期刊
ONCOGENE
卷 37, 期 35, 页码 4769-4780出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41388-018-0304-2
关键词
-
资金
- National Cancer Institute at the National Institutes of Health [R01CA207115-02]
E-cadherin is a key component of the adherens junctions that are integral in cell adhesion and maintaining epithelial phenotype of cells. Homophilic E-cadherin binding between cells is important in mediating contact inhibition of proliferation when cells reach confluence. Loss of E-cadherin expression results in loss of contact inhibition and is associated with increased cell motility and advanced stages of cancer. In this review we discuss the role of E-cadherin and its downstream signaling in regulation of contact inhibition and the development and progression of cancer.
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