The role of the mTOR pathway in models of drug-induced reward and the behavioural constituents of addiction

A specific prelimbic-nucleus accumbens pathway controls resilience versus vulnerability to food addiction

(2020) Laura Domingo-Rodriguez et al.   Nature Communications

The transition to compulsion in addiction

(2020) Christian Lüscher et al.   NATURE REVIEWS NEUROSCIENCE

mTORC1 pathway is involved in the kappa opioid receptor activation-induced increase in excessive alcohol drinking in mice

(2020) Yan Zhou et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Quantitative Systems Pharmacological Analysis of Drugs of Abuse Reveals the Pleiotropy of Their Targets and the Effector Role of mTORC1

(2019) Fen Pei et al.   Frontiers in Pharmacology

Morphine self-administration alters the expression of translational machinery genes in the amygdala of male Lewis rats

(2019) Marcos Ucha et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Activation of GSK 3β induced by recall of cocaine reward memories is dependent on GluN2A/B NMDA receptor signaling

(2019) Xiangdang Shi et al.   JOURNAL OF NEUROCHEMISTRY

Proteomic Profile of a Chronic Binge Ethanol Exposure Model

(2019) Phillip Starski et al.   JOURNAL OF PROTEOME RESEARCH

Protein Translation and Psychiatric Disorders

(2019) Sophie Laguesse et al.   NEUROSCIENTIST

Role of accumbal GSK3β in drug reward, aversion, and place memory

(2019) Xiangdang Shi et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Ventral pallidum is essential for cocaine relapse after voluntary abstinence in rats

(2019) Mitchell R. Farrell et al.   NEUROPSYCHOPHARMACOLOGY

Comparison of Methods for Differential Co-expression Analysis for Disease Biomarker Prediction

(2019) Tulika Kakati et al.   COMPUTERS IN BIOLOGY AND MEDICINE

Glycogen Synthase Kinase 3β in the Ventral Hippocampus is Important for Cocaine Reward and Object Location Memory

(2019) Jeffrey L. Barr et al.   NEUROSCIENCE

mTORC1 in the orbitofrontal cortex promotes habitual alcohol seeking

(2019) Nadege Morisot et al.   eLife

Mammalian target of rapamycin complex 1 and its downstream effector collapsin response mediator protein-2 drive reinstatement of alcohol reward seeking

(2018) Sami Ben Hamida et al.   ADDICTION BIOLOGY

A Model of Δ 9 -Tetrahydrocannabinol Self-administration and Reinstatement That Alters Synaptic Plasticity in Nucleus Accumbens

(2018) Sade Spencer et al.   BIOLOGICAL PSYCHIATRY

Protein Translation in the Nucleus Accumbens Is Dysregulated during Cocaine Withdrawal and Required for Expression of Incubation of Cocaine Craving

(2018) Craig T. Werner et al.   JOURNAL OF NEUROSCIENCE

mTORC2, but not mTORC1, is required for hippocampal mGluR-LTD and associated behaviors

(2018) Ping Jun Zhu et al.   NATURE NEUROSCIENCE

mTORC2 in the dorsomedial striatum of mice contributes to alcohol-dependent F-Actin polymerization, structural modifications, and consumption

(2018) Sophie Laguesse et al.   NEUROPSYCHOPHARMACOLOGY

Opiate-associated contextual memory formation and retrieval are differentially modulated by dopamine D1 and D2 signaling in hippocampal–prefrontal connectivity

(2018) Yunpeng Wang et al.   NEUROPSYCHOPHARMACOLOGY

Addictive behaviour in experimental animals: prospects for translation

(2018) Barry J. Everitt et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

mTOR signaling in the nucleus accumbens mediates behavioral sensitization to methamphetamine

(2018) Shin-Han Huang et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

PI3K activation within ventromedial prefrontal cortex regulates the expression of drug-seeking in two rodent species

(2018) Karen K. Szumlinski et al.   ADDICTION BIOLOGY

Prosapip1-Dependent Synaptic Adaptations in the Nucleus Accumbens Drive Alcohol Intake, Seeking, and Reward

(2017) Sophie Laguesse et al.   NEURON

Glycogen synthase kinase 3 beta alters anxiety-, depression-, and addiction-related behaviors and neuronal activity in the nucleus accumbens shell

(2017) Elizabeth J. Crofton et al.   NEUROPHARMACOLOGY

Gene expression profiling in the human alcoholic brain

(2017) Anna S. Warden et al.   NEUROPHARMACOLOGY

VTA mTOR Signaling Regulates Dopamine Dynamics, Cocaine-Induced Synaptic Alterations, and Reward

(2017) Xiaojie Liu et al.   NEUROPSYCHOPHARMACOLOGY

SAMTOR is anS-adenosylmethionine sensor for the mTORC1 pathway

(2017) Xin Gu et al.   SCIENCE

Region specific activation of the AKT and mTORC1 pathway in response to excessive alcohol intake in rodents

(2016) Sophie Laguesse et al.   ADDICTION BIOLOGY

How Preclinical Models Evolved to Resemble the Diagnostic Criteria of Drug Addiction

(2016) Aude Belin-Rauscent et al.   BIOLOGICAL PSYCHIATRY

The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway

(2016) Lynne Chantranupong et al.   CELL

Rapamycin reduces motivated responding for cocaine and alters GluA1 expression in the ventral but not dorsal striatum

(2016) Morgan H. James et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cannabidiol Counteracts Amphetamine-Induced Neuronal and Behavioral Sensitization of the Mesolimbic Dopamine Pathway through a Novel mTOR/p70S6 Kinase Signaling Pathway

(2016) Justine Renard et al.   JOURNAL OF NEUROSCIENCE

The First Alcohol Drink Triggers mTORC1-Dependent Synaptic Plasticity in Nucleus Accumbens Dopamine D1 Receptor Neurons

(2016) J. T. Beckley et al.   JOURNAL OF NEUROSCIENCE

mTORC1-dependent translation of collapsin response mediator protein-2 drives neuroadaptations underlying excessive alcohol-drinking behaviors

(2016) F Liu et al.   MOLECULAR PSYCHIATRY

Mechanism of arginine sensing by CASTOR1 upstream of mTORC1

(2016) Robert A. Saxton et al.   NATURE

The CB1 cannabinoid receptor signals striatal neuroprotection via a PI3K/Akt/mTORC1/BDNF pathway

(2015) C Blázquez et al.   CELL DEATH AND DIFFERENTIATION

Modulation of mTOR Activity byμ-Opioid Receptor is Dependent upon the Association of Receptor and FK506-Binding Protein 12

(2015) Yan Wang et al.   CNS Neuroscience & Therapeutics

Memory Retrieval Requires Ongoing Protein Synthesis and NMDA Receptor Activity-Mediated AMPA Receptor Trafficking

(2015) J. Lopez et al.   JOURNAL OF NEUROSCIENCE

mTORC2/Rictor Signaling Disrupts Dopamine-Dependent Behaviors via Defects in Striatal Dopamine Neurotransmission

(2015) O. I. Dadalko et al.   JOURNAL OF NEUROSCIENCE

SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1

(2015) Manuele Rebsamen et al.   NATURE

Differential requirement of F-actin and microtubule cytoskeleton in cue-induced local protein synthesis in axonal growth cones

(2015) Michael Piper et al.   Neural Development

Epigenetic and Proteomic Expression Changes Promoted by Eating Addictive-Like Behavior

(2015) Samantha Mancino et al.   NEUROPSYCHOPHARMACOLOGY

Glycogen synthase kinase-3 (GSK3): Regulation, actions, and diseases

(2015) Eleonore Beurel et al.   PHARMACOLOGY & THERAPEUTICS

Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1

(2015) S. Wang et al.   SCIENCE

Differential regulation of mTORC1 by leucine and glutamine

(2015) J. L. Jewell et al.   SCIENCE

PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex

(2015) P. Liu et al.   Cancer Discovery

A Positive Feedback Loop between Akt and mTORC2 via SIN1 Phosphorylation

(2015) Guang Yang et al.   Cell Reports

Frequency of alcohol consumption in humans; the role of metabotropic glutamate receptors and downstream signaling pathways

(2015) J L Meyers et al.   Translational Psychiatry

The dopamine D2/D3 receptor agonist quinpirole increases checking-like behaviour in an operant observing response task with uncertain reinforcement: A novel possible model of OCD

(2014) Dawn M. Eagle et al.   BEHAVIOURAL BRAIN RESEARCH

Pivotal Role of mTORC2 and Involvement of Ribosomal Protein S6 in Cardioprotective Signaling

(2014) Toshiyuki Yano et al.   CIRCULATION RESEARCH

The mammalian target of rapamycin pathway in the basolateral amygdala is critical for nicotine-induced behavioural sensitization

(2014) Yang Gao et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Opioid receptor–triggered spinal mTORC1 activation contributes to morphine tolerance and hyperalgesia

(2014) Ji-Tian Xu et al.   JOURNAL OF CLINICAL INVESTIGATION

mTOR complex 1: a key player in neuroadaptations induced by drugs of abuse

(2014) Jeremie Neasta et al.   JOURNAL OF NEUROCHEMISTRY

A Protein Synthesis-Dependent Mechanism Sustains Calcium-Permeable AMPA Receptor Transmission in Nucleus Accumbens Synapses during Withdrawal from Cocaine Self-Administration

(2014) A. F. Scheyer et al.   JOURNAL OF NEUROSCIENCE

Designer receptors show role for ventral pallidum input to ventral tegmental area in cocaine seeking

(2014) Stephen V Mahler et al.   NATURE NEUROSCIENCE

High Locomotor Reactivity to Novelty Is Associated with an Increased Propensity to Choose Saccharin Over Cocaine: New Insights into the Vulnerability to Addiction

(2014) Nathalie Vanhille et al.   NEUROPSYCHOPHARMACOLOGY

mTORC1 Inhibition in the Nucleus Accumbens ‘Protects’ Against the Expression of Drug Seeking and ‘Relapse’ and Is Associated with Reductions in GluA1 AMPAR and CAMKIIα Levels

(2014) Morgan H James et al.   NEUROPSYCHOPHARMACOLOGY

CRMP2

(2014) Jacque P.K. Ip et al.   NEUROSCIENTIST

The GSK3 Signaling Pathway Is Activated by Cocaine and Is Critical for Cocaine Conditioned Reward in Mice

(2014) Jonathan S. Miller et al.   PLoS One

Self-Administration of Ethanol, Cocaine, or Nicotine Does Not Decrease the Soma Size of Ventral Tegmental Area Dopamine Neurons

(2014) Michelle S. Mazei-Robison et al.   PLoS One

Reactivation of cocaine reward memory engages the Akt/GSK3/mTOR signaling pathway and can be disrupted by GSK3 inhibition

(2014) Xiangdang Shi et al.   PSYCHOPHARMACOLOGY

Methamphetamine induces autophagy as a pro-survival response against apoptotic endothelial cell death through the Kappa opioid receptor

(2014) J Ma et al.   Cell Death & Disease

The Sestrins Interact with GATOR2 to Negatively Regulate the Amino-Acid-Sensing Pathway Upstream of mTORC1

(2014) Lynne Chantranupong et al.   Cell Reports

Sestrins Inhibit mTORC1 Kinase Activation through the GATOR Complex

(2014) Anita Parmigiani et al.   Cell Reports

AGC protein kinases: From structural mechanism of regulation to allosteric drug development for the treatment of human diseases

(2013) José M. Arencibia et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Neurobiology of addiction versus drug use driven by lack of choice

(2013) Serge H Ahmed et al.   CURRENT OPINION IN NEUROBIOLOGY

mTORC2 phosphorylates protein kinase Cζ to regulate its stability and activity

(2013) Xin Li et al.   EMBO REPORTS

A role for the ventral pallidum in context-induced and primed reinstatement of alcohol seeking

(2013) Christina J. Perry et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Rapamycin prevents drug seeking via disrupting reconsolidation of reward memory in rats

(2013) Jue Lin et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Recruitment of folliculin to lysosomes supports the amino acid–dependent activation of Rag GTPases

(2013) Constance S. Petit et al.   JOURNAL OF CELL BIOLOGY

Ablation of the mTORC2 component rictor in brain or Purkinje cells affects size and neuron morphology

(2013) Venus Thomanetz et al.   JOURNAL OF CELL BIOLOGY

The Folliculin Tumor Suppressor Is a GAP for the RagC/D GTPases That Signal Amino Acid Levels to mTORC1

(2013) Zhi-Yang Tsun et al.   MOLECULAR CELL

Disruption of alcohol-related memories by mTORC1 inhibition prevents relapse

(2013) Segev Barak et al.   NATURE NEUROSCIENCE

mTORC2 controls actin polymerization required for consolidation of long-term memory

(2013) Wei Huang et al.   NATURE NEUROSCIENCE

Synaptic depression via mGluR1 positive allosteric modulation suppresses cue-induced cocaine craving

(2013) Jessica A Loweth et al.   NATURE NEUROSCIENCE

Metabotropic Glutamate Receptor I (mGluR1) Antagonism Impairs Cocaine-Induced Conditioned Place Preference via Inhibition of Protein Synthesis

(2013) Fei Yu et al.   NEUROPSYCHOPHARMACOLOGY

Dissociation of the Pharmacological Effects of THC by mTOR Blockade

(2013) Emma Puighermanal et al.   NEUROPSYCHOPHARMACOLOGY

Dysregulation of cannabinoid CB1 receptor and associated signaling networks in brains of cocaine addicts and cocaine-treated rodents

(2013) M. Álvaro-Bartolomé et al.   NEUROSCIENCE

Rats classified as low or high cocaine locomotor responders: A unique model involving striatal dopamine transporters that predicts cocaine addiction-like behaviors

(2013) Dorothy J. Yamamoto et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Ethanol Regulation of Serum Glucocorticoid Kinase 1 Expression in DBA2/J Mouse Prefrontal Cortex

(2013) Blair N. Costin et al.   PLoS One

Stimulation of de Novo Pyrimidine Synthesis by Growth Signaling Through mTOR and S6K1

(2013) I. Ben-Sahra et al.   SCIENCE

Quantitative Phosphoproteomics Reveal mTORC1 Activates de Novo Pyrimidine Synthesis

(2013) A. M. Robitaille et al.   SCIENCE

Nucleus Accumbens mGluR5-Associated Signaling Regulates Binge Alcohol Drinking Under Drinking-in-the-Dark Procedures

(2012) Debra K. Cozzoli et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB

(2012) Jose A. Martina et al.   Autophagy

Inhibition of GSK3 attenuates amphetamine-induced hyperactivity and sensitization in the mouse

(2012) Nicole M. Enman et al.   BEHAVIOURAL BRAIN RESEARCH

The Akt signaling pathway

(2012) SubbaRao V. Madhunapantula et al.   CANCER BIOLOGY & THERAPY

Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1

(2012) Liron Bar-Peled et al.   CELL

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

(2012) Carmine Settembre et al.   EMBO JOURNAL

5-HT6receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia

(2012) Julie Meffre et al.   EMBO Molecular Medicine

The mTOR Signalling Pathway in Human Cancer

(2012) Helena Pópulo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mammalian Target of Rapamycin Complex 1 (mTORC1) and 2 (mTORC2) Control the Dendritic Arbor Morphology of Hippocampal Neurons

(2012) Malgorzata Urbanska et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Small G Protein H-Ras in the Mesolimbic System Is a Molecular Gateway to Alcohol-Seeking and Excessive Drinking Behaviors

(2012) S. Ben Hamida et al.   JOURNAL OF NEUROSCIENCE

TBC1D7 Is a Third Subunit of the TSC1-TSC2 Complex Upstream of mTORC1

(2012) Christian C. Dibble et al.   MOLECULAR CELL

PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12

(2012) Xiaoqing Gan et al.   NATURE CELL BIOLOGY

A Memory Retrieval-Extinction Procedure to Prevent Drug Craving and Relapse

(2012) Y.-X. Xue et al.   SCIENCE

The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis

(2012) A. Roczniak-Ferguson et al.   Science Signaling

Taurine attenuates methamphetamine-induced autophagy and apoptosis in PC12 cells through mTOR signaling pathway

(2012) Yan Li et al.   TOXICOLOGY LETTERS

An Emerging Role for the Mammalian Target of Rapamycin in “Pathological” Protein Translation: Relevance to Cocaine Addiction

(2012) Christopher V. Dayas et al.   Frontiers in Pharmacology

Rapamycin attenuates the expression of cocaine-induced place preference and behavioral sensitization

(2011) Jeffrey Bailey et al.   ADDICTION BIOLOGY

AKT Signaling Pathway in the Nucleus Accumbens Mediates Excessive Alcohol Drinking Behaviors

(2011) Jérémie Neasta et al.   BIOLOGICAL PSYCHIATRY

Activation of mTORC2 by Association with the Ribosome

(2011) Vittoria Zinzalla et al.   CELL

mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway

(2011) Timothy R. Peterson et al.   CELL

Down-regulated striatal gene expression for synaptic plasticity-associated proteins in addiction and relapse vulnerable animals

(2011) Amanda L. Brown et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Glycogen synthase kinase 3β in the nucleus accumbens core is critical for methamphetamine-induced behavioral sensitization

(2011) Chun-mei Xu et al.   JOURNAL OF NEUROCHEMISTRY

Glycogen synthase kinase 3β in the basolateral amygdala is critical for the reconsolidation of cocaine reward memory

(2011) Ping Wu et al.   JOURNAL OF NEUROCHEMISTRY

Extracellular Signal-Regulated Kinase Signaling in the Ventral Tegmental Area Mediates Cocaine-Induced Synaptic Plasticity and Rewarding Effects

(2011) B. Pan et al.   JOURNAL OF NEUROSCIENCE

CLIP-170 and IQGAP1 Cooperatively Regulate Dendrite Morphology

(2011) L. Swiech et al.   JOURNAL OF NEUROSCIENCE

Cannabidiol Induces Programmed Cell Death in Breast Cancer Cells by Coordinating the Cross-talk between Apoptosis and Autophagy

(2011) A. Shrivastava et al.   MOLECULAR CANCER THERAPEUTICS

Role for mTOR Signaling and Neuronal Activity in Morphine-Induced Adaptations in Ventral Tegmental Area Dopamine Neurons

(2011) Michelle S. Mazei-Robison et al.   NEURON

Signaling pathways mediating phosphorylation and inactivation of glycogen synthase kinase-3β by the recombinant human δ-opioid receptor stably expressed in Chinese hamster ovary cells

(2011) Maria C. Olianas et al.   NEUROPHARMACOLOGY

Schedule-induced polydipsia as a model of compulsive behavior: neuropharmacological and neuroendocrine bases

(2011) Margarita Moreno et al.   PSYCHOPHARMACOLOGY

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

(2011) R. Zoncu et al.   SCIENCE

Neurobiology of the incubation of drug craving

(2011) Charles L. Pickens et al.   TRENDS IN NEUROSCIENCES

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

Metformin, Independent of AMPK, Inhibits mTORC1 in a Rag GTPase-Dependent Manner

(2010) Adem Kalender et al.   Cell Metabolism

DAP1, a Novel Substrate of mTOR, Negatively Regulates Autophagy

(2010) Itay Koren et al.   CURRENT BIOLOGY

Requirement of the mTOR Kinase for the Regulation of Maf1 Phosphorylation and Control of RNA Polymerase III-dependent Transcription in Cancer Cells

(2010) Boris Shor et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tti1 and Tel2 Are Critical Factors in Mammalian Target of Rapamycin Complex Assembly

(2010) Takeshi Kaizuka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nucleus Accumbens Core Mammalian Target of Rapamycin Signaling Pathway Is Critical for Cue-Induced Reinstatement of Cocaine Seeking in Rats

(2010) X. Wang et al.   JOURNAL OF NEUROSCIENCE

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

(2010) Katrin Düvel et al.   MOLECULAR CELL

Tsc2-Rheb signaling regulates EphA-mediated axon guidance

(2010) Duyu Nie et al.   NATURE NEUROSCIENCE

Activation of phosphatidylinositol 3-kinase/Akt-mammalian target of Rapamycin signaling pathway in the hippocampus is essential for the acquisition of morphine-induced place preference in rats

(2010) Yue Cui et al.   NEUROSCIENCE

Inhibition of the mammalian target of rapamycin pathway by rapamycin blocks cocaine-induced locomotor sensitization

(2010) J. Wu et al.   NEUROSCIENCE

Role for mammalian target of rapamycin complex 1 signaling in neuroadaptations underlying alcohol-related disorders

(2010) J. Neasta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists

(2010) N. Li et al.   SCIENCE

Dysregulation of the Norepinephrine Transporter Sustains Cortical Hypodopaminergia and Schizophrenia-Like Behaviors in Neuronal Rictor Null Mice

(2010) Michael A. Siuta et al.   PLOS BIOLOGY

DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival

(2009) Timothy R. Peterson et al.   CELL

Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets

(2009) Nahum Sonenberg et al.   CELL

Effect of rapamycin on cue-induced drug craving in abstinent heroin addicts

(2009) Jie Shi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy

(2009) Ian G. Ganley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glycogen synthase kinase 3β in the nucleus accumbens core mediates cocaine-induced behavioral sensitization

(2009) Chun-mei Xu et al.   JOURNAL OF NEUROCHEMISTRY

Binge Drinking Upregulates Accumbens mGluR5-Homer2-PI3K Signaling: Functional Implications for Alcoholism

(2009) D. K. Cozzoli et al.   JOURNAL OF NEUROSCIENCE

Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

(2009) Nao Hosokawa et al.   MOLECULAR BIOLOGY OF THE CELL

ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery

(2009) Chang Hwa Jung et al.   MOLECULAR BIOLOGY OF THE CELL

Cannabinoid modulation of hippocampal long-term memory is mediated by mTOR signaling

(2009) Emma Puighermanal et al.   NATURE NEUROSCIENCE

Cocaine-induced hyperactivity and sensitization are dependent on GSK3

(2009) Jonathan S. Miller et al.   NEUROPHARMACOLOGY

Separable Roles of the Nucleus Accumbens Core and Shell in Context- and Cue-Induced Alcohol-Seeking

(2009) Nadia Chaudhri et al.   NEUROPSYCHOPHARMACOLOGY

BDNF Activates mTOR to Regulate GluR1 Expression Required for Memory Formation

(2009) Leandro Slipczuk et al.   PLoS One

Inhibition of mTOR Signaling in Parkinson's Disease Prevents L-DOPA-Induced Dyskinesia

(2009) E. Santini et al.   Science Signaling

mTOR signaling: At the crossroads of plasticity, memory and disease

(2009) Charles A. Hoeffer et al.   TRENDS IN NEUROSCIENCES

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

(2008) Juan M. García-Martínez et al.   BIOCHEMICAL JOURNAL

Survivin expression in normal human bronchial epithelial cells: an early and critical step in tumorigenesis induced by tobacco exposure

(2008) Quanri Jin et al.   CARCINOGENESIS

Cytoplasmic and nuclear distribution of the protein complexes mTORC1 and mTORC2: rapamycin triggers dephosphorylation and delocalization of the mTORC2 components rictor and sin1

(2008) M. Rosner et al.   HUMAN MOLECULAR GENETICS

Cocaine regulates protein kinase B and glycogen synthase kinase-3 activity in selective regions of rat brain

(2008) Shane A. Perrine et al.   JOURNAL OF NEUROCHEMISTRY

Melatonin attenuates methamphetamine-induced deactivation of the mammalian target of rapamycin signaling to induce autophagy in SK-N-SH cells

(2008) Patthara Kongsuphol et al.   JOURNAL OF PINEAL RESEARCH

Formation of accumbens GluR2-lacking AMPA receptors mediates incubation of cocaine craving

(2008) Kelly L. Conrad et al.   NATURE

The application of the 5-choice serial reaction time task for the assessment of visual attentional processes and impulse control in rats

(2008) Andrea Bari et al.   Nature Protocols

Cocaine Seeking Habits Depend upon Dopamine-Dependent Serial Connectivity Linking the Ventral with the Dorsal Striatum

(2008) David Belin et al.   NEURON

Context-induced relapse to drug seeking: a review

(2008) H. S Crombag et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE

High Impulsivity Predicts the Switch to Compulsive Cocaine-Taking

(2008) D. Belin et al.   SCIENCE