblasts Promote Expression of Co-inhibitory Markers on CD4+ and CD8+ T-Cells
- (2019) Laia Gorchs et al. Frontiers in Immunology
- Mechanisms of immune evasion in breast cancer
- (2018) Joshua P. Bates et al. BMC CANCER
- Fibroblast Heterogeneity and Immunosuppressive Environment in Human Breast Cancer
- (2018) Ana Costa et al. CANCER CELL
- A peek into cancer-associated fibroblasts: origins, functions and translational impact
- (2018) Valerie S. LeBleu et al. Disease Models & Mechanisms
- TGF-β Inhibition and Immunotherapy: Checkmate
- (2018) Karuna Ganesh et al. IMMUNITY
- TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis
- (2018) Daniele V. F. Tauriello et al. NATURE
- Targeting the IL-6/JAK/STAT3 signalling axis in cancer
- (2018) Daniel E. Johnson et al. Nature Reviews Clinical Oncology
- Cancer-associated fibroblasts induce PDL1+ neutrophils through the IL6-STAT3 pathway that foster immune suppression in hepatocellular carcinoma
- (2018) Yusheng Cheng et al. Cell Death & Disease
- miR200-regulated CXCL12β promotes fibroblast heterogeneity and immunosuppression in ovarian cancers
- (2018) Anne-Marie Givel et al. Nature Communications
- Cancer-associated fibroblasts induce antigen-specific deletion of CD8+ T Cells to protect tumour cells
- (2018) Matthew A. Lakins et al. Nature Communications
- The Role of Macrophages in Acute and Chronic Wound Healing and Interventions to Promote Pro-wound Healing Phenotypes
- (2018) Paulina Krzyszczyk et al. Frontiers in Physiology
- TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells
- (2018) Sanjeev Mariathasan et al. NATURE
- FAP delineates heterogeneous and functionally divergent stromal cells in immune-excluded breast tumors
- (2018) Viviana Cremasco et al. Cancer Immunology Research
- Bone marrow–derived fibroblasts are a functionally distinct stromal cell population in breast cancer
- (2018) Yael Raz et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Deciphering cancer fibroblasts
- (2018) Giulia Biffi et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Spatially and functionally distinct subclasses of breast cancer-associated fibroblasts revealed by single cell RNA sequencing
- (2018) Michael Bartoschek et al. Nature Communications
- IL-1-induced JAK/STAT signaling is antagonized by TGF-beta to shape CAF heterogeneity in pancreatic ductal adenocarcinoma
- (2018) Giulia Biffi et al. Cancer Discovery
- Remodeling of the Collagen Matrix in Aging Skin Promotes Melanoma Metastasis and Affects Immune Cell Motility
- (2018) Amanpreet Kaur et al. Cancer Discovery
- Age-Related Changes in HAPLN1 Increase Lymphatic Permeability and Affect Routes of Melanoma Metastasis
- (2018) Brett L. Ecker et al. Cancer Discovery
- Non-hematopoietic Control of Peripheral Tissue T Cell Responses: Implications for Solid Tumors
- (2018) Ryan S. Lane et al. Frontiers in Immunology
- Macrophage Phenotypes Regulate Scar Formation and Chronic Wound Healing
- (2017) Mark Hesketh et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer
- (2017) Daniel Öhlund et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Fibroblasts drive an immunosuppressive and growth-promoting microenvironment in breast cancer via secretion of Chitinase 3-like 1
- (2017) N Cohen et al. ONCOGENE
- miRNA-1246 induces pro-inflammatory responses in mesenchymal stem/stromal cells by regulating PKA and PP2A
- (2017) Alexander Bott et al. Oncotarget
- Melanoma-associated fibroblasts decrease tumor cell susceptibility to NK cell-mediated killing through matrix-metalloproteinases secretion
- (2017) Linda Ziani et al. Oncotarget
- Myeloid-Derived Suppressor Cells
- (2017) Dmitry I. Gabrilovich Cancer Immunology Research
- FAP Promotes Immunosuppression by Cancer-Associated Fibroblasts in the Tumor Microenvironment via STAT3–CCL2 Signaling
- (2016) Xuguang Yang et al. CANCER RESEARCH
- Carcinoma-associated fibroblasts: orchestrating the composition of malignancy
- (2016) Philippe Gascard et al. GENES & DEVELOPMENT
- IL-6 and PD-L1 antibody blockade combination therapy reduces tumour progression in murine models of pancreatic cancer
- (2016) Thomas A Mace et al. GUT
- Dickkopf-related protein 1 (Dkk1) regulates the accumulation and function of myeloid derived suppressor cells in cancer
- (2016) Lucia D’Amico et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Mesenchymal stromal cells derived from cervical cancer produce high amounts of adenosine to suppress cytotoxic T lymphocyte functions
- (2016) María de Lourdes Mora-García et al. Journal of Translational Medicine
- Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy
- (2016) Hong Jiang et al. NATURE MEDICINE
- Hepatic carcinoma-associated fibroblasts enhance immune suppression by facilitating the generation of myeloid-derived suppressor cells
- (2016) Y Deng et al. ONCOGENE
- TNFα-activated mesenchymal stromal cells promote breast cancer metastasis by recruiting CXCR2+ neutrophils
- (2016) P F Yu et al. ONCOGENE
- Mesenchymal Stromal Cell Secretion of Programmed Death-1 Ligands Regulates T Cell Mediated Immunosuppression
- (2016) Lindsay C. Davies et al. STEM CELLS
- Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis
- (2016) Megan K. Ruhland et al. Nature Communications
- Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards
- (2016) Vincenzo Bronte et al. Nature Communications
- Depletion of FAP+ cells reduces immunosuppressive cells and improves metabolism and functions CD8+T cells within tumors
- (2016) Ying Zhang et al. Oncotarget
- Lung cancer-derived galectin-1 contributes to cancer associated fibroblast-mediated cancer progression and immune suppression through TDO2/kynurenine axis
- (2016) Ya-Ling Hsu et al. Oncotarget
- Targeting the cancer-associated fibroblasts as a treatment in triple-negative breast cancer
- (2016) Ken Takai et al. Oncotarget
- Cancer-associated fibroblasts promote an immunosuppressive microenvironment through the induction and accumulation of protumoral macrophages
- (2016) Hideyuki Takahashi et al. Oncotarget
- Hepatic carcinoma-associated fibroblasts induce IDO-producing regulatory dendritic cells through IL-6-mediated STAT3 activation
- (2016) J-t Cheng et al. Oncogenesis
- Stromal Myofibroblasts Are Associated with Poor Prognosis in Solid Cancers: A Meta-Analysis of Published Studies
- (2016) Liu Liu et al. PLoS One
- Tumor-Derived Osteopontin Reprograms Normal Mammary Fibroblasts to Promote Inflammation and Tumor Growth in Breast Cancer
- (2015) Y. Sharon et al. CANCER RESEARCH
- Cancer-associated fibroblast-targeted strategy enhances antitumor immune responses in dendritic cell-based vaccine
- (2015) Yasuhiko Ohshio et al. CANCER SCIENCE
- A potent immunotoxin targeting fibroblast activation protein for treatment of breast cancer in mice
- (2015) Jinxu Fang et al. INTERNATIONAL JOURNAL OF CANCER
- Fibroblastic Reticular Cells: Organization and Regulation of the T Lymphocyte Life Cycle
- (2015) Flavian D. Brown et al. JOURNAL OF IMMUNOLOGY
- Stromal gene expression defines poor-prognosis subtypes in colorectal cancer
- (2015) Alexandre Calon et al. NATURE GENETICS
- T cell exclusion, immune privilege, and the tumor microenvironment
- (2015) J. A. Joyce et al. SCIENCE
- The Next Hurdle in Cancer Immunotherapy: Overcoming the Non–T-Cell–Inflamed Tumor Microenvironment
- (2015) Thomas F. Gajewski SEMINARS IN ONCOLOGY
- Zoledronic acid prevents the tumor-promoting effects of mesenchymal stem cells via MCP-1 dependent recruitment of macrophages
- (2015) Xiao-Hua Jia et al. Oncotarget
- Targeting ECM Disrupts Cancer Progression
- (2015) Freja A. Venning et al. Frontiers in Oncology
- Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival
- (2014) Berna C. Özdemir et al. CANCER CELL
- Cancer-Associated Fibroblasts Expressing CXCL14 Rely upon NOS1-Derived Nitric Oxide Signaling for Their Tumor-Supporting Properties
- (2014) M. Augsten et al. CANCER RESEARCH
- Crosstalk between fibroblasts and inflammatory cells
- (2014) S. Van Linthout et al. CARDIOVASCULAR RESEARCH
- The Reprogramming of Tumor Stroma by HSF1 Is a Potent Enabler of Malignancy
- (2014) Ruth Scherz-Shouval et al. CELL
- Vitamin D Receptor-Mediated Stromal Reprogramming Suppresses Pancreatitis and Enhances Pancreatic Cancer Therapy
- (2014) Mara H. Sherman et al. CELL
- Interleukin-17 enhances immunosuppression by mesenchymal stem cells
- (2014) X Han et al. CELL DEATH AND DIFFERENTIATION
- Prevailing Role of Contact Guidance in Intrastromal T-cell Trapping in Human Pancreatic Cancer
- (2014) N. Hartmann et al. CLINICAL CANCER RESEARCH
- Fibroblast heterogeneity in the cancer wound
- (2014) Daniel Öhlund et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Disruption of CCR5-Dependent Homing of Regulatory T Cells Inhibits Tumor Growth in a Murine Model of Pancreatic Cancer
- (2014) M. C. B. Tan et al. JOURNAL OF IMMUNOLOGY
- CXCL12/CXCR4 Blockade by Oncolytic Virotherapy Inhibits Ovarian Cancer Growth by Decreasing Immunosuppression and Targeting Cancer-Initiating Cells
- (2014) Margaret Gil et al. JOURNAL OF IMMUNOLOGY
- A pro-tumourigenic loop at the human prostate tumour interface orchestrated by oestrogen, CXCL12 and mast cell recruitment
- (2014) Stuart J Ellem et al. JOURNAL OF PATHOLOGY
- Activation of Mesenchymal Stem Cells by Macrophages Prompts Human Gastric Cancer Growth through NF-κB Pathway
- (2014) Tingting Yang et al. PLoS One
- The Carcinoma-Associated Fibroblast Expressing Fibroblast Activation Protein and Escape from Immune Surveillance
- (2014) D. T. Fearon Cancer Immunology Research
- TGF-β Activation and Function in Immunity
- (2013) Mark A. Travis et al. Annual Review of Immunology
- Pancreatic Cancer-Associated Stellate Cells Promote Differentiation of Myeloid-Derived Suppressor Cells in a STAT3-Dependent Manner
- (2013) T. A. Mace et al. CANCER RESEARCH
- Depletion of stromal cells expressing fibroblast activation protein-α from skeletal muscle and bone marrow results in cachexia and anemia
- (2013) Edward W. Roberts et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Down-regulation of PLCγ2–β-catenin pathway promotes activation and expansion of myeloid-derived suppressor cells in cancer
- (2013) Aude-Hélène Capietto et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Microenvironmental regulation of tumor progression and metastasis
- (2013) Daniela F Quail et al. NATURE MEDICINE
- Cancer-associated fibroblasts and M2-polarized macrophages synergize during prostate carcinoma progression
- (2013) G Comito et al. ONCOGENE
- Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer
- (2013) C. Feig et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Targeting Fibroblast Activation Protein in Tumor Stroma with Chimeric Antigen Receptor T Cells Can Inhibit Tumor Growth and Augment Host Immunity without Severe Toxicity
- (2013) L.-C. S. Wang et al. Cancer Immunology Research
- TGF-β-miR-34a-CCL22 Signaling-Induced Treg Cell Recruitment Promotes Venous Metastases of HBV-Positive Hepatocellular Carcinoma
- (2012) Pengyuan Yang et al. CANCER CELL
- Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment
- (2012) Douglas Hanahan et al. CANCER CELL
- Chromatin Remodeling Underlies the Senescence-Associated Secretory Phenotype of Tumor Stromal Fibroblasts That Supports Cancer Progression
- (2012) E. Pazolli et al. CANCER RESEARCH
- CCR2-Dependent Recruitment of Macrophages by Tumor-Educated Mesenchymal Stromal Cells Promotes Tumor Development and Is Mimicked by TNFα
- (2012) Guangwen Ren et al. Cell Stem Cell
- Oncogenic BRAF(V600E) Promotes Stromal Cell-Mediated Immunosuppression Via Induction of Interleukin-1 in Melanoma
- (2012) J. S. Khalili et al. CLINICAL CANCER RESEARCH
- Matrix architecture defines the preferential localization and migration of T cells into the stroma of human lung tumors
- (2012) Hélène Salmon et al. JOURNAL OF CLINICAL INVESTIGATION
- From sentinel cells to inflammatory culprits: cancer-associated fibroblasts in tumour-related inflammation
- (2012) Charlotte Servais et al. JOURNAL OF PATHOLOGY
- Origins of the Tumor Microenvironment: Quantitative Assessment of Adipose-Derived and Bone Marrow–Derived Stroma
- (2012) Shannon Kidd et al. PLoS One
- Regulation of COX2 Expression in Mouse Mammary Tumor Cells Controls Bone Metastasis and PGE2-Induction of Regulatory T Cell Migration
- (2012) John Karavitis et al. PLoS One
- Cross-talk within the tumor microenvironment mediates Th2-type inflammation in pancreatic cancer
- (2012) Maria Pia Protti et al. OncoImmunology
- Bone Marrow-Derived Myofibroblasts Contribute to the Mesenchymal Stem Cell Niche and Promote Tumor Growth
- (2011) Michael Quante et al. CANCER CELL
- Hepatocellular carcinoma-associated fibroblasts trigger NK cell dysfunction via PGE2 and IDO
- (2011) Tuanjie Li et al. CANCER LETTERS
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Intratumor T helper type 2 cell infiltrate correlates with cancer-associated fibroblast thymic stromal lymphopoietin production and reduced survival in pancreatic cancer
- (2011) Lucia De Monte et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Myofibroblast differentiation during fibrosis: role of NAD(P)H oxidases
- (2011) Jeffrey L. Barnes et al. KIDNEY INTERNATIONAL
- Regulated release of nitric oxide by nonhematopoietic stroma controls expansion of the activated T cell pool in lymph nodes
- (2011) Veronika Lukacs-Kornek et al. NATURE IMMUNOLOGY
- Fibroblastic Reticular Cells From Lymph Nodes Attenuate T Cell Expansion by Producing Nitric Oxide
- (2011) Stefanie Siegert et al. PLoS One
- Senescent cells as a source of inflammatory factors for tumor progression
- (2010) Albert R. Davalos et al. CANCER AND METASTASIS REVIEWS
- Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-κB-Dependent Manner
- (2010) Neta Erez et al. CANCER CELL
- Hyaluronan Deficiency in Tumor Stroma Impairs Macrophage Trafficking and Tumor Neovascularization
- (2010) N. Kobayashi et al. CANCER RESEARCH
- Macrophage Diversity Enhances Tumor Progression and Metastasis
- (2010) Bin-Zhi Qian et al. CELL
- Importance of CCL2-CCR2A/2B signaling for monocyte migration into spheroids of breast cancer-derived fibroblasts
- (2010) Magdalena Ksiazkiewicz et al. IMMUNOBIOLOGY
- Reciprocal Functional Modulation of the Activation of T Lymphocytes and Fibroblasts Derived from Human Solid Tumors
- (2010) J. L. Barnas et al. JOURNAL OF IMMUNOLOGY
- Induction of Lymphoidlike Stroma and Immune Escape by Tumors That Express the Chemokine CCL21
- (2010) J. D. Shields et al. SCIENCE
- Suppression of Antitumor Immunity by Stromal Cells Expressing Fibroblast Activation Protein-
- (2010) M. Kraman et al. SCIENCE
- Cell-autonomous and environmental contributions to the interstitial migration of T cells
- (2010) Paulus Mrass et al. Seminars in Immunopathology
- Breast Cancer Lung Metastasis Requires Expression of Chemokine Receptor CCR4 and Regulatory T Cells
- (2009) P. B. Olkhanud et al. CANCER RESEARCH
- Targeting fibroblast activation protein inhibits tumor stromagenesis and growth in mice
- (2009) Angélica M. Santos et al. JOURNAL OF CLINICAL INVESTIGATION
- IL4Rα + Myeloid-Derived Suppressor Cell Expansion in Cancer Patients
- (2009) Susanna Mandruzzato et al. JOURNAL OF IMMUNOLOGY
- Cancer Associated Fibroblasts Promote Tumor Growth and Metastasis by Modulating the Tumor Immune Microenvironment in a 4T1 Murine Breast Cancer Model
- (2009) Debbie Liao et al. PLoS One
- Melanoma-associated fibroblasts modulate NK cell phenotype and antitumor cytotoxicity
- (2009) M. Balsamo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mesenchymal Stem Cell-Mediated Immunosuppression Occurs via Concerted Action of Chemokines and Nitric Oxide
- (2008) Guangwen Ren et al. Cell Stem Cell
- Effective Immunoconjugate Therapy in Cancer Models Targeting a Serine Protease of Tumor Fibroblasts
- (2008) E. Ostermann et al. CLINICAL CANCER RESEARCH
- PD-1 Ligand Expression by Human Colonic Myofibroblasts/Fibroblasts Regulates CD4+ T-Cell Activity
- (2008) Irina V. Pinchuk et al. GASTROENTEROLOGY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search