标题
The Role of Ras-Associated Protein 1 (Rap1) in Cancer: Bad Actor or Good Player?
作者
关键词
-
出版物
Biomedicines
Volume 8, Issue 9, Pages 334
出版商
MDPI AG
发表日期
2020-09-07
DOI
10.3390/biomedicines8090334
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Transglutaminase-2 facilitates extracellular vesicle-mediated establishment of the metastatic niche
- (2020) Aparna Shinde et al. Oncogenesis
- Rap1-GTPases control mTORC1 activity by coordinating lysosome organization with amino acid availability
- (2020) Anders P. Mutvei et al. Nature Communications
- Molecular Mechanisms and Potential Therapeutic Reversal of Pancreatic Cancer-Induced Immune Evasion
- (2020) Li-Lian Gan et al. Cancers
- Targeting mTOR and Src restricts hepatocellular carcinoma growth in a novel murine liver cancer model
- (2019) Sarah Walker et al. PLoS One
- Spleen tyrosine kinase-mediated autophagy is required for epithelial-mesenchymal plasticity and metastasis in breast cancer
- (2019) Aparna Shinde et al. CANCER RESEARCH
- Therapeutic challenges and current immunomodulatory strategies in targeting the immunosuppressive pancreatic tumor microenvironment
- (2019) Chin-King Looi et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Cell Adhesion Molecules and Their Roles and Regulation in the Immune and Tumor Microenvironment
- (2019) Heidi Harjunpää et al. Frontiers in Immunology
- The synergism of Clinacanthus nutans Lindau extracts with gemcitabine: downregulation of anti-apoptotic markers in squamous pancreatic ductal adenocarcinoma
- (2019) Ling-Wei Hii et al. BMC Complementary and Alternative Medicine
- SHARPIN Promotes Melanoma Progression via Rap1 Signaling Pathway
- (2019) Sitong Zhou et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- New Insights Into Implementation of Mesenchymal Stem Cells in Cancer Therapy: Prospects for Anti-angiogenesis Treatment
- (2019) Mohammad Reza Javan et al. Frontiers in Oncology
- Histone deacetylase (HDAC) inhibitors and doxorubicin combinations target both breast cancer stem cells and non-stem breast cancer cells simultaneously
- (2019) Ling-Wei Hii et al. BREAST CANCER RESEARCH AND TREATMENT
- Communication between EMT and PD-L1 signaling: New insights into tumor immune evasion
- (2019) Yuanyuan Jiang et al. CANCER LETTERS
- Role of Matrix Metalloproteinases in Angiogenesis and Cancer
- (2019) Saray Quintero-Fabián et al. Frontiers in Oncology
- Identification of inhibitors synergizing gemcitabine sensitivity in the squamous subtype of pancreatic ductal adenocarcinoma (PDAC)
- (2018) Jia Lin Er et al. APOPTOSIS
- E-cadherin: Its dysregulation in carcinogenesis and clinical implications
- (2018) Sonia How Ming Wong et al. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
- Epigenetics in Metastatic Breast Cancer: Its Regulation and Implications in Diagnosis, Prognosis and Therapeutics
- (2018) Yuan Seng Wu et al. CURRENT CANCER DRUG TARGETS
- Role of metabolism in cancer cell radioresistance and radiosensitization methods
- (2018) Le Tang et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Autocrine Fibronectin Inhibits Breast Cancer Metastasis
- (2018) Aparna Shinde et al. MOLECULAR CANCER RESEARCH
- E-cadherin in contact inhibition and cancer
- (2018) Alisha M. Mendonsa et al. ONCOGENE
- The downregulation of Rap1 GTPase-activating protein is associated with a poor prognosis in colorectal cancer and may impact on tumor progression
- (2018) Wei‑Li Gao et al. Oncology Letters
- mTOR Pathways in Cancer and Autophagy
- (2018) Mathieu Paquette et al. Cancers
- Downregulation of Rap1Gap: A Switch from DCIS to Invasive Breast Carcinoma via ERK/MAPK Activation
- (2018) Seema Shah et al. NEOPLASIA
- N-cadherin in cancer metastasis, its emerging role in haematological malignancies and potential as a therapeutic target in cancer
- (2018) Krzysztof Marek Mrozik et al. BMC CANCER
- Src regulates amino acid-mediated mTORC1 activation by disrupting GATOR1-Rag GTPase interaction
- (2018) Rituraj Pal et al. Nature Communications
- Not Just an Adhesion Molecule: LFA-1 Contact Tunes the T Lymphocyte Program
- (2017) Navin Kumar Verma et al. JOURNAL OF IMMUNOLOGY
- Cytoplasmic RAP1 mediates cisplatin resistance of non-small cell lung cancer
- (2017) Lu Xiao et al. Cell Death & Disease
- Crk adaptor protein promotes PD-L1 expression, EMT and immune evasion in a murine model of triple-negative breast cancer
- (2017) Sushil Kumar et al. OncoImmunology
- Roles of Rap1 signaling in tumor cell migration and invasion
- (2017) Zhang Yi-Lei et al. Cancer Biology & Medicine
- Cudraflavone C Induces Tumor-Specific Apoptosis in Colorectal Cancer Cells through Inhibition of the Phosphoinositide 3-Kinase (PI3K)-AKT Pathway
- (2017) Hsien-Chuen Soo et al. PLoS One
- Rap1 GTPases Are Master Regulators of Neural Cell Polarity in the Developing Neocortex
- (2016) Bhavin Shah et al. CEREBRAL CORTEX
- Low expression of Rap1GAP is associated with epithelial-mesenchymal transition (EMT) and poor prognosis in gastric cancer
- (2016) Ya Yang et al. Oncotarget
- Rap1A promotes ovarian cancer metastasis via activation of ERK/p38 and notch signaling
- (2016) Lili Lu et al. Cancer Medicine
- The C3G/Rap1 pathway promotes secretion of MMP-2 and MMP-9 and is involved in serous ovarian cancer metastasis
- (2015) Ya-Ling Che et al. CANCER LETTERS
- A Review of Cell Adhesion Studies for Biomedical and Biological Applications
- (2015) Amelia Khalili et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Combined Rational Design and a High Throughput Screening Platform for Identifying Chemical Inhibitors of a Ras-activating Enzyme
- (2015) Chris R. Evelyn et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- RAP1-GTPase signaling and platelet function
- (2015) Lucia Stefanini et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Expression of RAP1B is associated with poor prognosis and promotes an aggressive phenotype in gastric cancer
- (2015) YA YANG et al. ONCOLOGY REPORTS
- Tissue invasion and metastasis: Molecular, biological and clinical perspectives
- (2015) W.G. Jiang et al. SEMINARS IN CANCER BIOLOGY
- Glucocorticoids mediate induction of microRNA-708 to suppress ovarian cancer metastasis through targeting Rap1B
- (2015) Kai-Ti Lin et al. Nature Communications
- Biochemical and Pharmacological Characterizations of ESI-09 Based EPAC Inhibitors: Defining the ESI-09 “Therapeutic Window”
- (2015) Yingmin Zhu et al. Scientific Reports
- Projecting Cancer Incidence and Deaths to 2030: The Unexpected Burden of Thyroid, Liver, and Pancreas Cancers in the United States
- (2014) L. Rahib et al. CANCER RESEARCH
- The Ras-related Protein, Rap1A, Mediates Thrombin-stimulated, Integrin-dependent Glioblastoma Cell Proliferation and Tumor Growth
- (2014) Jacqueline Sayyah et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression
- (2014) Limo Chen et al. Nature Communications
- Oncology Meets Immunology: The Cancer-Immunity Cycle
- (2013) Daniel S. Chen et al. IMMUNITY
- Increased sugar uptake promotes oncogenesis via EPAC/RAP1 and O-GlcNAc pathways
- (2013) Yasuhito Onodera et al. JOURNAL OF CLINICAL INVESTIGATION
- β-Arrestin2 Regulates Lysophosphatidic Acid-Induced Human Breast Tumor Cell Migration and Invasion via Rap1 and IQGAP1
- (2013) Mistre Alemayehu et al. PLoS One
- Epac-Inhibitors: Facts and Artefacts
- (2013) Holger Rehmann Scientific Reports
- Rap1GAP regulates renal cell carcinoma invasion
- (2012) Wan-Ju Kim et al. CANCER LETTERS
- RAP1GAP inhibits cytoskeletal remodeling and motility in thyroid cancer cells
- (2012) Xiaoyun Dong et al. ENDOCRINE-RELATED CANCER
- miR-518b is down-regulated, and involved in cell proliferation and invasion by targeting Rap1b in esophageal squamous cell carcinoma
- (2012) Mingxin Zhang et al. FEBS LETTERS
- Cell Migration: Regulation of cytoskeleton by Rap1 in Dictyostelium discoideum
- (2012) Mi-Rae Lee et al. JOURNAL OF MICROBIOLOGY
- Rap1GAP alters leukemia cell differentiation, apoptosis and invasion in vitro
- (2012) TINGTING QIU et al. ONCOLOGY REPORTS
- Matrix metalloproteinase 9 expression and prognosis in colorectal cancer: a meta-analysis
- (2012) Chun-Yu Li et al. TUMOR BIOLOGY
- cAMP induces autophagy via a novel pathway involving ERK, cyclin E and Beclin 1
- (2011) Hege Ugland et al. Autophagy
- Rap1 promotes VEGFR2 activation and angiogenesis by a mechanism involving integrin v 3
- (2011) S. Lakshmikanthan et al. BLOOD
- Integrins and cadherins join forces to form adhesive networks
- (2011) G. F. Weber et al. JOURNAL OF CELL SCIENCE
- Inhibitory effects of Rap1GAP overexpression on proliferation and migration of endothelial cells via ERK and Akt pathways
- (2011) Wenyi Li et al. Journal of Huazhong University of Science and Technology-Medical Sciences
- Inhibition of Contact Sensitivity by Farnesylthiosalicylic Acid-Amide, a Potential Rap1 Inhibitor
- (2011) Adam Mor et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Rap1 GTPases: An emerging role in the cardiovasculature
- (2011) Selvi C. Jeyaraj et al. LIFE SCIENCES
- The tumor suppressor gene rap1GAP is silenced by miR-101-mediated EZH2 overexpression in invasive squamous cell carcinoma
- (2011) R Banerjee et al. ONCOGENE
- EGFR-dependent pancreatic carcinoma cell metastasis through Rap1 activation
- (2011) M Huang et al. ONCOGENE
- Downregulation of Rap1GAP through Epigenetic Silencing and Loss of Heterozygosity Promotes Invasion and Progression of Thyroid Tumors
- (2010) H. Zuo et al. CANCER RESEARCH
- Autophagy: cellular and molecular mechanisms
- (2010) Danielle Glick et al. JOURNAL OF PATHOLOGY
- Disruption of E-Cadherin by Matrix Metalloproteinase Directly Mediates Epithelial-Mesenchymal Transition Downstream of Transforming Growth Factor-β1 in Renal Tubular Epithelial Cells
- (2009) Guoping Zheng et al. AMERICAN JOURNAL OF PATHOLOGY
- Down-regulation of Rap1GAP via Promoter Hypermethylation Promotes Melanoma Cell Proliferation, Survival, and Migration
- (2009) H. Zheng et al. CANCER RESEARCH
- Activation of Rap1 Promotes Prostate Cancer Metastasis
- (2009) C. L. Bailey et al. CANCER RESEARCH
- Epithelial to Mesenchymal Transition Contributes to Drug Resistance in Pancreatic Cancer
- (2009) T. Arumugam et al. CANCER RESEARCH
- Rap1 Stabilizes -Catenin and Enhances -Catenin-Dependent Transcription and Invasion in Squamous Cell Carcinoma of the Head and Neck
- (2009) M. Goto et al. CLINICAL CANCER RESEARCH
- mTOR and cancer: many loops in one pathway
- (2009) Alejo Efeyan et al. CURRENT OPINION IN CELL BIOLOGY
- Future of Cancer Incidence in the United States: Burdens Upon an Aging, Changing Nation
- (2009) Benjamin D. Smith et al. JOURNAL OF CLINICAL ONCOLOGY
- Role of the small GTPase Rap1 for integrin activity regulation in endothelial cells and angiogenesis
- (2008) G. Carmona et al. BLOOD
- Rap1GAP Promotes Invasion via Induction of Matrix Metalloproteinase 9 Secretion, Which Is Associated with Poor Survival in Low N-Stage Squamous Cell Carcinoma
- (2008) R. S. Mitra et al. CANCER RESEARCH
- Matrix Metalloproteinase 9 Is a Mediator of Epidermal Growth Factor-Dependent E-Cadherin Loss in Ovarian Carcinoma Cells
- (2008) K. D. Cowden Dahl et al. CANCER RESEARCH
- Loss of Rap1GAP in Papillary Thyroid Cancer
- (2008) Anoma Nellore et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- The tumor suppressor gene ARHI regulates autophagy and tumor dormancy in human ovarian cancer cells
- (2008) Zhen Lu et al. JOURNAL OF CLINICAL INVESTIGATION
Become a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get StartedAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started