SMOC1 is a glucose-responsive hepatokine and therapeutic target for glycemic control

The liver as an endocrine organ - linking NAFLD and insulin resistance

(2019) Matthew J Watt et al.   ENDOCRINE REVIEWS

Genistein represses PEPCK-C expression in an insulin-independent manner in HepG2 cells and in alloxan-induced diabetic mice

(2017) Barilin Dkhar et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Regulation of hepatic glucose metabolism in health and disease

(2017) Max C. Petersen et al.   Nature Reviews Endocrinology

GCN5L1 modulates cross-talk between mitochondria and cell signaling to regulate FoxO1 stability and gluconeogenesis

(2017) Lingdi Wang et al.   Nature Communications

A Specific ChREBP and PPARα Cross-Talk Is Required for the Glucose-Mediated FGF21 Response

(2017) Alison Iroz et al.   Cell Reports

Type I neuregulin1α is a novel local mediator to suppress hepatic gluconeogenesis in mice

(2017) Takatomo Arai et al.   Scientific Reports

Perilipin 5 is dispensable for normal substrate metabolism and in the adaptation of skeletal muscle to exercise training

(2016) Ruzaidi A. M. Mohktar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Glucagon: acute actions on hepatic metabolism

(2016) Russell A. Miller et al.   DIABETOLOGIA

Targeting cAMP/PKA pathway for glycemic control and type 2 diabetes therapy

(2016) Haihua Yang et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

The Perseus computational platform for comprehensive analysis of (prote)omics data

(2016) Stefka Tyanova et al.   NATURE METHODS

Targeting hepatic glucose metabolism in the treatment of type 2 diabetes

(2016) Amy K. Rines et al.   NATURE REVIEWS DRUG DISCOVERY

Overexpression of sphingosine kinase 1 in liver reduces triglyceride content in mice fed a low but not high-fat diet

(2015) Greg M. Kowalski et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Role of secreted modular calcium-binding protein 1 (SMOC1) in transforming growth factor β signalling and angiogenesis

(2015) Khader Awwad et al.   CARDIOVASCULAR RESEARCH

Fetuin B Is a Secreted Hepatocyte Factor Linking Steatosis to Impaired Glucose Metabolism

(2015) Ruth C. Meex et al.   Cell Metabolism

Evaluation of Efficacy and Safety of the Glucagon Receptor Antagonist LY2409021 in Patients With Type 2 Diabetes: 12- and 24-Week Phase 2 Studies

(2015) Christof M. Kazda et al.   DIABETES CARE

Glucagon Receptor Blockade With a Human Antibody Normalizes Blood Glucose in Diabetic Mice and Monkeys

(2015) Haruka Okamoto et al.   ENDOCRINOLOGY

Phenotypic Characterization of Insulin-Resistant and Insulin-Sensitive Obesity

(2015) D. L. Chen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Identification of a Potent Inhibitor of CREB-Mediated Gene Transcription with Efficacious in Vivo Anticancer Activity

(2015) Fuchun Xie et al.   JOURNAL OF MEDICINAL CHEMISTRY

CREB phosphorylation at Ser133regulates transcription via distinct mechanisms downstream of cAMP and MAPK signalling

(2014) Shaista Naqvi et al.   BIOCHEMICAL JOURNAL

Hypothalamic Neurogenesis Is Not Required for the Improved Insulin Sensitivity Following Exercise Training

(2014) Melissa L. Borg et al.   DIABETES

PLIN5 deletion remodels intracellular lipid composition and causes insulin resistance in muscle

(2014) Rachael R. Mason et al.   Molecular Metabolism

A miniaturized assay for measuring small molecule phosphorylation in the presence of complex matrices

(2013) Christina Spry et al.   ANALYTICAL BIOCHEMISTRY

Lysosomal acid lipase and lipophagy are constitutive negative regulators of glucose-stimulated insulin secretion from pancreatic beta cells

(2013) Gemma L. Pearson et al.   DIABETOLOGIA

Mouse strain-dependent variation in obesity and glucose homeostasis in response to high-fat feeding

(2013) M. K. Montgomery et al.   DIABETOLOGIA

The Heparin-Binding Activity of Secreted Modular Calcium-Binding Protein 1 (SMOC-1) Modulates Its Cell Adhesion Properties

(2013) Marina Klemenčič et al.   PLoS One

Liver-Specific Disruption of the Murine Glucagon Receptor Produces  -Cell Hyperplasia: Evidence for a Circulating  -Cell Growth Factor

(2012) C. Longuet et al.   DIABETES

Glucagonocentric restructuring of diabetes: a pathophysiologic and therapeutic makeover

(2012) Roger H. Unger et al.   JOURNAL OF CLINICAL INVESTIGATION

Protection from Obesity and Diabetes by Blockade of TGF-β/Smad3 Signaling

(2011) Hariom Yadav et al.   Cell Metabolism

Upregulation of CREB-Mediated Transcription Enhances Both Short- and Long-Term Memory

(2011) A. Suzuki et al.   JOURNAL OF NEUROSCIENCE

CREB and the CRTC co-activators: sensors for hormonal and metabolic signals

(2011) Judith Y. Altarejos et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Secretome Analysis of Human BMSCs and Identification of SMOC1 as an Important ECM Protein in Osteoblast Differentiation

(2010) Young-Ae Choi et al.   JOURNAL OF PROTEOME RESEARCH

Prevention of Hepatic Steatosis and Hepatic Insulin Resistance by Knockdown of cAMP Response Element-Binding Protein

(2009) Derek M. Erion et al.   Cell Metabolism

Fully Human Monoclonal Antibodies Antagonizing the Glucagon Receptor Improve Glucose Homeostasis in Mice and Monkeys

(2009) H. Yan et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Nitric Oxide Inhibits Glomerular TGF-  Signaling via SMOC-1

(2009) E. Dreieicher et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY

Recombinant human SMOCs produced by in vitro refolding: Calcium-binding properties and interactions with serum proteins

(2008) Marko Novinec et al.   PROTEIN EXPRESSION AND PURIFICATION