Correction of β-thalassemia mutant by base editor in human embryos

Editor’s comment on “CRISPR/Cas9-mediated gene editing in human zygotes using Cas9 protein”

(2017) Stefan Hohmann   MOLECULAR GENETICS AND GENOMICS

CRISPR/Cas9-mediated gene editing in human zygotes using Cas9 protein

(2017) Lichun Tang et al.   MOLECULAR GENETICS AND GENOMICS

Precise Editing of a Target Base in the Rice Genome Using a Modified CRISPR/Cas9 System

(2017) Yuming Lu et al.   Molecular Plant

Generation of Targeted Point Mutations in Rice by a Modified CRISPR/Cas9 System

(2017) Jingying Li et al.   Molecular Plant

Correction of a pathogenic gene mutation in human embryos

(2017) Hong Ma et al.   NATURE

Precise base editing in rice, wheat and maize with a Cas9-cytidine deaminase fusion

(2017) Yuan Zong et al.   NATURE BIOTECHNOLOGY

Increasing the genome-targeting scope and precision of base editing with engineered Cas9-cytidine deaminase fusions

(2017) Y Bill Kim et al.   NATURE BIOTECHNOLOGY

Highly efficient RNA-guided base editing in mouse embryos

(2017) Kyoungmi Kim et al.   NATURE BIOTECHNOLOGY

Genome-wide target specificities of CRISPR RNA-guided programmable deaminases

(2017) Daesik Kim et al.   NATURE BIOTECHNOLOGY

A CRISPR/Cas9 toolkit for efficient targeted base editing to induce genetic variations in rice

(2017) Bin Ren et al.   Science China-Life Sciences

CRISPR/Cas9-mediated base-editing system efficiently generates gain-of-function mutations in Arabidopsis

(2017) Yiyu Chen et al.   Science China-Life Sciences

Highly efficient base editing in human tripronuclear zygotes

(2017) Changyang Zhou et al.   Protein & Cell

Highly efficient and precise base editing in discarded human tripronuclear embryos

(2017) Guanglei Li et al.   Protein & Cell

Effective gene editing by high-fidelity base editor 2 in mouse zygotes

(2017) Puping Liang et al.   Protein & Cell

Electroporation of Cas9 protein/sgRNA into early pronuclear zygotes generates non-mosaic mutants in the mouse

(2016) Masakazu Hashimoto et al.   DEVELOPMENTAL BIOLOGY

Introducing precise genetic modifications into human 3PN embryos by CRISPR/Cas-mediated genome editing

(2016) Xiangjin Kang et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

CRISPR/Cas9 β-globin gene targeting in human haematopoietic stem cells

(2016) Daniel P. Dever et al.   NATURE

Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage

(2016) Alexis C. Komor et al.   NATURE

Survival and complication rates in patients with thalassemia major in Taiwan

(2016) Han-Ping Wu et al.   PEDIATRIC BLOOD & CANCER

Efficient Production of Gene-Modified Mice using Staphylococcus aureus Cas9

(2016) Xiya Zhang et al.   Scientific Reports

Derivation of a Homozygous Human Androgenetic Embryonic Stem Cell Line

(2015) Chenhui Ding et al.   STEM CELLS AND DEVELOPMENT

CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes

(2015) Puping Liang et al.   Protein & Cell

The inherited diseases of hemoglobin are an emerging global health burden

(2010) D. J. Weatherall   BLOOD

Beta-thalassemia

(2010) Antonio Cao et al.   GENETICS IN MEDICINE

Beta-thalassemia

(2010) Renzo Galanello et al.   Orphanet Journal of Rare Diseases