DNA Double-Strand Break Accumulation in Alzheimer’s Disease: Evidence from Experimental Models and Postmortem Human Brains

Motor neuron disease-associated loss of nuclear TDP-43 is linked to DNA double-strand break repair defects

(2019) Joy Mitra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Early neuronal accumulation of DNA double strand breaks in Alzheimer’s disease

(2019) Niraj M. Shanbhag et al.   Acta Neuropathologica Communications

Gnal haploinsufficiency causes genomic instability and increased sensitivity to haloperidol

(2019) Mohammad Moshahid Khan et al.   EXPERIMENTAL NEUROLOGY

Aging Neurovascular Unit and Potential Role of DNA Damage and Repair in Combating Vascular and Neurodegenerative Disorders

(2019) Yan Li et al.   Frontiers in Neuroscience

DNA double-strand breaks: a potential therapeutic target for neurodegenerative diseases

(2019) Nidheesh Thadathil et al.   CHROMOSOME RESEARCH

Oxidative DNA damage is concurrently repaired by base excision repair (BER) and apyrimidinic endonuclease 1 (APE1)‐initiated nonhomologous end joining (NHEJ) in cortical neurons

(2019) J.‐L. Yang et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

DNA damage-associated oligodendrocyte degeneration precedes amyloid pathology and contributes to Alzheimer's disease and dementia

(2018) Kai-Hei Tse et al.   Alzheimers & Dementia

A recurrent de novo missense mutation in UBTF causes developmental neuroregression

(2018) Camilo Toro et al.   HUMAN MOLECULAR GENETICS

DNA Damage Response and Repair, DNA Methylation, and Cell Death in Human Neurons and Experimental Animal Neurons Are Different

(2018) Lee J Martin et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

DNA damage and neurodegenerative phenotypes in aged Ciz1 null mice

(2018) Mohammad Moshahid Khan et al.   NEUROBIOLOGY OF AGING

Histone H2AX deficiency causes neurobehavioral deficits and impaired redox homeostasis

(2018) Urbain Weyemi et al.   Nature Communications

Altered DNA repair; an early pathogenic pathway in Alzheimer’s disease and obesity

(2018) Hao Yu et al.   Scientific Reports

Alzheimer’s disease hypothesis and related therapies

(2018) Xiaoguang Du et al.   Translational Neurodegeneration

DNA double-strand breaks as drivers of neural genomic change, function, and disease

(2018) Frederick W. Alt et al.   DNA REPAIR

Consequences of Cre-mediated deletion of Ciz1 exon 5 in mice

(2018) Jianfeng Xiao et al.   FEBS LETTERS

Somatic APP gene recombination in Alzheimer’s disease and normal neurons

(2018) Ming-Hsiang Lee et al.   NATURE

The DNA Damage Response in Neurons: Die by Apoptosis or Survive in a Senescence-Like State?

(2017) Edward Fielder et al.   JOURNAL OF ALZHEIMERS DISEASE

DNA damage in the oligodendrocyte lineage and its role in brain aging

(2017) Kai-Hei Tse et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Genome instability in Alzheimer disease

(2017) Yujun Hou et al.   MECHANISMS OF AGEING AND DEVELOPMENT

DNA damage and neurodegeneration: the unusual suspect

(2017) Debra Toiber et al.   Neural Regeneration Research

A damaged genome’s transcriptional landscape through multilayered expression profiling around in situ-mapped DNA double-strand breaks

(2017) Fabio Iannelli et al.   Nature Communications

DNA Double Strand Breaks: A Common Theme in Neurodegenerative Diseases

(2016) Daniela Merlo et al.   Current Alzheimer Research

A unifying mechanism in neurodegeneration

(2016) Christopher A. Ross et al.   NATURE

Oxidative stress at low levels can induce clustered DNA lesions leading to NHEJ mediated mutations

(2016) Vyom Sharma et al.   Oncotarget

Altered DNA base excision repair profile in brain tissue and blood in Alzheimer’s disease

(2016) Meryl S. Lillenes et al.   Molecular Brain

The Vitamin A Derivative All-Trans Retinoic Acid Repairs Amyloid-β-Induced Double-Strand Breaks in Neural Cells and in the Murine Neocortex

(2016) Emmanuelle Gruz-Gibelli et al.   NEURAL PLASTICITY

DNA Damage Response and Immune Defense: Links and Mechanisms

(2016) Rania Nakad et al.   Frontiers in Genetics

Activity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes

(2015) Ram Madabhushi et al.   CELL

DNA Damage Responses: Beyond Double-Strand Break Repair

(2015) Andrea L. Bredemeyer et al.   CURRENT BIOLOGY

Transcriptional Elongation Factor ENL Phosphorylated by ATM Recruits Polycomb and Switches Off Transcription for DSB Repair

(2015) Ayako Ui et al.   MOLECULAR CELL

The Ubiquitin-Proteasome System and Molecular Chaperone Deregulation in Alzheimer’s Disease

(2015) Yanuar Alan Sulistio et al.   MOLECULAR NEUROBIOLOGY

γH2AX Assay as DNA Damage Biomarker for Human Population Studies: Defining Experimental Conditions

(2015) María Sánchez-Flores et al.   TOXICOLOGICAL SCIENCES

DNA repair factor BRCA1 depletion occurs in Alzheimer brains and impairs cognitive function in mice

(2015) Elsa Suberbielle et al.   Nature Communications

DNA Damage, DNA Repair, Aging, and Neurodegeneration

(2015) Scott Maynard et al.   Cold Spring Harbor Perspectives in Medicine

DNA polymerase β deficiency leads to neurodegeneration and exacerbates Alzheimer disease phenotypes

(2015) Peter Sykora et al.   NUCLEIC ACIDS RESEARCH

Chromatin Regulation of DNA Damage Repair and Genome Integrity in the Central Nervous System

(2014) Ling Pan et al.   JOURNAL OF MOLECULAR BIOLOGY

DNA Damage and Its Links to Neurodegeneration

(2014) Ram Madabhushi et al.   NEURON

Suppression of glia maturation factor expression prevents 1-methyl-4-phenylpyridinium (MPP+)-induced loss of mesencephalic dopaminergic neurons

(2014) M.M. Khan et al.   NEUROSCIENCE

DNA repair mechanisms in dividing and non-dividing cells

(2013) Teruaki Iyama et al.   DNA REPAIR

γH2AX as a marker of DNA double strand breaks and genomic instability in human population studies

(2013) Vanessa Valdiglesias et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-β

(2013) Elsa Suberbielle et al.   NATURE NEUROSCIENCE

Double-strand break repair: 53BP1 comes into focus

(2013) Stephanie Panier et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

DNA Repair Genes in Parkinson's Disease

(2012) Mehmet Gencer et al.   Genetic Testing and Molecular Biomarkers

Terminally differentiated astrocytes lack DNA damage response signaling and are radioresistant but retain DNA repair proficiency

(2011) L Schneider et al.   CELL DEATH AND DIFFERENTIATION

Accelerated Age-Related Cognitive Decline and Neurodegeneration, Caused by Deficient DNA Repair

(2011) N. Z. Borgesius et al.   JOURNAL OF NEUROSCIENCE

DNA repair deficiency in neurodegeneration

(2011) Dennis Kjølhede Jeppesen et al.   PROGRESS IN NEUROBIOLOGY

The MRN complex in double-strand break repair and telomere maintenance

(2010) Brandon J. Lamarche et al.   FEBS LETTERS

γH2AX: a sensitive molecular marker of DNA damage and repair

(2010) L-J Mah et al.   LEUKEMIA

DNA Damage and Repair in Alzheimers Disease

(2009) Fabio Coppede et al.   Current Alzheimer Research

Expression and Polymorphisms of Gene 8-Oxoguanine Glycosylase 1 and the Level of Oxidative DNA Damage in Peripheral Blood Lymphocytes of Patients with Alzheimer's Disease

(2009) Jolanta Dorszewska et al.   DNA AND CELL BIOLOGY

Evidence of DNA damage in Alzheimer disease: phosphorylation of histone H2AX in astrocytes

(2008) Na-Hye Myung et al.   AGE

The ubiquitin-proteasome system in Alzheimer's disease

(2008) Salvatore Oddo   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility

(2008) Nadya Dimitrova et al.   NATURE

 -H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin

(2008) A. Kinner et al.   NUCLEIC ACIDS RESEARCH

The γ-H2A.X: Is it just a surrogate marker of double-strand breaks or much more?

(2007) Ismail Hassan Ismail et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS