Ageing promotes early T follicular helper cell differentiation by modulating expression of RBPJ

Attenuation of TCR-induced transcription by Bach2 controls regulatory T cell differentiation and homeostasis

(2020) Tom Sidwell et al.   Nature Communications

Stromal cell control of conventional and ectopic germinal centre reactions

(2020) Alyssa Silva-Cayetano et al.   CURRENT OPINION IN IMMUNOLOGY

Age‐related factors that affect B cell responses to vaccination in mice and humans

(2020) Daniela Frasca et al.   IMMUNOLOGICAL REVIEWS

Follicular helper T cell profiles predict response to costimulation blockade in type 1 diabetes

(2020) Natalie M. Edner et al.   NATURE IMMUNOLOGY

IL-10–producing Tfh cells accumulate with age and link inflammation with age-related immune suppression

(2020) Maha Almanan et al.   Science Advances

T follicular helper cell heterogeneity: Time, space, and function

(2019) Wenzhi Song et al.   IMMUNOLOGICAL REVIEWS

T Follicular Helper Cell Biology: A Decade of Discovery and Diseases

(2019) Shane Crotty   IMMUNITY

Transcription factor networks in aged naïve CD4 T cells bias lineage differentiation

(2019) Bin Hu et al.   AGING CELL

The adjuvant GLA-SE promotes human Tfh cell expansion and emergence of public TCRβ clonotypes

(2019) Danika L. Hill et al.   JOURNAL OF EXPERIMENTAL MEDICINE

T follicular helper cells and T follicular regulatory cells in rheumatic diseases

(2019) Jun Deng et al.   Nature Reviews Rheumatology

Immunosenescence: A systems-level overview of immune cell biology and strategies for improving vaccine responses

(2019) Stephen N. Crooke et al.   EXPERIMENTAL GERONTOLOGY

The impact of aging on CD4+ T cell responses to influenza infection

(2018) Erica C. Lorenzo et al.   BIOGERONTOLOGY

Signal transduction changes in CD4 + and CD8 + T cell subpopulations with aging

(2018) Aurélie Le Page et al.   EXPERIMENTAL GERONTOLOGY

Notch signaling represents an important checkpoint between follicular T-helper and canonical T-helper 2 cell fate

(2018) Mark Dell’Aringa et al.   Mucosal Immunology

Immunosenescence and Inflamm-Aging As Two Sides of the Same Coin: Friends or Foes?

(2018) Tamas Fulop et al.   Frontiers in Immunology

Regulation of miR-181a expression in T cell aging

(2018) Zhongde Ye et al.   Nature Communications

Determination of T Follicular Helper Cell Fate by Dendritic Cells

(2018) Jayendra Kumar Krishnaswamy et al.   Frontiers in Immunology

Insights Into the Molecular Mechanisms of T Follicular Helper-Mediated Immunity and Pathology

(2018) Lei Qin et al.   Frontiers in Immunology

Activation of miR-21-Regulated Pathways in Immune Aging Selects against Signatures Characteristic of Memory T Cells

(2018) Chulwoo Kim et al.   Cell Reports

The IRF4 Gene Regulatory Module Functions as a Read-Write Integrator to Dynamically Coordinate T Helper Cell Fate

(2017) Veena Krishnamoorthy et al.   IMMUNITY

Structural and functional changes to lymph nodes in ageing mice

(2017) Vivian M. Turner et al.   IMMUNOLOGY

Ageing adversely affects the migration and function of marginal zone B cells

(2017) Vivian M. Turner et al.   IMMUNOLOGY

Signals that drive T follicular helper cell formation

(2017) Louise M. C. Webb et al.   IMMUNOLOGY

Follicular Helper T Cells

(2016) Carola G. Vinuesa et al.   Annual Review of Immunology

T follicular helper (Tfh) cells in lupus: Activation and involvement in SLE pathogenesis

(2016) Patrick Blanco et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

T follicular helper cell programming by cytokine-mediated events

(2016) Kaitlin A. Read et al.   IMMUNOLOGY

Cutting Edge: NFAT Transcription Factors Promote the Generation of Follicular Helper T Cells in Response to Acute Viral Infection

(2016) Gustavo J. Martinez et al.   JOURNAL OF IMMUNOLOGY

Activin A programs the differentiation of human TFH cells

(2016) Michela Locci et al.   NATURE IMMUNOLOGY

Notch signalling in context

(2016) Sarah J. Bray   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Age-related impairment of humoral response to influenza is associated with changes in antigen specific T follicular helper cell responses

(2016) Julie S Lefebvre et al.   Scientific Reports

The aged lymphoid tissue environment fails to support naïve T cell homeostasis

(2016) Bryan R. Becklund et al.   Scientific Reports

Defective TFH Cell Function and Increased TFR Cells Contribute to Defective Antibody Production in Aging

(2015) Peter T. Sage et al.   Cell Reports

Mapping the Diversity of Follicular Helper T Cells in Human Blood and Tonsils Using High-Dimensional Mass Cytometry Analysis

(2015) Michael T. Wong et al.   Cell Reports

Circulating CXCR5+PD-1+Response Predicts Influenza Vaccine Antibody Responses in Young Adults but not Elderly Adults

(2014) Ramin Sedaghat Herati et al.   JOURNAL OF IMMUNOLOGY

FELASA recommendations for the health monitoring of mouse, rat, hamster, guinea pig and rabbit colonies in breeding and experimental units

(2014) et al.   LABORATORY ANIMALS

The cytokine TGF-β co-opts signaling via STAT3-STAT4 to promote the differentiation of human TFH cells

(2014) Nathalie Schmitt et al.   NATURE IMMUNOLOGY

The effect of aging on the frequency, phenotype and cytokine production of human blood CD4 + CXCR5 + T follicular helper cells: comparison of aged and young subjects

(2014) Maohua Zhou et al.   Immunity & Ageing

Single Naive CD4+ T Cells from a Diverse Repertoire Produce Different Effector Cell Types during Infection

(2013) Noah J. Tubo et al.   CELL

Persistent Antigen and Germinal Center B Cells Sustain T Follicular Helper Cell Responses and Phenotype

(2013) Dirk Baumjohann et al.   IMMUNITY

How T follicular helper cells and the germinal centre response change with age

(2013) Michelle A Linterman   IMMUNOLOGY AND CELL BIOLOGY

Notch Signaling Regulates Follicular Helper T Cell Differentiation

(2013) F. Auderset et al.   JOURNAL OF IMMUNOLOGY

The transcription factor IRF4 is essential for TCR affinity–mediated metabolic programming and clonal expansion of T cells

(2013) Kevin Man et al.   NATURE IMMUNOLOGY

T Follicular Helper Cell Dynamics in Germinal Centers

(2013) Z. Shulman et al.   SCIENCE

Mutually exclusive regulation of T cell survival by IL-7R and antigen receptor-induced signals

(2013) Paul Koenen et al.   Nature Communications

The aged microenvironment contributes to the age-related functional defects of CD4 T cells in mice

(2012) Julie S. Lefebvre et al.   AGING CELL

The origins, function, and regulation of T follicular helper cells

(2012) Cindy S. Ma et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity

(2012) Guangjin Li et al.   NATURE MEDICINE

ICOS Receptor Instructs T Follicular Helper Cell versus Effector Cell Differentiation via Induction of the Transcriptional Repressor Bcl6

(2011) Youn Soo Choi et al.   IMMUNITY

Germinal Center B Cell and T Follicular Helper Cell Development Initiates in the Interfollicular Zone

(2011) Steven M. Kerfoot et al.   IMMUNITY

Bcl6 Protein Expression Shapes Pre-Germinal Center B Cell Dynamics and Follicular Helper T Cell Heterogeneity

(2011) Masahiro Kitano et al.   IMMUNITY

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

CD4+ T Cells and Immunosenescence – A Mini-Review

(2009) Alexander C. Maue et al.   GERONTOLOGY

Human Dendritic Cells Induce the Differentiation of Interleukin-21-Producing T Follicular Helper-like Cells through Interleukin-12

(2009) Nathalie Schmitt et al.   IMMUNITY

Early commitment of naïve human CD4+ T cells to the T follicular helper (TFH ) cell lineage is induced by IL-12

(2009) Cindy S Ma et al.   IMMUNOLOGY AND CELL BIOLOGY

The function of follicular helper T cells is regulated by the strength of T cell antigen receptor binding

(2009) Nicolas Fazilleau et al.   NATURE IMMUNOLOGY

CD28− T cells: their role in the age-associated decline of immune function

(2009) Nan-ping Weng et al.   TRENDS IN IMMUNOLOGY

Slug is a direct Notch target required for initiation of cardiac cushion cellularization

(2008) Kyle Niessen et al.   JOURNAL OF CELL BIOLOGY