The cGAS‐STING pathway: The role of self‐DNA sensing in inflammatory lung disease

Airway Epithelial cGAS Is Critical for Induction of Experimental Allergic Airway Inflammation

(2020) Yinling Han et al.   JOURNAL OF IMMUNOLOGY

A new coronavirus associated with human respiratory disease in China

(2020) Fan Wu et al.   NATURE

Self DNA perpetuates IPF lung fibroblast senescence in a cGAS-dependent manner

(2020) Michael Schuliga et al.   CLINICAL SCIENCE

The cGAS/STING/TBK1/IRF3 innate immunity pathway maintains chromosomal stability through regulation of p21 levels

(2020) Abdul Basit et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

mtDNA Activates cGAS Signaling and Suppresses the YAP-Mediated Endothelial Cell Proliferation Program to Promote Inflammatory Injury

(2020) Long Shuang Huang et al.   IMMUNITY

The origin of extracellular DNA in bacterial biofilm infections in vivo

(2020) Maria Alhede et al.   Pathogens and Disease

Research Advances in How the cGAS-STING Pathway Controls the Cellular Inflammatory Response

(2020) Dongshan Wan et al.   Frontiers in Immunology

Neutrophil Extracellular Traps (NETs) Contribute to Immunothrombosis in COVID-19 Acute Respiratory Distress Syndrome

(2020) Elizabeth A Middleton et al.   BLOOD

cGAS in action: Expanding roles in immunity and inflammation

(2019) Andrea Ablasser et al.   SCIENCE

Structural basis of STING binding with and phosphorylation by TBK1

(2019) Conggang Zhang et al.   NATURE

Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP–AMP

(2019) Guijun Shang et al.   NATURE

Autophagy induction via STING trafficking is a primordial function of the cGAS pathway

(2019) Xiang Gui et al.   NATURE

Dnase1 -deficient mice spontaneously develop a systemic lupus erythematosus-like disease

(2019) Elaine F. Kenny et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Extracellular DNA, Neutrophil Extracellular Traps, and Inflammasome Activation in Severe Asthma

(2019) Marrah E Lachowicz-Scroggins et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Interleukin-1β Induces mtDNA Release to Activate Innate Immune Signaling via cGAS-STING

(2019) Lauren D. Aarreberg et al.   MOLECULAR CELL

A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1

(2019) Baoyu Zhao et al.   NATURE

Hierarchy of clinical manifestations in SAVI N153S and V154M mouse models

(2019) Mona Motwani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sterile Lung Inflammation Induced by Silica Exacerbates Mycobacterium tuberculosis Infection via STING-Dependent Type 2 Immunity

(2019) Sulayman Benmerzoug et al.   Cell Reports

Type I IFN expression is stimulated by cytosolic Mt DNA released from pneumolysin‐damaged mitochondria via the STING signaling pathway in macrophages

(2019) Xuexue Hu et al.   FEBS Journal

DNA sensing by the cGAS–STING pathway in health and disease

(2019) Mona Motwani et al.   NATURE REVIEWS GENETICS

Extracellular DNA traps in inflammation, injury and healing

(2019) Christoph Daniel et al.   Nature Reviews Nephrology

PINK1 attenuates mtDNA release in alveolar epithelial cells and TLR9 mediated profibrotic responses

(2019) Marta Bueno et al.   PLoS One

Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression

(2019) Lodoe Lama et al.   Nature Communications

Cyclic GMP-AMP Triggers Asthma in an IL-33-Dependent Manner That Is Blocked by Amlexanox, a TBK1 Inhibitor

(2019) Koji Ozasa et al.   Frontiers in Immunology

Bronchoscopic instillation of DNase to manage refractory lobar atelectasis in a lung cancer patient

(2019) Hussein Assallum et al.   Annals of Translational Medicine

Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis

(2019) Ki Wung Chung et al.   Cell Metabolism

Self-DNA release and STING-dependent sensing drives inflammation to cigarette smoke in mice

(2019) Mégane Nascimento et al.   Scientific Reports

Mitochondrial Damage Causes Inflammation via cGAS-STING Signaling in Acute Kidney Injury

(2019) Hiroshi Maekawa et al.   Cell Reports

The triggers of the cGAS-STING pathway and the connection with inflammatory and autoimmune diseases

(2019) Ruoyu Zhou et al.   INFECTION GENETICS AND EVOLUTION

Tight nuclear tethering of cGAS is essential for preventing autoreactivity

(2019) Hannah E Volkman et al.   eLife

Novel TMEM173 Mutation and the Role of Disease Modifying Alleles

(2019) Salla Keskitalo et al.   Frontiers in Immunology

Mitochondrial DNA as an inflammatory mediator in cardiovascular diseases

(2018) Hiroyuki Nakayama et al.   BIOCHEMICAL JOURNAL

STING Signaling Promotes Inflammation in Experimental Acute Pancreatitis

(2018) Qinglan Zhao et al.   GASTROENTEROLOGY

TMEM173 variants and potential importance to human biology and disease

(2018) Seema Patel et al.   GENES AND IMMUNITY

The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer

(2018) Tuo Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mechanisms of Gasdermin Family Members in Inflammasome Signaling and Cell Death

(2018) Shouya Feng et al.   JOURNAL OF MOLECULAR BIOLOGY

Chromosomal instability drives metastasis through a cytosolic DNA response

(2018) Samuel F. Bakhoum et al.   NATURE

BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis

(2018) Kate McArthur et al.   SCIENCE

DNA-induced liquid phase condensation of cGAS activates innate immune signaling

(2018) Mingjian Du et al.   SCIENCE

Pro-inflammation Associated with a Gain-of-Function Mutation (R284S) in the Innate Immune Sensor STING

(2018) Hiroyasu Konno et al.   Cell Reports

The cGas–Sting Signaling Pathway Is Required for the Innate Immune Response Against Ectromelia Virus

(2018) Wen-Yu Cheng et al.   Frontiers in Immunology

Detection of Microbial Infections Through Innate Immune Sensing of Nucleic Acids

(2018) Xiaojun Tan et al.   Annual Review of Microbiology

Mitochondrial dysfunction contributes to the senescent phenotype of IPF lung fibroblasts

(2018) Michael Schuliga et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Oxidative stress in chronic lung disease: From mitochondrial dysfunction to dysregulated redox signaling

(2018) Albert van der Vliet et al.   MOLECULAR ASPECTS OF MEDICINE

Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage

(2018) Gillian Dunphy et al.   MOLECULAR CELL

Mitochondria in innate immune signaling

(2018) Balaji Banoth et al.   Translational Research

TREX1 D18N mice fail to process erythroblast DNA resulting in inflammation and dysfunctional erythropoiesis

(2018) Stephen L. Rego et al.   AUTOIMMUNITY

STING-mediated inflammation in Kupffer cells contributes to progression of nonalcoholic steatohepatitis

(2018) Yongsheng Yu et al.   JOURNAL OF CLINICAL INVESTIGATION

The Ca2+ sensor STIM1 regulates the type I interferon response by retaining the signaling adaptor STING at the endoplasmic reticulum

(2018) Sonal Srikanth et al.   NATURE IMMUNOLOGY

STING-dependent sensing of self-DNA drives silica-induced lung inflammation

(2018) Sulayman Benmerzoug et al.   Nature Communications

The allosteric activation of cGAS underpins its dynamic signaling landscape

(2018) Richard M Hooy et al.   eLife

Disease-associated mutations identify a novel region in human STING necessary for the control of type I interferon signaling

(2017) Isabelle Melki et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

DNase-active TREX1 frame-shift mutants induce serologic autoimmunity in mice

(2017) Tomomi Sakai et al.   JOURNAL OF AUTOIMMUNITY

Discrimination of cytosolic self and non-self RNA by RIG-I-like receptors

(2017) Charlotte Lässig et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

STING-associated vasculopathy develops independently of IRF3 in mice

(2017) James D. Warner et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Idiopathic pulmonary fibrosis

(2017) Luca Richeldi et al.   LANCET

cGAS surveillance of micronuclei links genome instability to innate immunity

(2017) Karen J. Mackenzie et al.   NATURE

Cytoplasmic chromatin triggers inflammation in senescence and cancer

(2017) Zhixun Dou et al.   NATURE

cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein–DNA ladders

(2017) Liudmila Andreeva et al.   NATURE

cGAS drives noncanonical-inflammasome activation in age-related macular degeneration

(2017) Nagaraj Kerur et al.   NATURE MEDICINE

Host DNA released by NETosis promotes rhinovirus-induced type-2 allergic asthma exacerbation

(2017) Marie Toussaint et al.   NATURE MEDICINE

DsbA-L prevents obesity-induced inflammation and insulin resistance by suppressing the mtDNA release-activated cGAS-cGAMP-STING pathway

(2017) Juli Bai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Type I interferon-mediated autoinflammation due to DNase II deficiency

(2017) Mathieu P. Rodero et al.   Nature Communications

Trafficking-Mediated STING Degradation Requires Sorting to Acidified Endolysosomes and Can Be Targeted to Enhance Anti-tumor Response

(2017) Vijay K. Gonugunta et al.   Cell Reports

Interstitial Lung Disease Caused by STING-associated Vasculopathy with Onset in Infancy

(2016) Sarah L. N. Clarke et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Familial chilblain lupus due to a gain-of-function mutation in STING

(2016) Nadja König et al.   ANNALS OF THE RHEUMATIC DISEASES

Neutrophil autophagy and extracellular DNA traps contribute to airway inflammation in severe asthma

(2016) D. L. Pham et al.   CLINICAL AND EXPERIMENTAL ALLERGY

cGAS-cGAMP-STING: The three musketeers of cytosolic DNA sensing and signaling

(2016) Jianli Tao et al.   IUBMB LIFE

Mitochondria in lung disease

(2016) Suzanne M. Cloonan et al.   JOURNAL OF CLINICAL INVESTIGATION

Activation of STING requires palmitoylation at the Golgi

(2016) Kojiro Mukai et al.   Nature Communications

Prognostic utility of admission cell-free DNA levels in patients with chronic obstructive pulmonary disease exacerbations

(2016) Avital Avriel et al.   International Journal of Chronic Obstructive Pulmonary Disease

Neutrophil Extracellular Traps in Pulmonary Diseases: Too Much of a Good Thing?

(2016) Bárbara Nery Porto et al.   Frontiers in Immunology

STING Activation by Translocation from the ER Is Associated with Infection and Autoinflammatory Disease

(2015) Nicole Dobbs et al.   Cell Host & Microbe

AIM2 inflammasome in infection, cancer, and autoimmunity: Role in DNA sensing, inflammation, and innate immunity

(2015) Si Ming Man et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Cutting Edge: Antimalarial Drugs Inhibit IFN-β Production through Blockade of Cyclic GMP-AMP Synthase–DNA Interaction

(2015) Jie An et al.   JOURNAL OF IMMUNOLOGY

DNA-Mediated Cyclic GMP–AMP Synthase–Dependent and –Independent Regulation of Innate Immune Responses

(2015) Kou Motani et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: cGAS Is Required for Lethal Autoimmune Disease in the Trex1-Deficient Mouse Model of Aicardi–Goutières Syndrome

(2015) Elizabeth E. Gray et al.   JOURNAL OF IMMUNOLOGY

Mitochondrial DNA stress primes the antiviral innate immune response

(2015) A. Phillip West et al.   NATURE

Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease

(2015) Jessica L. Grieves et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases

(2015) Daxing Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulation of the cGAS-STING DNA sensing pathway by gammaherpesviruses

(2015) Zhe Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

(2015) S. Liu et al.   SCIENCE

DNA damage and cellular abnormalities in tuberculosis, lung cancer and chronic obstructive pulmonary disease

(2015) Andréa Lúcia Gonçalves da Silva et al.   MULTIDISCIPLINARY RESPIRATORY MEDICINE

Stimulator of Interferon Genes–Associated Vasculopathy With Onset in Infancy

(2015) Justine Munoz et al.   JAMA Dermatology

Interferon-Stimulated Genes: A Complex Web of Host Defenses

(2014) William M. Schneider et al.   Annual Review of Immunology

Innate Immune Sensing and Signaling of Cytosolic Nucleic Acids

(2014) Jiaxi Wu et al.   Annual Review of Immunology

Apoptotic Caspases Suppress mtDNA-Induced STING-Mediated Type I IFN Production

(2014) Michael J. White et al.   CELL

Apoptotic Caspases Prevent the Induction of Type I Interferons by Mitochondrial DNA

(2014) Anthony Rongvaux et al.   CELL

Cytosolic RNA:DNA hybrids activate the cGAS–STING axis

(2014) Arun K Mankan et al.   EMBO JOURNAL

Inherited STING-activating mutation underlies a familial inflammatory syndrome with lupus-like manifestations

(2014) Nadia Jeremiah et al.   JOURNAL OF CLINICAL INVESTIGATION

Cystic Fibrosis Sputum DNA Has NETosis Characteristics and Neutrophil Extracellular Trap Release Is Regulated by Macrophage Migration-Inhibitory Factor

(2014) Markryan Dwyer et al.   Journal of Innate Immunity

Cytosolic-DNA-Mediated, STING-Dependent Proinflammatory Gene Induction Necessitates Canonical NF- B Activation through TBK1

(2014) T. Abe et al.   JOURNAL OF VIROLOGY

The cGAS-cGAMP-STING Pathway of Cytosolic DNA Sensing and Signaling

(2014) Xin Cai et al.   MOLECULAR CELL

Activated STING in a Vascular and Pulmonary Syndrome

(2014) Yin Liu et al.   NEW ENGLAND JOURNAL OF MEDICINE

DNA Degradation and Its Defects

(2014) K. Kawane et al.   Cold Spring Harbor Perspectives in Biology

Structure-Function Analysis of STING Activation by c[G(2′,5′)pA(3′,5′)p] and Targeting by Antiviral DMXAA

(2013) Pu Gao et al.   CELL

Sputum neutrophil counts are associated with more severe asthma phenotypes using cluster analysis

(2013) Wendy C. Moore et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING

(2013) Xu Zhang et al.   MOLECULAR CELL

cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING

(2013) Andrea Ablasser et al.   NATURE

Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity

(2013) John W. Schoggins et al.   NATURE

Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects

(2013) X.-D. Li et al.   SCIENCE

Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses

(2013) D. Gao et al.   SCIENCE

Dysfunction of Endothelial Progenitor Cells from Smokers and Chronic Obstructive Pulmonary Disease Patients Due to Increased DNA Damage and Senescence

(2013) Koralia E. Paschalaki et al.   STEM CELLS

Innate immune detection of microbial nucleic acids

(2013) Claudia Gürtler et al.   TRENDS IN MICROBIOLOGY

Structure of Human cGAS Reveals a Conserved Family of Second-Messenger Enzymes in Innate Immunity

(2013) Philip J. Kranzusch et al.   Cell Reports

The Innate Immune DNA Sensor cGAS Produces a Noncanonical Cyclic Dinucleotide that Activates Human STING

(2013) Elie J. Diner et al.   Cell Reports

Targeting mitochondrial dysfunction in lung diseases: emphasis on mitophagy

(2013) Angara Sureshbabu et al.   Frontiers in Physiology

NET balancing: a problem in inflammatory lung diseases

(2013) Olivia Z. Cheng et al.   Frontiers in Immunology

Autoimmunity Initiates in Nonhematopoietic Cells and Progresses via Lymphocytes in an Interferon-Dependent Autoimmune Disease

(2012) Alevtina Gall et al.   IMMUNITY

Neutrophil Extracellular Traps: Double-Edged Swords of Innate Immunity

(2012) M. J. Kaplan et al.   JOURNAL OF IMMUNOLOGY

Crystal structures of STING protein reveal basis for recognition of cyclic di-GMP

(2012) Guijun Shang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

(2012) J. Wu et al.   SCIENCE

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

Nucleic Acid Recognition by the Innate Immune System

(2011) Roman Barbalat et al.   Annual Review of Immunology

Evaluation of the TREX1 gene in a large multi-ancestral lupus cohort

(2011) B Namjou et al.   GENES AND IMMUNITY

Immune Signaling by RIG-I-like Receptors

(2011) Yueh-Ming Loo et al.   IMMUNITY

STING is a direct innate immune sensor of cyclic di-GMP

(2011) Dara L. Burdette et al.   NATURE

Loss-of-function variant in DNASE1L3 causes a familial form of systemic lupus erythematosus

(2011) Sulaiman M Al-Mayouf et al.   NATURE GENETICS

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

DNase 1 activity in patients with systemic lupus erythematosus: relationship with epidemiological, clinical, immunological and therapeutical features

(2009) F Martinez-Valle et al.   LUPUS

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

(2009) Teresa Fernandes-Alnemri et al.   NATURE

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

(2009) Veit Hornung et al.   NATURE

An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome

(2009) Tilmann Bürckstümmer et al.   NATURE IMMUNOLOGY

Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response

(2009) T. Saitoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trex1 Prevents Cell-Intrinsic Initiation of Autoimmunity

(2008) Daniel B. Stetson et al.   CELL

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE