Targeting mTOR and Src restricts hepatocellular carcinoma growth in a novel murine liver cancer model

Modeling NAFLD disease burden in China, France, Germany, Italy, Japan, Spain, United Kingdom, and United States for the period 2016–2030

(2018) Chris Estes et al.   JOURNAL OF HEPATOLOGY

Regorafenib for patients with hepatocellular carcinoma who progressed on sorafenib treatment (RESORCE): a randomised, double-blind, placebo-controlled, phase 3 trial

(2017) Jordi Bruix et al.   LANCET

Sorafenib with or without everolimus in patients with advanced hepatocellular carcinoma (HCC): a randomized multicenter, multinational phase II trial (SAKK 77/08 and SASL 29)

(2016) D. Koeberle et al.   ANNALS OF ONCOLOGY

The Natural Course of Non-Alcoholic Fatty Liver Disease

(2016) Luis Calzadilla Bertot et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Novel roles of Src in cancer cell epithelial-to-mesenchymal transition, vascular permeability, microinvasion and metastasis

(2016) Ami Patel et al.   LIFE SCIENCES

Phase I/II study of temsirolimus for patients with unresectable Hepatocellular Carcinoma (HCC)- a correlative study to explore potential biomarkers for response

(2015) Winnie Yeo et al.   BMC CANCER

Adiponectin Reduces Hepatic Stellate Cell Migration by Promoting Tissue Inhibitor of Metalloproteinase-1 (TIMP-1) Secretion

(2015) Mehdi Ramezani-Moghadam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rapamycin Enhances the Anti-Cancer Effect of Dasatinib by Suppressing Src/PI3K/mTOR Pathway in NSCLC Cells

(2015) Bin Chen et al.   PLoS One

Src signaling pathways in prostate cancer

(2014) Andreas Varkaris et al.   CANCER AND METASTASIS REVIEWS

Combined SFK/mTOR Inhibition Prevents Rapamycin-Induced Feedback Activation of AKT and Elicits Efficient Tumor Regression

(2014) Jennifer L. Yori et al.   CANCER RESEARCH

Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012

(2014) Jacques Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

Effect of Everolimus on Survival in Advanced Hepatocellular Carcinoma After Failure of Sorafenib

(2014) Andrew X. Zhu et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Multifaceted roles of Adiponectin in cancer

(2013) Lionel Hebbard et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Targeting the mTOR pathway in hepatocellular carcinoma: Current state and future trends

(2013) Matthias S. Matter et al.   JOURNAL OF HEPATOLOGY

Noncirrhotic hepatocellular carcinoma: derivation from hepatocellular adenoma? Clinicopathologic analysis

(2013) Ta-Chiang Liu et al.   MODERN PATHOLOGY

The global NAFLD epidemic

(2013) Rohit Loomba et al.   Nature Reviews Gastroenterology & Hepatology

NAFLD—the next global epidemic

(2013) Katrina Ray   Nature Reviews Gastroenterology & Hepatology

Targeted therapy for melanoma: rational combinatorial approaches

(2013) L N Kwong et al.   ONCOGENE

Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation

(2011) Weiwei Yang et al.   NATURE

Hepatocyte IKKβ/NF-κB Inhibits Tumor Promotion and Progression by Preventing Oxidative Stress-Driven STAT3 Activation

(2010) Guobin He et al.   CANCER CELL

Maternal Embryonic Leucine Zipper Kinase Is Upregulated and Required in Mammary Tumor-Initiating Cells In vivo

(2010) L. W. Hebbard et al.   CANCER RESEARCH

Significance of serum adiponectin levels in patients with chronic liver disease

(2010) Maria Luisa Balmer et al.   CLINICAL SCIENCE

Adiponectin Modulates C-Jun N-Terminal Kinase and Mammalian Target of Rapamycin and Inhibits Hepatocellular Carcinoma

(2010) Neeraj K. Saxena et al.   GASTROENTEROLOGY

Non-alcoholic fatty liver disease progresses to hepatocellular carcinoma in the absence of apparent cirrhosis

(2010) Judith Ertle et al.   INTERNATIONAL JOURNAL OF CANCER

Animal models of nonalcoholic fatty liver disease

(2010) Lionel Hebbard et al.   Nature Reviews Gastroenterology & Hepatology

Control of mammary tumor differentiation by SKI-606 (bosutinib)

(2010) L Hebbard et al.   ONCOGENE

Latent Bone Metastasis in Breast Cancer Tied to Src-Dependent Survival Signals

(2009) Xiang H.-F. Zhang et al.   CANCER CELL

Adiponectin Deficiency Limits Tumor Vascularization in the MMTV-PyV-mT Mouse Model of Mammary Cancer

(2009) M. S. Denzel et al.   CLINICAL CANCER RESEARCH

Hepatocellular carcinomas in patients with metabolic syndrome often develop without significant liver fibrosis: A pathological analysis

(2009) Valérie Paradis et al.   HEPATOLOGY

Adiponectin knockout mice on high fat diet develop fibrosing steatohepatitis

(2009) Takeharu Asano et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Mammalian Target of Rapamycin: Discovery of Rapamycin Reveals a Signaling Pathway Important for Normal and Cancer Cell Growth

(2009) James J. Gibbons et al.   SEMINARS IN ONCOLOGY

Pivotal Role of mTOR Signaling in Hepatocellular Carcinoma

(2008) Augusto Villanueva et al.   GASTROENTEROLOGY

Adiponectin suppresses colorectal carcinogenesis under the high-fat diet condition

(2008) T Fujisawa et al.   GUT

Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial

(2008) Ann-Lii Cheng et al.   LANCET ONCOLOGY

Sorafenib in Advanced Hepatocellular Carcinoma

(2008) Josep M. Llovet et al.   NEW ENGLAND JOURNAL OF MEDICINE

Adiponectin deficiency enhances colorectal carcinogenesis and liver tumor formation induced by azoxymethane in mice

(2008) Tamao Nishihara et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Regulation of mTORC1 Signaling by Src Kinase Activity Is Akt1-Independent in RSV-Transformed Cells

(2008) Martina Vojtěchová et al.   NEOPLASIA