Hypoxia-Inducible Factor Stabilizers: a New Avenue for Reducing BP While Helping Hemoglobin?
出版年份 2016 全文链接
标题
Hypoxia-Inducible Factor Stabilizers: a New Avenue for Reducing BP While Helping Hemoglobin?
作者
关键词
Hypoxia-inducible factor, HIF-1α, HIF-2 α, Anemia, Erythropoietin, Iron, Prolyl-hydroxylase domain, PHD inhibitors, Hypertension, Nitric oxide, Pulmonary hypertension
出版物
CURRENT HYPERTENSION REPORTS
Volume 18, Issue 3, Pages -
出版商
Springer Nature
发表日期
2016-02-19
DOI
10.1007/s11906-016-0629-6
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Altered Hypoxic–Adenosine Axis and Metabolism in Group III Pulmonary Hypertension
- (2016) Luis J. Garcia-Morales et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- Circulating Hepcidin Is Independently Associated with Systolic Blood Pressure in Apparently Healthy Individuals
- (2015) Milton Fabian Suárez-Ortegón et al. ARCHIVES OF MEDICAL RESEARCH
- Hypoxia-inducible factor-1alpha in hepatic fibrosis: A promising therapeutic target
- (2015) Lei Zhan et al. BIOCHIMIE
- Hepcidin: regulation of the master iron regulator
- (2015) Gautam Rishi et al. BIOSCIENCE REPORTS
- Association of Serum Erythropoietin With Cardiovascular Events, Kidney Function Decline, and MortalityCLINICAL PERSPECTIVE
- (2015) Pranav S Garimella et al. Circulation-Heart Failure
- Understanding the Recent Increase in Ferritin Levels in United States Dialysis Patients: Potential Impact of Changes in Intravenous Iron and Erythropoiesis-Stimulating Agent Dosing
- (2015) A. Karaboyas et al. Clinical Journal of the American Society of Nephrology
- Is hepcidin-25 a predictor of atherosclerosis in hemodialysis patients?
- (2015) Alaaddin Kali et al. Hemodialysis International
- Elevated Endothelial Hypoxia-Inducible Factor-1α Contributes to Glomerular Injury and Promotes Hypertensive Chronic Kidney DiseaseNovelty and Significance
- (2015) Renna Luo et al. HYPERTENSION
- HIF-1α disturbs osteoblasts and osteoclasts coupling in bone remodeling by up-regulating OPG expression
- (2015) Jin Shao et al. IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
- Novel mechanism of cardiac protection by valsartan: synergetic roles of TGF-β1 and HIF-1α in Ang II-mediated fibrosis after myocardial infarction
- (2015) Xizhong Sui et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Hypoxia-inducible factors and hypertension: lessons from sleep apnea syndrome
- (2015) Jayasri Nanduri et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Four-Week Studies of Oral Hypoxia-Inducible Factor-Prolyl Hydroxylase Inhibitor GSK1278863 for Treatment of Anemia
- (2015) L. Holdstock et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Roxadustat (FG-4592): Correction of Anemia in Incident Dialysis Patients
- (2015) A. Besarab et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Inducible glomerular erythropoietin production in the adult kidney
- (2015) Katharina Gerl et al. KIDNEY INTERNATIONAL
- Hypoxia Inducible Factor Pathway and Physiological Adaptation: A Cell Survival Pathway?
- (2015) Hemant Kumar et al. MEDIATORS OF INFLAMMATION
- Iron and oxygen sensing: a tale of 2 interacting elements?
- (2015) Robert J. Simpson et al. Metallomics
- Randomized placebo-controlled dose-ranging and pharmacodynamics study of roxadustat (FG-4592) to treat anemia in nondialysis-dependent chronic kidney disease (NDD-CKD) patients
- (2015) Anatole Besarab et al. NEPHROLOGY DIALYSIS TRANSPLANTATION
- HIF-1α pathway: role, regulation and intervention for cancer therapy
- (2015) Georgina N. Masoud et al. Acta Pharmaceutica Sinica B
- Iron Stores, Hepcidin, and Aortic Stiffness in Individuals with Hypertension
- (2015) Luca Valenti et al. PLoS One
- Reevaluation of erythropoietin production by the nephron
- (2014) Takanori Nagai et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Hepcidin and the Global Burden of Iron Deficiency
- (2014) T. Ganz CLINICAL CHEMISTRY
- Investigating the real role of HIF-1 and HIF-2 in iron recycling by macrophages
- (2014) J. R. R. Mathieu et al. HAEMATOLOGICA
- Rapid elevation of transferrin saturation and serum hepcidin concentration in hemodialysis patients after intravenous iron infusion
- (2014) N. Kitsati et al. HAEMATOLOGICA
- Endothelial HIF-2 mediates protection and recovery from ischemic kidney injury
- (2014) Pinelopi P. Kapitsinou et al. JOURNAL OF CLINICAL INVESTIGATION
- Claudins and the Kidney
- (2014) A. S. L. Yu JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- A Breath of Fresh Air for Diabetic Nephropathy
- (2014) V. H. Haase JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- The Dominant Humoral Epitope in Phospholipase A2 Receptor-1: Presentation Matters When Serving Up a Slice of
- (2014) L. H. Beck JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Chronic Hypoxia-Inducible Transcription Factor-2 Activation Stably Transforms Juxtaglomerular Renin Cells into Fibroblast-Like Cells In Vivo
- (2014) B. Kurt et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Mimicking Hypoxia to Treat Anemia: HIF-Stabilizer BAY 85-3934 (Molidustat) Stimulates Erythropoietin Production without Hypertensive Effects
- (2014) Ingo Flamme et al. PLoS One
- Silencing of HIF Prolyl-Hydroxylase 2 Gene in the Renal Medulla Attenuates Salt-Sensitive Hypertension in Dahl S Rats
- (2013) Q. Zhu et al. AMERICAN JOURNAL OF HYPERTENSION
- Cardiovascular Toxicity of Epoetin-Alfa in Patients with Chronic Kidney Disease
- (2013) Peter A. McCullough et al. AMERICAN JOURNAL OF NEPHROLOGY
- Activation of hypoxia-inducible factor-1 in pulmonary arterial smooth muscle cells by endothelin-1
- (2013) Sarah Pisarcik et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- Serum Hepcidin Is Associated With Presence of Plaque in Postmenopausal Women of a General Population
- (2013) Tessel E. Galesloot et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Pan-genomic binding of hypoxia-inducible transcription factors
- (2013) Johannes Schödel et al. BIOLOGICAL CHEMISTRY
- Linking Oxygen to Time: The Bidirectional Interaction Between the Hypoxic Signaling Pathway and the Circadian Clock
- (2013) Margit Egg et al. CHRONOBIOLOGY INTERNATIONAL
- Extensive regulation of the non-coding transcriptome by hypoxia: role of HIF in releasing paused RNApol2
- (2013) Hani Choudhry et al. EMBO REPORTS
- Hypoxia-induced epigenetic modifications are associated with cardiac tissue fibrosis and the development of a myofibroblast-like phenotype
- (2013) Chris J. Watson et al. HUMAN MOLECULAR GENETICS
- HIF and pulmonary vascular responses to hypoxia
- (2013) Larissa A. Shimoda et al. JOURNAL OF APPLIED PHYSIOLOGY
- Erythrocytosis and Pulmonary Hypertension in a Mouse Model of HumanHIF2AGain of Function Mutation
- (2013) Qiulin Tan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Deletion of von Hippel-Lindau Protein Converts Renin-Producing Cells into Erythropoietin-Producing Cells
- (2013) B. Kurt et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Systemic Iron Homeostasis
- (2013) Tomas Ganz PHYSIOLOGICAL REVIEWS
- HIF isoforms in the skin differentially regulate systemic arterial pressure
- (2013) A. S. Cowburn et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- HIF1 is required for osteoclast activation by estrogen deficiency in postmenopausal osteoporosis
- (2013) Y. Miyauchi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mutual antagonism between hypoxia-inducible factors 1 and 2 regulates oxygen sensing and cardio-respiratory homeostasis
- (2013) G. Yuan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Salt sensitivity of blood pressure in non-dialysis patients with chronic kidney disease
- (2013) Lin Meng et al. RENAL FAILURE
- Iron and hepcidin: a story of recycling and balance
- (2013) C. Camaschella Hematology-American Society of Hematology Education Program
- Overexpression of HIF-1α transgene in the renal medulla attenuated salt sensitive hypertension in Dahl S rats
- (2012) Qing Zhu et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Transmembrane prolyl 4-hydroxylase is a fourth prolyl 4-hydroxylase regulating EPO production and erythropoiesis
- (2012) A. Laitala et al. BLOOD
- The HIF Signaling Pathway in Osteoblasts Directly Modulates Erythropoiesis through the Production of EPO
- (2012) Erinn B. Rankin et al. CELL
- Nitric Oxide Produced Endogenously Is Responsible for Hypoxia-Induced HIF-1α Stabilization in Colon Carcinoma Cells
- (2012) Rajdeep Chowdhury et al. CHEMICAL RESEARCH IN TOXICOLOGY
- The updated biology of hypoxia-inducible factor
- (2012) Samantha N Greer et al. EMBO JOURNAL
- Endothelin-1 induces hypoxia inducible factor 1α expression in pulmonary artery smooth muscle cells
- (2012) Manxiang Li et al. FEBS LETTERS
- Mechanisms of Anemia in CKD
- (2012) J. L. Babitt et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Hepcidin-25 is related to cardiovascular events in chronic haemodialysis patients
- (2012) Neelke C. van der Weerd et al. NEPHROLOGY DIALYSIS TRANSPLANTATION
- Vascular Endothelial Growth Factor A in Intraocular Vascular Disease
- (2012) Joan W. Miller et al. OPHTHALMOLOGY
- Effect of oral l-arginine supplementation on blood pressure: A meta-analysis of randomized, double-blind, placebo-controlled trials
- (2011) Jia-Yi Dong et al. AMERICAN HEART JOURNAL
- Deletion of HIF-2 in the enterocytes decreases the severity of tissue iron loading in hepcidin knockout mice
- (2011) M. Mastrogiannaki et al. BLOOD
- Cardiopulmonary function in two human disorders of the hypoxia-inducible factor (HIF) pathway: von Hippel-Lindau disease and HIF-2α gain-of-function mutation
- (2011) Federico Formenti et al. FASEB JOURNAL
- Hypoxia-Inducible Factor-2α Mediates the Adaptive Increase of Intestinal Ferroportin During Iron Deficiency in Mice
- (2011) Matthew Taylor et al. GASTROENTEROLOGY
- Hepatic hypoxia-inducible factor-2 down-regulates hepcidin expression in mice through an erythropoietin-mediated increase in erythropoiesis
- (2011) M. Mastrogiannaki et al. HAEMATOLOGICA
- Intestinal Hypoxia-inducible Factor-2α (HIF-2α) Is Critical for Efficient Erythropoiesis
- (2011) Erik R. Anderson et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Indoxyl sulfate, a representative uremic toxin, suppresses erythropoietin production in a HIF-dependent manner
- (2011) Chih-Kang Chiang et al. LABORATORY INVESTIGATION
- Hepcidin as well as TNF- are significant predictors of arterial stiffness in patients on maintenance hemodialysis
- (2011) T. Kuragano et al. NEPHROLOGY DIALYSIS TRANSPLANTATION
- Hypoxia. 2. Hypoxia regulates cellular metabolism
- (2010) William W. Wheaton et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Activation of the hypoxia-inducible factor-1 in overloaded temporomandibular joint, and induction of osteoclastogenesis
- (2010) Maya Shirakura et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- The Therapeutic Potential of Erythropoiesis-Stimulating Agents for Tissue Protection: A Tale of Two Receptors
- (2010) Michael Brines BLOOD PURIFICATION
- Hypoxia-inducible factor regulates osteoclast-mediated bone resorption: role of angiopoietin-like 4
- (2010) Helen J. Knowles et al. FASEB JOURNAL
- Differential activation and antagonistic function of HIF- isoforms in macrophages are essential for NO homeostasis
- (2010) N. Takeda et al. GENES & DEVELOPMENT
- Hypoxia-Inducible Factor Prolyl-Hydroxylase 2 Senses High-Salt Intake to Increase Hypoxia Inducible Factor 1α Levels in the Renal Medulla
- (2010) Zhengchao Wang et al. HYPERTENSION
- The von Hippel–Lindau Chuvash mutation promotes pulmonary hypertension and fibrosis in mice
- (2010) Michele M. Hickey et al. JOURNAL OF CLINICAL INVESTIGATION
- Increased size of solid organs in patients with Chuvash polycythemia and in mice with altered expression of HIF-1α and HIF-2α
- (2010) Donghoon Yoon et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Inhibition of Prolyl Hydroxylases Increases Erythropoietin Production in ESRD
- (2010) W. M. Bernhardt et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Reactivation of Hepatic EPO Synthesis in Mice After PHD Loss
- (2010) Y. A. Minamishima et al. SCIENCE
- The Role of Hepcidin in Iron Metabolism
- (2009) Elizabeta Nemeth et al. ACTA HAEMATOLOGICA
- Erythropoiesis Stimulatory Agent- Resistant Anemia in Dialysis Patients: Review of Causes and Management
- (2009) Mehmet Kanbay et al. BLOOD PURIFICATION
- Intestinal Hypoxia-Inducible Transcription Factors Are Essential for Iron Absorption following Iron Deficiency
- (2009) Yatrik M. Shah et al. Cell Metabolism
- Arterial Hypertension Induced by Erythropoietin and Erythropoiesis-Stimulating Agents (ESA)
- (2009) R. Krapf et al. Clinical Journal of the American Society of Nephrology
- Erythrocytosis associated with a novel missense mutation in the HIF2A gene
- (2009) R. van Wijk et al. HAEMATOLOGICA
- Erythrocytosis-associated HIF-2α Mutations Demonstrate a Critical Role for Residues C-terminal to the Hydroxylacceptor Proline
- (2009) Paul W. Furlow et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- HIF-2α, but not HIF-1α, promotes iron absorption in mice
- (2009) Maria Mastrogiannaki et al. JOURNAL OF CLINICAL INVESTIGATION
- Plasma hepcidin levels are elevated but responsive to erythropoietin therapy in renal disease
- (2009) Damien R. Ashby et al. KIDNEY INTERNATIONAL
- Hypoxia-inducible factor-2α-expressing interstitial fibroblasts are the only renal cells that express erythropoietin under hypoxia-inducible factor stabilization
- (2009) Alexander Paliege et al. KIDNEY INTERNATIONAL
- A Trial of Darbepoetin Alfa in Type 2 Diabetes and Chronic Kidney Disease
- (2009) Marc A. Pfeffer et al. NEW ENGLAND JOURNAL OF MEDICINE
- Evidence for a Lack of a Direct Transcriptional Suppression of the Iron Regulatory Peptide Hepcidin by Hypoxia-Inducible Factors
- (2009) Melanie Volke et al. PLoS One
- Autosomal dominant erythrocytosis and pulmonary arterial hypertension associated with an activating HIF2 mutation
- (2008) D. P. Gale et al. BLOOD
- Salt-Sensitive Hypertension Induced by Decoy of Transcription Factor Hypoxia-Inducible Factor-1α in the Renal Medulla
- (2008) Ningjun Li et al. CIRCULATION RESEARCH
- A novel heterozygous HIF2AM535I mutation reinforces the role of oxygen sensing pathway disturbances in the pathogenesis of familial erythrocytosis
- (2008) M. Martini et al. HAEMATOLOGICA
- Abnormal Sympathoadrenal Development and Systemic Hypotension in PHD3-/- Mice
- (2008) T. Bishop et al. MOLECULAR AND CELLULAR BIOLOGY
- Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins
- (2007) K. Takeda et al. BLOOD
- Furin-mediated release of soluble hemojuvelin: a new link between hypoxia and iron homeostasis
- (2007) L. Silvestri et al. BLOOD
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search