The Role of NLRP3 Inflammasome in the Pathogenesis of Traumatic Brain Injury

Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target

(2020) Haibo Zhang et al.   INTENSIVE CARE MEDICINE

Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding

(2020) Roujian Lu et al.   LANCET

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

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Traumatic Brain Injury

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Mesenchymal stem cell therapy alleviates the neuroinflammation associated with acquired brain injury

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β-catenin promotes NLRP3 inflammasome activation via increasing the association between NLRP3 and ASC

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Management of Traumatic Brain Injury: From Present to Future

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Inflammasome proteins as biomarkers of traumatic brain injury

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Severe Acute Respiratory Syndrome Coronavirus Viroporin 3a Activates the NLRP3 Inflammasome

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HSP70 is a negative regulator of NLRP3 inflammasome activation

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Revised Airlie House consensus guidelines for design and implementation of ALS clinical trials

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Rapamycin improves the neuroprotection effect of inhibition of NLRP3 inflammasome activation after TBI

(2019) Yuhua Chen et al.   BRAIN RESEARCH

A novel small molecular NLRP3 inflammasome inhibitor alleviates neuroinflammatory response following traumatic brain injury

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DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome

(2019) Parimal Samir et al.   NATURE

EK7 Regulates NLRP3 Inflammasome Activation and Neuroinflammation Post-traumatic Brain Injury

(2019) Yuhua Chen et al.   Frontiers in Molecular Neuroscience

Emerging insights into molecular mechanisms underlying pyroptosis and functions of inflammasomes in diseases

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Traumatic Brain Injuries: Pathophysiology and Potential Therapeutic Targets

(2019) Si Yun Ng et al.   Frontiers in Cellular Neuroscience

Tranilast directly targets NLRP3 to treat inflammasome‐driven diseases

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Inflammasome: Its role in traumatic brain and spinal cord injury

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Estimating the global incidence of traumatic brain injury

(2018) Michael C. Dewan et al.   JOURNAL OF NEUROSURGERY

MCC950, the Selective Inhibitor of Nucleotide Oligomerization Domain-Like Receptor Protein-3 Inflammasome, Protects Mice against Traumatic Brain Injury

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Activated renal tubular Wnt/β-catenin signaling triggers renal inflammation during overload proteinuria

(2018) Dickson W.L. Wong et al.   KIDNEY INTERNATIONAL

Targeting the NLRP3 inflammasome in inflammatory diseases

(2018) Matthew S. J. Mangan et al.   NATURE REVIEWS DRUG DISCOVERY

Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity

(2018) Hongbin He et al.   Nature Communications

Administration of Dexmedetomidine inhibited NLRP3 inflammasome and microglial cell activities in hippocampus of traumatic brain injury rats

(2018) Bin Zheng et al.   BIOSCIENCE REPORTS

Targeting Peroxiredoxin 1 by a Curcumin Analogue, AI-44, Inhibits NLRP3 Inflammasome Activation and Attenuates Lipopolysaccharide-Induced Sepsis in Mice

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Combination of Drug and Stem cells Neurotherapy: Potential Interventions in Neurotrauma and Traumatic Brain Injury

(2018) Kazem Zibara et al.   NEUROPHARMACOLOGY

Interleukin-1β Maturation Triggers Its Relocation to the Plasma Membrane for Gasdermin-D-Dependent and -Independent Secretion

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The Overlooked Aspect of Excitotoxicity: Glutamate‐Independent Excitotoxicity in Traumatic Brain Injuries

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Omega-3 fatty acids regulate NLRP3 inflammasome activation and prevent behavior deficits after traumatic brain injury

(2017) Chao Lin et al.   EXPERIMENTAL NEUROLOGY

Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases

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NLRC3 protein inhibits inflammation by disrupting NALP3 inflammasome assembly via competition with the adaptor protein ASC for pro-caspase-1 binding

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Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders

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NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes

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NLRP3 inflammasome assembly is regulated by phosphorylation of the pyrin domain

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Inflammation in epileptogenesis after traumatic brain injury

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Disrupted Ionic Homeostasis in Ischemic Stroke and New Therapeutic Targets

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NADPH oxidase in brain injury and neurodegenerative disorders

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Hippo signalling governs cytosolic nucleic acid sensing through YAP/TAZ-mediated TBK1 blockade

(2017) Qian Zhang et al.   NATURE CELL BIOLOGY

The far-reaching scope of neuroinflammation after traumatic brain injury

(2017) Dennis W. Simon et al.   Nature Reviews Neurology

Cerebrospinal Fluid NLRP3 is Increased After Severe Traumatic Brain Injury in Infants and Children

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Neuroimmunology of Traumatic Brain Injury: Time for a Paradigm Shift

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NADPH Oxidase 2 Regulates NLRP3 Inflammasome Activation in the Brain after Traumatic Brain Injury

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Mechanical stress activates NMDA receptors in the absence of agonists

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Microglial Activation in Traumatic Brain Injury

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Disrupted Ionic Homeostasis in Ischemic Stroke and New Therapeutic Targets

(2017) Hui-Jie Hu et al.   Journal of Stroke & Cerebrovascular Diseases

Research Gaps and Controversies in Chronic Traumatic Encephalopathy

(2017) Breton M. Asken et al.   JAMA Neurology

Lack of the Nlrp3 Inflammasome Improves Mice Recovery Following Traumatic Brain Injury

(2017) Natasha Irrera et al.   Frontiers in Pharmacology

Cerebrospinal Fluid and Microdialysis Cytokines in Severe Traumatic Brain Injury: A Scoping Systematic Review

(2017) Frederick A. Zeiler et al.   Frontiers in Neurology

Pathological correlations between traumatic brain injury and chronic neurodegenerative diseases

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The Role of Interleukin-18, Oxidative Stress and Metabolic Syndrome in Alzheimer’s Disease

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Knowing What We Don’t Know: Long-Term Psychiatric Outcomes following Adult Concussion in Sports

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High glucocorticoid levels during gestation activate the inflammasome in hippocampal oligodendrocytes of the offspring

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Astrocyte roles in traumatic brain injury

(2016) Joshua E. Burda et al.   EXPERIMENTAL NEUROLOGY

Microglia in the TBI brain: The good, the bad, and the dysregulated

(2016) David J. Loane et al.   EXPERIMENTAL NEUROLOGY

Propofol Inhibits NLRP3 Inflammasome and Attenuates Blast-Induced Traumatic Brain Injury in Rats

(2016) Jie Ma et al.   INFLAMMATION

Self-Reported Traumatic Brain Injury and Mild Cognitive Impairment: Increased Risk and Earlier Age of Diagnosis

(2016) Christian LoBue et al.   JOURNAL OF ALZHEIMERS DISEASE

Severity of experimental traumatic brain injury modulates changes in concentrations of cerebral free amino acids

(2016) Angela Maria Amorini et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Telmisartan reduced cerebral edema by inhibiting NLRP3 inflammasome in mice with cold brain injury

(2016) Xin Wei et al.   Journal of Huazhong University of Science and Technology-Medical Sciences

Nonessential Role for the NLRP1 Inflammasome Complex in a Murine Model of Traumatic Brain Injury

(2016) Thomas Brickler et al.   MEDIATORS OF INFLAMMATION

Pore-forming activity and structural autoinhibition of the gasdermin family

(2016) Jingjin Ding et al.   NATURE

NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux

(2016) Yuan He et al.   NATURE

Keeping it in check: chronic viral infection and antiviral immunity in the brain

(2016) Katelyn D. Miller et al.   NATURE REVIEWS NEUROSCIENCE

Guidelines for the Management of Severe Traumatic Brain Injury, Fourth Edition

(2016) Nancy Carney et al.   NEUROSURGERY

IP3receptors: Take four IP3to open

(2016) Colin W. Taylor et al.   Science Signaling

Regulating effect of activated NF-κB on edema induced by traumatic brain injury of rats

(2016) Zi-Ran Wang et al.   Asian Pacific Journal of Tropical Medicine

IP3receptors: Take four IP3to open

(2016) Colin W. Taylor et al.   Science Signaling

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

Phagoptosis - Cell Death By Phagocytosis - Plays Central Roles in Physiology, Host Defense and Pathology

(2015) G. Brown et al.   CURRENT MOLECULAR MEDICINE

NLRP3 inflammasome is expressed by astrocytes in the SOD1 mouse model of ALS and in human sporadic ALS patients

(2015) Sonja Johann et al.   GLIA

The PYRIN Domain-only Protein POP1 Inhibits Inflammasome Assembly and Ameliorates Inflammatory Disease

(2015) Lucia de Almeida et al.   IMMUNITY

A Genome-wide CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) Screen Identifies NEK7 as an Essential Component of NLRP3 Inflammasome Activation

(2015) Jonathan L. Schmid-Burgk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recombinant human interleukin-1 receptor antagonist promotes M1 microglia biased cytokines and chemokines following human traumatic brain injury

(2015) Adel Helmy et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

(2015) Rebecca C Coll et al.   NATURE MEDICINE

Cerebrospinal Fluid Markers of Macrophage and Lymphocyte Activation After Traumatic Brain Injury in Children

(2015) Elizabeth Newell et al.   Pediatric Critical Care Medicine

NLRP3 Inflammasome Activation by Viroporins of Animal Viruses

(2015) Hui-Chen Guo et al.   Viruses-Basel

Relevance of Viroporin Ion Channel Activity on Viral Replication and Pathogenesis

(2015) Jose Nieto-Torres et al.   Viruses-Basel

Small heterodimer partner interacts with NLRP3 and negatively regulates activation of the NLRP3 inflammasome

(2015) Chul-Su Yang et al.   Nature Communications

Inflammation and Neuroprotection in Traumatic Brain Injury

(2015) Kara N. Corps et al.   JAMA Neurology

An autophagic mechanism is involved in apoptotic death of rat striatal neurons induced by the non-N-methyl-D-aspartate receptor agonist kainic acid

(2014) Yan Wang et al.   Autophagy

Recombinant Human Interleukin-1 Receptor Antagonist in Severe Traumatic Brain Injury: A Phase II Randomized Control Trial

(2014) Adel Helmy et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

NLRP3 Deficiency Ameliorates Neurovascular Damage in Experimental Ischemic Stroke

(2014) Fan Yang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Brain transient receptor potential channels and stroke

(2014) Eric Zhang et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Activation of NF-κB Mediates Astrocyte Swelling and Brain Edema in Traumatic Brain Injury

(2014) Arumugam R. Jayakumar et al.   JOURNAL OF NEUROTRAUMA

NADPH oxidase inhibition improves neurological outcome in experimental traumatic brain injury

(2014) Xin-Yu Lu et al.   NEUROCHEMISTRY INTERNATIONAL

Expression and clinical significance of non-phagocytic cell oxidase 2 and 4 after human traumatic brain injury

(2014) Zhen Li et al.   NEUROLOGICAL SCIENCES

Proton-sensitive cation channels and ion exchangers in ischemic brain injury: New therapeutic targets for stroke?

(2014) Tiandong Leng et al.   PROGRESS IN NEUROBIOLOGY

Reactive oxygen species at the crossroads of inflammasome and inflammation

(2014) Anantha Harijith et al.   Frontiers in Physiology

The pathophysiology of traumatic brain injury at a glance

(2013) M. Prins et al.   Disease Models & Mechanisms

Cellular and temporal expression of NADPH oxidase (NOX) isotypes after brain injury

(2013) Sean J Cooney et al.   Journal of Neuroinflammation

Progressive Neurodegeneration After Experimental Brain Trauma

(2013) David J. Loane et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Group-Based Trajectory Analysis Applications for Prognostic Biomarker Model Development in Severe TBI: A Practical Example

(2013) Christian Niyonkuru et al.   JOURNAL OF NEUROTRAUMA

Expression of the NLRP3 Inflammasome in Cerebral Cortex After Traumatic Brain Injury in a Rat Model

(2013) Huan-Dong Liu et al.   NEUROCHEMICAL RESEARCH

Increased Levels of Serum IL-18 Are Associated with the Long-Term Outcome of Severe Traumatic Brain Injury

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Direct cost associated with acquired brain injury in Ontario

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The NOX toolbox: validating the role of NADPH oxidases in physiology and disease

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Oxidative stress, neurodegeneration, and the balance of protein degradation and protein synthesis

(2012) Kalavathi Dasuri et al.   FREE RADICAL BIOLOGY AND MEDICINE

Innate immunity in the central nervous system

(2012) Richard M. Ransohoff et al.   JOURNAL OF CLINICAL INVESTIGATION

Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth

(2012) Mélanie Bruchard et al.   NATURE MEDICINE

Critical Role of NADPH Oxidase in Neuronal Oxidative Damage and Microglia Activation following Traumatic Brain Injury

(2012) Quan-Guang Zhang et al.   PLoS One

GBP5 Promotes NLRP3 Inflammasome Assembly and Immunity in Mammals

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(2011) Pallab Singh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

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The Cytokine Response to Human Traumatic Brain Injury: Temporal Profiles and Evidence for Cerebral Parenchymal Production

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The Inflammasome Sensor, NLRP3, Regulates CNS Inflammation and Demyelination via Caspase-1 and Interleukin-18

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Influenza virus activates inflammasomes via its intracellular M2 ion channel

(2010) Takeshi Ichinohe et al.   NATURE IMMUNOLOGY

p53 mediates mitochondria dysfunction-triggered autophagy activation and cell death in rat striatum

(2009) Xing-Ding Zhang et al.   Autophagy

Emerging treatments for traumatic brain injury

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Therapeutic Neutralization of the NLRP1 Inflammasome Reduces the Innate Immune Response and Improves Histopathology after Traumatic Brain Injury

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Initial calcium release from intracellular stores followed by calcium dysregulation is linked to secondary axotomy following transient axonal stretch injury

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How Ca2+-ATPase pumps ions across the sarcoplasmic reticulum membrane

(2008) Chikashi Toyoshima   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

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