Relevance of Viroporin Ion Channel Activity on Viral Replication and Pathogenesis

Initiation and perpetuation of NLRP3 inflammasome activation and assembly

(2015) Eric I. Elliott et al.   IMMUNOLOGICAL REVIEWS

Severe Acute Respiratory Syndrome Coronaviruses with Mutations in the E Protein Are Attenuated and Promising Vaccine Candidates

(2015) Jose A. Regla-Nava et al.   JOURNAL OF VIROLOGY

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

(2015) Rebecca C Coll et al.   NATURE MEDICINE

MERS coronavirus envelope protein has a single transmembrane domain that forms pentameric ion channels

(2015) Wahyu Surya et al.   VIRUS RESEARCH

Inhibition of the Human Respiratory Syncytial Virus Small Hydrophobic Protein and Structural Variations in a Bicelle Environment

(2014) Y. Li et al.   JOURNAL OF VIROLOGY

Stepwise Priming by Acidic pH and a High K+ Concentration Is Required for Efficient Uncoating of Influenza A Virus Cores after Penetration

(2014) S. Stauffer et al.   JOURNAL OF VIROLOGY

Ion flux in the lung: virus-induced inflammasome activation

(2014) Kathy Triantafilou et al.   TRENDS IN MICROBIOLOGY

The PDZ-Binding Motif of Severe Acute Respiratory Syndrome Coronavirus Envelope Protein Is a Determinant of Viral Pathogenesis

(2014) Jose M. Jimenez-Guardeño et al.   PLoS Pathogens

Severe Acute Respiratory Syndrome Coronavirus Envelope Protein Ion Channel Activity Promotes Virus Fitness and Pathogenesis

(2014) Jose L. Nieto-Torres et al.   PLoS Pathogens

Rhinovirus-Induced Calcium Flux Triggers NLRP3 and NLRC5 Activation in Bronchial Cells

(2013) Kathy Triantafilou et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Analysis of SARS-CoV E protein ion channel activity by tuning the protein and lipid charge

(2013) Carmina Verdiá-Báguena et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The ORF4a protein of human coronavirus 229E functions as a viroporin that regulates viral production

(2013) Ronghua Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

(2013) Raúl Muñoz-Planillo et al.   IMMUNITY

Hepatitis C Virus Induces Interleukin-1  (IL-1 )/IL-18 in Circulatory and Resident Liver Macrophages

(2013) S. Shrivastava et al.   JOURNAL OF VIROLOGY

Inhibition of NF- B-Mediated Inflammation in Severe Acute Respiratory Syndrome Coronavirus-Infected Mice Increases Survival

(2013) M. L. DeDiego et al.   JOURNAL OF VIROLOGY

Porcine reproductive and respiratory syndrome virus activates inflammasomes of porcine alveolar macrophages via its small envelope protein E

(2013) Kao Zhang et al.   VIROLOGY

Engineering a Replication-Competent, Propagation-Defective Middle East Respiratory Syndrome Coronavirus as a Vaccine Candidate

(2013) F. Almazan et al.   mBio

Activation of the NLRP3 Inflammasome by IAV Virulence Protein PB1-F2 Contributes to Severe Pathophysiology and Disease

(2013) Julie L. McAuley et al.   PLoS Pathogens

The inflammasome in lung diseases

(2012) Gimena dos Santos et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

PEDV ORF3 encodes an ion channel protein and regulates virus production

(2012) Kai Wang et al.   FEBS LETTERS

Rotaviral Enterotoxin Nonstructural Protein 4 Targets Mitochondria for Activation of Apoptosis during Infection

(2012) Rahul Bhowmick et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High-Risk Human Papillomavirus E5 Oncoprotein Displays Channel-Forming Activity Sensitive to Small-Molecule Inhibitors

(2012) L. F. Wetherill et al.   JOURNAL OF VIROLOGY

Classical Swine Fever Virus p7 Protein Is a Viroporin Involved in Virulence in Swine

(2012) D. P. Gladue et al.   JOURNAL OF VIROLOGY

Inflammasomes in health and disease

(2012) Till Strowig et al.   NATURE

Viroporins: structure and biological functions

(2012) José Luis Nieva et al.   NATURE REVIEWS MICROBIOLOGY

Critical role for calcium mobilization in activation of the NLRP3 inflammasome

(2012) T. Murakami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy hijacked through viroporin-activated calcium/calmodulin-dependent kinase kinase-  signaling is required for rotavirus replication

(2012) S. E. Crawford et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human respiratory syncytial virus viroporin SH: a viral recognition pathway used by the host to signal inflammasome activation

(2012) Kathy Triantafilou et al.   THORAX

Coronavirus E protein forms ion channels with functionally and structurally-involved membrane lipids

(2012) Carmina Verdiá-Báguena et al.   VIROLOGY

A Single Polar Residue and Distinct Membrane Topologies Impact the Function of the Infectious Bronchitis Coronavirus E Protein

(2012) Travis R. Ruch et al.   PLoS Pathogens

Encephalomyocarditis Virus Viroporin 2B Activates NLRP3 Inflammasome

(2012) Minako Ito et al.   PLoS Pathogens

The Acute Respiratory Distress Syndrome: Pathogenesis and Treatment

(2011) Michael A. Matthay et al.   Annual Review of Pathology-Mechanisms of Disease

Unknown

(2011) Jochen Grommes et al.   MOLECULAR MEDICINE

Subcellular location and topology of severe acute respiratory syndrome coronavirus envelope protein

(2011) Jose L. Nieto-Torres et al.   VIROLOGY

Ion channel activity of HIV-1 Vpu is dispensable for counteraction of CD317

(2011) Sebastian Bolduan et al.   VIROLOGY

Severe Acute Respiratory Syndrome Coronavirus Envelope Protein Regulates Cell Stress Response and Apoptosis

(2011) Marta L. DeDiego et al.   PLoS Pathogens

A novel Hepatitis C virus p7 ion channel inhibitor, BIT225, inhibits bovine viral diarrhea virus in vitro and shows synergism with recombinant interferon-α-2b and nucleoside analogues

(2010) Carolyn A. Luscombe et al.   ANTIVIRAL RESEARCH

Influenza Virus M2 Protein Mediates ESCRT-Independent Membrane Scission

(2010) Jeremy S. Rossman et al.   CELL

Phosphorylation and Mutation of Phospholamban Alter Physical Interactions With the Sarcoplasmic Reticulum Calcium Pump

(2010) John Paul Glaves et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure of the amantadine binding site of influenza M2 proton channels in lipid bilayers

(2010) Sarah D. Cady et al.   NATURE

Influenza virus activates inflammasomes via its intracellular M2 ion channel

(2010) Takeshi Ichinohe et al.   NATURE IMMUNOLOGY

The Proapoptotic Influenza A Virus Protein PB1-F2 Forms a Nonselective Ion Channel

(2010) Michael Henkel et al.   PLoS One

Structure and mechanism of proton transport through the transmembrane tetrameric M2 protein bundle of the influenza A virus

(2010) R. Acharya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Na+/K+-ATPase β1 subunit interacts with M2 proteins of influenza A and B viruses and affects the virus replication

(2010) ShuoFu Mi et al.   Science China-Life Sciences

Combination Chemotherapy for Influenza

(2010) Elena A. Govorkova et al.   Viruses-Basel

Hepatitis C Virus P7—A Viroporin Crucial for Virus Assembly and an Emerging Target for Antiviral Therapy

(2010) Eike Steinmann et al.   Viruses-Basel

Intracellular Proton Conductance of the Hepatitis C Virus p7 Protein and Its Contribution to Infectious Virus Production

(2010) Ann L. Wozniak et al.   PLoS Pathogens

Potential enhancement of osteoclastogenesis by severe acute respiratory syndrome coronavirus 3a/X1 protein

(2009) Saemi Obitsu et al.   ARCHIVES OF VIROLOGY

Influenza virus M2 protein inhibits epithelial sodium channels by increasing reactive oxygen species

(2009) Ahmed Lazrak et al.   FASEB JOURNAL

The Open Reading Frame 3a Protein of Severe Acute Respiratory Syndrome-Associated Coronavirus Promotes Membrane Rearrangement and Cell Death

(2009) E. C. Freundt et al.   JOURNAL OF VIROLOGY

Influenza A Virus Lacking M2 Protein as a Live Attenuated Vaccine

(2009) S. Watanabe et al.   JOURNAL OF VIROLOGY

The 3-dimensional structure of a hepatitis C virus p7 ion channel by electron microscopy

(2009) P. Luik et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and Inhibition of the SARS Coronavirus Envelope Protein Ion Channel

(2009) Konstantin Pervushin et al.   PLoS Pathogens

SARS-CoV proteins decrease levels and activity of human ENaC via activation of distinct PKC isoforms

(2008) Hong-Long Ji et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Structural Flexibility of the Pentameric SARS Coronavirus Envelope Protein Ion Channel

(2008) Krupakar Parthasarathy et al.   BIOPHYSICAL JOURNAL

The Interferon-Induced Protein BST-2 Restricts HIV-1 Release and Is Downregulated from the Cell Surface by the Viral Vpu Protein

(2008) Nanette Van Damme et al.   Cell Host & Microbe

Genotype-dependent sensitivity of hepatitis C virus to inhibitors of the p7 ion channel

(2008) Stephen Griffin et al.   HEPATOLOGY

Functional Analysis of Picornavirus 2B Proteins: Effects on Calcium Homeostasis and Intracellular Protein Trafficking

(2008) A. S. de Jong et al.   JOURNAL OF VIROLOGY

The Influenza Virus M2 Protein Cytoplasmic Tail Interacts with the M1 Protein and Influences Virus Assembly at the Site of Virus Budding

(2008) B. J. Chen et al.   JOURNAL OF VIROLOGY

Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu

(2008) Stuart J. D. Neil et al.   NATURE

Structure and ion channel activity of the human respiratory syncytial virus (hRSV) small hydrophobic protein transmembrane domain

(2008) Siok Wan Gan et al.   PROTEIN SCIENCE

SARS coronavirus accessory proteins

(2007) Krishna Narayanan et al.   VIRUS RESEARCH