rs1990622 variant associates with Alzheimer’s disease and regulates TMEM106B expression in human brain tissues

rs4147929 variant minor allele increases ABCA7 gene expression and ABCA7 shows increased gene expression in Alzheimer’s disease patients compared with controls

(2020) Guiyou Liu et al.   ACTA NEUROPATHOLOGICA

Eliciting priors and relaxing the single causal variant assumption in colocalisation analyses

(2020) Chris Wallace   PLoS Genetics

Loss of TMEM106B leads to myelination deficits: implications for frontotemporal dementia treatment strategies

(2020) Xiaolai Zhou et al.   BRAIN

Genetics of Gene Expression in the Aging Human Brain Reveal TDP-43 Proteinopathy Pathophysiology

(2020) Hyun-Sik Yang et al.   NEURON

The impact of sex on gene expression across human tissues

(2020) Meritxell Oliva et al.   SCIENCE

The GTEx Consortium atlas of genetic regulatory effects across human tissues

(2020)   SCIENCE

Large eQTL meta-analysis reveals differing patterns between cerebral cortical and cerebellar brain regions

(2020) Solveig K. Sieberts et al.   Scientific Data

Genetic variant rs17185536 regulates SIM1 gene expression in human brain hypothalamus

(2019) Guiyou Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

(2019) Brian W. Kunkle et al.   NATURE GENETICS

TMEM106B Effect on cognition in Parkinson disease and frontotemporal dementia

(2019) Thomas F. Tropea et al.   ANNALS OF NEUROLOGY

Population Difference and Disease Status Affect the Association Between Genetic Variants and Gene Expression

(2019) Guiyou Liu et al.   GASTROENTEROLOGY

The TMEM106B FTLD-protective variant, rs1990621, is also associated with increased neuronal proportion

(2019) Zeran Li et al.   ACTA NEUROPATHOLOGICA

Rs2293871 regulates HTRA1 expression and affects cerebral small vessel stroke and Alzheimer's disease

(2019) Guiyou Liu et al.   BRAIN

Exploring lithium’s transcriptional mechanisms of action in bipolar disorder: a multi-step study

(2019) Ibrahim A. Akkouh et al.   NEUROPSYCHOPHARMACOLOGY

Genetic variants regulate NR1H3 expression and contribute to multiple sclerosis risk

(2018) Yan Zhang et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

TMEM106B haplotypes have distinct gene expression patterns in aged brain

(2018) Yingxue Ren et al.   Molecular Neurodegeneration

Genome-wide pleiotropy analysis of neuropathological traits related to Alzheimer’s disease

(2018) Jaeyoon Chung et al.   Alzheimers Research & Therapy

GWAS on family history of Alzheimer’s disease

(2018) Riccardo E. Marioni et al.   Translational Psychiatry

Alzheimer’s Disease Risk Variant rs2373115 Regulates GAB2 and NARS2 Expression in Human Brain Tissues

(2018) Guiyou Liu et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Identification of expression quantitative trait loci associated with schizophrenia and affective disorders in normal brain tissue

(2018) Oneil G. Bhalala et al.   PLoS Genetics

New insights into the role of TREM2 in Alzheimer’s disease

(2018) Maud Gratuze et al.   Molecular Neurodegeneration

Disease status affects the association between rs4813620 and the expression of Alzheimer’s disease susceptibility geneTRIB3

(2018) Guiyou Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SORL1 Variants Show Different Association with Early-Onset and Late-Onset Alzheimer’s Disease Risk

(2017) Guiyou Liu et al.   JOURNAL OF ALZHEIMERS DISEASE

GAB2 rs2373115 variant contributes to Alzheimer's disease risk specifically in European population

(2017) Yang Hu et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Association analysis of polymorphisms in VMAT2 and TMEM106B genes for Parkinson's disease, amyotrophic lateral sclerosis and multiple system atrophy

(2017) Tao Hu et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Genetic effects on gene expression across human tissues

(2017) François Aguet et al.   NATURE

An xQTL map integrates the genetic architecture of the human brain's transcriptome and epigenome

(2017) Bernard Ng et al.   NATURE NEUROSCIENCE

Gene-based association study of genes linked to hippocampal sclerosis of aging neuropathology: GRN , TMEM106B , ABCC9 , and KCNMB2

(2017) Yuriko Katsumata et al.   NEUROBIOLOGY OF AGING

Rs4878104 contributes to Alzheimer’s disease risk and regulates DAPK1 gene expression

(2017) Yang Hu et al.   NEUROLOGICAL SCIENCES

Autoimmune disease variants regulateGSDMBgene expression in human immune cells and whole blood

(2017) Yang Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic variant rs763361 regulates multiple sclerosisCD226gene expression

(2017) Guiyou Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of genes associated with dissociation of cognitive performance and neuropathological burden: Multistep analysis of genetic, epigenetic, and transcriptional data

(2017) Charles C. White et al.   PLOS MEDICINE

Differential Aging Analysis in Human Cerebral Cortex Identifies Variants in TMEM106B and GRN that Regulate Aging Phenotypes

(2017) Herve Rhinn et al.   Cell Systems

Parkinson's disease-associated genetic variation is linked to quantitative expression of inflammatory genes

(2017) Steven Pierce et al.   PLoS One

What we know about TMEM106B in neurodegeneration

(2016) Alexandra M. Nicholson et al.   ACTA NEUROPATHOLOGICA

Parkinson-associated risk variant in distal enhancer of α-synuclein modulates target gene expression

(2016) Frank Soldner et al.   NATURE

Reply to Liu et al.: Translation of rat congenic data to humans on a conserved MHC-III haplotype associated with rheumatoid arthritis

(2016) Anthony C. Y. Yau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cis-eQTLs regulate reducedLST1gene andNCR3gene expression and contribute to increased autoimmune disease risk: Table 1.

(2016) Guiyou Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comprehensive promoter level expression quantitative trait loci analysis of the human frontal lobe

(2016) Cornelis Blauwendraat et al.   Genome Medicine

Insight into Genotype-Phenotype Associations through eQTL Mapping in Multiple Cell Types in Health and Immune-Mediated Disease

(2016) James E. Peters et al.   PLoS Genetics

Alzheimer’s Disease Risk Polymorphisms Regulate Gene Expression in the ZCWPW1 and the CELF1 Loci

(2016) Celeste M. Karch et al.   PLoS One

A novel Alzheimer disease locus located near the gene encoding tau protein

(2015) G Jun et al.   MOLECULAR PSYCHIATRY

The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans

(2015) et al.   SCIENCE

Analyzing large-scale samples confirms the association between rs16892766 polymorphism and colorectal cancer susceptibility

(2015) Mingzhi Liao et al.   Scientific Reports

Identifying the Association Between Alzheimer’s Disease and Parkinson’s Disease Using Genome-Wide Association Studies and Protein-Protein Interaction Network

(2014) Guiyou Liu et al.   MOLECULAR NEUROBIOLOGY

Genetic variability in the regulation of gene expression in ten regions of the human brain

(2014) Adaikalavan Ramasamy et al.   NATURE NEUROSCIENCE

TMEM106B expression is reduced in Alzheimer’s disease brains

(2014) Jun-ichi Satoh et al.   Alzheimers Research & Therapy

Bayesian Test for Colocalisation between Pairs of Genetic Association Studies Using Summary Statistics

(2014) Claudia Giambartolomei et al.   PLoS Genetics

Measles Contributes to Rheumatoid Arthritis: Evidence from Pathway and Network Analyses of Genome-Wide Association Studies

(2013) Guiyou Liu et al.   PLoS One

Brain Expression Genome-Wide Association Study (eGWAS) Identifies Human Disease-Associated Variants

(2012) Fanggeng Zou et al.   PLoS Genetics

Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy

(2011) Günter U Höglinger et al.   NATURE GENETICS

Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions

(2010) Vivianna M Van Deerlin et al.   NATURE GENETICS