Neratinib degrades MST4 via autophagy that reduces membrane stiffness and is essential for the inactivation of PI3K, ERK1/2, and YAP/TAZ signaling

Neratinib inhibits Hippo/YAP signaling, reduces mutant K-RAS expression, and kills pancreatic and blood cancer cells

(2019) Paul Dent et al.   ONCOGENE

Not the comfy chair! Cancer drugs that act against multiple active sites

(2019) Laurence Booth et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

The role of cell signaling in the crosstalk between autophagy and apoptosis in the regulation of tumor cell survival in response to sorafenib and neratinib

(2019) Laurence A. Booth et al.   SEMINARS IN CANCER BIOLOGY

Neratinib protects pancreatic beta cells in diabetes

(2019) Amin Ardestani et al.   Nature Communications

Targeted genomic CRISPR-Cas9 screen identifies MAP4K4 as essential for glioblastoma invasion

(2019) Laura M. Prolo et al.   Scientific Reports

Signaling alterations caused by drugs and autophagy

(2019) Paul Dent et al.   CELLULAR SIGNALLING

The NDR/LATS protein kinases in immunology and cancer biology

(2018) Ahmad A.D. Sharif et al.   SEMINARS IN CANCER BIOLOGY

MAP4K4 controlled integrin β1 activation and c-Met endocytosis are associated with invasive behavior of medulloblastoma cells

(2018) Dimitra Tripolitsioti et al.   Oncotarget

Inhibitor-induced HER2-HER3 heterodimerisation promotes proliferation through a novel dimer interface

(2018) Jeroen Claus et al.   eLife

Activation mechanisms of the Hippo kinase signaling cascade

(2018) Sung Jun Bae et al.   BIOSCIENCE REPORTS

The MST4–MOB4 complex disrupts the MST1–MOB1 complex in the Hippo–YAP pathway and plays a pro-oncogenic role in pancreatic cancer

(2018) Min Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neratinib augments the lethality of [regorafenib + sildenafil]

(2018) Laurence Booth et al.   JOURNAL OF CELLULAR PHYSIOLOGY

RAP2 mediates mechanoresponses of the Hippo pathway

(2018) Zhipeng Meng et al.   NATURE

Neratinib and entinostat combine to rapidly reduce the expression of K-RAS, N-RAS, Gαq and Gα11 and kill uveal melanoma cells

(2018) Laurence Booth et al.   CANCER BIOLOGY & THERAPY

Post-translational modifications of Beclin 1 provide multiple strategies for autophagy regulation

(2018) Sandra M. Hill et al.   CELL DEATH AND DIFFERENTIATION

LAP it up, fuzz ball: a short history of LC3-associated phagocytosis

(2018) Jennifer Martinez   CURRENT OPINION IN IMMUNOLOGY

Hippo pathway inhibition by blocking the YAP/TAZ–TEAD interface: a patent review

(2018) James J. Crawford et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Rubicon: LC3-associated phagocytosis and beyond

(2017) Sing-Wai Wong et al.   FEBS Journal

Hippo Signaling in the Liver Regulates Organ Size, Cell Fate, and Carcinogenesis

(2017) Sachin H. Patel et al.   GASTROENTEROLOGY

The target landscape of clinical kinase drugs

(2017) Susan Klaeger et al.   SCIENCE

HDAC inhibitors enhance neratinib activity and when combined enhance the actions of an anti-PD-1 immunomodulatory antibody in vivo

(2017) Laurence Booth et al.   Oncotarget

Rassf Proteins as Modulators of Mst1 Kinase Activity

(2017) Aruna Bitra et al.   Scientific Reports

MAP4K4 deficiency in CD4 + T cells aggravates lung damage induced by ozone-oxidized black carbon particles

(2016) Ming Jin et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

MAP4K4 promotes epithelial-mesenchymal transition and metastasis in hepatocellular carcinoma

(2016) Xiao-Jun Feng et al.   TUMOR BIOLOGY

The Roles of NDR Protein Kinases in Hippo Signalling

(2016) Alexander Hergovich   Genes

MST kinases in development and disease

(2015) Barry J. Thompson et al.   JOURNAL OF CELL BIOLOGY

Identification of Ezrin-Radixin-Moesin proteins as novel regulators of pathogenic B-cell receptor signaling and tumor growth in diffuse large B-cell lymphoma

(2015) D Pore et al.   LEUKEMIA

MAP4K4 regulates integrin-FERM binding to control endothelial cell motility

(2015) Philip Vitorino et al.   NATURE

Regulation of mammalian Ste20 (Mst) kinases

(2015) Sonali J. Rawat et al.   TRENDS IN BIOCHEMICAL SCIENCES

MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway

(2015) Zhipeng Meng et al.   Nature Communications

MAP4K4 deletion inhibits proliferation and activation of CD4+ T cell and promotes T regulatory cell generation in vitro

(2014) Hongpeng Huang et al.   CELLULAR IMMUNOLOGY

Hippo signaling pathway in liver and pancreas: the potential drug target for tumor therapy

(2014) Delin Kong et al.   JOURNAL OF DRUG TARGETING

Activated ERM Protein Plays a Critical Role in Drug Resistance of MOLT4 Cells Induced by CCL25

(2013) Li Zhang et al.   PLoS One

Filopodia and Membrane Blebs Drive Efficient Matrix Invasion of Macrophages Transformed by the Intracellular Parasite Theileria annulata

(2013) Min Ma et al.   PLoS One

Regulation and functions of mammalian LATS/NDR kinases: looking beyond canonical Hippo signalling

(2013) Alexander Hergovich   Cell and Bioscience

Identification of Map4k4 as a Novel Suppressor of Skeletal Muscle Differentiation

(2012) M. Wang et al.   MOLECULAR AND CELLULAR BIOLOGY

WAVE1 regulates P-glycoprotein expression via Ezrin in leukemia cells

(2011) Ming-Hua Yang et al.   LEUKEMIA & LYMPHOMA

Comprehensive analysis of kinase inhibitor selectivity

(2011) Mindy I Davis et al.   NATURE BIOTECHNOLOGY

Merlin, a “Magic” Linker Between the Extracellular Cues and Intracellular Signaling Pathways that Regulate Cell Motility, Proliferation, and Survival

(2010) Ivan Stamenkovic et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Ezrin is a key molecule in the metastasis of MOLT4 cells induced by CCL25/CCR9

(2009) Beibei Zhou et al.   LEUKEMIA RESEARCH

NF2/Merlin Is a Novel Negative Regulator of mTOR Complex 1, and Activation of mTORC1 Is Associated with Meningioma and Schwannoma Growth

(2009) M. F. James et al.   MOLECULAR AND CELLULAR BIOLOGY

Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation

(2009) Myriam Aouadi et al.   NATURE

Profiles of Foxp3+ regulatory T cells in eczematous dermatitis, psoriasis vulgaris and mycosis fungoides

(2008) T. Fujimura et al.   BRITISH JOURNAL OF DERMATOLOGY