期刊
CANCER LETTERS
卷 431, 期 -, 页码 115-122出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2018.05.040
关键词
Exosomes; Immunocytes; Tumor immunology; Cancer; Therapeutic target
类别
资金
- National Key Technology RD Program [2015BAI12B12]
- Natural Science Foundation of China [81472471]
Exosomes are a group of nano-sized membrane vesicles that transfer proteins, nucleic acids, and lipids to nearby and faraway cells, playing an important role in the intercellular communication within the extracellular environment. Emerging evidences show that exosomes derived from immunocytes, including dendritic cells, T cells, B cells, macrophages, natural killer cells and myeloid-derived suppressor cells, can play an intimate role in the crosstalk among immunocytes in a tumor microenvironment. In this review, we highlight that under tumor conditions, immune cells and tumor cells can be influenced by immunocyte-derived exosomes, resulting in modifications of their phenotype and function. Thus, a better understanding of exosomes derived from different immunocytes would provide novel strategies in generating effective vaccines or improving treatment efficacy in anticancer therapies.
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