Cryo-EM structures reveal distinct mechanisms of inhibition of the human multidrug transporter ABCB1

Structural insight into substrate and inhibitor discrimination by human P-glycoprotein

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Software tools for automated transmission electron microscopy

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Mechanism of allosteric modulation of P-glycoprotein by transport substrates and inhibitors

(2019) Reza Dastvan et al.   SCIENCE

Large-scale purification of functional human P-glycoprotein (ABCB1)

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ATP-dependent thermostabilization of human P-glycoprotein (ABCB1) is blocked by modulators

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Vinca alkaloids and analogues as anti-cancer agents: Looking back, peering ahead

(2018) Emanuela Martino et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structural basis of small-molecule inhibition of human multidrug transporter ABCG2

(2018) Scott M. Jackson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of a zosuquidar and UIC2-bound human-mouse chimeric ABCB1

(2018) Amer Alam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular structure of human P-glycoprotein in the ATP-bound, outward-facing conformation

(2018) Youngjin Kim et al.   SCIENCE

Structural basis of small-molecule inhibition of human multidrug transporter ABCG2

(2018) Scott M. Jackson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A novel source of arterial valve cells linked to bicuspid aortic valve without raphe in mice

(2018) Lorriane Eley et al.   eLife

Evidence for the critical role of transmembrane helices 1 and 7 in substrate transport by human P-glycoprotein (ABCB1)

(2018) Andaleeb Sajid et al.   PLoS One

Mapping discontinuous epitopes for MRK-16, UIC2 and 4E3 antibodies to extracellular loops 1 and 4 of human P-glycoprotein

(2018) Shahrooz Vahedi et al.   Scientific Reports

Double-sides sticking mechanism of vinblastine interacting with α,β-tubulin to get activity against cancer cells

(2018) Xiaowen Zhou et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Cryo-EM structures of a human ABCG2 mutant trapped in ATP-bound and substrate-bound states

(2018) Ioannis Manolaridis et al.   NATURE

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

Sensitivity of docetaxel-resistant MCF-7 breast cancer cells to microtubule-destabilizing agents including vinca alkaloids and colchicine-site binding agents

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MolProbity: More and better reference data for improved all-atom structure validation

(2017) Christopher J. Williams et al.   PROTEIN SCIENCE

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

Mechanistic diversity in ATP-binding cassette (ABC) transporters

(2016) Kaspar P Locher   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanistic diversity in ATP-binding cassette (ABC) transporters

(2016) Kaspar P Locher   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural Basis of Microtubule Destabilization by Potent Auristatin Anti-Mitotics

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Providing a molecular mechanism for P-glycoprotein; why would I bother?

(2015) R. Callaghan   BIOCHEMICAL SOCIETY TRANSACTIONS

Snapshots of ligand entry, malleable binding and induced helical movement in P-glycoprotein

(2015) Paul Szewczyk et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The central cavity of ABCB1 undergoes alternating access during ATP hydrolysis

(2014) Jessica H. van Wonderen et al.   FEBS Journal

Structural basis for gating mechanisms of a eukaryotic P-glycoprotein homolog

(2014) A. Kodan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complex Interplay between the P-Glycoprotein Multidrug Efflux Pump and the Membrane: Its Role in Modulating Protein Function

(2014) Frances Jane Sharom   Frontiers in Oncology

Improving the stability and function of purified ABCB1 and ABCA4: The influence of membrane lipids

(2013) Naomi L. Pollock et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Multiple Transport-Active Binding Sites Are Available for a Single Substrate on Human P-Glycoprotein (ABCB1)

(2013) Eduardo E. Chufan et al.   PLoS One

Crystal structure of the multidrug transporter P-glycoprotein from Caenorhabditis elegans

(2012) Mi Sun Jin et al.   NATURE

Structure of AMP-PNP-bound vitamin B12 transporter BtuCD–F

(2012) Vladimir M. Korkhov et al.   NATURE

Conformational Analysis of Human ATP-binding Cassette Transporter ABCB1 in Lipid Nanodiscs and Inhibition by the Antibodies MRK16 and UIC2

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LigPlot+: Multiple Ligand–Protein Interaction Diagrams for Drug Discovery

(2011) Roman A. Laskowski et al.   Journal of Chemical Information and Modeling

Ixabepilone, a Novel Microtubule-Targeting Agent for Breast Cancer, Is a Substrate for P-Glycoprotein (P-gp/MDR1/ABCB1) but not Breast Cancer Resistance Protein (BCRP/ABCG2)

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Features and development ofCoot

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PHENIX: a comprehensive Python-based system for macromolecular structure solution

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Zosuquidar, a novel modulator of P-glycoprotein, does not improve the outcome of older patients with newly diagnosed acute myeloid leukemia: a randomized, placebo-controlled trial of the Eastern Cooperative Oncology Group 3999

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Transmembrane helix 12 plays a pivotal role in coupling energy provision and drug binding in ABCB1

(2010) Emily Crowley et al.   FEBS Journal

Membrane transporters in drug development

(2010)   NATURE REVIEWS DRUG DISCOVERY

electronic Ligand Builder and Optimization Workbench(eLBOW): a tool for ligand coordinate and restraint generation

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Transmembrane Helix 12 Modulates Progression of the ATP Catalytic Cycle in ABCB1

(2009) Emily Crowley et al.   BIOCHEMISTRY

Structure of a multidrug transporter

(2009) Michael M Gottesman et al.   NATURE BIOTECHNOLOGY

Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding

(2009) S. G. Aller et al.   SCIENCE

Membrane reconstitution of ABC transporters and assays of translocator function

(2008) Eric R Geertsma et al.   Nature Protocols