AR12 (OSU-03012) suppresses GRP78 expression and inhibits SARS-CoV-2 replication

Neratinib degrades MST4 via autophagy that reduces membrane stiffness and is essential for the inactivation of PI3K, ERK1/2, and YAP/TAZ signaling

(2020) Paul Dent et al.   JOURNAL OF CELLULAR PHYSIOLOGY

A Randomized Phase II Preoperative Study of Autophagy Inhibition with High-Dose Hydroxychloroquine and Gemcitabine/Nab-Paclitaxel in Pancreatic Cancer Patients

(2020) Herbert J. Zeh et al.   CLINICAL CANCER RESEARCH

Azithromycin Downregulates Gene Expression of IL-1β and Pathways Involving TMPRSS2 and TMPRSS11D Required by SARS-CoV-2

(2020) Axel E. Renteria et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The Crohn’s disease polymorphism, ATG16L1 T300A, alters the gut microbiota and enhances the local Th1/Th17 response

(2019) Sydney Lavoie et al.   eLife

Neratinib inhibits Hippo/YAP signaling, reduces mutant K-RAS expression, and kills pancreatic and blood cancer cells

(2019) Paul Dent et al.   ONCOGENE

The Unique Cofactor Region of Zika Virus NS2B–NS3 Protease Facilitates Cleavage of Key Host Proteins

(2018) Maureen E. Hill et al.   ACS Chemical Biology

The celecoxib derivative kinase inhibitor AR-12 (OSU-03012) inhibits Zika virus via down-regulation of the PI3K/Akt pathway and protects Zika virus-infected A129 mice: A host-targeting treatment strategy

(2018) Jasper Fuk-Woo Chan et al.   ANTIVIRAL RESEARCH

AR-12 Inhibits Multiple Chaperones Concomitant With Stimulating Autophagosome Formation Collectively Preventing Virus Replication

(2016) Laurence Booth et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Multi-kinase inhibitors can associate with heat shock proteins through their NH2-termini by which they suppress chaperone function

(2016) Laurence Booth et al.   Oncotarget

The Thr300Ala variant in ATG16L1 is associated with improved survival in human colorectal cancer and enhanced production of type I interferon

(2015) Wesley A Grimm et al.   GUT

GRP78/BiP/HSPA5/Dna K is a universal therapeutic target for human disease

(2015) Laurence Booth et al.   JOURNAL OF CELLULAR PHYSIOLOGY

OSU-03012 and Viagra Treatment Inhibits the Activity of Multiple Chaperone Proteins and Disrupts the Blood-Brain Barrier: Implications for Anti-Cancer Therapies

(2015) Laurence Booth et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Role of the unfolded protein response, GRP78 and GRP94 in organ homeostasis

(2015) Genyuan Zhu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

GRP78/Dna K Is a Target for Nexavar/Stivarga/Votrient in the Treatment of Human Malignancies, Viral Infections and Bacterial Diseases

(2015) Jane L. Roberts et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Blockade of autophagy reduces pancreatic cancer stem cell activity and potentiates the tumoricidal effect of gemcitabine

(2015) Ming-Chen Yang et al.   Molecular Cancer

Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins

(2015) Jennifer Martinez et al.   NATURE CELL BIOLOGY

TheATG16L1–T300Aallele impairs clearance of pathosymbionts in the inflamed ileal mucosa of Crohn's disease patients

(2014) Mehdi Sadaghian Sadabad et al.   GUT

Regulation of OSU-03012 Toxicity by ER Stress Proteins and ER Stress-Inducing Drugs

(2014) L. Booth et al.   MOLECULAR CANCER THERAPEUTICS

Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense

(2014) K. G. Lassen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

OSU-03012 suppresses GRP78/BiP expression that causes PERK-dependent increases in tumor cell killing

(2012) Laurence Booth et al.   CANCER BIOLOGY & THERAPY

Nondegradative Role of Atg5-Atg12/ Atg16L1 Autophagy Protein Complex in Antiviral Activity of Interferon Gamma

(2012) Seungmin Hwang et al.   Cell Host & Microbe

Contribution of higher risk genes and European admixture to Crohnʼs disease in African Americans

(2012) Ming-Hsi Wang et al.   INFLAMMATORY BOWEL DISEASES

A Transmembrane Serine Protease Is Linked to the Severe Acute Respiratory Syndrome Coronavirus Receptor and Activates Virus Entry

(2010) A. Shulla et al.   JOURNAL OF VIROLOGY