Transcriptome Analyses of β-Thalassemia −28(A>G) Mutation Using Isogenic Cell Models Generated by CRISPR/Cas9 and Asymmetric Single-Stranded Oligodeoxynucleotides (assODNs)

Human erythroblasts with c-Kit activating mutations have reduced cell culture costs and remain capable of terminal maturation

(2019) Tyler Couch et al.   EXPERIMENTAL HEMATOLOGY

Gene expression in blood from an individual with β‐thalassemia: An RNA sequence analysis

(2019) Forough Taghavifar et al.   Molecular Genetics & Genomic Medicine

Metascape provides a biologist-oriented resource for the analysis of systems-level datasets

(2019) Yingyao Zhou et al.   Nature Communications

Inflammation induces stress erythropoiesis through heme-dependent activation of SPI-C

(2019) Laura F. Bennett et al.   Science Signaling

GATA2 Promotes Hematopoietic Development and Represses Cardiac Differentiation of Human Mesoderm

(2019) Julio Castaño et al.   Stem Cell Reports

Hematopoietic Differentiation of Human Pluripotent Stem Cells: HOX and GATA Transcription Factors as Master Regulators

(2019) Khaled Alsayegh et al.   CURRENT GENOMICS

Direct Promoter Repression by BCL11A Controls the Fetal to Adult Hemoglobin Switch

(2018) Nan Liu et al.   CELL

Thalassaemia

(2018) Ali T Taher et al.   LANCET

Natural regulatory mutations elevate the fetal globin gene via disruption of BCL11A or ZBTB7A binding

(2018) Gabriella E. Martyn et al.   NATURE GENETICS

Hsp90 chaperones hemoglobin maturation in erythroid and nonerythroid cells

(2018) Arnab Ghosh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Domain-focused CRISPR screen identifies HRI as a fetal hemoglobin regulator in human erythroid cells

(2018) Jeremy D. Grevet et al.   SCIENCE

PI3k/AKT signaling pathway: Erythropoiesis and beyond

(2018) Mahjoobeh Jafari et al.   JOURNAL OF CELLULAR PHYSIOLOGY

AnimalTFDB 3.0: a comprehensive resource for annotation and prediction of animal transcription factors

(2018) Hui Hu et al.   NUCLEIC ACIDS RESEARCH

Wake-up Sleepy Gene: Reactivating Fetal Globin for β-Hemoglobinopathies

(2018) Beeke Wienert et al.   TRENDS IN GENETICS

CRISPR/Cas9-mediated correction of human genetic disease

(2017) Ke Men et al.   Science China-Life Sciences

CRISPR/Cas9 system: a powerful technology for in vivo and ex vivo gene therapy

(2017) Xiaohui Zhang et al.   Science China-Life Sciences

Correction of β-thalassemia mutant by base editor in human embryos

(2017) Puping Liang et al.   Protein & Cell

The prevalence of thalassemia in mainland China: evidence from epidemiological surveys

(2017) Ketong Lai et al.   Scientific Reports

Comparison of different methods for erythroid differentiation in the K562 cell line

(2016) Laleh Shariati et al.   BIOTECHNOLOGY LETTERS

β-Thalassemia

(2016) Raffaella Origa   GENETICS IN MEDICINE

Cell and Gene Therapy for the Beta-Thalassemias: Advances and Prospects

(2016) Jorge Mansilla-Soto et al.   HUMAN GENE THERAPY

Combining Single Strand Oligodeoxynucleotides and CRISPR/Cas9 to Correct Gene Mutations in β-Thalassemia-induced Pluripotent Stem Cells

(2016) Xiaohua Niu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Efficient introduction of specific homozygous and heterozygous mutations using CRISPR/Cas9

(2016) Dominik Paquet et al.   NATURE

A genome-editing strategy to treat β-hemoglobinopathies that recapitulates a mutation associated with a benign genetic condition

(2016) Elizabeth A Traxler et al.   NATURE MEDICINE

Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin

(2016) T. Masuda et al.   SCIENCE

Selection-free genome editing of the sickle mutation in human adult hematopoietic stem/progenitor cells

(2016) M. A. DeWitt et al.   Science Translational Medicine

Clinical development of gene therapy: results and lessons from recent successes

(2016) Sandeep RP Kumar et al.   Molecular Therapy-Methods & Clinical Development

Current and future alternative therapies for beta-thalassemia major

(2016) Edouard de Dreuzy et al.   Biomedical Journal

StringTie enables improved reconstruction of a transcriptome from RNA-seq reads

(2015) Mihaela Pertea et al.   NATURE BIOTECHNOLOGY

HISAT: a fast spliced aligner with low memory requirements

(2015) Daehwan Kim et al.   NATURE METHODS

Both TALENs and CRISPR/Cas9 directly target the HBB IVS2–654 (C > T) mutation in β-thalassemia-derived iPSCs

(2015) Peng Xu et al.   Scientific Reports

iRegulon: From a Gene List to a Gene Regulatory Network Using Large Motif and Track Collections

(2014) Rekin's Janky et al.   PLoS Computational Biology

Emodin can induce K562 cells to erythroid differentiation and improve the expression of globin genes

(2013) Yan-Ni Ma et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Establishment of Immortalized Human Erythroid Progenitor Cell Lines Able to Produce Enucleated Red Blood Cells

(2013) Ryo Kurita et al.   PLoS One

Characterization of the transcriptome profiles related to globin gene switching during in vitro erythroid maturation

(2012) Biaoru Li et al.   BMC GENOMICS

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

(2012) Guangchuang Yu et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Molecular signatures database (MSigDB) 3.0

(2011) A. Liberzon et al.   BIOINFORMATICS

Efficient correction of hemoglobinopathy-causing mutations by homologous recombination in integration-free patient iPSCs

(2011) Mo Li et al.   CELL RESEARCH

Integrative genomics viewer

(2011) James T Robinson et al.   NATURE BIOTECHNOLOGY

BEDTools: a flexible suite of utilities for comparing genomic features

(2010) Aaron R. Quinlan et al.   BIOINFORMATICS

Advances in the understanding of haemoglobin switching

(2010) Vijay G. Sankaran et al.   BRITISH JOURNAL OF HAEMATOLOGY

Beta-thalassemia

(2010) Antonio Cao et al.   GENETICS IN MEDICINE

The Population Genetics and Dynamics of the Thalassemias

(2010) D.J. Weatherall et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

miR-451enhances erythroid differentiation in K562 cells

(2010) Hana Bruchova-Votavova et al.   LEUKEMIA & LYMPHOMA

KLF1 regulates BCL11A expression and γ- to β-globin gene switching

(2010) Dewang Zhou et al.   NATURE GENETICS

Beta-thalassemia

(2010) Renzo Galanello et al.   Orphanet Journal of Rare Diseases

The Sequence Alignment/Map format and SAMtools

(2009) H. Li et al.   BIOINFORMATICS

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

BCL11A represses HBG transcription in K562 cells

(2009) Zhiyi Chen et al.   BLOOD CELLS MOLECULES AND DISEASES