Article
Pathology
Takao Kondo, Yuto Otsuka, Hiromasa Aoki, Yoh Goto, Yohei Kawaguchi, Yuko Waguri-Nagaya, Ken Miyazawa, Shigemi Goto, Mineyoshi Aoyama
Summary: The study revealed the significant role of inducible nitric oxide synthase (iNOS) in osteoclast (OC) differentiation under hypoxia, and nitric oxide plays a regulatory role in OC formation.
AMERICAN JOURNAL OF PATHOLOGY
(2021)
Article
Endocrinology & Metabolism
Hyo Jeong Kim, Ka-Young Ryu, Yong-Gun Kim, Myoung Ok Kim, Ji Hye Lee, Min-Kyoung Song, Young-Jin Youn, Nitin Kumar Pohkrel, Sung-Hyun Kim, Jae-Young Kim, Hye-Jin Jung, Woo-Shin Kim, Chang-Won Hong, Hong-Hee Kim, Youngkyun Lee
Summary: The study revealed the crucial role of PTP1B in osteoclast differentiation, with PTP1B deficiency leading to decreased osteoclast number and activity. This highlights the potential of PTP1B as a therapeutic target for bone-lytic diseases.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Cell Biology
YunJeong Choi, Soon Chul Heo, Yu Na Kim, Ji-Young Joo, Jae Joon Hwang, Moon-Kyoung Bae, Hyung Joon Kim
Summary: GRP modulates osteoclastogenesis by influencing the differentiation of bone marrow-derived cells, potentially contributing to the pathogenesis of periodontitis. Stimulation by P. gingivalis can enhance crosstalk between epithelial cells and bone marrow-derived cells, leading to increased osteoclast formation.
Article
Medicine, Research & Experimental
Biao Wu, Jie Shang, Shiyuan Lin, Ning Jiang, Baizhou Xing, Rong Peng, Xianghe Xu, Huading Lu
Summary: Increased bone resorption caused by excessive osteoclasts is the main cause of osteoporosis. The expression of RILP, a protein, is induced by receptor activator of NF-KB ligand, and its inhibition decreases the number and function of osteoclasts. Inhibition of RILP also reduces preosteoclast migration and bone resorption. The study suggests that RILP plays a crucial role in osteoclast formation and bone resorption, and could be a therapeutic target for bone diseases caused by excessive osteoclasts.
LABORATORY INVESTIGATION
(2023)
Review
Biochemistry & Molecular Biology
Wangli Huang, Yining Gong, Liang Yan
Summary: Endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) are triggered by the accumulation of unfolded and misfolded proteins. Recent studies have explored the role of ER stress and UPR in osteoclastogenesis and bone resorption. This review provides a detailed analysis of the UPR signaling cascade response, osteoclastogenesis-related signaling pathways, and the role of UPR in osteoclastogenesis and bone resorption.
Review
Cell Biology
Kazuki Inoue, Courtney Ng, Yuhan Xia, Baohong Zhao
Summary: The translation discusses the role of osteoclasts in bone development and remodeling, as well as the significance of epigenetic regulation and microRNAs in gene expression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jin-Young Lee, Da-Ae Kim, Eun-Young Kim, Eun-Ju Chang, So-Jeong Park, Beom-Jun Kim
Summary: Lumican inhibits osteoclastogenesis by suppressing Akt activity, leading to an osteoprotective role by simultaneously increasing bone formation and decreasing bone resorption, suggesting it represents a dual-action therapeutic target for osteoporosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell & Tissue Engineering
Xiankun Cao, Wenxin He, Kewei Rong, Shenggui Xu, Zhiqian Chen, Yuwei Liang, Shuai Han, Yifan Zhou, Xiao Yang, Hui Ma, An Qin, Jie Zhao
Summary: This study revealed that DZNep enhances osteoblast differentiation and mineralization through the EZH2-H3K27me3-Wnt4 axis, while also promotes osteoclast formation via the EZH2-H3K27me3-Foxc1 axis. This enhanced osteogenesis and osteoclastogenesis resulted in accelerated bone defect healing in mice.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Cell Biology
Liqing Zang, Kazuhiro Kagotani, Hiroko Nakayama, Jacky Bhagat, Yuki Fujimoto, Akihito Hayashi, Ryoji Sono, Hirotaka Katsuzaki, Norihiro Nishimura, Yasuhito Shimada
Summary: The study found that 10-gingerol can suppress osteoclastic activity in both in vitro and in vivo conditions, promoting normal bone regeneration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Jingshen Zhuang, Xuebing Chen, Guixing Cai, Dizheng Wu, Chen Tu, Siyuan Zhu, Yusheng Huang, Ping Xu, Zhaoming Zhong
Summary: Accumulation of AOPPs is associated with enhanced osteoclastogenesis and deterioration of bone microstructure in aged mice. In vitro experiments showed that AOPPs directly induce osteoclastogenesis by activating various signaling pathways, leading bone marrow monocytes to differentiate into mature osteoclasts.
CELL DEATH & DISEASE
(2021)
Article
Dentistry, Oral Surgery & Medicine
Bingdong Sui, Jin Liu, Chenxi Zheng, Lei Dang, Ji Chen, Yuan Cao, Kaichao Zhang, Lu Liu, Minyan Dang, Liqiang Zhang, Nan Chen, Tao He, Kun Xuan, Fang Jin, Ge Zhang, Yan Jin, Chenghu Hu
Summary: This study reveals the crucial role of sympathetic cues in regulating bone homeostasis and neurostress-induced bone loss. The research focuses on the impact of sympatho-adrenergic activation on osteoclastogenesis and identifies miR-21 as a key regulator in this process. Targeted inhibition of miR-21 or suppression of osteoclastogenesis using drugs can protect bone against stress-induced osteopenias.
INTERNATIONAL JOURNAL OF ORAL SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Chenhui Cai, Wenhui Hu, Ying Zhang, Xu Hu, Sizhen Yang, Hao Qiu, Rujie Wang, Min Ma, Yiyun Qiu, Tongwei Chu
Summary: BCI treatment attenuates osteoclast differentiation and alleviates osteoporosis by inhibiting STAT3 and NF-kappa B signaling pathways, suggesting a potential effective approach for treating osteoporosis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Hao Tian, Tao Jiang, Kai Yang, Ruonan Ning, Tianqi Wang, Qi Zhou, Niandong Qian, Ping Huang, Lei Guo, Min Jiang, Xiaobing Xi, Xing Xu, Lianfu Deng
Summary: This study found that alpha-asarone (ASA), a compound derived from the traditional Chinese medicinal herb Acorus tatarinowii, can inhibit the activity of overactivated osteoclasts and reduce bone resorption. ASA's effects on osteoclastogenesis are dose-dependent and mediated through multiple signaling pathways. In an estrogen-deficiency-induced osteoporosis model, ASA also improved bone microstructure.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Vinicius de Paiva Goncalves, Marta Liliana Musskopf, Angeliz Rivera-Concepcion, Christina Yu, Sing Wai Wong, Stephen A. Tuin, Yizu Jiao, Cristiano Susin, Luis Carlos Spolidorio, Patricia Almeida Miguez
Summary: This study showed that hesperidin impaired osteoclastogenesis in vitro, but high-dose dietary hesperidin increased osteoclast numbers and promoted inflammation-induced alveolar bone loss in vivo. However, hesperidin at a dose of 500 mg/kg exhibited a bone-sparing effect on skeletal bones under physiological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Yue Hu, Xinqing Hao, Cangwei Liu, Chunxia Ren, Shuangshuang Wang, Guangxing Yan, Yuan Meng, Yuji Mishina, Ce Shi, Hongchen Sun
Summary: The study showed that deletion of Acvr1 in the mandible leads to bone loss, mainly due to compromised osteoblast differentiation and enhanced osteoclastogenesis. In vitro experiments demonstrated that Acvr1 deficiency in mandibular bone marrow stromal cells resulted in increased proliferation and differentiation of osteoclasts. Additionally, the increased osteoclastogenesis may be partially attributed to the secretion of sRANKL.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Oncology
Philippa A. Hulley, Tammie Bishop, Aude Vernet, Jurgen E. Schneider, James R. Edwards, Nick A. Athanasou, Helen J. Knowles
JOURNAL OF PATHOLOGY
(2017)
Review
Endocrinology & Metabolism
Helen J. Knowles
FRONTIERS IN ENDOCRINOLOGY
(2017)
Article
Oncology
T. Zhang, A. Kastrenopoulou, Q. Larrouture, N. A. Athanasou, H. J. Knowles
Article
Oncology
Isabelle Messner, Giuseppe Cadeddu, Wolfgang Huckenbeck, Helen J. Knowles, Helmut E. Gabbert, Stephan E. Baldus, Karl-Ludwig Schaefer
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2013)
Article
Oncology
Karl J. Morten, Luned Badder, Helen J. Knowles
JOURNAL OF PATHOLOGY
(2013)
Article
Multidisciplinary Sciences
Catherine Swales, Nicholas A. Athanasou, Helen J. Knowles
Article
Multidisciplinary Sciences
Kao Chin Ngeow, Hans J. Friedrichsen, Linxin Li, Zhicliang Zeng, Sarah Andrews, Laurent Volpon, Hannah Brunsdon, Georgina Berridge, Sarah Picaud, Roman Fischer, Richard Lisle, Stefan Knapp, Panagis Filippakopoulos, Helen Knowles, Eirikur Steingrimsson, Katherine L. B. Borden, E. Elizabeth Patton, Colin R. Goding
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Cell Biology
R. C. Poulsen, H. J. Knowles, A. J. Carr, P. A. Hulley
CELL DEATH & DISEASE
(2014)
Article
Cell Biology
Helen J. Knowles
Article
Multidisciplinary Sciences
Sarah Gooding, Sam W. Z. Olechnowicz, Emma Morris, Andrew E. Armitage, Joao Arezes, Joe Frost, Emmanouela Repapi, James R. Edwards, Neil Ashley, Craig Waugh, Nicola Gray, Erik Martinez-Hackert, Pei Jin Lim, Sant-Rayn Pasricha, Helen Knowles, Adam J. Mead, Karthik Ramasamy, Hal Drakesmith, Claire M. Edwards
NATURE COMMUNICATIONS
(2019)
Article
Multidisciplinary Sciences
Helen J. Knowles
SCIENTIFIC REPORTS
(2020)
Article
Biochemistry & Molecular Biology
Lucia Cottone, Lorena Ligammari, Hang-Mao Lee, Helen J. Knowles, Stephen Henderson, Sara Bianco, Christopher Davies, Sandra Strauss, Fernanda Amary, Ana Paula Leite, Roberto Tirabosco, Kristian Haendler, Joachim L. Schultze, Javier Herrero, Paul O'Donnell, Agamemnon E. Grigoriadis, Paolo Salomoni, Adrienne M. Flanagan
Summary: Oncohistones provide compelling evidence for the role of epigenetic perturbations in cancer. Giant cell tumors of bone (GCTs) are characterized by a mutated histone H3.3 as the sole genetic driver in bone-forming osteoprogenitor cells. We show that the H3.3-G34W mutation leads to changes in the transcriptome and epigenome of mesenchymal cells, resulting in increased recruitment of osteoclasts. This mechanism helps explain the response of GCT to denosumab, a drug that depletes osteoclasts in the tumor.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Cell Biology
Philippa A. Hulley, Helen J. Knowles
Summary: This study presents a novel approach to differentiate primary human CD14+ monocyte-derived osteoclasts in 3D collagen gels. The method allows for the enrichment and study of differentiating subpopulations of osteoclasts, providing a new avenue for investigating molecular mechanisms of human osteoclasts.
Article
Endocrinology & Metabolism
Philippa A. Hulley, Ioanna Papadimitriou-Olivgeri, Helen J. Knowles
Article
Endocrinology & Metabolism
Helen J. Knowles
CALCIFIED TISSUE INTERNATIONAL
(2017)