Cancer-derived exosomal TRIM59 regulates macrophage NLRP3 inflammasome activation to promote lung cancer progression

TRIM59 deficiency curtails breast cancer metastasis through SQSTM1-selective autophagic degradation of PDCD10

(2019) Peng Tan et al.   Autophagy

Cancer statistics, 2019

(2019) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Exosomes in the tumor microenvironment as mediators of cancer therapy resistance

(2019) Irene Li et al.   Molecular Cancer

Emerging roles and therapeutic value of exosomes in cancer metastasis

(2019) Miaowei Wu et al.   Molecular Cancer

Chemotherapy-induced distal enhancers drive transcriptional program to maintain the chemoresistant state in ovarian cancer.

(2019) Stephen Shang et al.   CANCER RESEARCH

Metabolic Adaptation Sets the Fate of Regulatory Macrophages

(2019) Jorge Domínguez-Andrés et al.   Cell Metabolism

Macrophages and Metabolism in the Tumor Microenvironment

(2019) Ilio Vitale et al.   Cell Metabolism

IL-1 Family Members in Cancer; Two Sides to Every Story

(2019) Kevin J. Baker et al.   Frontiers in Immunology

TRIM59 loss in M2 macrophages promotes melanoma migration and invasion by upregulating MMP-9 and Madcam1

(2019) Yuan Tian et al.   Aging-US

CDK5-dependent phosphorylation and nuclear translocation of TRIM59 promotes macroH2A1 ubiquitination and tumorigenicity

(2019) Youzhou Sang et al.   Nature Communications

TRIM59 promotes tumor growth in hepatocellular carcinoma and regulates the cell cycle by degradation of protein phosphatase 1B

(2019) Hanning Ying et al.   CANCER LETTERS

T Cell Dysfunction in Cancer

(2018) Daniela S. Thommen et al.   CANCER CELL

New insights into the biological impacts of immune cell-derived exosomes within the tumor environment

(2018) Meng Shen et al.   CANCER LETTERS

Cancer-Cell-Intrinsic Mechanisms Shaping the Tumor Immune Landscape

(2018) Max D. Wellenstein et al.   IMMUNITY

Metabolic Modulation in Macrophage Effector Function

(2018) Ciana Diskin et al.   Frontiers in Immunology

Loss of Abhd5 Promotes Colorectal Tumor Development and Progression by Inducing Aerobic Glycolysis and Epithelial-Mesenchymal Transition

(2018) Juanjuan Ou et al.   Cell Reports

An TRIM59-CDK6 axis regulates growth and metastasis of lung cancer

(2018) Biao Geng et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

TRIM59 promotes breast cancer motility by suppressing p62-selective autophagic degradation of PDCD10

(2018) Peng Tan et al.   PLOS BIOLOGY

Architecture of the human interactome defines protein communities and disease networks

(2017) Edward L. Huttlin et al.   NATURE

Exosomes: Key mediators of metastasis and pre-metastatic niche formation

(2017) Richard J. Lobb et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

TRIM Family Proteins: Roles in Autophagy, Immunity, and Carcinogenesis

(2017) Shigetsugu Hatakeyama   TRENDS IN BIOCHEMICAL SCIENCES

Exosome-delivered EGFR regulates liver microenvironment to promote gastric cancer liver metastasis

(2017) Haiyang Zhang et al.   Nature Communications

Molecular Basis of ABHD5 Lipolysis Activation

(2017) Matthew A. Sanders et al.   Scientific Reports

Macrophages, Inflammation, and Lung Cancer

(2016) Emma M. Conway et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis

(2016) Annette Becker et al.   CANCER CELL

Exosomes and tumor-mediated immune suppression

(2016) Theresa L. Whiteside   JOURNAL OF CLINICAL INVESTIGATION

The biology and function of exosomes in cancer

(2016) Raghu Kalluri   JOURNAL OF CLINICAL INVESTIGATION

Macrophage CGI-58 deficiency promotes IL-1β transcription by activating the SOCS3–FOXO1 pathway

(2015) Hongming Miao et al.   CLINICAL SCIENCE

Structure of a CGI-58 Motif Provides the Molecular Basis of Lipid Droplet Anchoring

(2015) Andras Boeszoermenyi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Immunometabolism governs dendritic cell and macrophage function

(2015) Luke A.J. O’Neill et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cancer prevention and therapy through the modulation of the tumor microenvironment

(2015) Stephanie C. Casey et al.   SEMINARS IN CANCER BIOLOGY

Immune evasion in cancer: Mechanistic basis and therapeutic strategies

(2015) Dass S. Vinay et al.   SEMINARS IN CANCER BIOLOGY

Contribution of metabolic reprogramming to macrophage plasticity and function

(2015) Karim C. EL Kasmi et al.   SEMINARS IN IMMUNOLOGY

TRIM59 Is Up-regulated in Gastric Tumors, Promoting Ubiquitination and Degradation of p53

(2014) Zhicheng Zhou et al.   GASTROENTEROLOGY

The Interleukin-1 Family: Back to the Future

(2013) Cecilia Garlanda et al.   IMMUNITY

Macrophage Diversity Enhances Tumor Progression and Metastasis

(2010) Bin-Zhi Qian et al.   CELL