期刊
JOURNAL OF CHROMATOGRAPHY A
卷 1490, 期 -, 页码 2-9出版社
ELSEVIER
DOI: 10.1016/j.chroma.2016.11.010
关键词
Downstream processing; Process analytical technology; Spectroscopy; Chemometrics; Biologics
资金
- European Union's Horizon 2020 research and innovation programme [635557]
Process analytical technologies (PAT) for the manufacturing of biologics have drawn increased interest in the last decade. Besides being encouraged by the Food and Drug Administration's (FDA's) PAT initiative, PAT promises to improve process understanding, reduce overall production costs and help to implement continuous manufacturing. This article focuses on spectroscopic tools for PAT in downstream processing (DSP). Recent advances and future perspectives will be reviewed. In order to exploit the full potential of gathered data, chemometric tools are widely used for the evaluation of complex spectroscopic information. Thus, an introduction into the field will be given. (C) 2016 The Authors. Published by Elsevier B.V.
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