IL-10–producing Tfh cells accumulate with age and link inflammation with age-related immune suppression

Regulatory roles of IL-10–producing human follicular T cells

(2019) Pablo F. Cañete et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cre-loxP Reporter Mouse Reveals Stochastic Activity of the Foxp3 Promoter

(2019) Peter D. Bittner-Eddy et al.   Frontiers in Immunology

TSLP signaling in CD4+T cells programs a pathogenic T helper 2 cell state

(2018) Yrina Rochman et al.   Science Signaling

TSLP signaling in CD4+T cells programs a pathogenic T helper 2 cell state

(2018) Yrina Rochman et al.   Science Signaling

Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty

(2018) Luigi Ferrucci et al.   Nature Reviews Cardiology

The integration of inflammaging in age-related diseases

(2018) Tamas Fulop et al.   SEMINARS IN IMMUNOLOGY

Single-cell RNA sequencing unveils an IL-10-producing helper subset that sustains humoral immunity during persistent infection

(2018) Gang Xin et al.   Nature Communications

Tissue-specific control of latent CMV reactivation by regulatory T cells

(2017) Maha Almanan et al.   PLoS Pathogens

Telomere Shortening, Inflammatory Cytokines, and Anti-Cytomegalovirus Antibody Follow Distinct Age-Associated Trajectories in Humans

(2017) Ana Lustig et al.   Frontiers in Immunology

Age-related changes in gut microbiota composition from newborn to centenarian: a cross-sectional study

(2016) Toshitaka Odamaki et al.   BMC MICROBIOLOGY

Aging-dependent decline of IL-10 producing B cells coincides with production of antinuclear antibodies but not rheumatoid factors

(2016) Kornelis S.M. van der Geest et al.   EXPERIMENTAL GERONTOLOGY

Inflammatory Markers and the Risk of Hip and Vertebral Fractures in Men: the Osteoporotic Fractures in Men (MrOS)

(2016) Jane A Cauley et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Vaccine efficacy and T helper cell differentiation change with aging

(2016) Julie S. Lefebvre et al.   Oncotarget

T-Cell Immunity to Influenza in Older Adults: A Pathophysiological Framework for Development of More Effective Vaccines

(2016) Janet E. McElhaney et al.   Frontiers in Immunology

Age-related impairment of humoral response to influenza is associated with changes in antigen specific T follicular helper cell responses

(2016) Julie S Lefebvre et al.   Scientific Reports

Loss of Phagocytic and Antigen Cross-Presenting Capacity in Aging Dendritic Cells Is Associated with Mitochondrial Dysfunction

(2015) Claire A. Chougnet et al.   JOURNAL OF IMMUNOLOGY

Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation

(2015) Nicola Gagliani et al.   NATURE

IL-6-mediated environmental conditioning of defective Th1 differentiation dampens antitumour immune responses in old age

(2015) Hirotake Tsukamoto et al.   Nature Communications

Defective TFH Cell Function and Increased TFR Cells Contribute to Defective Antibody Production in Aging

(2015) Peter T. Sage et al.   Cell Reports

IL-10: The Master Regulator of Immunity to Infection

(2014) Kevin N. Couper et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: STAT1 Is Required for IL-6-Mediated Bcl6 Induction for Early Follicular Helper Cell Differentiation

(2013) Y. S. Choi et al.   JOURNAL OF IMMUNOLOGY

Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells

(2013) Nicola Gagliani et al.   NATURE MEDICINE

The effect of aging of the immune system on vaccination responses

(2013) Janet M. Lord   Human Vaccines & Immunotherapeutics

Age-associated alterations in CD8α+ dendritic cells impair CD8 T-cell expansion in response to an intracellular bacterium

(2012) Gang Li et al.   AGING CELL

Homeostasis and function of regulatory T cells in aging

(2012) Jana Raynor et al.   CURRENT OPINION IN IMMUNOLOGY

Interleukin-6 induces the generation of IL-10-producing Tr1 cells and suppresses autoimmune tissue inflammation

(2012) Jun-O Jin et al.   JOURNAL OF AUTOIMMUNITY

Signaling pathways in aged T cells – A reflection of T cell differentiation, cell senescence and host environment

(2012) Jörg J. Goronzy et al.   SEMINARS IN IMMUNOLOGY

Superior immunogenicity of seasonal influenza vaccines containing full dose of MF59®adjuvant

(2012) Giovanni Della Cioppa et al.   Human Vaccines & Immunotherapeutics

Follicular Helper CD4 T Cells (TFH)

(2011) Shane Crotty   Annual Review of Immunology

Impaired in vivo CD4+ T cell expansion and differentiation in aged mice is not solely due to T cell defects: Decreased stimulation by aged dendritic cells

(2011) Luciana F. Pereira et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Fate mapping of IL-17-producing T cells in inflammatory responses

(2011) Keiji Hirota et al.   NATURE IMMUNOLOGY

IL-21 and IL-6 Are Critical for Different Aspects of B Cell Immunity and Redundantly Induce Optimal Follicular Helper CD4 T Cell (Tfh) Differentiation

(2011) Danelle Eto et al.   PLoS One

IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses

(2010) Michelle A. Linterman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Major Role for Bim in Regulatory T Cell Homeostasis

(2010) C. A. Chougnet et al.   JOURNAL OF IMMUNOLOGY

Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota

(2010) J. L. Round et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proinflammatory Adjuvants Enhance the Cognate Helper Activity of Aged CD4 T Cells

(2009) Alexander C. Maue et al.   JOURNAL OF IMMUNOLOGY

Nonredundant Roles for B Cell-Derived IL-10 in Immune Counter-Regulation

(2009) R. Madan et al.   JOURNAL OF IMMUNOLOGY

Bcl6 and Blimp-1 Are Reciprocal and Antagonistic Regulators of T Follicular Helper Cell Differentiation

(2009) R. J. Johnston et al.   SCIENCE

A Fundamental Role for Interleukin-21 in the Generation of T Follicular Helper Cells

(2008) Alexis Vogelzang et al.   IMMUNITY

Generation of T Follicular Helper Cells Is Mediated by Interleukin-21 but Independent of T Helper 1, 2, or 17 Cell Lineages

(2008) Roza I. Nurieva et al.   IMMUNITY