Structural basis of small-molecule inhibition of human multidrug transporter ABCG2

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

(2017) Ali Punjani et al.   NATURE METHODS

High-content screening of clinically tested anticancer drugs identifies novel inhibitors of human MRP1 (ABCC1)

(2017) Brian G. Peterson et al.   PHARMACOLOGICAL RESEARCH

Localization of the placental BCRP/ ABCG2 transporter to lipid rafts: Role for cholesterol in mediating efflux activity

(2017) John T. Szilagyi et al.   PLACENTA

The structure of the human ABC transporter ABCG2 reveals a novel mechanism for drug extrusion

(2017) Narakorn Khunweeraphong et al.   Scientific Reports

Blood-Brain Barrier and Breast Cancer Resistance Protein: A Limit to the Therapy of CNS Tumors and Neurodegenerative Diseases

(2016) Anna Lisa Iorio et al.   Anti-Cancer Agents in Medicinal Chemistry

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

Crystal structure of the human sterol transporter ABCG5/ABCG8

(2016) Jyh-Yeuan Lee et al.   NATURE

Jump into a New Fold—A Homology Based Model for the ABCG2/BCRP Multidrug Transporter

(2016) Laura László et al.   PLoS One

Accelerated cryo-EM structure determination with parallelisation using GPUs in RELION-2

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Identification of residues in ABCG2 affecting protein trafficking and drug transport, using co-evolutionary analysis of ABCG sequences

(2015) A. J. Haider et al.   BIOSCIENCE REPORTS

The linker region of breast cancer resistance protein ABCG2 is critical for coupling of ATP-dependent drug transport

(2015) S. Macalou et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

HM30181 Derivatives as Novel Potent and Selective Inhibitors of the Breast Cancer Resistance Protein (BCRP/ABCG2)

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Role of the Breast Cancer Resistance Protein (BCRP/ABCG2) in Drug Transport—an Update

(2014) Qingcheng Mao et al.   AAPS Journal

Quinoline Carboxamide-Type ABCG2 Modulators: Indole and Quinoline Moieties as Anilide Replacements

(2013) Stefanie Bauer et al.   ChemMedChem

Quantifying the local resolution of cryo-EM density maps

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Benzanilide–Biphenyl Replacement: A Bioisosteric Approach to Quinoline Carboxamide-Type ABCG2 Modulators

(2013) Cristian Ochoa-Puentes et al.   ACS Medicinal Chemistry Letters

Identification of Proline Residues in or near the Transmembrane Helices of the Human Breast Cancer Resistance Protein (BCRP/ABCG2) That Are Important for Transport Activity and Substrate Specificity

(2011) Zhanglin Ni et al.   BIOCHEMISTRY

Solid phase synthesis of tariquidar-related modulators of ABC transporters preferring breast cancer resistance protein (ABCG2)

(2011) Cristian Ochoa Puentes et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Advances in the Molecular Detection of ABC Transporters Involved in Multidrug Resistance in Cancer

(2011) Jean-Pierre Gillet et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

The P-glycoprotein multidrug transporter

(2011) Frances J. Sharom   Essays in Biochemistry

The “Specific” P-Glycoprotein Inhibitor Tariquidar Is Also a Substrate and an Inhibitor for Breast Cancer Resistance Protein (BCRP/ABCG2)

(2010) Pavitra Kannan et al.   ACS Chemical Neuroscience

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PHENIX: a comprehensive Python-based system for macromolecular structure solution

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Transmembrane helices 1 and 6 of the human breast cancer resistance protein (BCRP/ABCG2): identification of polar residues important for drug transport

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Specific Inhibitors of the Breast Cancer Resistance Protein (BCRP)

(2010) Anne Pick et al.   ChemMedChem

Structure and Function of the Human Breast Cancer Resistance Protein (BCRP/ABCG2)

(2010) Zhanglin Ni et al.   CURRENT DRUG METABOLISM

Protein-binding assays in biological liquids using microscale thermophoresis

(2010) Christoph J. Wienken et al.   Nature Communications

electronic Ligand Builder and Optimization Workbench(eLBOW): a tool for ligand coordinate and restraint generation

(2009) Nigel W. Moriarty et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Potent and Selective Inhibitors of Breast Cancer Resistance Protein (ABCG2) Derived from thep-Glycoprotein (ABCB1) Modulator Tariquidar

(2009) Matthias Kühnle et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding

(2009) S. G. Aller et al.   SCIENCE

Physiological and pharmacological roles of ABCG2 (BCRP): Recent findings in Abcg2 knockout mice

(2008) Maria L.H. Vlaming et al.   ADVANCED DRUG DELIVERY REVIEWS

ABCG2: A perspective

(2008) Robert W. Robey et al.   ADVANCED DRUG DELIVERY REVIEWS

Effect of Cysteine Mutagenesis on the Function and Disulfide Bond Formation of Human ABCG2

(2008) Y. Liu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Membrane reconstitution of ABC transporters and assays of translocator function

(2008) Eric R Geertsma et al.   Nature Protocols

Major SNP (Q141K) Variant of Human ABC Transporter ABCG2 Undergoes Lysosomal and Proteasomal Degradations

(2008) Tomoka Furukawa et al.   PHARMACEUTICAL RESEARCH

The multidrug transporter ABCG2 (BCRP) is inhibited by plant-derived cannabinoids

(2007) M L Holland et al.   BRITISH JOURNAL OF PHARMACOLOGY

A Functional Steroid-Binding Element in an ATP-Binding Cassette Multidrug Transporter

(2007) S. Velamakanni et al.   MOLECULAR PHARMACOLOGY