Discovery of cell-internalizing artificial nucleic acid aptamers for lung fibroblasts and targeted drug delivery

Side chain determinants of biopolymer function during selection and replication

(2019) Phillip A. Lichtor et al.   Nature Chemical Biology

Highly stable hexitol based XNA aptamers targeting the vascular endothelial growth factor

(2019) Elena Eremeeva et al.   NUCLEIC ACIDS RESEARCH

Gene Expression Changes Associated with Nintedanib Treatment in Idiopathic Pulmonary Fibrosis Fibroblasts: A Next-Generation Sequencing and Bioinformatics Study

(2019) Chau-Chyun Sheu et al.   Journal of Clinical Medicine

Synthesis and Evolution of a Threose Nucleic Acid Aptamer Bearing 7-Deaza-7-Substituted Guanosine Residues

(2018) Hui Mei et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Crystal structures of thrombin in complex with chemically modified thrombin DNA aptamers reveal the origins of enhanced affinity

(2018) Rafal Dolot et al.   NUCLEIC ACIDS RESEARCH

Development of oligonucleotide-based antagonists of Ebola virus protein 24 inhibiting its interaction with karyopherin alpha 1

(2018) Keisuke Tanaka et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Tunable cytotoxic aptamer–drug conjugates for the treatment of prostate cancer

(2018) Bethany Powell Gray et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Global Gene Expression Analysis in an in vitro Fibroblast Model of Idiopathic Pulmonary Fibrosis Reveals Potential Role for CXCL14/CXCR4

(2018) Luis R. Rodriguez et al.   Scientific Reports

Aptamers in the Therapeutics and Diagnostics Pipelines

(2018) Harleen Kaur et al.   Theranostics

AptaSUITE: A Full-Featured Bioinformatics Framework for the Comprehensive Analysis of Aptamers from HT-SELEX Experiments

(2018) Jan Hoinka et al.   Molecular Therapy-Nucleic Acids

Fibroblast-to-myofibroblast transition in bronchial asthma

(2018) Marta Michalik et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Genetic Alphabet Expansion Provides Versatile Specificities and Activities of Unnatural-Base DNA Aptamers Targeting Cancer Cells

(2018) Kazunobu Futami et al.   Molecular Therapy-Nucleic Acids

Treatment of pulmonary fibrosis with siRNA against a collagen-specific chaperone HSP47 in vitamin A-coupled liposomes

(2017) Mitsuo Otsuka et al.   EXPERIMENTAL LUNG RESEARCH

Chemical Modifications of Nucleic Acid Aptamers for Therapeutic Purposes

(2017) Shuaijian Ni et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Biological applications of xeno nucleic acids

(2017) Kunihiko Morihiro et al.   Molecular BioSystems

Strategies and challenges for the next generation of antibody–drug conjugates

(2017) Alain Beck et al.   NATURE REVIEWS DRUG DISCOVERY

Selection of DNA aptamers with two modified bases

(2017) Bharat N. Gawande et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aptamer-Drug Conjugates of Active Metabolites of Nucleoside Analogs and Cytotoxic Agents Inhibit Pancreatic Tumor Cell Growth

(2017) Sorah Yoon et al.   Molecular Therapy-Nucleic Acids

In Vitro Selection of Cell-Internalizing DNA Aptamers in a Model System of Inflammatory Kidney Disease

(2017) Glory Ranches et al.   Molecular Therapy-Nucleic Acids

Idiopathic pulmonary fibrosis

(2017) Fernando J. Martinez et al.   Nature Reviews Disease Primers

Consecutive incorporation of functionalized nucleotides with amphiphilic side chains by novel KOD polymerase mutant

(2016) Hidekazu Hoshino et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Incidence and prevalence of idiopathic pulmonary fibrosis in US adults 18–64 years old

(2016) Ganesh Raghu et al.   EUROPEAN RESPIRATORY JOURNAL

Cell-SELEX-based selection and characterization of a G-quadruplex DNA aptamer against mouse dendritic cells

(2016) M. Moghadam et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Aptamers as targeted therapeutics: current potential and challenges

(2016) Jiehua Zhou et al.   NATURE REVIEWS DRUG DISCOVERY

Qualitative European survey of patients with idiopathic pulmonary fibrosis: patients’ perspectives of the disease and treatment

(2016) Anne-Marie Russell et al.   BMC Pulmonary Medicine

Clinical and economic burden of idiopathic pulmonary fibrosis: a retrospective cohort study

(2016) Karina Raimundo et al.   BMC Pulmonary Medicine

Forna (force-directed RNA): Simple and effective online RNA secondary structure diagrams

(2015) Peter Kerpedjiev et al.   BIOINFORMATICS

Characterization and target identification of a DNA aptamer that labels pluripotent stem cells

(2015) Zhonggang Hou et al.   CELL RESEARCH

Nucleic Acid Aptamer-Guided Cancer Therapeutics and Diagnostics: the Next Generation of Cancer Medicine

(2015) Dongxi Xiang et al.   Theranostics

Epidemiologic Survey of Japanese Patients with Idiopathic Pulmonary Fibrosis and Investigation of Ethnic Differences

(2014) Motoki Natsuizaka et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Fibrotic extracellular matrix activates a profibrotic positive feedback loop

(2014) Matthew W. Parker et al.   JOURNAL OF CLINICAL INVESTIGATION

Nucleic Acid Ligands With Protein-like Side Chains: Modified Aptamers and Their Use as Diagnostic and Therapeutic Agents

(2014) John C Rohloff et al.   Molecular Therapy-Nucleic Acids

2′,4′-BNA/LNA aptamers: CE-SELEX using a DNA-based library of full-length 2′-O,4′-C-methylene-bridged/linked bicyclic ribonucleotides

(2013) Yuuya Kasahara et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Generation of high-affinity DNA aptamers using an expanded genetic alphabet

(2013) Michiko Kimoto et al.   NATURE BIOTECHNOLOGY

Development of an Efficient Targeted Cell-SELEX Procedure for DNA Aptamer Reagents

(2013) Susanne Meyer et al.   PLoS One

Identification of RNA aptamers that internalize into HPV-16 E6/E7 transformed tonsillar epithelial cells

(2013) Francoise A. Gourronc et al.   VIROLOGY

The XNA world: progress towards replication and evolution of synthetic genetic polymers

(2012) Vitor B Pinheiro et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Delivery of chemo-sensitizing siRNAs to HER2+-breast cancer cells using RNA aptamers

(2012) Kristina W. Thiel et al.   NUCLEIC ACIDS RESEARCH

Efficacy of a Novel Class of RNA Interference Therapeutic Agents

(2012) Tomohiro Hamasaki et al.   PLoS One

Unique motifs and hydrophobic interactions shape the binding of modified DNA ligands to protein targets

(2012) D. R. Davies et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Delayed Access and Survival in Idiopathic Pulmonary Fibrosis

(2011) Daniela J. Lamas et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Integrating mechanisms of pulmonary fibrosis

(2011) Thomas A. Wynn   JOURNAL OF EXPERIMENTAL MEDICINE

Aptamer-Based Multiplexed Proteomic Technology for Biomarker Discovery

(2011) Larry Gold et al.   PLoS One

Identification of an aptamer targeting hnRNP A1 by tissue slide‐based SELEX

(2009) Shaohua Li et al.   JOURNAL OF PATHOLOGY

Lung Fibroblast Repair Functions in Patients with Chronic Obstructive Pulmonary Disease Are Altered by Multiple Mechanisms

(2008) Shinsaku Togo et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE