Rapid characterization of biotherapeutic proteins by size-exclusion chromatography coupled to native mass spectrometry

High resolution separation of recombinant monoclonal antibodies by size-exclusion ultra-high performance liquid chromatography (SE-UHPLC)

(2015) Renee Yang et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Functional assessment of antibody oxidation by native mass spectrometry

(2015) Markus Haberger et al.   mAbs

Antibodies to watch in 2015

(2014) Janice M Reichert   mAbs

The therapeutic monoclonal antibody market

(2014) Dawn M Ecker et al.   mAbs

Assessment of chemical modifications of sites in the CDRs of recombinant antibodies

(2014) Markus Haberger et al.   mAbs

Detailed mass analysis of structural heterogeneity in monoclonal antibodies using native mass spectrometry

(2014) Sara Rosati et al.   Nature Protocols

Bispecific antibodies rise again

(2014) Ken Garber   NATURE REVIEWS DRUG DISCOVERY

Characterization of monoclonal antibody size variants containing extra light chains

(2013) Connie Lu et al.   mAbs

Complex mixtures of antibodies generated from a single production qualitatively and quantitatively evaluated by native Orbitrap mass spectrometry

(2013) Natalie J Thompson et al.   mAbs

Qualitative and Semiquantitative Analysis of Composite Mixtures of Antibodies by Native Mass Spectrometry

(2012) Sara Rosati et al.   ANALYTICAL CHEMISTRY

Biosimilar, Biobetter, and Next Generation Antibody Characterization by Mass Spectrometry

(2012) Alain Beck et al.   ANALYTICAL CHEMISTRY

Native ion mobility-mass spectrometry and related methods in structural biology

(2012) A. Konijnenberg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Progress in overcoming the chain association issue in bispecific heterodimeric IgG antibodies

(2012) Christian Klein et al.   mAbs

Simultaneous Assessment of Asp Isomerization and Asn Deamidation in Recombinant Antibodies by LC-MS following Incubation at Elevated Temperatures

(2012) Katharina Diepold et al.   PLoS One

Novel protein scaffolds as emerging therapeutic proteins: from discovery to clinical proof-of-concept

(2012) Thierry Wurch et al.   TRENDS IN BIOTECHNOLOGY

Therapeutic Fc-fusion proteins and peptides as successful alternatives to antibodies

(2011) Alain Beck et al.   mAbs

Immunoglobulin domain crossover as a generic approach for the production of bispecific IgG antibodies

(2011) W. Schaefer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantitative Analysis of the Interaction Strength and Dynamics of Human IgG4 Half Molecules by Native Mass Spectrometry

(2011) Rebecca J. Rose et al.   STRUCTURE

Mass Spectrometric Analysis of Intact Human Monoclonal Antibody Aggregates Fractionated by Size-Exclusion Chromatography

(2010) Başak Kükrer et al.   PHARMACEUTICAL RESEARCH

Extending Mass Spectrometry Contribution to Therapeutic Monoclonal Antibody Lead Optimization: Characterization of Immune Complexes Using Noncovalent ESI-MS

(2009) Cédric Atmanene et al.   ANALYTICAL CHEMISTRY

Label-free determination of protein-ligand binding constants using mass spectrometry and validation using surface plasmon resonance and isothermal titration calorimetry

(2009) Matthias C. Jecklin et al.   JOURNAL OF MOLECULAR RECOGNITION

The critical role of mobile phase composition in size exclusion chromatography of protein pharmaceuticals

(2009) Tsutomu Arakawa et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Mass spectrometry for structural characterization of therapeutic antibodies

(2008) Zhongqi Zhang et al.   MASS SPECTROMETRY REVIEWS

Native mass spectrometry: a bridge between interactomics and structural biology

(2008) Albert J R Heck   NATURE METHODS