Biomaterials to enhance antigen-specific T cell expansion for cancer immunotherapy

CUE-101, a Novel HPV16 E7-pHLA-IL-2-Fc Fusion Protein, Enhances Tumor Antigen Specific T Cell Activation for the Treatment of HPV16-Driven Malignancies

(2020) Steven N Quayle et al.   CLINICAL CANCER RESEARCH

Sugar-Nanocapsules Imprinted with Microbial Molecular Patterns for mRNA Vaccination

(2020) Sejin Son et al.   NANO LETTERS

Genome-wide CRISPR–Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1

(2020) Michael D. Crowther et al.   NATURE IMMUNOLOGY

Activation and expansion of human T cells using artificial antigen-presenting cell scaffolds

(2020) David K. Y. Zhang et al.   Nature Protocols

In situ genetic engineering of tumors for long-lasting and systemic immunotherapy

(2020) Stephany Y. Tzeng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An RNA vaccine drives expansion and efficacy of claudin-CAR-T cells against solid tumors

(2020) Katharina Reinhard et al.   SCIENCE

Artificial Mini Dendritic Cells Boost T Cell–Based Immunotherapy for Ovarian Cancer

(2020) Shanshan Cheng et al.   Advanced Science

Highly efficient and tumor-selective nanoparticles for dual-targeted immunogene therapy against cancer

(2020) Kuan-Wei Huang et al.   Science Advances

A biomaterial-based vaccine eliciting durable tumour-specific responses against acute myeloid leukaemia

(2020) Nisarg J. Shah et al.   Nature Biomedical Engineering

DNA‐Edited Ligand Positioning on Red Blood Cells to Enable Optimized T Cell Activation for Adoptive Immunotherapy

(2020) Zhuang Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Injectable dual-scale mesoporous silica cancer vaccine enabling efficient delivery of antigen/adjuvant-loaded nanoparticles to dendritic cells recruited in local macroporous scaffold

(2020) Thanh Loc Nguyen et al.   BIOMATERIALS

Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals

(2020) Alba Grifoni et al.   CELL

Supramolecular attack particles are autonomous killing entities released from cytotoxic T cells

(2020) Š. Bálint et al.   SCIENCE

Stealth Coating of Nanoparticles in Drug-Delivery Systems

(2020) See Yee Fam et al.   Nanomaterials

Prolonged Persistence of Chimeric Antigen Receptor (CAR) T Cell in Adoptive Cancer Immunotherapy: Challenges and Ways Forward

(2020) Leila Jafarzadeh et al.   Frontiers in Immunology

Biomaterials as Local Niches for Immunomodulation

(2020) Kwasi Adu-Berchie et al.   ACCOUNTS OF CHEMICAL RESEARCH

Controlling timing and location in vaccines

(2020) Darrell J. Irvine et al.   ADVANCED DRUG DELIVERY REVIEWS

Engineered Cell‐Membrane‐Coated Nanoparticles Directly Present Tumor Antigens to Promote Anticancer Immunity

(2020) Yao Jiang et al.   ADVANCED MATERIALS

CCL21-loaded 3D hydrogels for T cell expansion and differentiation

(2020) Eduardo Pérez del Río et al.   BIOMATERIALS

cDC1 dysregulation in cancer: An opportunity for intervention

(2020) Thomas F. Gajewski et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Adaptive Nanoparticle Platforms for High Throughput Expansion and Detection of Antigen-Specific T cells

(2020) John W. Hickey et al.   NANO LETTERS

Programmable multistage drug delivery to lymph nodes

(2020) Alex Schudel et al.   Nature Nanotechnology

Engineering Nanoparticles toward the Modulation of Emerging Cancer Immunotherapy

(2020) Shuren Wang et al.   Advanced Healthcare Materials

Rational Design of Antigen Incorporation Into Subunit Vaccine Biomaterials Can Enhance Antigen-Specific Immune Responses

(2020) Alexandra N. Tsoras et al.   Frontiers in Immunology

Leveraging the Modularity of Biomaterial Carriers to Tune Immune Responses

(2020) Shannon J. Tsai et al.   ADVANCED FUNCTIONAL MATERIALS

T-cell activation is modulated by the 3D mechanical microenvironment

(2020) Fatemeh S. Majedi et al.   BIOMATERIALS

Safety and Tolerability of Adoptive Cell Therapy in Cancer

(2019) Benita Wolf et al.   DRUG SAFETY

Turning the corner on therapeutic cancer vaccines

(2019) Robert E. Hollingsworth et al.   npj Vaccines

Use of Dendritic Cell Receptors as Targets for Enhancing Anti-Cancer Immune Responses

(2019) Md Hossain et al.   Cancers

An injectable bone marrow–like scaffold enhances T cell immunity after hematopoietic stem cell transplantation

(2019) Nisarg J. Shah et al.   NATURE BIOTECHNOLOGY

NR4A transcription factors limit CAR T cell function in solid tumours

(2019) Joyce Chen et al.   NATURE

Engineering an Artificial T‐Cell Stimulating Matrix for Immunotherapy

(2019) John W. Hickey et al.   ADVANCED MATERIALS

Photothermal therapy mediated by phase-transformation nanoparticles facilitates delivery of anti-PD1 antibody and synergizes with antitumor immunotherapy for melanoma

(2019) Ni Zhang et al.   JOURNAL OF CONTROLLED RELEASE

Rational design of anti-GITR-based combination immunotherapy

(2019) Roberta Zappasodi et al.   NATURE MEDICINE

An artificial antigen-presenting cell delivering 11 immune molecules expands tumor antigen-specific CTLs in ex vivo and in vivo murine melanoma models

(2019) Lei Zhang et al.   Cancer Immunology Research

Material design for lymph node drug delivery

(2019) Alex Schudel et al.   Nature Reviews Materials

Antigen structure affects cellular routing through DC-SIGN

(2019) Cassie M. Jarvis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TOX and TOX2 transcription factors cooperate with NR4A transcription factors to impose CD8+ T cell exhaustion

(2019) Hyungseok Seo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Determinants for Neoantigen Identification

(2019) Andrea Garcia-Garijo et al.   Frontiers in Immunology

Enhanced CAR T cell expansion and prolonged persistence in pediatric patients with ALL treated with a low-affinity CD19 CAR

(2019) Sara Ghorashian et al.   NATURE MEDICINE

Physical and chemical profiles of nanoparticles for lymphatic targeting

(2019) Xiyu Ke et al.   ADVANCED DRUG DELIVERY REVIEWS

Recognition of human gastrointestinal cancer neoantigens by circulating PD-1+ lymphocytes

(2019) Alena Gros et al.   JOURNAL OF CLINICAL INVESTIGATION

The Role of Nanovaccine in Cross-Presentation of Antigen-Presenting Cells for the Activation of CD8+ T Cell Responses

(2019) Cheol Gyun Kim et al.   Pharmaceutics

Degradation-regulated architecture of injectable smart hydrogels enhances humoral immune response and potentiates antitumor activity in human lung carcinoma

(2019) Huu Thuy Trang Duong et al.   BIOMATERIALS

T Cell Dysfunction in Cancer

(2018) Daniela S. Thommen et al.   CANCER CELL

Personalized medicine: motivation, challenges, and progress

(2018) Laura H. Goetz et al.   FERTILITY AND STERILITY

Immune checkpoint blockade therapy for cancer: An overview of FDA-approved immune checkpoint inhibitors

(2018) Kristian M. Hargadon et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Sustained release of anti-PD-1 peptide for perdurable immunotherapy together with photothermal ablation against primary and distant tumors

(2018) Lihua Luo et al.   JOURNAL OF CONTROLLED RELEASE

Combination immunotherapies implementing adoptive T-cell transfer for advanced-stage melanoma

(2018) Kendra C. Foley et al.   MELANOMA RESEARCH

Discrepancies in the evaluation of the safety of the human papillomavirus vaccine

(2018) Jorge L Cervantes et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

Separating T Cell Targeting Components onto Magnetically Clustered Nanoparticles Boosts Activation

(2018) Alyssa K. Kosmides et al.   NANO LETTERS

Enhancing T cell therapy through TCR-signaling-responsive nanoparticle drug delivery

(2018) Li Tang et al.   NATURE BIOTECHNOLOGY

Immune recognition of somatic mutations leading to complete durable regression in metastatic breast cancer

(2018) Nikolaos Zacharakis et al.   NATURE MEDICINE

Full control of ligand positioning reveals spatial thresholds for T cell receptor triggering

(2018) Haogang Cai et al.   Nature Nanotechnology

Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia

(2018) Shannon L. Maude et al.   NEW ENGLAND JOURNAL OF MEDICINE

Personalized cancer vaccine effectively mobilizes antitumor T cell immunity in ovarian cancer

(2018) Janos L. Tanyi et al.   Science Translational Medicine

Antigen-Specific Tolerization and Targeted Delivery as Therapeutic Strategies for Autoimmune Diseases

(2018) Akhilesh Kumar Shakya et al.   TRENDS IN BIOTECHNOLOGY

Antitumor Activity Associated with Prolonged Persistence of Adoptively Transferred NY-ESO-1 c259 T Cells in Synovial Sarcoma

(2018) Sandra P. D'Angelo et al.   Cancer Discovery

Mouse DC-SIGN/CD209a as Target for Antigen Delivery and Adaptive Immunity

(2018) Sjoerd T. T. Schetters et al.   Frontiers in Immunology

Efficient magnetic enrichment of antigen-specific T cells by engineering particle properties

(2018) John W. Hickey et al.   BIOMATERIALS

Isolation of a Structural Mechanism for Uncoupling T Cell Receptor Signaling from Peptide-MHC Binding

(2018) Leah V. Sibener et al.   CELL

Biomaterial-assisted targeted modulation of immune cells in cancer treatment

(2018) Hua Wang et al.   NATURE MATERIALS

Genetic mechanisms of target antigen loss in CAR19 therapy of acute lymphoblastic leukemia

(2018) Elena J. Orlando et al.   NATURE MEDICINE

Targeted delivery of immune therapeutics to lymph nodes prolongs cardiac allograft survival

(2018) Baharak Bahmani et al.   JOURNAL OF CLINICAL INVESTIGATION

Injectable Biodegradable Chitosan-Alginate 3D Porous Gel Scaffold for mRNA Vaccine Delivery

(2018) Jingxuan Yan et al.   MACROMOLECULAR BIOSCIENCE

Tisagenlecleucel in Adult Relapsed or Refractory Diffuse Large B-Cell Lymphoma

(2018) Stephen J. Schuster et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dendritic Cell Membrane Vesicles for Activation and Maintenance of Antigen-Specific T Cells

(2018) Lukasz J. Ochyl et al.   Advanced Healthcare Materials

TCR and CD28 Concomitant Stimulation Elicits a Distinctive Calcium Response in Naive T Cells

(2018) Fan Xia et al.   Frontiers in Immunology

Injectable Biomimetic Hydrogels as Tools for Efficient T Cell Expansion and Delivery

(2018) Jorieke Weiden et al.   Frontiers in Immunology

Biopolymers codelivering engineered T cells and STING agonists can eliminate heterogeneous tumors

(2017) Tyrel T. Smith et al.   JOURNAL OF CLINICAL INVESTIGATION

T-lymphocyte homing: an underappreciated yet critical hurdle for successful cancer immunotherapy

(2017) Robert Sackstein et al.   LABORATORY INVESTIGATION

Biologically Inspired Design of Nanoparticle Artificial Antigen-Presenting Cells for Immunomodulation

(2017) John W. Hickey et al.   NANO LETTERS

Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection

(2017) Justin Eyquem et al.   NATURE

Peptide–MHC-based nanomedicines for autoimmunity function as T-cell receptor microclustering devices

(2017) Santiswarup Singha et al.   Nature Nanotechnology

Mechanical Communication at the Immunological Synapse

(2017) Roshni Basu et al.   TRENDS IN CELL BIOLOGY

T cell-targeting nanoparticles focus delivery of immunotherapy to improve antitumor immunity

(2017) Daniela Schmid et al.   Nature Communications

Identification of patient-specific and tumor-shared T cell receptor sequences in renal cell carcinoma patients

(2017) Chiara Massa et al.   Oncotarget

CRISPR/Cas9-mediated PD-1 disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells

(2017) Levi J. Rupp et al.   Scientific Reports

Bioengineering of Artificial Antigen Presenting Cells and Lymphoid Organs

(2017) Chao Wang et al.   Theranostics

Effects of ovalbumin protein nanoparticle vaccine size and coating on dendritic cell processing

(2017) Timothy Z. Chang et al.   Biomaterials Science

Different TCR-induced T lymphocyte responses are potentiated by stiffness with variable sensitivity

(2017) Michael Saitakis et al.   eLife

Enhancing vaccine antibody responses by targeting Clec9A on dendritic cells

(2017) Hae-Young Park et al.   npj Vaccines

Intrinsic immunogenicity of rapidly-degradable polymers evolves during degradation

(2016) James I. Andorko et al.   Acta Biomaterialia

Chitosan thermogels for local expansion and delivery of tumor-specific T lymphocytes towards enhanced cancer immunotherapies

(2016) Anne Monette et al.   BIOMATERIALS

The effect of surface modification of mesoporous silica micro-rod scaffold on immune cell activation and infiltration

(2016) Weiwei Aileen Li et al.   BIOMATERIALS

Acquisition of a CD19-negative myeloid phenotype allows immune escape of MLL-rearranged B-ALL from CD19 CAR-T-cell therapy

(2016) R. Gardner et al.   BLOOD

Dual CD19 and CD123 targeting prevents antigen-loss relapses after CD19-directed immunotherapies

(2016) Marco Ruella et al.   JOURNAL OF CLINICAL INVESTIGATION

How many TCR clonotypes does a body maintain?

(2016) Grant Lythe et al.   JOURNAL OF THEORETICAL BIOLOGY

Prospects for gene-engineered T cell immunotherapy for solid cancers

(2016) Christopher A Klebanoff et al.   NATURE MEDICINE

Gel-Trapped Lymphorganogenic Chemokines Trigger Artificial Tertiary Lymphoid Organs and Mount Adaptive Immune Responses In Vivo

(2016) Yuka Kobayashi et al.   Frontiers in Immunology

Enrichment and Expansion with Nanoscale Artificial Antigen Presenting Cells for Adoptive Immunotherapy

(2015) Karlo Perica et al.   ACS Nano

Synthetic Nanoparticles for Vaccines and Immunotherapy

(2015) Darrell J. Irvine et al.   CHEMICAL REVIEWS

Translational Implications of Tumor Heterogeneity

(2015) M. Jamal-Hanjani et al.   CLINICAL CANCER RESEARCH

The dendritic cell cytoskeleton promotes T cell adhesion and activation by constraining ICAM-1 mobility

(2015) William A. Comrie et al.   JOURNAL OF CELL BIOLOGY

Controlled Drug Delivery: Historical perspective for the next generation

(2015) Yeon Hee Yun et al.   JOURNAL OF CONTROLLED RELEASE

Adoptive cell transfer as personalized immunotherapy for human cancer

(2015) S. A. Rosenberg et al.   SCIENCE

Biodegradable Nanoellipsoidal Artificial Antigen Presenting Cells for Antigen Specific T-Cell Activation

(2015) Randall A. Meyer et al.   Small

Injectable cryogel-based whole-cell cancer vaccines

(2015) Sidi A. Bencherif et al.   Nature Communications

Macropinocytosis in phagocytes: regulation of MHC class-II-restricted antigen presentation in dendritic cells

(2015) Zhenzhen Liu et al.   Frontiers in Physiology

Tumor cell lysates as immunogenic sources for cancer vaccine design

(2015) Fermín E González et al.   Human Vaccines & Immunotherapeutics

Magnetic Field-Induced T Cell Receptor Clustering by Nanoparticles Enhances T Cell Activation and Stimulates Antitumor Activity

(2014) Karlo Perica et al.   ACS Nano

Current concepts in the diagnosis and management of cytokine release syndrome

(2014) D. W. Lee et al.   BLOOD

4-1BB (CD137), an inducible costimulatory receptor, as a specific target for cancer therapy

(2014) Dass S. Vinay et al.   BMB Reports

Accumulation of Dynamic Catch Bonds between TCR and Agonist Peptide-MHC Triggers T Cell Signaling

(2014) Baoyu Liu et al.   CELL

Targeting DNGR-1 (CLEC9A) with antibody/MUC1 peptide conjugates as a vaccine for carcinomas

(2014) Gianfranco Picco et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Artificial antigen-presenting cells expressing CD80, CD70, and 4-1BB ligand efficiently expand functional T cells specific to tumor-associated antigens

(2014) Wanyong Zeng et al.   IMMUNOBIOLOGY

PD-1 identifies the patient-specific CD8+ tumor-reactive repertoire infiltrating human tumors

(2014) Alena Gros et al.   JOURNAL OF CLINICAL INVESTIGATION

Differential Impact of CD27 and 4-1BB Costimulation on Effector and Memory CD8 T Cell Generation following Peptide Immunization

(2014) J. E. Willoughby et al.   JOURNAL OF IMMUNOLOGY

Cancer Cell Membrane-Coated Nanoparticles for Anticancer Vaccination and Drug Delivery

(2014) Ronnie H. Fang et al.   NANO LETTERS

Structure-based programming of lymph-node targeting in molecular vaccines

(2014) Haipeng Liu et al.   NATURE

Biopolymer implants enhance the efficacy of adoptive T-cell therapy

(2014) Sirkka B Stephan et al.   NATURE BIOTECHNOLOGY

Injectable, spontaneously assembling, inorganic scaffolds modulate immune cells in vivo and increase vaccine efficacy

(2014) Jaeyun Kim et al.   NATURE BIOTECHNOLOGY

A carbon nanotube–polymer composite for T-cell therapy

(2014) Tarek R. Fadel et al.   Nature Nanotechnology

Antigen-specific activation and cytokine-facilitated expansion of naive, human CD8+ T cells

(2014) Matthias Wölfl et al.   Nature Protocols

Tetramer guided, cell sorter assisted production of clinical grade autologous NY-ESO-1 specific CD8+ T cells

(2014) Seth M Pollack et al.   Journal for ImmunoTherapy of Cancer

The Dendritic Cell Lineage: Ontogeny and Function of Dendritic Cells and Their Subsets in the Steady State and the Inflamed Setting

(2013) Miriam Merad et al.   Annual Review of Immunology

Particle shape dependence of CD8+ T cell activation by artificial antigen presenting cells

(2013) Joel C. Sunshine et al.   BIOMATERIALS

Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma

(2013) G. P. Linette et al.   BLOOD

CD137 Accurately Identifies and Enriches for Naturally Occurring Tumor-Reactive T Cells in Tumor

(2013) Q. Ye et al.   CLINICAL CANCER RESEARCH

Latex bead-based artificial antigen-presenting cells induce tumor-specific CTL responses in the native T-cell repertoires and inhibit tumor growth

(2013) Chuanlai Shen et al.   IMMUNOLOGY LETTERS

Cancer Regression and Neurological Toxicity Following Anti-MAGE-A3 TCR Gene Therapy

(2013) Richard A. Morgan et al.   JOURNAL OF IMMUNOTHERAPY

Cross Talk between CD3 and CD28 Is Spatially Modulated by Protein Lateral Mobility

(2013) K. T. Bashour et al.   MOLECULAR AND CELLULAR BIOLOGY

Treatment of Metastatic Renal Cell Carcinoma With CAIX CAR-engineered T cells: Clinical Evaluation and Management of On-target Toxicity

(2013) Cor HJ Lamers et al.   MOLECULAR THERAPY

Nanoscale Ligand Spacing Influences Receptor Triggering in T Cells and NK Cells

(2013) Derfogail Delcassian et al.   NANO LETTERS

Fine Tuning and Efficient T Cell Activation with Stimulatory aCD3 Nanoarrays

(2013) Jovana Matic et al.   NANO LETTERS

Nanoscale artificial antigen presenting cells for T cell immunotherapy

(2013) Karlo Perica et al.   Nanomedicine-Nanotechnology Biology and Medicine

Mechanosensing in T Lymphocyte Activation

(2012) Edward Judokusumo et al.   BIOPHYSICAL JOURNAL

Adoptive Transfer of Cytotoxic T Lymphocytes Targeting Two Different Antigens Limits Antigen Loss and Tumor Escape

(2012) Karen M. Kaluza et al.   HUMAN GENE THERAPY

The dendritic cell receptor DNGR-1 controls endocytic handling of necrotic cell antigens to favor cross-priming of CTLs in virus-infected mice

(2012) Santiago Zelenay et al.   JOURNAL OF CLINICAL INVESTIGATION

The DC receptor DNGR-1 mediates cross-priming of CTLs during vaccinia virus infection in mice

(2012) Salvador Iborra et al.   JOURNAL OF CLINICAL INVESTIGATION

Substrate Rigidity Regulates Human T Cell Activation and Proliferation

(2012) R. S. O'Connor et al.   JOURNAL OF IMMUNOLOGY

Sorting Through Subsets

(2012) Christopher A. Klebanoff et al.   JOURNAL OF IMMUNOTHERAPY

RAFTsomes Containing Epitope-MHC-II Complexes Mediated CD4+ T Cell Activation and Antigen-Specific Immune Responses

(2012) Qian Ding et al.   PHARMACEUTICAL RESEARCH

Transferred melanoma-specific CD8+ T cells persist, mediate tumor regression, and acquire central memory phenotype

(2012) A. G. Chapuis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impact of Clinical and Pathologic Features on Tumor-Infiltrating Lymphocyte Expansion from Surgically Excised Melanoma Metastases for Adoptive T-cell Therapy

(2011) R. W. Joseph et al.   CLINICAL CANCER RESEARCH

Durable Complete Responses in Heavily Pretreated Patients with Metastatic Melanoma Using T-Cell Transfer Immunotherapy

(2011) S. A. Rosenberg et al.   CLINICAL CANCER RESEARCH

T-cell-inducing vaccines - what’s the future

(2011) Sarah C. Gilbert   IMMUNOLOGY

An Artificial Antigen-presenting Cell with Paracrine Delivery of IL-2 Impacts the Magnitude and Direction of the T Cell Response

(2011) Erin R. Steenblock et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exhaustion of tumor-specific CD8+ T cells in metastases from melanoma patients

(2011) Lukas Baitsch et al.   JOURNAL OF CLINICAL INVESTIGATION

The vesicle size of DDA:TDB liposomal adjuvants plays a role in the cell-mediated immune response but has no significant effect on antibody production

(2011) Malou Henriksen-Lacey et al.   JOURNAL OF CONTROLLED RELEASE

Costimulation Through the CD137/4-1BB Pathway Protects Human Melanoma Tumor-infiltrating Lymphocytes From Activation-induced Cell Death and Enhances Antitumor Effector Function

(2011) Jessica Ann Hernandez-Chacon et al.   JOURNAL OF IMMUNOTHERAPY

A Neonatal Fc Receptor-Targeted Mucosal Vaccine Strategy Effectively Induces HIV-1 Antigen-Specific Immunity to Genital Infection

(2011) L. Lu et al.   JOURNAL OF VIROLOGY

T cell exhaustion

(2011) E John Wherry   NATURE IMMUNOLOGY

Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T cells genetically engineered to recognize CD19

(2010) J. N. Kochenderfer et al.   BLOOD

Overview of a HLA-Ig based “Lego-like system” for T cell monitoring, modulation and expansion

(2010) Mathias Oelke et al.   IMMUNOLOGIC RESEARCH

Killer artificial antigen-presenting cells: the synthetic embodiment of a ‘guided missile’

(2010) Christian Schütz et al.   Immunotherapy

Structural characterization of the TCR complex by electron microscopy

(2010) Ignacio Arechaga et al.   INTERNATIONAL IMMUNOLOGY

Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen–specific CD8+T cell dysfunction in melanoma patients

(2010) Julien Fourcade et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Route of Antigen Uptake Differentially Impacts Presentation by Dendritic Cells and Activated Monocytes

(2010) A. O. Kamphorst et al.   JOURNAL OF IMMUNOLOGY

Case Report of a Serious Adverse Event Following the Administration of T Cells Transduced With a Chimeric Antigen Receptor Recognizing ERBB2

(2010) Richard A Morgan et al.   MOLECULAR THERAPY

T Cells Targeting Carcinoembryonic Antigen Can Mediate Regression of Metastatic Colorectal Cancer but Induce Severe Transient Colitis

(2010) Maria R Parkhurst et al.   MOLECULAR THERAPY

Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen

(2009) L. A. Johnson et al.   BLOOD

Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired

(2009) M. Ahmadzadeh et al.   BLOOD

In vivo Administration of Artificial Antigen-Presenting Cells Activates Low-Avidity T Cells for Treatment of Cancer

(2009) S. Ugel et al.   CANCER RESEARCH

The αβ T Cell Receptor Is an Anisotropic Mechanosensor

(2009) Sun Taek Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Self-antigen–specific CD8+T cell precursor frequency determines the quality of the antitumor immune response

(2009) Gabrielle A. Rizzuto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Chimeric Receptors Containing CD137 Signal Transduction Domains Mediate Enhanced Survival of T Cells and Increased Antileukemic Efficacy In Vivo

(2009) Michael C. Milone et al.   MOLECULAR THERAPY

TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation

(2009) Björn F Lillemeier et al.   NATURE IMMUNOLOGY

Infection-mimicking materials to program dendritic cells in situ

(2009) Omar A. Ali et al.   NATURE MATERIALS

Synthetic CD4+ T Cell-Targeted Antigen-Presenting Cells Elicit Protective Antitumor Responses

(2008) S. Caserta et al.   CANCER RESEARCH

The effect of artificial antigen-presenting cells with preclustered anti-CD28/-CD3/-LFA-1 monoclonal antibodies on the induction of ex vivo expansion of functional human antitumor T cells

(2008) R. Zappasodi et al.   HAEMATOLOGICA

A Comprehensive Platform for Ex Vivo T-cell Expansion Based on Biodegradable Polymeric Artificial Antigen-presenting Cells

(2008) Erin R Steenblock et al.   MOLECULAR THERAPY

Enhanced Cellular Activation with Single Walled Carbon Nanotube Bundles Presenting Antibody Stimuli

(2008) Tarek R. Fadel et al.   NANO LETTERS

Treatment of Metastatic Melanoma with Autologous CD4+ T Cells against NY-ESO-1

(2008) Naomi N. Hunder et al.   NEW ENGLAND JOURNAL OF MEDICINE

Micropatterning of costimulatory ligands enhances CD4+ T cell function

(2008) K. Shen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA