VTA mTOR Signaling Regulates Dopamine Dynamics, Cocaine-Induced Synaptic Alterations, and Reward

Rapamycin reduces motivated responding for cocaine and alters GluA1 expression in the ventral but not dorsal striatum

(2016) Morgan H. James et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Epac Signaling Is Required for Cocaine-Induced Change in AMPA Receptor Subunit Composition in the Ventral Tegmental Area

(2016) X. Liu et al.   JOURNAL OF NEUROSCIENCE

The First Alcohol Drink Triggers mTORC1-Dependent Synaptic Plasticity in Nucleus Accumbens Dopamine D1 Receptor Neurons

(2016) J. T. Beckley et al.   JOURNAL OF NEUROSCIENCE

Dynamic Alterations of Rat Nucleus Accumbens Dendritic Spines over 2 Months of Abstinence from Extended-Access Cocaine Self-Administration

(2016) Daniel T Christian et al.   NEUROPSYCHOPHARMACOLOGY

mTOR signalling in the nucleus accumbens shell is critical for augmented effect of TFF3 on behavioural response to cocaine

(2016) Yi-Xiao Luo et al.   Scientific Reports

Dysregulation of Mammalian Target of Rapamycin Signaling in Mouse Models of Autism

(2015) K. M. Huber et al.   JOURNAL OF NEUROSCIENCE

mTORC2/Rictor Signaling Disrupts Dopamine-Dependent Behaviors via Defects in Striatal Dopamine Neurotransmission

(2015) O. I. Dadalko et al.   JOURNAL OF NEUROSCIENCE

Essential role of D1R in the regulation of mTOR complex1 signaling induced by cocaine

(2015) Laurie P. Sutton et al.   NEUROPHARMACOLOGY

mTOR complex 1: a key player in neuroadaptations induced by drugs of abuse

(2014) Jeremie Neasta et al.   JOURNAL OF NEUROCHEMISTRY

Cyclin-Dependent Kinase 5 in the Ventral Tegmental Area Regulates Depression-Related Behaviors

(2014) P. Zhong et al.   JOURNAL OF NEUROSCIENCE

mTORC1 Inhibition in the Nucleus Accumbens ‘Protects’ Against the Expression of Drug Seeking and ‘Relapse’ and Is Associated with Reductions in GluA1 AMPAR and CAMKIIα Levels

(2014) Morgan H James et al.   NEUROPSYCHOPHARMACOLOGY

Reactivation of cocaine reward memory engages the Akt/GSK3/mTOR signaling pathway and can be disrupted by GSK3 inhibition

(2014) Xiangdang Shi et al.   PSYCHOPHARMACOLOGY

The neural rejuvenation hypothesis of cocaine addiction

(2014) Yan Dong et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Disruption of alcohol-related memories by mTORC1 inhibition prevents relapse

(2013) Segev Barak et al.   NATURE NEUROSCIENCE

mTORC2 controls actin polymerization required for consolidation of long-term memory

(2013) Wei Huang et al.   NATURE NEUROSCIENCE

mTOR complexes in neurodevelopmental and neuropsychiatric disorders

(2013) Mauro Costa-Mattioli et al.   NATURE NEUROSCIENCE

Expression of Cocaine-Evoked Synaptic Plasticity by GluN3A-Containing NMDA Receptors

(2013) Tifei Yuan et al.   NEURON

Excitatory/Inhibitory Synaptic Imbalance Leads to Hippocampal Hyperexcitability in Mouse Models of Tuberous Sclerosis

(2013) Helen S. Bateup et al.   NEURON

Metabotropic Glutamate Receptor I (mGluR1) Antagonism Impairs Cocaine-Induced Conditioned Place Preference via Inhibition of Protein Synthesis

(2013) Fei Yu et al.   NEUROPSYCHOPHARMACOLOGY

Cocaine Disinhibits Dopamine Neurons by Potentiation of GABA Transmission in the Ventral Tegmental Area

(2013) C. Bocklisch et al.   SCIENCE

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

PTEN Regulation of Local and Long-Range Connections in Mouse Auditory Cortex

(2012) Q. Xiong et al.   JOURNAL OF NEUROSCIENCE

Multiple Roles for Mammalian Target of Rapamycin Signaling in Both Glutamatergic and GABAergic Synaptic Transmission

(2012) M. C. Weston et al.   JOURNAL OF NEUROSCIENCE

Serum Response Factor and cAMP Response Element Binding Protein Are Both Required for Cocaine Induction of  FosB

(2012) V. Vialou et al.   JOURNAL OF NEUROSCIENCE

Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons

(2012) Dipesh Chaudhury et al.   NATURE

Regulation of Presynaptic Neurotransmission by Macroautophagy

(2012) Daniela Hernandez et al.   NEURON

An Emerging Role for the Mammalian Target of Rapamycin in “Pathological” Protein Translation: Relevance to Cocaine Addiction

(2012) Christopher V. Dayas et al.   Frontiers in Pharmacology

Rapamycin attenuates the expression of cocaine-induced place preference and behavioral sensitization

(2011) Jeffrey Bailey et al.   ADDICTION BIOLOGY

Pten Knockdown In Vivo Increases Excitatory Drive onto Dentate Granule Cells

(2011) B. W. Luikart et al.   JOURNAL OF NEUROSCIENCE

Demon Voltammetry and Analysis software: Analysis of cocaine-induced alterations in dopamine signaling using multiple kinetic measures

(2011) Jordan T. Yorgason et al.   JOURNAL OF NEUROSCIENCE METHODS

High-throughput, detailed, cell-specific neuroanatomy of dendritic spines using microinjection and confocal microscopy

(2011) Dani Dumitriu et al.   Nature Protocols

Role for mTOR Signaling and Neuronal Activity in Morphine-Induced Adaptations in Ventral Tegmental Area Dopamine Neurons

(2011) Michelle S. Mazei-Robison et al.   NEURON

Kv3-Like Potassium Channels Are Required for Sustained High-Frequency Firing in Basal Ganglia Output Neurons

(2010) Shengyuan Ding et al.   JOURNAL OF NEUROPHYSIOLOGY

Nucleus Accumbens Core Mammalian Target of Rapamycin Signaling Pathway Is Critical for Cue-Induced Reinstatement of Cocaine Seeking in Rats

(2010) X. Wang et al.   JOURNAL OF NEUROSCIENCE

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Inhibition of the mammalian target of rapamycin pathway by rapamycin blocks cocaine-induced locomotor sensitization

(2010) J. Wu et al.   NEUROSCIENCE

Laminar and compartmental regulation of dendritic growth in mature cortex

(2009) David K Chow et al.   NATURE NEUROSCIENCE

Cocaine-evoked synaptic plasticity: persistence in the VTA triggers adaptations in the NAc

(2009) Manuel Mameli et al.   NATURE NEUROSCIENCE

mTOR signaling: At the crossroads of plasticity, memory and disease

(2009) Charles A. Hoeffer et al.   TRENDS IN NEUROSCIENCES

Preferential Enhancement of Dopamine Transmission within the Nucleus Accumbens Shell by Cocaine Is Attributable to a Direct Increase in Phasic Dopamine Release Events

(2008) B. J. Aragona et al.   JOURNAL OF NEUROSCIENCE

Mechanism and Time Course of Cocaine-Induced Long-Term Potentiation in the Ventral Tegmental Area

(2008) E. Argilli et al.   JOURNAL OF NEUROSCIENCE

Endocannabinoid Signaling Mediates Cocaine-Induced Inhibitory Synaptic Plasticity in Midbrain Dopamine Neurons

(2008) B. Pan et al.   JOURNAL OF NEUROSCIENCE