期刊
CELL METABOLISM
卷 29, 期 6, 页码 1240-1242出版社
CELL PRESS
DOI: 10.1016/j.cmet.2019.05.012
关键词
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资金
- Spinoza grant of the Netherlands Organization for Scientific Research
In this issue of Cell Metabolism, Du et al. (2019) describe how insulin-like growth factor 2 (IGF-2), a protein with structural similarity to insulin, induces an anti-inflammatory phenotype in maturing macrophages through reprogramming of their mitochondrial metabolism. These anti-inflammatory properties are maintained upon secondary stimulation and alleviate experimental autoimmune encephalomyelitis (EAE) in vivo.
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