FAK activity in cancer‐associated fibroblasts is a prognostic marker and a druggable key metastatic player in pancreatic cancer

Cancer associated fibroblast FAK regulates malignant cell metabolism

(2020) Fevzi Demircioglu et al.   Nature Communications

Pancreatic Cancer Associated Fibroblasts (CAF): Under-Explored Target for Pancreatic Cancer Treatment

(2020) Jeffrey Norton et al.   Cancers

Fibroblasts in Pancreatic Ductal Adenocarcinoma: biological mechanisms and therapeutic targets

(2019) Martin C. Whittle et al.   GASTROENTEROLOGY

Tumour budding in pancreatic cancer revisited: validation of the ITBCC scoring system

(2018) Eva Karamitopoulou et al.   HISTOPATHOLOGY

Prognostic value of increased integrin-beta 1 expression in solid cancers: a meta-analysis

(2018) Quanwu Sun et al.   OncoTargets and Therapy

Chemokine-Induced Macrophage Polarization in Inflammatory Conditions

(2018) Pieter Ruytinx et al.   Frontiers in Immunology

Stratification of Pancreatic Ductal Adenocarcinomas Based on Tumor and Microenvironment Features

(2018) Francesco Puleo et al.   GASTROENTEROLOGY

Inter- and intra-tumoral heterogeneity in cancer-associated fibroblasts of human pancreatic ductal adenocarcinoma

(2018) Cindy Neuzillet et al.   JOURNAL OF PATHOLOGY

Typing of pancreatic cancer-associated fibroblasts identifies different subpopulations

(2018) Michael Friberg Bruun Nielsen et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer

(2017) Daniel Öhlund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics

(2017) Alexandra Naba et al.   JOURNAL OF PROTEOME RESEARCH

Cell-derived matrices for studying cell proliferation and directional migration in a complex 3D microenvironment

(2017) Riina Kaukonen et al.   Nature Protocols

Deconstruction of a Metastatic Tumor Microenvironment Reveals a Common Matrix Response in Human Cancers

(2017) Oliver M.T. Pearce et al.   Cancer Discovery

Tissue-resident versus monocyte-derived macrophages in the tumor microenvironment

(2016) Qods Lahmar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy

(2016) Hong Jiang et al.   NATURE MEDICINE

Tensile Forces Originating from Cancer Spheroids Facilitate Tumor Invasion

(2016) Katarzyna S. Kopanska et al.   PLoS One

Nuclear FAK Controls Chemokine Transcription, Tregs, and Evasion of Anti-tumor Immunity

(2015) Alan Serrels et al.   CELL

The regulation of immune cell trafficking by the extracellular matrix

(2015) Rupert Hallmann et al.   CURRENT OPINION IN CELL BIOLOGY

Pharmacological targeting of the protein synthesis mTOR/4E-BP1 pathway in cancer-associated fibroblasts abrogates pancreatic tumour chemoresistance

(2015) C. Duluc et al.   EMBO Molecular Medicine

Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma

(2015) Richard A Moffitt et al.   NATURE GENETICS

The extracellular matrix modulates the hallmarks of cancer

(2014) M. W. Pickup et al.   EMBO REPORTS

Guidelines for time-to-event end-point definitions in trials for pancreatic cancer. Results of the DATECAN initiative (Definition for the Assessment of Time-to-event End-points in CANcer trials)

(2014) Franck Bonnetain et al.   EUROPEAN JOURNAL OF CANCER

Inhibition of endothelial FAK activity prevents tumor metastasis by enhancing barrier function

(2014) Christine Jean et al.   JOURNAL OF CELL BIOLOGY

LIF Mediates Proinvasive Activation of Stromal Fibroblasts in Cancer

(2014) Jean Albrengues et al.   Cell Reports

Antifibrotic Effects of Focal Adhesion Kinase Inhibitor in Bleomycin-Induced Pulmonary Fibrosis in Mice

(2013) Katsuhiro Kinoshita et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Tumor-Secreted LOXL2 Activates Fibroblasts through FAK Signaling

(2013) H. E. Barker et al.   MOLECULAR CANCER RESEARCH

New insights into pancreatic cancer biology

(2012) M. Hidalgo   ANNALS OF ONCOLOGY

The Pancreas Cancer Microenvironment

(2012) C. Feig et al.   CLINICAL CANCER RESEARCH

The Impact of the Activated Stroma on Pancreatic Ductal Adenocarcinoma Biology and Therapy Resistance

(2012) Mert Erkan et al.   CURRENT MOLECULAR MEDICINE

Dangerous liaisons: Pancreatic stellate cells and pancreatic cancer cells

(2012) Minoti V Apte et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Safety, pharmacokinetic, pharmacodynamic, and efficacy data for the oral MEK inhibitor trametinib: a phase 1 dose-escalation trial

(2012) Jeffrey R Infante et al.   LANCET ONCOLOGY

Extensive quantitative remodeling of the proteome between normal colon tissue and adenocarcinoma

(2012) Jacek R Wiśniewski et al.   Molecular Systems Biology

The tumor microenvironment controls drug sensitivity

(2012) Arne Östman   NATURE MEDICINE

Why the stroma matters in breast cancer

(2012) Matthew W. Conklin et al.   Cell Adhesion & Migration

Inhibition of focal adhesion kinase prevents experimental lung fibrosis and myofibroblast formation

(2011) David Lagares et al.   ARTHRITIS AND RHEUMATISM

A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer

(2011) Steven N. Hochwald et al.   CELL CYCLE

Inhibition of Focal Adhesion Kinase by PF-562,271 Inhibits the Growth and Metastasis of Pancreatic Cancer Concomitant with Altering the Tumor Microenvironment

(2011) J. B. Stokes et al.   MOLECULAR CANCER THERAPEUTICS

Global quantification of mammalian gene expression control

(2011) Björn Schwanhäusser et al.   NATURE

Tumors as Organs: Complex Tissues that Interface with the Entire Organism

(2010) Mikala Egeblad et al.   DEVELOPMENTAL CELL

Hallmarks of cancer: Interactions with the tumor stroma

(2010) Kristian Pietras et al.   EXPERIMENTAL CELL RESEARCH

Knock-in Mutation Reveals an Essential Role for Focal Adhesion Kinase Activity in Blood Vessel Morphogenesis and Cell Motility-Polarity but Not Cell Proliferation

(2010) Ssang-Taek Lim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of RhoA and FAK induces ERK-mediated osteopontin expression in mechanical force-subjected periodontal ligament fibroblasts

(2009) So-Yeon Hong et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

(2009) K. P. Olive et al.   SCIENCE

Tube Travel: The Role of Proteases in Individual and Collective Cancer Cell Invasion

(2008) P. Friedl et al.   CANCER RESEARCH

Cancer-Associated Stromal Fibroblasts Promote Pancreatic Tumor Progression

(2008) R. F. Hwang et al.   CANCER RESEARCH

Periostin deposition in the stroma of invasive and intraductal neoplasms of the pancreas

(2008) Noriyoshi Fukushima et al.   MODERN PATHOLOGY